Aliases for TRBC1 Gene

Aliases for TRBC1 Gene

  • T Cell Receptor Beta Constant 1 2 3 4 5
  • BV05S1J2.2 2 3
  • TCRBC1 2 3
  • V_segment Translation Product 3
  • TRBC1 5
  • TCRB 3

External Ids for TRBC1 Gene

Previous GeneCards Identifiers for TRBC1 Gene

  • GC07U990262
  • GC07P141883
  • GC07P141962
  • GC07P141978
  • GC07P142007
  • GC07P141757
  • GC07P141672
  • GC07P142213
  • GC07P142227
  • GC07P142239
  • GC07P142251
  • GC07P142264
  • GC07P142278
  • GC07P142289
  • GC07Pg41892
  • GC07Pg41908
  • GC07P142297
  • GC07Pg41923
  • GC07Pg41929
  • GC07Pg41935
  • GC07Pg41941
  • GC07P9T0995
  • GC07P9T0100
  • GC07P142868
  • GC07P142924
  • GC07P144230
  • GC07P144365
  • GC07P144493
  • GC07P144735
  • GC07P143133
  • GC07P143200
  • GC07P143394
  • GC07P143540
  • GC07P143672
  • GC07P143813
  • GC07P143952
  • GC07P144086

Summaries for TRBC1 Gene

GeneCards Summary for TRBC1 Gene

TRBC1 (T Cell Receptor Beta Constant 1) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is TRBC2.

UniProtKB/Swiss-Prot Summary for TRBC1 Gene

  • Constant region of T cell receptor (TR) alpha chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:9382891, PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

Additional gene information for TRBC1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRBC1 Gene

Genomics for TRBC1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRBC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J142782 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.5 502 18.8 CTCF TEAD4 POLR2A LARP7 ZNF143 ZNF24 REST RAD21 IKZF2 TRIM22 LT601552 TRBC1 TRBV28 PRSS3P1 EPHB6 TRBV7-3 TRPV6 TRBD2 TRBJ1-3 TRBJ1-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRBC1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for TRBC1 Gene

Genomic Locations for TRBC1 Gene
chr7:142,791,694-142,793,368
(GRCh38/hg38)
Size:
1,675 bases
Orientation:
Plus strand

Genomic View for TRBC1 Gene

Genes around TRBC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRBC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRBC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRBC1 Gene

Proteins for TRBC1 Gene

  • Protein details for TRBC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01850-TRBC1_HUMAN
    Recommended name:
    T cell receptor beta constant 1
    Protein Accession:
    P01850
    Secondary Accessions:
    • A0A0J9YYE9
    • A0A5B8
    • A6NH51

    Protein attributes for TRBC1 Gene

    Size:
    176 amino acids
    Molecular mass:
    19769 Da
    Quaternary structure:
    • Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octomeric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.
    SequenceCaution:
    • Sequence=CAA25134.1; Type=Miscellaneous discrepancy; Note=Chimeric mRNA corresponding to regions V, J and C of T cell receptor (TR) alpha chain.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRBC1 Gene

neXtProt entry for TRBC1 Gene

Post-translational modifications for TRBC1 Gene

  • Glycosylation at Asn69
  • Modification sites at PhosphoSitePlus

Other Protein References for TRBC1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRBC1 Gene

Domains & Families for TRBC1 Gene

Gene Families for TRBC1 Gene

Protein Domains for TRBC1 Gene

Suggested Antigen Peptide Sequences for TRBC1 Gene

GenScript: Design optimal peptide antigens:
  • BV05S1J2.2 protein (Q5ZGJ7_HUMAN)
  • T-cell receptor beta-1 chain C region (TRBC1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01850

UniProtKB/Swiss-Prot:

TRBC1_HUMAN :
  • The connecting peptide (CP) domain is essential for signal transmission in response to antigenic stimulation, likely downstream from ZAP70 recruitment.
Domain:
  • The connecting peptide (CP) domain is essential for signal transmission in response to antigenic stimulation, likely downstream from ZAP70 recruitment.
  • The TM domain mediates the interaction with the CD3 subunits.
genes like me logo Genes that share domains with TRBC1: view

Function for TRBC1 Gene

Molecular function for TRBC1 Gene

UniProtKB/Swiss-Prot Function:
Constant region of T cell receptor (TR) alpha chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:9382891, PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

Phenotypes From GWAS Catalog for TRBC1 Gene

Gene Ontology (GO) - Molecular Function for TRBC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA 21873635
GO:0034987 immunoglobulin receptor binding IBA 21873635
genes like me logo Genes that share ontologies with TRBC1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRBC1 Gene

Localization for TRBC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRBC1 Gene

Cell membrane.

Gene Ontology (GO) - Cellular Components for TRBC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane NAS 6336315
GO:0016021 integral component of membrane IEA --
GO:0042101 T cell receptor complex IEA --
genes like me logo Genes that share ontologies with TRBC1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TRBC1 Gene

Pathways & Interactions for TRBC1 Gene

genes like me logo Genes that share pathways with TRBC1: view

Interacting Proteins for TRBC1 Gene

Gene Ontology (GO) - Biological Process for TRBC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006910 phagocytosis, recognition IBA 21873635
GO:0006911 phagocytosis, engulfment IBA 21873635
GO:0006955 immune response NAS 6336315
GO:0006958 complement activation, classical pathway IBA 21873635
GO:0042742 defense response to bacterium IBA 21873635
genes like me logo Genes that share ontologies with TRBC1: view

No data available for SIGNOR curated interactions for TRBC1 Gene

Drugs & Compounds for TRBC1 Gene

(1) Drugs for TRBC1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
3-Indolebutyric acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with TRBC1: view

Transcripts for TRBC1 Gene

mRNA/cDNA for TRBC1 Gene

1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRBC1 Gene

No ASD Table

Relevant External Links for TRBC1 Gene

GeneLoc Exon Structure for
TRBC1

Expression for TRBC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRBC1 Gene

Protein differential expression in normal tissues from HIPED for TRBC1 Gene

This gene is overexpressed in Tlymphocyte (51.6), CD4 Tcells (8.8), and Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRBC1 Gene



Protein tissue co-expression partners for TRBC1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRBC1

genes like me logo Genes that share expression patterns with TRBC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRBC1 Gene

Orthologs for TRBC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRBC1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRBV25-1 31
  • 79 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TRBV25-1 31
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 38 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 31 (a)
ManyToMany
-- 31
  • 20 (a)
ManyToMany
Species where no ortholog for TRBC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TRBC1 Gene

ENSEMBL:
Gene Tree for TRBC1 (if available)
TreeFam:
Gene Tree for TRBC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRBC1: view image

Paralogs for TRBC1 Gene

Variants for TRBC1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TRBC1 Gene

TRBC1_HUMAN-P01850
There are several alleles. The sequence shown is that of IMGT allele TRBC1*01.

Additional Variant Information for TRBC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRBC1

SNP Genotyping and Copy Number Assay Products

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRBC1 Gene

Disorders for TRBC1 Gene

No disorders were found for TRBC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRBC1 Gene

Publications for TRBC1 Gene

  1. Sequence and evolution of the human T-cell antigen receptor beta-chain genes. (PMID: 3860845) Tunnacliffe A … Rabbitts TH (Proceedings of the National Academy of Sciences of the United States of America 1985) 2 3 4
  2. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PMID: 8650574) Rowen L … Hood L (Science (New York, N.Y.) 1996) 3 4
  3. A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. (PMID: 6336315) Yanagi Y … Mak TW (Nature 1984) 3 4
  4. Light-Controlled Affinity Purification of Protein Complexes Exemplified by the Resting ZAP70 Interactome. (PMID: 30863395) Hörner M … Schamel WWA (Frontiers in immunology 2019) 3
  5. A conserved αβ transmembrane interface forms the core of a compact T-cell receptor-CD3 structure within the membrane. (PMID: 27791034) Krshnan L … Call ME (Proceedings of the National Academy of Sciences of the United States of America 2016) 4

Products for TRBC1 Gene

Sources for TRBC1 Gene