Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRBV5-1 Gene

Aliases for TRBV5-1 Gene

  • T Cell Receptor Beta Variable 5-1 2 3 5
  • TCRBV5S1A1T 3 4
  • TCRBV5S1 3
  • TRBV51 3

External Ids for TRBV5-1 Gene

Previous GeneCards Identifiers for TRBV5-1 Gene

  • GC07U990237
  • GC07P141351
  • GC07P141428
  • GC07P141475
  • GC07P141668
  • GC07P142163
  • GC07P142185
  • GC07P142322
  • GC07P142371
  • GC07P142409
  • GC07P142460
  • GC07P142582
  • GC07P142673
  • GC07P142741
  • GC07P142803
  • GC07P142602
  • GC07P142836
  • GC07P142999
  • GC07P143147
  • GC07P143347
  • GC07P143492
  • GC07P143628
  • GC07P143760

Summaries for TRBV5-1 Gene

GeneCards Summary for TRBV5-1 Gene

TRBV5-1 (T Cell Receptor Beta Variable 5-1) is a Protein Coding gene. An important paralog of this gene is TRBV5-3.

UniProtKB/Swiss-Prot for TRBV5-1 Gene

  • V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

Additional gene information for TRBV5-1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRBV5-1 Gene

Genomics for TRBV5-1 Gene

GeneHancer (GH) Regulatory Elements for TRBV5-1 Gene

Promoters and enhancers for TRBV5-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J142321 Enhancer 0.7 ENCODE dbSUPER 650.7 -0.5 -490 0.2 CTCF ZNF3 ZNF316 ZNF143 MAFK TRBV5-1 TRBV4-1 TRB
GH07J142320 Enhancer 0.4 Ensembl dbSUPER 650.7 +0.3 324 0.4 TRBV5-1 TRBV4-1 TRBV6-1 TRB
GH07J142322 Enhancer 0.4 ENCODE dbSUPER 650.7 +0.9 860 0.2 TRBV5-1 TRBV6-1 LOC105375539 TRB
GH07J142323 Enhancer 0.9 ENCODE dbSUPER 0.7 +3.2 3158 0.2 CTCF RB1 KLF17 BACH1 ZIC2 RAD21 HIC1 GLIS2 ZBTB48 PATZ1 TRBV5-1 TRBV6-1 LOC105375539 TRB
GH07J142326 Enhancer 0.8 ENCODE dbSUPER 0.4 +6.1 6121 0.5 ZNF362 ATF1 ZBTB21 ATF2 ZSCAN21 ZNF629 CREB1 NBN ATF7 FOS TRBV6-1 LOC105375539 TRBV5-1 TRB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRBV5-1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRBV5-1 Gene

Genomic Locations for TRBV5-1 Gene
chr7:142,320,677-142,321,544
(GRCh38/hg38)
Size:
868 bases
Orientation:
Plus strand
chr7:142,020,496-142,021,363
(GRCh37/hg19)

Genomic View for TRBV5-1 Gene

Genes around TRBV5-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRBV5-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRBV5-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRBV5-1 Gene

Proteins for TRBV5-1 Gene

  • Protein details for TRBV5-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A578-TVB51_HUMAN
    Recommended name:
    T cell receptor beta variable 5-1
    Protein Accession:
    A0A578

    Protein attributes for TRBV5-1 Gene

    Size:
    114 amino acids
    Molecular mass:
    12600 Da
    Quaternary structure:
    • Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octomeric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.

    Three dimensional structures from OCA and Proteopedia for TRBV5-1 Gene

neXtProt entry for TRBV5-1 Gene

Post-translational modifications for TRBV5-1 Gene

No Post-translational modifications

Other Protein References for TRBV5-1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRBV5-1 Gene

Domains & Families for TRBV5-1 Gene

Gene Families for TRBV5-1 Gene

Protein Domains for TRBV5-1 Gene

Suggested Antigen Peptide Sequences for TRBV5-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRBV5-1: view

No data available for UniProtKB/Swiss-Prot for TRBV5-1 Gene

Function for TRBV5-1 Gene

Molecular function for TRBV5-1 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRBV5-1 Gene

Localization for TRBV5-1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRBV5-1 Gene

Cell membrane.

Gene Ontology (GO) - Cellular Components for TRBV5-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with TRBV5-1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TRBV5-1 Gene

Pathways & Interactions for TRBV5-1 Gene

SuperPathways for TRBV5-1 Gene

No Data Available

Interacting Proteins for TRBV5-1 Gene

Gene Ontology (GO) - Biological Process for TRBV5-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
genes like me logo Genes that share ontologies with TRBV5-1: view

No data available for Pathways by source and SIGNOR curated interactions for TRBV5-1 Gene

Drugs & Compounds for TRBV5-1 Gene

No Compound Related Data Available

Transcripts for TRBV5-1 Gene

mRNA/cDNA for TRBV5-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRBV5-1 Gene

No ASD Table

Relevant External Links for TRBV5-1 Gene

GeneLoc Exon Structure for
TRBV5-1
ECgene alternative splicing isoforms for
TRBV5-1

Expression for TRBV5-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRBV5-1 Gene

mRNA differential expression in normal tissues according to GTEx for TRBV5-1 Gene

This gene is overexpressed in Whole Blood (x34.2) and Spleen (x4.6).
genes like me logo Genes that share expression patterns with TRBV5-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRBV5-1 Gene

Orthologs for TRBV5-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRBV5-1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
ManyToMany
-- 34
  • 47 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
OneToMany
Species where no ortholog for TRBV5-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRBV5-1 Gene

ENSEMBL:
Gene Tree for TRBV5-1 (if available)
TreeFam:
Gene Tree for TRBV5-1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRBV5-1: view image

Paralogs for TRBV5-1 Gene

Paralogs for TRBV5-1 Gene

genes like me logo Genes that share paralogs with TRBV5-1: view

Variants for TRBV5-1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TRBV5-1 Gene

TVB51_HUMAN-A0A578
There are several alleles. The sequence shown is that of IMGT allele TRBV5-1*01.

Additional Variant Information for TRBV5-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRBV5-1

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRBV5-1 Gene

Disorders for TRBV5-1 Gene

No disorders were found for TRBV5-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRBV5-1 Gene

Publications for TRBV5-1 Gene

  1. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PMID: 8650574) Rowen L … Hood L (Science (New York, N.Y.) 1996) 2 3 4 58
  2. Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy. (PMID: 26758806) Raman MC … Jakobsen BK (Scientific reports 2016) 4 58
  3. T cell antigen receptor recognition of antigen-presenting molecules. (PMID: 25493333) Rossjohn J … McCluskey J (Annual review of immunology 2015) 4 58
  4. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4 58
  5. T cell receptor signalling networks: branched, diversified and bounded. (PMID: 23524462) Brownlie RJ … Zamoyska R (Nature reviews. Immunology 2013) 4 58

Products for TRBV5-1 Gene

Sources for TRBV5-1 Gene

Content
Loading form....