Aliases for TRBV25-1 Gene

Aliases for TRBV25-1 Gene

  • T Cell Receptor Beta Variable 25-1 2 3 4 5
  • V_segment Translation Product 3
  • TCRBV11S1A1T 3
  • TCRBV25S1 3
  • TRBV251 3

External Ids for TRBV25-1 Gene

Previous GeneCards Identifiers for TRBV25-1 Gene

  • GC07U990185
  • GC07P141742
  • GC07P141818
  • GC07P141864
  • GC07P142058
  • GC07Pg41749
  • GC07P142381
  • GC07P142382
  • GC07P142394
  • GC07P142437
  • GC07P142483
  • GC07P142640
  • GC07P142710
  • GC07P142772
  • GC07P142819
  • GC07P142882
  • GC07P144203
  • GC07P144337
  • GC07P144467
  • GC07P143016
  • GC07P143162
  • GC07P143362
  • GC07P143512
  • GC07P143641
  • GC07P143783
  • GC07P143921
  • GC07P144057

Summaries for TRBV25-1 Gene

GeneCards Summary for TRBV25-1 Gene

TRBV25-1 (T Cell Receptor Beta Variable 25-1) is a Protein Coding gene. An important paralog of this gene is TRBV10-3.

UniProtKB/Swiss-Prot Summary for TRBV25-1 Gene

  • V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

Additional gene information for TRBV25-1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRBV25-1 Gene

Genomics for TRBV25-1 Gene

GeneHancer (GH) Regulatory Elements for TRBV25-1 Gene

Promoters and enhancers for TRBV25-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J142669 Enhancer 0.7 Ensembl ENCODE 500.7 -0.6 -582 3.9 CTCF REST RAD21 TRIM22 SMC3 SPI1 IKZF1 NR2F1 IKZF2 TRBV25-1 TRBV28 EPHB6 piR-31636-005 lnc-PRSS2-6 TRB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRBV25-1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRBV25-1 Gene

Genomic Locations for TRBV25-1 Gene
chr7:142,670,740-142,671,244
(GRCh38/hg38)
Size:
505 bases
Orientation:
Plus strand
chr7:142,378,572-142,379,076
(GRCh37/hg19)
Size:
505 bases
Orientation:
Plus strand

Genomic View for TRBV25-1 Gene

Genes around TRBV25-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRBV25-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRBV25-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRBV25-1 Gene

Proteins for TRBV25-1 Gene

  • Protein details for TRBV25-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A075B6N4-TVBY1_HUMAN
    Recommended name:
    T cell receptor beta variable 25-1
    Protein Accession:
    A0A075B6N4

    Protein attributes for TRBV25-1 Gene

    Size:
    114 amino acids
    Molecular mass:
    12983 Da
    Quaternary structure:
    • Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octomeric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.

neXtProt entry for TRBV25-1 Gene

Post-translational modifications for TRBV25-1 Gene

Other Protein References for TRBV25-1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRBV25-1 Gene

Domains & Families for TRBV25-1 Gene

Gene Families for TRBV25-1 Gene

Protein Domains for TRBV25-1 Gene

Suggested Antigen Peptide Sequences for TRBV25-1 Gene

GenScript: Design optimal peptide antigens:
  • V_segment translation product (A0A5C2_HUMAN)
genes like me logo Genes that share domains with TRBV25-1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TRBV25-1 Gene

Function for TRBV25-1 Gene

Molecular function for TRBV25-1 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

Phenotypes From GWAS Catalog for TRBV25-1 Gene

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRBV25-1 Gene

Localization for TRBV25-1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRBV25-1 Gene

Cell membrane.

Gene Ontology (GO) - Cellular Components for TRBV25-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0042101 T cell receptor complex IEA --
genes like me logo Genes that share ontologies with TRBV25-1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TRBV25-1 Gene

Pathways & Interactions for TRBV25-1 Gene

PathCards logo

SuperPathways for TRBV25-1 Gene

No Data Available

Interacting Proteins for TRBV25-1 Gene

;

Gene Ontology (GO) - Biological Process for TRBV25-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with TRBV25-1: view

No data available for Pathways by source and SIGNOR curated interactions for TRBV25-1 Gene

Drugs & Compounds for TRBV25-1 Gene

No Compound Related Data Available

Transcripts for TRBV25-1 Gene

mRNA/cDNA for TRBV25-1 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRBV25-1 Gene

No ASD Table

Relevant External Links for TRBV25-1 Gene

GeneLoc Exon Structure for
TRBV25-1

Expression for TRBV25-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRBV25-1 Gene

mRNA differential expression in normal tissues according to GTEx for TRBV25-1 Gene

This gene is overexpressed in Whole Blood (x17.9) and Brain - Nucleus accumbens (basal ganglia) (x6.9).

Protein differential expression in normal tissues from HIPED for TRBV25-1 Gene

This gene is overexpressed in Tlymphocyte (51.6), CD4 Tcells (8.8), and Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRBV25-1 Gene



Protein tissue co-expression partners for TRBV25-1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRBV25-1

genes like me logo Genes that share expression patterns with TRBV25-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRBV25-1 Gene

Orthologs for TRBV25-1 Gene

Evolution for TRBV25-1 Gene

ENSEMBL:
Gene Tree for TRBV25-1 (if available)
TreeFam:
Gene Tree for TRBV25-1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRBV25-1: view image

No data available for Orthologs for TRBV25-1 Gene

Paralogs for TRBV25-1 Gene

Variants for TRBV25-1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TRBV25-1 Gene

TVBY1_HUMAN-A0A075B6N4
There are several alleles. The sequence shown is that of IMGT allele TRBV25-1*01.

Additional Variant Information for TRBV25-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRBV25-1

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRBV25-1 Gene

Disorders for TRBV25-1 Gene

No disorders were found for TRBV25-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRBV25-1 Gene

Publications for TRBV25-1 Gene

  1. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PMID: 8650574) Rowen L … Hood L (Science (New York, N.Y.) 1996) 2 3 54
  2. T cell antigen receptor recognition of antigen-presenting molecules. (PMID: 25493333) Rossjohn J … McCluskey J (Annual review of immunology 2015) 4 54
  3. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4 54
  4. T cell receptor signalling networks: branched, diversified and bounded. (PMID: 23524462) Brownlie RJ … Zamoyska R (Nature reviews. Immunology 2013) 4 54
  5. Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling. (PMID: 20452950) Wucherpfennig KW … Call ME (Cold Spring Harbor perspectives in biology 2010) 4 54

Products for TRBV25-1 Gene

Sources for TRBV25-1 Gene