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Aliases for TRDV3 Gene

Aliases for TRDV3 Gene

  • T Cell Receptor Delta Variable 3 2 3
  • T-Cell Receptor Delta Variable 3 5
  • HDV103S1 3

External Ids for TRDV3 Gene

Previous GeneCards Identifiers for TRDV3 Gene

  • GC14U990266
  • GC14M020928
  • GC14M022007
  • GC14M022939

Summaries for TRDV3 Gene

Entrez Gene Summary for TRDV3 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRDV3 Gene

TRDV3 (T Cell Receptor Delta Variable 3) is a Protein Coding gene.

Additional gene information for TRDV3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRDV3 Gene

Genomics for TRDV3 Gene

GeneHancer (GH) Regulatory Elements for TRDV3 Gene

Promoters and enhancers for TRDV3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I022468 Enhancer 0.9 Ensembl ENCODE dbSUPER 550.8 -0.1 -71 2.6 MITF MEIS2 ZNF282 PKNOX1 USF1 REST TRDV3 ABHD4 TRAJ61 ENSG00000251002 LOC105370401 TRA
GH14I022471 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.8 -2.1 -2103 0.4 HDGF NFIB BMI1 ZBTB40 RAD21 RFX5 ELK1 ZNF143 ZNF207 BCLAF1 TRAJ61 TRDV3 ENSG00000251002 LOC105370401 TRA
GH14I022463 Enhancer 1 ENCODE dbSUPER 0.8 +3.8 3773 4.6 PKNOX1 BMI1 BATF IRF4 ZNF23 ATF7 ETV6 IKZF2 RUNX3 SMARCA5 PABPN1 ENSG00000258458 TRDC TRDV3 LOC105370401 ENSG00000251002 TRD TRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRDV3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRDV3 Gene

Genomic Locations for TRDV3 Gene
chr14:22,469,041-22,469,698
(GRCh38/hg38)
Size:
658 bases
Orientation:
Minus strand
chr14:22,938,033-22,938,690
(GRCh37/hg19)

Genomic View for TRDV3 Gene

Genes around TRDV3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRDV3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRDV3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRDV3 Gene

Proteins for TRDV3 Gene

  • Protein details for TRDV3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0JD37
    Recommended name:
    HDV103S1
    Protein Accession:
    A0JD37

    Protein attributes for TRDV3 Gene

    Size:
    113 amino acids
    Molecular mass:
    12981 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TRDV3 Gene

neXtProt entry for TRDV3 Gene

Post-translational modifications for TRDV3 Gene

No Post-translational modifications

Other Protein References for TRDV3 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRDV3 Gene

Domains & Families for TRDV3 Gene

Gene Families for TRDV3 Gene

Protein Domains for TRDV3 Gene

Suggested Antigen Peptide Sequences for TRDV3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRDV3: view

No data available for UniProtKB/Swiss-Prot for TRDV3 Gene

Function for TRDV3 Gene

Phenotypes From GWAS Catalog for TRDV3 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRDV3 Gene

Localization for TRDV3 Gene

Gene Ontology (GO) - Cellular Components for TRDV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with TRDV3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TRDV3 Gene

Pathways & Interactions for TRDV3 Gene

SuperPathways for TRDV3 Gene

No Data Available

Interacting Proteins for TRDV3 Gene

Gene Ontology (GO) - Biological Process for TRDV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with TRDV3: view

No data available for Pathways by source and SIGNOR curated interactions for TRDV3 Gene

Drugs & Compounds for TRDV3 Gene

No Compound Related Data Available

Transcripts for TRDV3 Gene

mRNA/cDNA for TRDV3 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRDV3 Gene

No ASD Table

Relevant External Links for TRDV3 Gene

GeneLoc Exon Structure for
TRDV3
ECgene alternative splicing isoforms for
TRDV3

Expression for TRDV3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRDV3 Gene

mRNA differential expression in normal tissues according to GTEx for TRDV3 Gene

This gene is overexpressed in Whole Blood (x16.7).

NURSA nuclear receptor signaling pathways regulating expression of TRDV3 Gene:

TRDV3
genes like me logo Genes that share expression patterns with TRDV3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRDV3 Gene

Orthologs for TRDV3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRDV3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TRDV3 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRDV3 34
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRDV3 34
  • 44 (a)
OneToOne
Species where no ortholog for TRDV3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRDV3 Gene

ENSEMBL:
Gene Tree for TRDV3 (if available)
TreeFam:
Gene Tree for TRDV3 (if available)

Paralogs for TRDV3 Gene

No data available for Paralogs for TRDV3 Gene

Variants for TRDV3 Gene

Additional Variant Information for TRDV3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRDV3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRDV3 Gene

Disorders for TRDV3 Gene

Additional Disease Information for TRDV3

No disorders were found for TRDV3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRDV3 Gene

Publications for TRDV3 Gene

  1. Human T-cell-receptor delta chain: genomic organization, diversity, and expression in populations of cells. (PMID: 2974163) Loh EY … Lanier LL (Proceedings of the National Academy of Sciences of the United States of America 1988) 2 3 58
  2. Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones. (PMID: 9110172) Boysen C … Hood L (Genome research 1997) 3 58
  3. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K … Shimizu N (Genome research 1997) 3 58
  4. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop BF … Hood L (Genomics 1994) 3 58

Products for TRDV3 Gene

Sources for TRDV3 Gene

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