Aliases for TREM1 Gene
External Ids for TREM1 Gene
Previous GeneCards Identifiers for TREM1 Gene
This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
GeneCards Summary for TREM1 Gene
TREM1 (Triggering Receptor Expressed On Myeloid Cells 1) is a Protein Coding gene. Diseases associated with TREM1 include Suppurative Cholangitis and Acute Cholangitis. Among its related pathways are Cell surface interactions at the vascular wall and Toll-like Receptor Signaling Pathway. Gene Ontology (GO) annotations related to this gene include scaffold protein binding.
UniProtKB/Swiss-Prot Summary for TREM1 Gene
Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.