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Aliases for TREML2 Gene

Aliases for TREML2 Gene

  • Triggering Receptor Expressed On Myeloid Cells Like 2 2 3 5
  • Triggering Receptor Expressed On Myeloid Cells-Like Protein 2 3 4
  • C6orf76 3 4
  • TLT-2 3 4
  • TLT2 3 4
  • Triggering Receptor Expressed On Myeloid Cells-Like 2 2
  • Chromosome 6 Open Reading Frame 76 2
  • Trem-Like Transcript 2 Protein 3
  • TREM-Like Transcript 2 2
  • DJ238O23.1 3

External Ids for TREML2 Gene

Previous HGNC Symbols for TREML2 Gene

  • C6orf76

Previous GeneCards Identifiers for TREML2 Gene

  • GC06M041206
  • GC06M041266
  • GC06M040875

Summaries for TREML2 Gene

Entrez Gene Summary for TREML2 Gene

  • TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TREML2 Gene

TREML2 (Triggering Receptor Expressed On Myeloid Cells Like 2) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot for TREML2 Gene

  • Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.

Additional gene information for TREML2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TREML2 Gene

Genomics for TREML2 Gene

GeneHancer (GH) Regulatory Elements for TREML2 Gene

Promoters and enhancers for TREML2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I041198 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.2 -236 6.2 HDGF ATF1 SMAD1 ARNT TCF12 RUNX3 ZNF263 NCOA1 ZNF592 MBD2 TREML2 TREML4 TREML3P TREM2 USP49 ADCY10P1 NFYA TREML5P TREML1 ENSG00000218809
GH06I041171 Enhancer 0.7 ENCODE 12.2 +29.4 29364 0.8 HDAC1 TEAD4 TAL1 MAX ZKSCAN1 TCF12 CTBP1 NCOR1 CBFA2T2 SOX6 TREML2 TSPO2 UNC5CL TREM2 LOC105375056
GH06I041271 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 6.1 -71.0 -70965 2.3 CTCF POLR2A ZFP64 MAX CREB1 MYC ZKSCAN1 GABPA ENSG00000218809 TREM1 TREML4 NFYA TREML3P TFEB TREML2 TREML1 GC06M041280
GH06I041278 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 4.6 -78.0 -78006 0.8 HDGF ATF1 SMAD1 ARNT IRF4 NCOA2 TCF12 ZNF766 GATA2 E2F8 TREM1 USP49 NFYA TFEB TREML2 TREML4 GC06M041280 ENSG00000218809
GH06I041181 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 4.7 +18.6 18562 1.7 CTCF USF1 TEAD4 MAX RAD21 TCF12 ZNF143 ZNF654 L3MBTL2 TRIM22 TREM1 ADCY10P1 TREML1 TREML4 NFYA TREML2 TREM2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TREML2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TREML2 gene promoter:

Genomic Locations for TREML2 Gene

Genomic Locations for TREML2 Gene
chr6:41,189,749-41,201,194
(GRCh38/hg38)
Size:
11,446 bases
Orientation:
Minus strand
chr6:41,157,552-41,168,932
(GRCh37/hg19)

Genomic View for TREML2 Gene

Genes around TREML2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TREML2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TREML2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREML2 Gene

Proteins for TREML2 Gene

  • Protein details for TREML2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T2D2-TRML2_HUMAN
    Recommended name:
    Trem-like transcript 2 protein
    Protein Accession:
    Q5T2D2
    Secondary Accessions:
    • Q08AP8
    • Q08AP9
    • Q8IWY0
    • Q9H8E9

    Protein attributes for TREML2 Gene

    Size:
    321 amino acids
    Molecular mass:
    35127 Da
    Quaternary structure:
    • Interacts with CD276 and this interaction enhances T-cell activation.
    SequenceCaution:
    • Sequence=AAI25079.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI25080.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14668.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19858.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19909.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TREML2 Gene

Post-translational modifications for TREML2 Gene

  • Glycosylation at isoforms=89
  • Modification sites at PhosphoSitePlus

Other Protein References for TREML2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TREML2 Gene

Domains & Families for TREML2 Gene

Gene Families for TREML2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for TREML2 Gene

Suggested Antigen Peptide Sequences for TREML2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TREML2: view

No data available for UniProtKB/Swiss-Prot for TREML2 Gene

Function for TREML2 Gene

Molecular function for TREML2 Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.
UniProtKB/Swiss-Prot Induction:
Induced in CD4 T-cells by concanavalin-A.

Phenotypes From GWAS Catalog for TREML2 Gene

Gene Ontology (GO) - Molecular Function for TREML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA 18650384
GO:0005515 protein binding IPI 18650384
genes like me logo Genes that share ontologies with TREML2: view
genes like me logo Genes that share phenotypes with TREML2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TREML2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TREML2 Gene

Localization for TREML2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREML2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TREML2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TREML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 18650384
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TREML2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TREML2 Gene

Pathways & Interactions for TREML2 Gene

genes like me logo Genes that share pathways with TREML2: view

Pathways by source for TREML2 Gene

Gene Ontology (GO) - Biological Process for TREML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042110 T cell activation IDA 18650384
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with TREML2: view

No data available for SIGNOR curated interactions for TREML2 Gene

Drugs & Compounds for TREML2 Gene

No Compound Related Data Available

Transcripts for TREML2 Gene

mRNA/cDNA for TREML2 Gene

Unigene Clusters for TREML2 Gene

Triggering receptor expressed on myeloid cells-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TREML2 Gene

No ASD Table

Relevant External Links for TREML2 Gene

GeneLoc Exon Structure for
TREML2
ECgene alternative splicing isoforms for
TREML2

Expression for TREML2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TREML2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TREML2 Gene

This gene is overexpressed in Whole Blood (x43.0).

Protein differential expression in normal tissues from HIPED for TREML2 Gene

This gene is overexpressed in Serum (30.4), Lung (23.2), and Peripheral blood mononuclear cells (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TREML2 Gene



Protein tissue co-expression partners for TREML2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TREML2 Gene:

TREML2

SOURCE GeneReport for Unigene cluster for TREML2 Gene:

Hs.164797

mRNA Expression by UniProt/SwissProt for TREML2 Gene:

Q5T2D2-TRML2_HUMAN
Tissue specificity: Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation.
genes like me logo Genes that share expression patterns with TREML2: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TREML2 Gene

Orthologs for TREML2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TREML2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TREML2 33 34
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia LOC481791 33
  • 79.53 (n)
TREML2 34
  • 44 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TREML2 33 34
  • 74.83 (n)
mouse
(Mus musculus)
Mammalia Treml2 33 16 34
  • 69.06 (n)
rat
(Rattus norvegicus)
Mammalia Treml2 33
  • 68.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TREML2 34
  • 38 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TREML2 34
  • 34 (a)
OneToOne
Species where no ortholog for TREML2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TREML2 Gene

ENSEMBL:
Gene Tree for TREML2 (if available)
TreeFam:
Gene Tree for TREML2 (if available)

Paralogs for TREML2 Gene

Pseudogenes.org Pseudogenes for TREML2 Gene

genes like me logo Genes that share paralogs with TREML2: view

No data available for Paralogs for TREML2 Gene

Variants for TREML2 Gene

Sequence variations from dbSNP and Humsavar for TREML2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000134381 -- 41,203,048(-) G/A upstream_transcript_variant
rs1000272195 -- 41,202,796(-) T/C upstream_transcript_variant
rs1000465879 -- 41,191,568(-) C/G 3_prime_UTR_variant
rs1000732933 -- 41,202,915(-) G/A upstream_transcript_variant
rs1001011354 -- 41,190,047(-) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for TREML2 Gene

Variant ID Type Subtype PubMed ID
esv994929 CNV deletion 20482838
nsv602970 CNV gain 21841781

Variation tolerance for TREML2 Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.09; 69.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TREML2 Gene

Human Gene Mutation Database (HGMD)
TREML2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TREML2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TREML2 Gene

Disorders for TREML2 Gene

Additional Disease Information for TREML2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TREML2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TREML2 Gene

Publications for TREML2 Gene

  1. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. (PMID: 12645956) Allcock RJ … Trowsdale J (European journal of immunology 2003) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses. (PMID: 18650384) Hashiguchi M … Azuma M (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for TREML2 Gene

Sources for TREML2 Gene

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