Aliases for TRBV17 Gene

Aliases for TRBV17 Gene

  • T Cell Receptor Beta Variable 17 (Non-Functional) 2 3 5
  • TCRBV26S1P 2 3
  • TCRBV17S1 2 3
  • Probable Non-Functional T Cell Receptor Beta Variable 17 4
  • TRBV17 5

External Ids for TRBV17 Gene

Previous GeneCards Identifiers for TRBV17 Gene

  • GC07U990193
  • GC07P141674
  • GC07P141751
  • GC07P141797
  • GC07P141798
  • GC07P141994
  • GC07P142022
  • GC07P142039
  • GC07P142059
  • GC07P142074
  • GC07P142089
  • GC07P142104
  • GC07P142131
  • GC07Pg41681
  • GC07P142826
  • GC07P142976
  • GC07P144307
  • GC07P144440
  • GC07P144657
  • GC07P144897
  • GC07P143129
  • GC07P143340
  • GC07P143478
  • GC07P143618
  • GC07P143754
  • GC07P143897
  • GC07P144034
  • GC07P144165
  • GC07P145154

Summaries for TRBV17 Gene

GeneCards Summary for TRBV17 Gene

TRBV17 (T Cell Receptor Beta Variable 17 (Non-Functional)) is a Protein Coding gene. Among its related pathways are Immune response Function of MEF2 in T lymphocytes and Th17 cell differentiation. An important paralog of this gene is TRBV7-3.

UniProtKB/Swiss-Prot Summary for TRBV17 Gene

  • Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate to the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

Additional gene information for TRBV17 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRBV17 Gene

Genomics for TRBV17 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRBV17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J142603 Enhancer 0.2 Ensembl 250.7 +1.4 1372 0.4 TRBV17 TRBV18 lnc-PRSS2-6 TRB
GH07J142602 Enhancer 0.2 Ensembl 250.7 +0.9 873 0.2 TRBV17 TRBV18 lnc-PRSS2-6 TRB
GH07J142597 Enhancer 0.2 Ensembl 0.7 -3.8 -3827 0.8 TRBV16 TRBV15 TRBV17 lnc-PRSS2-6 TRB
GH07J142592 Enhancer 0.2 Ensembl 0.4 -8.6 -8627 0.4 TRBV15 TRBV16 TRBV17 lnc-PRSS2-6 TRB
GH07J142612 Enhancer 0.2 Ensembl 0.4 +10.7 10655 1.4 TRBV18 TRBV17 lnc-PRSS2-6 TRB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRBV17 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for TRBV17 Gene

Latest Assembly
chr7:142,601,628-142,602,360
(GRCh38/hg38)
Size:
733 bases
Orientation:
Plus strand

Genomic View for TRBV17 Gene

Genes around TRBV17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRBV17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRBV17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRBV17 Gene

Proteins for TRBV17 Gene

  • Protein details for TRBV17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A087X0K7-TVB17_HUMAN
    Recommended name:
    Probable non-functional T cell receptor beta variable 17
    Protein Accession:
    A0A087X0K7

    Protein attributes for TRBV17 Gene

    Size:
    114 amino acids
    Molecular mass:
    12963 Da
    Quaternary structure:
    • Most probably, the alpha-beta TR is not assembled due to incorrect folding of the beta chain (Probable). Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octomeric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.

neXtProt entry for TRBV17 Gene

Post-translational modifications for TRBV17 Gene

No Post-translational modifications

Other Protein References for TRBV17 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRBV17 Gene

Domains & Families for TRBV17 Gene

Gene Families for TRBV17 Gene

Protein Domains for TRBV17 Gene

genes like me logo Genes that share domains with TRBV17: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TRBV17 Gene

Function for TRBV17 Gene

Molecular function for TRBV17 Gene

UniProtKB/Swiss-Prot Function:
Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate to the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRBV17 Gene

Localization for TRBV17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRBV17 Gene

Cell membrane.

Gene Ontology (GO) - Cellular Components for TRBV17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0042101 T cell receptor complex IEA --
genes like me logo Genes that share ontologies with TRBV17: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TRBV17 Gene

Pathways & Interactions for TRBV17 Gene

PathCards logo

SuperPathways for TRBV17 Gene

SuperPathway Contained pathways
1 Immune response NFAT in immune response
.56
.56
.52
.52
2 G-protein signaling N-RAS regulation pathway
.52
.52
3 G-protein signaling_Rap1A regulation pathway
-
4 G-protein signaling_Regulation of RAC1 activity
-
5 Antigen processing-Cross presentation
.51
genes like me logo Genes that share pathways with TRBV17: view

Pathways by source for TRBV17 Gene

15 GeneGo (Thomson Reuters) pathways for TRBV17 Gene
  • G-protein signaling N-RAS regulation pathway
  • G-protein signaling_Rap1A regulation pathway
  • G-protein signaling_Regulation of RAC1 activity
  • Immune response Antigen presentation by MHC class I
  • Immune response Antigen presentation by MHC class II

Interacting Proteins for TRBV17 Gene

Gene Ontology (GO) - Biological Process for TRBV17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0007166 cell surface receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with TRBV17: view

No data available for SIGNOR curated interactions for TRBV17 Gene

Drugs & Compounds for TRBV17 Gene

No Compound Related Data Available

Transcripts for TRBV17 Gene

mRNA/cDNA for TRBV17 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRBV17 Gene

No ASD Table

Relevant External Links for TRBV17 Gene

GeneLoc Exon Structure for
TRBV17

Expression for TRBV17 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRBV17 Gene

Orthologs for TRBV17 Gene

Evolution for TRBV17 Gene

ENSEMBL:
Gene Tree for TRBV17 (if available)
TreeFam:
Gene Tree for TRBV17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRBV17: view image

No data available for Orthologs for TRBV17 Gene

Paralogs for TRBV17 Gene

Variants for TRBV17 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TRBV17 Gene

TVB17_HUMAN-A0A087X0K7
There are several alleles. The sequence shown is that of IMGT allele TRBV17*02.

Additional Variant Information for TRBV17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRBV17

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRBV17 Gene

Disorders for TRBV17 Gene

No disorders were found for TRBV17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRBV17 Gene

Publications for TRBV17 Gene

  1. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PMID: 8650574) Rowen L … Hood L (Science (New York, N.Y.) 1996) 2 3
  2. T cell antigen receptor recognition of antigen-presenting molecules. (PMID: 25493333) Rossjohn J … McCluskey J (Annual review of immunology 2015) 4
  3. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4
  4. T cell receptor signalling networks: branched, diversified and bounded. (PMID: 23524462) Brownlie RJ … Zamoyska R (Nature reviews. Immunology 2013) 4
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for TRBV17 Gene

Sources for TRBV17 Gene