Aliases for TRBV2 Gene

Aliases for TRBV2 Gene

  • T Cell Receptor Beta Variable 2 2 3 4 5
  • V_segment Translation Product 3
  • TCRBV22S1A2N1T 3
  • TCRBV2S1 3

External Ids for TRBV2 Gene

Previous GeneCards Identifiers for TRBV2 Gene

  • GC07U990243
  • GC07P141331
  • GC07P141408
  • GC07P141457
  • GC07P141647
  • GC07P142156
  • GC07P142182
  • GC07P142319
  • GC07P142360
  • GC07P142402
  • GC07P142447
  • GC07P142579
  • GC07P142669
  • GC07P142737
  • GC07P142800
  • GC07P142561
  • GC07P142831
  • GC07P144123
  • GC07P144271
  • GC07P144406
  • GC07P142984
  • GC07P143144
  • GC07P143344
  • GC07P143489
  • GC07P143623
  • GC07P143757
  • GC07P143904
  • GC07P144039

Summaries for TRBV2 Gene

GeneCards Summary for TRBV2 Gene

TRBV2 (T Cell Receptor Beta Variable 2) is a Protein Coding gene. An important paralog of this gene is TRBV7-2.

UniProtKB/Swiss-Prot Summary for TRBV2 Gene

  • V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

Additional gene information for TRBV2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRBV2 Gene

Genomics for TRBV2 Gene

GeneHancer (GH) Regulatory Elements for TRBV2 Gene

Promoters and enhancers for TRBV2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J142301 Promoter/Enhancer 0.6 Ensembl dbSUPER 500.7 +0.4 377 0.2 POLR2A TRBV2 TRB HSALNG0061883
GH07J142300 Enhancer 0.6 ENCODE dbSUPER 500.7 -0.1 -51 0.2 CTCF RAD21 CTCFL ZNF143 TRB TRBV1 TRBV2 lnc-MGAM2-8
GH07J142302 Enhancer 0.3 dbSUPER 500.7 +2.0 1998 1.1 CTCF TRBV2 TRBV4-1 ENSG00000186163 TRB HSALNG0061883
GH07J142303 Enhancer 0.8 Ensembl ENCODE dbSUPER 0.7 +3.0 2992 0.6 CTCF SMC3 RAD21 POLR2A ENSG00000186163 HSALNG0061883 TRB TRBV2
GH07J142304 Enhancer 0.3 Ensembl dbSUPER 0.7 +3.6 3577 0.2 HSALNG0061883 TRBV2 TRB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRBV2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRBV2 Gene

Genomic Locations for TRBV2 Gene
chr7:142,300,924-142,301,432
(GRCh38/hg38)
Size:
509 bases
Orientation:
Plus strand
chr7:142,000,747-142,001,255
(GRCh37/hg19)
Size:
509 bases
Orientation:
Plus strand

Genomic View for TRBV2 Gene

Genes around TRBV2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRBV2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRBV2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRBV2 Gene

Proteins for TRBV2 Gene

  • Protein details for TRBV2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A1B0GX68-TVB2_HUMAN
    Recommended name:
    T cell receptor beta variable 2
    Protein Accession:
    A0A1B0GX68

    Protein attributes for TRBV2 Gene

    Size:
    115 amino acids
    Molecular mass:
    13403 Da
    Quaternary structure:
    • Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octomeric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.

neXtProt entry for TRBV2 Gene

Post-translational modifications for TRBV2 Gene

Other Protein References for TRBV2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRBV2 Gene

Domains & Families for TRBV2 Gene

Gene Families for TRBV2 Gene

Protein Domains for TRBV2 Gene

Suggested Antigen Peptide Sequences for TRBV2 Gene

GenScript: Design optimal peptide antigens:
  • V_segment translation product (A0A575_HUMAN)
genes like me logo Genes that share domains with TRBV2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TRBV2 Gene

Function for TRBV2 Gene

Molecular function for TRBV2 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRBV2 Gene

Localization for TRBV2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRBV2 Gene

Cell membrane.

Gene Ontology (GO) - Cellular Components for TRBV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0042101 T cell receptor complex IEA --
genes like me logo Genes that share ontologies with TRBV2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TRBV2 Gene

Pathways & Interactions for TRBV2 Gene

PathCards logo

SuperPathways for TRBV2 Gene

No Data Available

Interacting Proteins for TRBV2 Gene

Selected Interacting proteins: A0A1B0GX68-TVB2_HUMAN for TRBV2 Gene via IID

;

Gene Ontology (GO) - Biological Process for TRBV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with TRBV2: view

No data available for Pathways by source and SIGNOR curated interactions for TRBV2 Gene

Drugs & Compounds for TRBV2 Gene

No Compound Related Data Available

Transcripts for TRBV2 Gene

mRNA/cDNA for TRBV2 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRBV2 Gene

No ASD Table

Relevant External Links for TRBV2 Gene

GeneLoc Exon Structure for
TRBV2

Expression for TRBV2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRBV2 Gene

mRNA differential expression in normal tissues according to GTEx for TRBV2 Gene

This gene is overexpressed in Whole Blood (x32.6) and Spleen (x4.8).
genes like me logo Genes that share expression patterns with TRBV2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRBV2 Gene

Orthologs for TRBV2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRBV2 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 35 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 30 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 31
  • 29 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 24 (a)
OneToMany
Species where no ortholog for TRBV2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRBV2 Gene

ENSEMBL:
Gene Tree for TRBV2 (if available)
TreeFam:
Gene Tree for TRBV2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRBV2: view image

Paralogs for TRBV2 Gene

Variants for TRBV2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TRBV2 Gene

TVB2_HUMAN-A0A1B0GX68
There are several alleles. The sequence shown is that of IMGT allele TRBV2*01.

Additional Variant Information for TRBV2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRBV2

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRBV2 Gene

Disorders for TRBV2 Gene

No disorders were found for TRBV2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRBV2 Gene

Publications for TRBV2 Gene

  1. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PMID: 8650574) Rowen L … Hood L (Science (New York, N.Y.) 1996) 2 3 54
  2. T cell antigen receptor recognition of antigen-presenting molecules. (PMID: 25493333) Rossjohn J … McCluskey J (Annual review of immunology 2015) 4 54
  3. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4 54
  4. T cell receptor signalling networks: branched, diversified and bounded. (PMID: 23524462) Brownlie RJ … Zamoyska R (Nature reviews. Immunology 2013) 4 54
  5. Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling. (PMID: 20452950) Wucherpfennig KW … Call ME (Cold Spring Harbor perspectives in biology 2010) 4 54

Products for TRBV2 Gene

Sources for TRBV2 Gene