Aliases for TREML1 Gene
External Ids for TREML1 Gene
Previous GeneCards Identifiers for TREML1 Gene
This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]
GeneCards Summary for TREML1 Gene
TREML1 (Triggering Receptor Expressed On Myeloid Cells Like 1) is a Protein Coding gene. Diseases associated with TREML1 include Gray Platelet Syndrome and Shwartzman Phenomenon. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is PIGR.
UniProtKB/Swiss-Prot Summary for TREML1 Gene
Cell surface receptor that may play a role in the innate and adaptive immune response.