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Aliases for TRB Gene

Aliases for TRB Gene

  • T Cell Receptor Beta Locus 2 3
  • T-Cell Antigen Receptor, Beta Polypeptide, T-Cell Receptor, Beta Cluster 2 3
  • TCRB, TRB@ 2 3
  • T-Cell Receptor, Beta Cluster 3
  • TCRB 3
  • TRB@ 3

External Ids for TRB Gene

Previous HGNC Symbols for TRB Gene

  • TCRB
  • TRB@

Previous GeneCards Identifiers for TRB Gene

  • GC07P142763
  • GC07P142839
  • GC07P142876
  • GC07P143009
  • GC07P143157
  • GC07P143354
  • GC07P143505
  • GC07P143637
  • GC07P143777

Summaries for TRB Gene

Entrez Gene Summary for TRB Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRB Gene

TRB (T Cell Receptor Beta Locus) is a Protein Coding gene. Diseases associated with TRB include Precursor T-Cell Acute Lymphoblastic Leukemia and Granulomatous Slack Skin Disease. Among its related pathways are G-protein signaling N-RAS regulation pathway and T-Cell Receptor and Co-stimulatory Signaling.

Additional gene information for TRB Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRB Gene

Genomics for TRB Gene

GeneHancer (GH) Regulatory Elements for TRB Gene

Promoters and enhancers for TRB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I142297 Enhancer 0.6 dbSUPER 550.8 -0.8 -760 0.7 CTCF USF1 MAX BACH1 USF2 SP1 ZNF316 ZNF143 NFE2 TRB TRBV1 PRSS3P3
GH07I142300 Enhancer 0.6 ENCODE dbSUPER 550.8 +1.9 1862 0.2 CTCF ZNF143 TRB TRBV1 TRBV2
GH07I142301 Enhancer 0.6 Ensembl dbSUPER 0.8 +2.2 2190 0.4 CTCF POLR2A TRBV2 TRB TRBV3-1
GH07I142303 Enhancer 0.5 ENCODE dbSUPER 0.8 +4.8 4764 0.1 CTCF TRB TRBV2 TRBV3-1
GH07I142323 Enhancer 0.9 ENCODE dbSUPER 0.3 +24.8 24824 0.2 CTCF RB1 KLF17 BACH1 ZIC2 RAD21 HIC1 GLIS2 ZBTB48 PATZ1 TRBV6-1 TRBV5-1 LOC105375539 TRB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRB on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRB Gene

Genomic Locations for TRB Gene
514,277 bases
Plus strand

Genomic View for TRB Gene

Genes around TRB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRB Gene

Proteins for TRB Gene

  • Protein details for TRB Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    TRB protein
    Protein Accession:

    Protein attributes for TRB Gene

    174 amino acids
    Molecular mass:
    19651 Da
    Quaternary structure:
    No Data Available
  • Protein details for TRB Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    TRB protein
    Protein Accession:

    Protein attributes for TRB Gene

    200 amino acids
    Molecular mass:
    22541 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRB Gene

Post-translational modifications for TRB Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRB Gene

Domains & Families for TRB Gene

Gene Families for TRB Gene

Protein Domains for TRB Gene

Suggested Antigen Peptide Sequences for TRB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRB: view

No data available for UniProtKB/Swiss-Prot for TRB Gene

Function for TRB Gene

Phenotypes From GWAS Catalog for TRB Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRB Gene

Localization for TRB Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TRB Gene

Drugs & Compounds for TRB Gene

(5) Drugs for TRB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for TRB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRB: view

Transcripts for TRB Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRB Gene

No ASD Table

Relevant External Links for TRB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

No data available for mRNA/cDNA for TRB Gene

Expression for TRB Gene

NURSA nuclear receptor signaling pathways regulating expression of TRB Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRB Gene

Orthologs for TRB Gene

No data available for Orthologs and Evolution for TRB Gene

Paralogs for TRB Gene

No data available for Paralogs for TRB Gene

Variants for TRB Gene

Additional Variant Information for TRB Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRB Gene

Disorders for TRB Gene

MalaCards: The human disease database

(10) MalaCards diseases for TRB Gene - From: HGMD, Orphanet, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
granulomatous slack skin disease
  • granulomatous slack skin
b-cell expansion with nfkb and t-cell anergy
  • persistent polyclonal b-cell lymphocytosis
acute t cell leukemia
  • precursor t lymphoblastic leukemia
pure red-cell aplasia
  • primary red cell aplasia
- elite association - COSMIC cancer census association via MalaCards
Search TRB in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with TRB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRB Gene

Publications for TRB Gene

  1. Molecular analysis of T-cell receptor beta genes in cutaneous T-cell lymphoma reveals Jbeta1 bias. (PMID: 16741518) Morgan SM … Smith JL (The Journal of investigative dermatology 2006) 3 22 58
  2. Location of gene for beta subunit of human T-cell receptor at band 7q35, a region prone to rearrangements in T cells. (PMID: 3983641) Isobe M … Croce CM (Science (New York, N.Y.) 1985) 2 3 58
  3. Composition and Variation Analysis of the T Cell Receptor β-Chain Complementarity Determining Region 3 Repertoire in Neonatal Sepsis. (PMID: 28891256) Sun J … Zhou W (Scandinavian journal of immunology 2017) 3 58
  4. The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed β2-Microglobulin through Distinct Binding Sites. (PMID: 28671821) Merkle PS … Rand KD (Biochemistry 2017) 3 58
  5. Analysis of the Repertoire Features of TCR Beta Chain CDR3 in Human by High-Throughput Sequencing. (PMID: 27442436) Hou X … Diao H (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016) 3 58

Products for TRB Gene

Sources for TRB Gene

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