Aliases for TRBD1 Gene

Aliases for TRBD1 Gene

  • T Cell Receptor Beta Diversity 1 2 3 4 5
  • TCRBD1 2 3
  • TRBD1 5

External Ids for TRBD1 Gene

Previous GeneCards Identifiers for TRBD1 Gene

  • GC07U990260
  • GC07P141877
  • GC07P141954
  • GC07P142000
  • GC07P142194
  • GC07Pg41885
  • GC07P142525
  • GC07P142540
  • GC07P142551
  • GC07P142565
  • GC07P142594
  • GC07P142661
  • GC07P142730
  • GC07P142795
  • GC07P142854
  • GC07P142915
  • GC07P144221
  • GC07P144356
  • GC07P144485
  • GC07P144726
  • GC07P143042
  • GC07P143190
  • GC07P143386
  • GC07P143531
  • GC07P143664
  • GC07P143804
  • GC07P143943
  • GC07P144076

Summaries for TRBD1 Gene

GeneCards Summary for TRBD1 Gene

TRBD1 (T Cell Receptor Beta Diversity 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for TRBD1 Gene

  • D region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

Additional gene information for TRBD1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRBD1 Gene

Genomics for TRBD1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRBD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J142782 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 +6.0 5983 18.8 CTCF TEAD4 POLR2A LARP7 ZNF143 ZNF24 REST RAD21 IKZF2 TRIM22 LT601552 TRBC1 TRBV28 PRSS3P1 EPHB6 TRBV7-3 TRPV6 TRBD2 TRBJ1-3 TRBJ1-4
GH07J142783 Enhancer 0.3 Ensembl 0.7 -3.9 -3912 0.2 ATF2 LT601549 NONHSAG049015.2 TRBD1 WBP1LP1 PRSS2 lnc-PRSS2-6 TRB
GH07J142776 Enhancer 0.2 Ensembl 0.4 -9.7 -9713 1.8 NONHSAG049014.2-002 NONHSAG049015.2 WBP1LP1 TRBD1 PRSS2 TRB lnc-PRSS2-6
GH07J142771 Enhancer 0.2 Ensembl 0.4 -14.4 -14413 1.6 NONHSAG049014.2-002 lnc-PRSS1-2 PRSS2 TRBD1 TRB lnc-PRSS2-6
GH07J142770 Enhancer 0.2 Ensembl 0.4 -15.5 -15512 0.2 NONHSAG049014.2-002 lnc-PRSS1-2 PRSS2 TRBD1 TRB lnc-PRSS2-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRBD1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for TRBD1 Gene

Genomic Locations for TRBD1 Gene
chr7:142,786,213-142,786,224
(GRCh38/hg38)
Size:
12 bases
Orientation:
Plus strand
chr7:142,494,022-142,494,030
(GRCh37/hg19)
Size:
9 bases
Orientation:
Plus strand

Genomic View for TRBD1 Gene

Genes around TRBD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRBD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRBD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRBD1 Gene

Proteins for TRBD1 Gene

  • Protein details for TRBD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DPI4-TDB01_HUMAN
    Recommended name:
    T cell receptor beta diversity 1
    Protein Accession:
    P0DPI4

    Protein attributes for TRBD1 Gene

    Size:
    4 amino acids
    Molecular mass:
    290 Da
    Quaternary structure:
    • Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octomeric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.

neXtProt entry for TRBD1 Gene

Post-translational modifications for TRBD1 Gene

No Post-translational modifications

Other Protein References for TRBD1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRBD1 Gene

Domains & Families for TRBD1 Gene

Gene Families for TRBD1 Gene

Protein Domains for TRBD1 Gene

ProtoNet:
genes like me logo Genes that share domains with TRBD1: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TRBD1 Gene

Function for TRBD1 Gene

Molecular function for TRBD1 Gene

UniProtKB/Swiss-Prot Function:
D region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

Phenotypes From GWAS Catalog for TRBD1 Gene

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRBD1 Gene

Localization for TRBD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRBD1 Gene

Cell membrane.

Gene Ontology (GO) - Cellular Components for TRBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0042101 T cell receptor complex IEA --
genes like me logo Genes that share ontologies with TRBD1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TRBD1 Gene

Pathways & Interactions for TRBD1 Gene

PathCards logo

SuperPathways for TRBD1 Gene

No Data Available

Interacting Proteins for TRBD1 Gene

Gene Ontology (GO) - Biological Process for TRBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with TRBD1: view

No data available for Pathways by source and SIGNOR curated interactions for TRBD1 Gene

Drugs & Compounds for TRBD1 Gene

No Compound Related Data Available

Transcripts for TRBD1 Gene

mRNA/cDNA for TRBD1 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRBD1 Gene

No ASD Table

Relevant External Links for TRBD1 Gene

GeneLoc Exon Structure for
TRBD1

Expression for TRBD1 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRBD1 Gene

Orthologs for TRBD1 Gene

Evolution for TRBD1 Gene

ENSEMBL:
Gene Tree for TRBD1 (if available)
TreeFam:
Gene Tree for TRBD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRBD1: view image

No data available for Orthologs for TRBD1 Gene

Paralogs for TRBD1 Gene

No data available for Paralogs for TRBD1 Gene

Variants for TRBD1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TRBD1 Gene

TDB01_HUMAN-P0DPI4
There are several alleles. The sequence shown is that of IMGT allele TRBD1*01.

Additional Variant Information for TRBD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRBD1

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRBD1 Gene

Disorders for TRBD1 Gene

No disorders were found for TRBD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRBD1 Gene

Publications for TRBD1 Gene

  1. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PMID: 8650574) Rowen L … Hood L (Science (New York, N.Y.) 1996) 2 3
  2. T cell antigen receptor recognition of antigen-presenting molecules. (PMID: 25493333) Rossjohn J … McCluskey J (Annual review of immunology 2015) 4
  3. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4
  4. T cell receptor signalling networks: branched, diversified and bounded. (PMID: 23524462) Brownlie RJ … Zamoyska R (Nature reviews. Immunology 2013) 4
  5. Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling. (PMID: 20452950) Wucherpfennig KW … Call ME (Cold Spring Harbor perspectives in biology 2010) 4

Products for TRBD1 Gene

Sources for TRBD1 Gene