Aliases for TRBV24-1 Gene

Aliases for TRBV24-1 Gene

  • T Cell Receptor Beta Variable 24-1 2 3 4 5
  • V_segment Translation Product 3
  • TCRBV15S1 3
  • TCRBV24S1 3
  • TRBV241 3

External Ids for TRBV24-1 Gene

Previous GeneCards Identifiers for TRBV24-1 Gene

  • GC07U990186
  • GC07P141727
  • GC07P141804
  • GC07P141850
  • GC07P142043
  • GC07Pg41735
  • GC07P142367
  • GC07P142369
  • GC07P142392
  • GC07P142434
  • GC07P142481
  • GC07P142638
  • GC07P142708
  • GC07P142770
  • GC07P142815
  • GC07P142879
  • GC07P144201
  • GC07P144335
  • GC07P144452
  • GC07P143011
  • GC07P143160
  • GC07P143359
  • GC07P143508
  • GC07P143639
  • GC07P143778
  • GC07P143919
  • GC07P144055

Summaries for TRBV24-1 Gene

GeneCards Summary for TRBV24-1 Gene

TRBV24-1 (T Cell Receptor Beta Variable 24-1) is a Protein Coding gene. An important paralog of this gene is TRBV10-3.

UniProtKB/Swiss-Prot Summary for TRBV24-1 Gene

  • V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

Additional gene information for TRBV24-1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRBV24-1 Gene

Genomics for TRBV24-1 Gene

GeneHancer (GH) Regulatory Elements for TRBV24-1 Gene

Promoters and enhancers for TRBV24-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J142645 Promoter/Enhancer 0.8 Ensembl ENCODE 0.4 -10.3 -10265 1.3 GATA3 RCOR1 GATA2 CREB1 TRBV23-1 TRBV28 SSBP1 TRBV24-1 lnc-PRSS2-6 TRB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRBV24-1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRBV24-1 Gene

Genomic Locations for TRBV24-1 Gene
chr7:142,656,701-142,657,213
(GRCh38/hg38)
Size:
513 bases
Orientation:
Plus strand
chr7:142,364,198-142,364,710
(GRCh37/hg19)
Size:
513 bases
Orientation:
Plus strand

Genomic View for TRBV24-1 Gene

Genes around TRBV24-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRBV24-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRBV24-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRBV24-1 Gene

Proteins for TRBV24-1 Gene

  • Protein details for TRBV24-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A075B6N3-TVBX1_HUMAN
    Recommended name:
    T cell receptor beta variable 24-1
    Protein Accession:
    A0A075B6N3

    Protein attributes for TRBV24-1 Gene

    Size:
    115 amino acids
    Molecular mass:
    12929 Da
    Quaternary structure:
    • Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octomeric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.

neXtProt entry for TRBV24-1 Gene

Post-translational modifications for TRBV24-1 Gene

Other Protein References for TRBV24-1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRBV24-1 Gene

Domains & Families for TRBV24-1 Gene

Gene Families for TRBV24-1 Gene

Protein Domains for TRBV24-1 Gene

genes like me logo Genes that share domains with TRBV24-1: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TRBV24-1 Gene

Function for TRBV24-1 Gene

Molecular function for TRBV24-1 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

Phenotypes From GWAS Catalog for TRBV24-1 Gene

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRBV24-1 Gene

Localization for TRBV24-1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRBV24-1 Gene

Cell membrane.

Gene Ontology (GO) - Cellular Components for TRBV24-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0042101 T cell receptor complex IEA --
genes like me logo Genes that share ontologies with TRBV24-1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TRBV24-1 Gene

Pathways & Interactions for TRBV24-1 Gene

PathCards logo

SuperPathways for TRBV24-1 Gene

No Data Available

Interacting Proteins for TRBV24-1 Gene

;

Gene Ontology (GO) - Biological Process for TRBV24-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with TRBV24-1: view

No data available for Pathways by source and SIGNOR curated interactions for TRBV24-1 Gene

Drugs & Compounds for TRBV24-1 Gene

No Compound Related Data Available

Transcripts for TRBV24-1 Gene

mRNA/cDNA for TRBV24-1 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRBV24-1 Gene

No ASD Table

Relevant External Links for TRBV24-1 Gene

GeneLoc Exon Structure for
TRBV24-1

Expression for TRBV24-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRBV24-1 Gene

mRNA differential expression in normal tissues according to GTEx for TRBV24-1 Gene

This gene is overexpressed in Whole Blood (x21.2) and Brain - Nucleus accumbens (basal ganglia) (x4.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRBV24-1

genes like me logo Genes that share expression patterns with TRBV24-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRBV24-1 Gene

Orthologs for TRBV24-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRBV24-1 Gene

Organism Taxonomy Gene Similarity Type Details
chicken
(Gallus gallus)
Aves -- 31
  • 36 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 30 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
Species where no ortholog for TRBV24-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRBV24-1 Gene

ENSEMBL:
Gene Tree for TRBV24-1 (if available)
TreeFam:
Gene Tree for TRBV24-1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRBV24-1: view image

Paralogs for TRBV24-1 Gene

Variants for TRBV24-1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TRBV24-1 Gene

TVBX1_HUMAN-A0A075B6N3
There are several alleles. The sequence shown is that of IMGT allele TRBV24-1*01.

Additional Variant Information for TRBV24-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRBV24-1

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRBV24-1 Gene

Disorders for TRBV24-1 Gene

No disorders were found for TRBV24-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRBV24-1 Gene

Publications for TRBV24-1 Gene

  1. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PMID: 8650574) Rowen L … Hood L (Science (New York, N.Y.) 1996) 2 3 54
  2. T cell antigen receptor recognition of antigen-presenting molecules. (PMID: 25493333) Rossjohn J … McCluskey J (Annual review of immunology 2015) 4 54
  3. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4 54
  4. T cell receptor signalling networks: branched, diversified and bounded. (PMID: 23524462) Brownlie RJ … Zamoyska R (Nature reviews. Immunology 2013) 4 54
  5. Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling. (PMID: 20452950) Wucherpfennig KW … Call ME (Cold Spring Harbor perspectives in biology 2010) 4 54

Products for TRBV24-1 Gene

Sources for TRBV24-1 Gene