This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced ... See more...

Aliases for TREM1 Gene

Aliases for TREM1 Gene

  • Triggering Receptor Expressed On Myeloid Cells 1 2 3 4 5
  • Triggering Receptor Expressed On Monocytes 1 3 4
  • TREM-1 3 4
  • CD354 Antigen 4
  • CD354 3

External Ids for TREM1 Gene

Previous GeneCards Identifiers for TREM1 Gene

  • GC06M041245
  • GC06M041290
  • GC06M041351
  • GC06M041243
  • GC06M040962

Summaries for TREM1 Gene

Entrez Gene Summary for TREM1 Gene

  • This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

GeneCards Summary for TREM1 Gene

TREM1 (Triggering Receptor Expressed On Myeloid Cells 1) is a Protein Coding gene. Diseases associated with TREM1 include Suppurative Cholangitis and Acute Cholangitis. Among its related pathways are Toll-like Receptor Signaling Pathway and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include scaffold protein binding.

UniProtKB/Swiss-Prot Summary for TREM1 Gene

  • Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.

Gene Wiki entry for TREM1 Gene

Additional gene information for TREM1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TREM1 Gene

Genomics for TREM1 Gene

GeneHancer (GH) Regulatory Elements for TREM1 Gene

Promoters and enhancers for TREM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J041286 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 500.7 -0.1 -57 2.1 POLR2A RFX1 EP300 GABPA CTCF CEBPG FOS CEBPB RFX5 RXRA TREM1 5MWI_A-161
GH06J041285 Promoter/Enhancer 1 FANTOM5 Ensembl dbSUPER 509.8 +1.8 1765 0.5 RFX1 RBM25 ZNF24 CEBPB TREM1 TFEB NFYA TREML2 TREML4 lnc-TREML2-2
GH06J041288 Enhancer 0.8 ENCODE dbSUPER 500.7 -1.5 -1539 0.2 ZBTB40 POLR2A FOS ARNT NBN BATF IKZF1 NFATC3 MAZ ATF2 TREM1 5MWI_A-161
GH06J041181 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 40.6 +103.9 103938 1.4 CTCF USF1 REST MYC RAD21 TRIM22 SMC3 MAX SPI1 NR2F1 TREM1 ADCY10P1 TREML1 TREML4 NFYA TREML2 lnc-TREM2-1
GH06J041273 Enhancer 1 FANTOM5 ENCODE dbSUPER 41.6 +14.6 14629 0.8 CREB1 CTCF SPI1 GABPA ZFP64 POLR2A MYC MAX SP1 ENSG00000218809 lnc-TREML2-4 TREM1 TREML4 TREML3P NFYA TFEB TREML2 TREML1 lnc-TREML2-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TREM1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TREM1

Top Transcription factor binding sites by QIAGEN in the TREM1 gene promoter:
  • AP-1
  • AREB6
  • Bach2
  • Brachyury
  • ISGF-3
  • Nkx2-5
  • Pax-4a
  • Roaz
  • STAT5A

Genomic Locations for TREM1 Gene

Genomic Locations for TREM1 Gene
chr6:41,267,385-41,286,719
(GRCh38/hg38)
Size:
19,335 bases
Orientation:
Minus strand
chr6:41,235,664-41,254,457
(GRCh37/hg19)
Size:
18,794 bases
Orientation:
Minus strand

Genomic View for TREM1 Gene

Genes around TREM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TREM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TREM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREM1 Gene

Proteins for TREM1 Gene

  • Protein details for TREM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP99-TREM1_HUMAN
    Recommended name:
    Triggering receptor expressed on myeloid cells 1
    Protein Accession:
    Q9NP99
    Secondary Accessions:
    • B4DWG2
    • K7EJW1
    • Q53FL8
    • Q5T2C9
    • Q86YU1

    Protein attributes for TREM1 Gene

    Size:
    234 amino acids
    Molecular mass:
    26387 Da
    Quaternary structure:
    • Interacts with TYROBP/DAP12.

    Three dimensional structures from OCA and Proteopedia for TREM1 Gene

    Alternative splice isoforms for TREM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TREM1 Gene

Post-translational modifications for TREM1 Gene

No data available for DME Specific Peptides for TREM1 Gene

Domains & Families for TREM1 Gene

Gene Families for TREM1 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TREM1 Gene

Blocks:
  • Immunoglobulin subtype
  • Immunoglobulin V-set
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TREM1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ93589, Homo sapiens triggering receptor expressed on myeloid cells 1 (TREM1), mRNA (Q38L15_HUMAN)
  • Triggering receptor expressed on monocytes 1 (TREM1_HUMAN)
genes like me logo Genes that share domains with TREM1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TREM1 Gene

Function for TREM1 Gene

Molecular function for TREM1 Gene

UniProtKB/Swiss-Prot Function:
Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.
UniProtKB/Swiss-Prot Induction:
Up-regulated by bacteria, fungi and bacterial lipopolysaccharides (LPS).

Phenotypes From GWAS Catalog for TREM1 Gene

Gene Ontology (GO) - Molecular Function for TREM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038023 signaling receptor activity TAS,IEA --
GO:0097110 scaffold protein binding IPI 11602640
genes like me logo Genes that share ontologies with TREM1: view
genes like me logo Genes that share phenotypes with TREM1: view

Animal Models for TREM1 Gene

MGI Knock Outs for TREM1:
  • Trem1 Trem1<tm1.1Ahoru>
  • Trem1 Trem1<tm1(KOMP)Vlcg>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TREM1 Gene

Localization for TREM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREM1 Gene

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.
[Isoform 2]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TREM1 gene
Compartment Confidence
plasma membrane 4
extracellular 4
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
cytosol 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TREM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TREM1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TREM1 Gene

Pathways & Interactions for TREM1 Gene

genes like me logo Genes that share pathways with TREM1: view

Pathways by source for TREM1 Gene

1 Qiagen pathway for TREM1 Gene
  • TREM1 Pathway

Interacting Proteins for TREM1 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000244709 Q9NP99-TREM1_HUMAN for TREM1 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for TREM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002526 acute inflammatory response IEA --
GO:0006959 humoral immune response TAS 10799849
GO:0035556 intracellular signal transduction TAS 10799849
GO:0045087 innate immune response TAS --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with TREM1: view

No data available for SIGNOR curated interactions for TREM1 Gene

Drugs & Compounds for TREM1 Gene

(3) Drugs for TREM1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D-tartaric acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with TREM1: view

Transcripts for TREM1 Gene

mRNA/cDNA for TREM1 Gene

3 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TREM1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for TREM1 Gene

GeneLoc Exon Structure for
TREM1

Expression for TREM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TREM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TREM1 Gene

This gene is overexpressed in Whole Blood (x44.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TREM1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TREM1

SOURCE GeneReport for Unigene cluster for TREM1 Gene:

Hs.283022

mRNA Expression by UniProt/SwissProt for TREM1 Gene:

Q9NP99-TREM1_HUMAN
Tissue specificity: Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.

Evidence on tissue expression from TISSUES for TREM1 Gene

  • Blood(4.6)
  • Lung(4.6)
  • Spleen(2.5)
  • Intestine(2.4)
  • Bone marrow(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with TREM1: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TREM1 Gene

Orthologs for TREM1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TREM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TREM1 31 30
  • 99.29 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TREM1 31 30
  • 73.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TREM1 31 30
  • 67.4 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trem1 30
  • 64.22 (n)
mouse
(Mus musculus)
Mammalia Trem1 17 31 30
  • 62.88 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 33 (a)
OneToMany
-- 31
  • 31 (a)
OneToMany
Species where no ortholog for TREM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TREM1 Gene

ENSEMBL:
Gene Tree for TREM1 (if available)
TreeFam:
Gene Tree for TREM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TREM1: view image

Paralogs for TREM1 Gene

Pseudogenes.org Pseudogenes for TREM1 Gene

genes like me logo Genes that share paralogs with TREM1: view

No data available for Paralogs for TREM1 Gene

Variants for TREM1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TREM1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
723369 Benign: not provided 41,282,397(-) T/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
729412 Likely Benign: not provided 41,282,456(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
768088 Benign: not provided 41,276,188(-) G/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
768089 Benign: not provided 41,276,197(-) A/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
VAR_035525 A breast cancer sample p.Arg97Ser

Additional dbSNP identifiers (rs#s) for TREM1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TREM1 Gene

Variant ID Type Subtype PubMed ID
esv3608789 CNV loss 21293372

Variation tolerance for TREM1 Gene

Residual Variation Intolerance Score: 68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TREM1 Gene

Human Gene Mutation Database (HGMD)
TREM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TREM1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TREM1 Gene

Disorders for TREM1 Gene

MalaCards: The human disease database

(19) MalaCards diseases for TREM1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
suppurative cholangitis
acute cholangitis
relapsing polychondritis
  • chondromalacia, systemic
septic arthritis
  • infectious arthritis
pneumonia
  • acute pneumonia
- elite association - COSMIC cancer census association via MalaCards
Search TREM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TREM1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TREM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TREM1 Gene

Publications for TREM1 Gene

  1. TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development. (PMID: 11922939) Gingras MC … Margolin JF (Molecular immunology 2002) 2 3 4 23 54
  2. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. (PMID: 10799849) Bouchon A … Colonna M (Journal of immunology (Baltimore, Md. : 1950) 2000) 2 3 4 23 54
  3. Lack of association between TREM-1 gene polymorphisms and severe sepsis in a Chinese Han population. (PMID: 18396215) Chen Q … Fang X (Human immunology 2008) 3 23 41 54
  4. Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A. (PMID: 15351648) Kelker MS … Wilson IA (Journal of molecular biology 2004) 3 4 23 54
  5. Crystal structure of the human myeloid cell activating receptor TREM-1. (PMID: 14656437) Radaev S … Sun PD (Structure (London, England : 1993) 2003) 3 4 23 54

Products for TREM1 Gene

Sources for TREM1 Gene