Aliases for TRDMT1 Gene
- TRNA Aspartic Acid Methyltransferase 1 2 3 5
- TRNA (Cytosine(38)-C(5))-Methyltransferase 2 3 4
- DNA (Cytosine-5)-Methyltransferase-Like Protein 2 3 4
- DNA MTase Homolog HsaIIP 3 4
- DNMT2 3 4
- DNA (Cytosine-5-)-Methyltransferase 2 2
- TRNA (Cytosine-5-)-Methyltransferase 3
- DNA Methyltransferase Homolog HsaIIP 4
- DNA Cytosine-5 Methyltransferase 2 3
- DNA Methyltransferase-2 3
External Ids for TRDMT1 Gene
Previous HGNC Symbols for TRDMT1 Gene
Previous GeneCards Identifiers for TRDMT1 Gene
This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. [provided by RefSeq, Jun 2010]
GeneCards Summary for TRDMT1 Gene
TRDMT1 (TRNA Aspartic Acid Methyltransferase 1) is a Protein Coding gene. Diseases associated with TRDMT1 include Neuropathy, Hereditary Sensory, Type Ie and Amebiasis. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include RNA binding and DNA (cytosine-5-)-methyltransferase activity. An important paralog of this gene is DNMT1.
UniProtKB/Swiss-Prot Summary for TRDMT1 Gene
Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).
Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.