Aliases for TREML2 Gene
External Ids for TREML2 Gene
Previous HGNC Symbols for TREML2 Gene
Previous GeneCards Identifiers for TREML2 Gene
TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]
GeneCards Summary for TREML2 Gene
TREML2 (Triggering Receptor Expressed On Myeloid Cells Like 2) is a Protein Coding gene. Diseases associated with TREML2 include Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is NCR2.
UniProtKB/Swiss-Prot Summary for TREML2 Gene
Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.