TRBV11-2 Gene (Protein Coding)

T Cell Receptor Beta Variable 11-2

GC07P145422
GIFtS:
12
See more...

Aliases for TRBV11-2 Gene

Aliases for TRBV11-2 Gene

  • T Cell Receptor Beta Variable 11-2 2 3 4 5
  • TCRBV21S3A2N2T 2 3 4
  • TCRBV11S2 2 3
  • TRBV112 2 3
  • V_segment Translation Product 3
  • NONHSAG048998.2 91
  • Lnc-MGAM2-1 165
  • TRBV11-2 5

External Ids for TRBV11-2 Gene

Previous GeneCards Identifiers for TRBV11-2 Gene

  • GC07U990204
  • GC07P141486
  • GC07P141563
  • GC07P141609
  • GC07P141802
  • GC07M142191
  • GC07P136450
  • GC07M142199
  • GC07M142203
  • GC07M142209
  • GC07M142219
  • GC07M142235
  • GC07M142278
  • GC07M142302
  • GC07P142681
  • GC07P142950
  • GC07P144296
  • GC07P144429
  • GC07P144646
  • GC07P144886
  • GC07P143093
  • GC07P143249
  • GC07P143446
  • GC07P143591
  • GC07P143733
  • GC07P143863
  • GC07P144007
  • GC07P144152
  • GC07P145143

Summaries for TRBV11-2 Gene

GeneCards Summary for TRBV11-2 Gene

TRBV11-2 (T Cell Receptor Beta Variable 11-2) is a Protein Coding gene. Among its related pathways are Immune response Function of MEF2 in T lymphocytes and Th17 cell differentiation.

UniProtKB/Swiss-Prot Summary for TRBV11-2 Gene

  • V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

Additional gene information for TRBV11-2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRBV11-2 Gene

Genomics for TRBV11-2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TRBV11-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J142432 Enhancer 0.2 Ensembl 250.7 -1.9 -1894 0.8 TRBV11-2 TRBV10-2 TRBV6-5 lnc-PRSS2-6 TRB
GH07J142434 Enhancer 0.2 Ensembl 250.7 +0.6 606 1.8 TRBV11-2 TRBV10-2 TRBV12-2 TRBV6-5 lnc-PRSS2-6 TRB
GH07J142964 Enhancer 0.8 Ensembl 4.7 +530.5 530506 0.8 MNT IKZF1 BHLHE40 ZNF395 MAFF ZEB2 TAF9B NCOR1 MYNN ZNF316 TCAF1 TRBV11-2 KEL HSALNG0061937 OR9A2
GH07J143012 Enhancer 0.8 Ensembl ENCODE 4.9 +581.8 581806 8.6 ZFP91 ZNF316 NFE2 MAFK SRF JUND MAFG MAFF POLR2A SPI1 ZYX OR9P1P OR6V1 TAS2R39 KEL LLCFC1 TRPV5 TRBV11-2 HSALNG0061937 OR9A2
GH07J142974 Enhancer 0.2 Ensembl 5.8 +540.9 540906 0.4 TRBV11-2 TCAF2 KEL HSALNG0061937 OR9A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRBV11-2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for TRBV11-2 Gene

Latest Assembly
chr7:142,433,895-142,434,394
(GRCh38/hg38)
Size:
500 bases
Orientation:
Plus strand

Previous Assembly
chr7:142,197,570-142,198,008
(GRCh37/hg19 by Entrez Gene)
Size:
439 bases
Orientation:
Minus strand

chr7:142,197,570-142,198,069
(GRCh37/hg19 by Ensembl)
Size:
500 bases
Orientation:
Minus strand

Genomic View for TRBV11-2 Gene

Genes around TRBV11-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRBV11-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRBV11-2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TRBV11-2 Gene

Proteins for TRBV11-2 Gene

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  • Protein details for TRBV11-2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A584-TVBK2_HUMAN
    Recommended name:
    T cell receptor beta variable 11-2
    Protein Accession:
    A0A584

    Protein attributes for TRBV11-2 Gene

    Size:
    115 amino acids
    Molecular mass:
    12743 Da
    Quaternary structure:
    • Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octomeric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.

    Three dimensional structures from OCA and Proteopedia for TRBV11-2 Gene

neXtProt entry for TRBV11-2 Gene

Post-translational modifications for TRBV11-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRBV11-2 Gene

Domains & Families for TRBV11-2 Gene

Gene Families for TRBV11-2 Gene

HGNC:

Protein Domains for TRBV11-2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRBV11-2 Gene

GenScript: Design optimal peptide antigens:
  • V_segment translation product (A0A584_HUMAN)
genes like me logo Genes that share domains with TRBV11-2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TRBV11-2 Gene

Function for TRBV11-2 Gene

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  6. Cell Lines for research

Molecular function for TRBV11-2 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRBV11-2 Gene

Localization for TRBV11-2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRBV11-2 Gene

Cell membrane.

Gene Ontology (GO) - Cellular Components for TRBV11-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0042101 T cell receptor complex IEA --
genes like me logo Genes that share ontologies with TRBV11-2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TRBV11-2 Gene

Pathways & Interactions for TRBV11-2 Gene

PathCards logo

SuperPathways for TRBV11-2 Gene

SuperPathway Contained pathways
1 Immune response NFAT in immune response
Immune response ICOS pathway in T-helper cell
.56
Immune response NFAT in immune response
.56
Immune response T cell receptor signaling pathway
.52
Immune response CD28 signaling
.52
2 G-protein signaling N-RAS regulation pathway
G-protein signaling N-RAS regulation pathway
.52
Immune response Antigen presentation by MHC class II
.52
3 G-protein signaling_Rap1A regulation pathway
G-protein signaling_Rap1A regulation pathway
-
4 G-protein signaling_Regulation of RAC1 activity
G-protein signaling_Regulation of RAC1 activity
-
5 Antigen processing-Cross presentation
Immune response Antigen presentation by MHC class I
.51
genes like me logo Genes that share pathways with TRBV11-2: view

Pathways by source for TRBV11-2 Gene

15 GeneGo (Thomson Reuters) pathways for TRBV11-2 Gene
  • G-protein signaling N-RAS regulation pathway
  • G-protein signaling_Rap1A regulation pathway
  • G-protein signaling_Regulation of RAC1 activity
  • Immune response Antigen presentation by MHC class I
  • Immune response Antigen presentation by MHC class II

Interacting Proteins for TRBV11-2 Gene

Gene Ontology (GO) - Biological Process for TRBV11-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0007166 cell surface receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with TRBV11-2: view

No data available for SIGNOR curated interactions for TRBV11-2 Gene

Drugs & Compounds for TRBV11-2 Gene

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No Compound Related Data Available

Transcripts for TRBV11-2 Gene

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mRNA/cDNA for TRBV11-2 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 RNACentral transcripts :
1 NONCODE transcripts :
1 LNCipedia transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for TRBV11-2 Gene

No ASD Table

Relevant External Links for TRBV11-2 Gene

GeneLoc Exon Structure for
TRBV11-2

Expression for TRBV11-2 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRBV11-2 Gene

mRNA expression in normal human tissues for TRBV11-2 Gene
mRNA expression by GTEx for TRBV11-2 Gene

mRNA differential expression in normal tissues according to GTEx for TRBV11-2 Gene

This gene is overexpressed in Whole Blood (x30.0) and Spleen (x5.3).
genes like me logo Genes that share expression patterns with TRBV11-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRBV11-2 Gene

Orthologs for TRBV11-2 Gene

Evolution for TRBV11-2 Gene

ENSEMBL:
Gene Tree for TRBV11-2 (if available)
TreeFam:
Gene Tree for TRBV11-2 (if available)

No data available for Orthologs for TRBV11-2 Gene

Paralogs for TRBV11-2 Gene

No data available for Paralogs for TRBV11-2 Gene

Variants for TRBV11-2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TRBV11-2 Gene

TVBK2_HUMAN-A0A584
There are several alleles. The sequence shown is that of IMGT allele TRBV11-2*01.

Additional Variant Information for TRBV11-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRBV11-2

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRBV11-2 Gene

Disorders for TRBV11-2 Gene

Additional Disease Information for TRBV11-2

Open Targets Platform
Open Targets Platform

No disorders were found for TRBV11-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRBV11-2 Gene

Publications for TRBV11-2 Gene

  1. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PMID: 8650574) Rowen L … Hood L (Science (New York, N.Y.) 1996) 2 3 4
  2. T cell antigen receptor recognition of antigen-presenting molecules. (PMID: 25493333) Rossjohn J … McCluskey J (Annual review of immunology 2015) 4
  3. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4
  4. T cell receptor signalling networks: branched, diversified and bounded. (PMID: 23524462) Brownlie RJ … Zamoyska R (Nature reviews. Immunology 2013) 4
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

ExternalLinks

View latest publications for TRBV11-2 gene in Mastermind

Products for TRBV11-2 Gene

Sources for TRBV11-2 Gene