TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008] See more...

Aliases for TREML2 Gene

Aliases for TREML2 Gene

  • Triggering Receptor Expressed On Myeloid Cells Like 2 2 3 5
  • TLT2 2 3 4
  • Triggering Receptor Expressed On Myeloid Cells-Like Protein 2 3 4
  • Trem-Like Transcript 2 Protein 3 4
  • DJ238O23.1 2 3
  • C6orf76 3 4
  • TLT-2 3 4
  • Triggering Receptor Expressed On Myeloid Cells-Like 2 2
  • Chromosome 6 Open Reading Frame 76 2
  • TREM-Like Transcript 2 2
  • FLJ13693 2
  • TREML2 5

External Ids for TREML2 Gene

Previous HGNC Symbols for TREML2 Gene

  • C6orf76

Previous GeneCards Identifiers for TREML2 Gene

  • GC06M041206
  • GC06M041266
  • GC06M041157
  • GC06M040875
  • GC06M041228
  • GC06M041363

Summaries for TREML2 Gene

Entrez Gene Summary for TREML2 Gene

  • TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TREML2 Gene

TREML2 (Triggering Receptor Expressed On Myeloid Cells Like 2) is a Protein Coding gene. Diseases associated with TREML2 include Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is NCR2.

UniProtKB/Swiss-Prot Summary for TREML2 Gene

  • Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.

Additional gene information for TREML2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TREML2 Gene

Genomics for TREML2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TREML2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J041198 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 600.7 -0.2 -197 6.2 PRDM10 RFX1 LEF1 IKZF1 BACH1 JUND MTA2 ZNF24 MTA1 IKZF2 TREML2 TREML4 TREML3P TREM2 USP49 ADCY10P1 NFYA TREML5P TREML1 ENSG00000218809
GH06J041171 Enhancer 0.8 Ensembl ENCODE 12.3 +29.8 29783 1.7 HDAC1 SOX6 CTBP1 HDAC2 ZKSCAN1 NCOR1 TAL1 DPF2 TCF12 KDM1A lnc-TREM2-2 TREML2 TSPO2 UNC5CL KR153194-170 lnc-TREM2-1 TREM2 LOC105375056
GH06J041242 Enhancer 0.6 FANTOM5 Ensembl 15.7 -41.2 -41168 0.8 ZNF24 ZFP91 ZNF579 HSALNG0050001 TREML4 TREML2 UNC5CL TREML1 TSPO2 TREM1 NFYA TFEB TREML5P
GH06J041278 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.6 -78.0 -77979 0.8 RNF2 GATAD2A CTCF LEF1 IKZF1 ZNF692 JUND ZNF300 PRDM1 ZNF143 TREM1 USP49 NFYA TFEB TREML2 TREML4 lnc-TREML2-2 lnc-TREML2-4
GH06J041181 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 4.7 +18.5 18452 1.4 CTCF JUND REST RAD21 TRIM22 EP300 MGA USF1 NR2C2 SMC3 TREM1 ADCY10P1 TREML1 TREML4 NFYA TREML2 LOC107986595 lnc-TREM2-1 TREM2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TREML2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TREML2

Top Transcription factor binding sites by QIAGEN in the TREML2 gene promoter:
  • Arnt
  • ARP-1
  • c-Ets-1
  • LyF-1
  • NRF-2
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • PPAR-alpha

Genomic Locations for TREML2 Gene

Genomic Locations for TREML2 Gene
chr6:41,189,749-41,201,233
(GRCh38/hg38)
Size:
11,485 bases
Orientation:
Minus strand
chr6:41,157,552-41,168,932
(GRCh37/hg19)
Size:
11,381 bases
Orientation:
Minus strand

Genomic View for TREML2 Gene

Genes around TREML2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TREML2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TREML2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREML2 Gene

Proteins for TREML2 Gene

  • Protein details for TREML2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T2D2-TRML2_HUMAN
    Recommended name:
    Trem-like transcript 2 protein
    Protein Accession:
    Q5T2D2
    Secondary Accessions:
    • Q08AP8
    • Q08AP9
    • Q8IWY0
    • Q9H8E9

    Protein attributes for TREML2 Gene

    Size:
    321 amino acids
    Molecular mass:
    35127 Da
    Quaternary structure:
    • Interacts with CD276 and this interaction enhances T-cell activation.
    SequenceCaution:
    • Sequence=AAI25079.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI25080.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14668.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TREML2 Gene

Post-translational modifications for TREML2 Gene

  • Glycosylation at Asn89
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • TRML2_HUMAN (1980)

Other Protein References for TREML2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TREML2 Gene

Domains & Families for TREML2 Gene

Gene Families for TREML2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for TREML2 Gene

InterPro:
Blocks:
  • Immunoglobulin V-set
ProtoNet:

Suggested Antigen Peptide Sequences for TREML2 Gene

GenScript: Design optimal peptide antigens:
  • Triggering receptor expressed on myeloid cells-like protein 2 (TRML2_HUMAN)
genes like me logo Genes that share domains with TREML2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TREML2 Gene

Function for TREML2 Gene

Molecular function for TREML2 Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.
UniProtKB/Swiss-Prot Induction:
Induced in CD4 T-cells by concanavalin-A.

Phenotypes From GWAS Catalog for TREML2 Gene

Gene Ontology (GO) - Molecular Function for TREML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18650384
GO:0038023 signaling receptor activity IDA 18650384
genes like me logo Genes that share ontologies with TREML2: view
genes like me logo Genes that share phenotypes with TREML2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TREML2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TREML2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TREML2 Gene

Localization for TREML2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREML2 Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TREML2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TREML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IBA,IDA 18650384
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TREML2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TREML2 Gene

Pathways & Interactions for TREML2 Gene

genes like me logo Genes that share pathways with TREML2: view

Pathways by source for TREML2 Gene

Gene Ontology (GO) - Biological Process for TREML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042110 T cell activation IBA,IDA 18650384
GO:0045088 regulation of innate immune response IBA 21873635
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with TREML2: view

No data available for SIGNOR curated interactions for TREML2 Gene

Drugs & Compounds for TREML2 Gene

No Compound Related Data Available

Transcripts for TREML2 Gene

mRNA/cDNA for TREML2 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TREML2

Alternative Splicing Database (ASD) splice patterns (SP) for TREML2 Gene

No ASD Table

Relevant External Links for TREML2 Gene

GeneLoc Exon Structure for
TREML2

Expression for TREML2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TREML2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TREML2 Gene

This gene is overexpressed in Whole Blood (x43.0).

Protein differential expression in normal tissues from HIPED for TREML2 Gene

This gene is overexpressed in Serum (30.4), Lung (23.2), and Peripheral blood mononuclear cells (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TREML2 Gene



Protein tissue co-expression partners for TREML2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TREML2

SOURCE GeneReport for Unigene cluster for TREML2 Gene:

Hs.164797

mRNA Expression by UniProt/SwissProt for TREML2 Gene:

Q5T2D2-TRML2_HUMAN
Tissue specificity: Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation.

Evidence on tissue expression from TISSUES for TREML2 Gene

  • Blood(2.1)
  • Spleen(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with TREML2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TREML2 Gene

Orthologs for TREML2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TREML2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TREML2 30 31
  • 99.38 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC481791 30
  • 79.53 (n)
TREML2 31
  • 44 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia TREML2 30 31
  • 74.83 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Treml2 30 17 31
  • 69.06 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Treml2 30
  • 68.35 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia TREML2 31
  • 38 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TREML2 31
  • 34 (a)
OneToOne
Species where no ortholog for TREML2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TREML2 Gene

ENSEMBL:
Gene Tree for TREML2 (if available)
TreeFam:
Gene Tree for TREML2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TREML2: view image

Paralogs for TREML2 Gene

Paralogs for TREML2 Gene

Pseudogenes.org Pseudogenes for TREML2 Gene

genes like me logo Genes that share paralogs with TREML2: view

Variants for TREML2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TREML2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
769682 Benign: not provided 41,198,416(-) G/C MISSENSE_VARIANT
rs35512890 - p.Val50Met
rs35521209 - p.Val285Ile
rs3747742 - p.Ser144Gly
rs4418164 - p.Gly19Cys

Additional dbSNP identifiers (rs#s) for TREML2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TREML2 Gene

Variant ID Type Subtype PubMed ID
esv994929 CNV deletion 20482838
nsv602970 CNV gain 21841781

Variation tolerance for TREML2 Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.09; 69.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TREML2 Gene

Human Gene Mutation Database (HGMD)
TREML2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TREML2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TREML2 Gene

Disorders for TREML2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TREML2 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TREML2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TREML2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TREML2 Gene

Publications for TREML2 Gene

  1. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. (PMID: 12645956) Allcock RJ … Trowsdale J (European journal of immunology 2003) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses. (PMID: 18650384) Hashiguchi M … Azuma M (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4

Products for TREML2 Gene

  • Boster Bio Antibodies for TREML2
  • Boster Bio ELISA Kits for TREML2
  • Signalway Proteins for TREML2

Sources for TREML2 Gene