T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed... See more...

Aliases for TRB Gene

Aliases for TRB Gene

  • T Cell Receptor Beta Locus 2 3
  • T-Cell Antigen Receptor, Beta Polypeptide, T-Cell Receptor, Beta Cluster 2 3
  • TCRB, TRB@ 2 3
  • M1-Specific T Cell Receptor Beta Chain 4
  • TR Beta Chain TRBV25-1*01J2S3*01C2*01 4
  • TR Beta Chain TRBV19*01J2S7*01C*02 4
  • T Cell Receptor Beta Chain MC.7.G5 4
  • T-Cell Receptor, Beta Cluster 3
  • MC.7.G5 TRB 4
  • TCRB 3
  • TRB@ 3

External Ids for TRB Gene

Previous HGNC Symbols for TRB Gene

  • TCRB
  • TRB@

Previous GeneCards Identifiers for TRB Gene

  • GC07P142763
  • GC07P142839
  • GC07P142876
  • GC07P143009
  • GC07P144290
  • GC07P144424
  • GC07P144641
  • GC07P144881
  • GC07P143157
  • GC07P143354
  • GC07P143505
  • GC07P143637
  • GC07P143777
  • GC07P143918
  • GC07P144054
  • GC07P144143
  • GC07P145138

Summaries for TRB Gene

Entrez Gene Summary for TRB Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRB Gene

TRB (T Cell Receptor Beta Locus) is a Protein Coding gene. Diseases associated with TRB include Trypsinogen Deficiency and Prss1-Related Hereditary Pancreatitis. Among its related pathways are Immune response Function of MEF2 in T lymphocytes and Cytokines and Inflammatory Response.

UniProtKB/Swiss-Prot Summary for TRB Gene

  • The beta chain of TRAV27*01J42*01C*01/TRBV19*01J2S7*01C*02 alpha-beta T cell receptor (TR) clonotype that is specific for HLA-A*02:01-restricted M/matrix protein 1 immunodominant epitope GILGFVFTL of influenza A virus (IAV). Classified as a public TCR clonotype, it is preferentially selected in effector memory CD8-positive T cells among multiple HLA-A*02:01 carriers/individuals and confers long-lived immunity against IAV infection. Can cross-recognize sporadically emerging IAV variants by molecular mimicry, inducing immunity toward different influenza strains (PubMed:1833769, PubMed:7807026, PubMed:29997621, PubMed:27036003, PubMed:12796775, PubMed:18275829). Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity).
  • The beta chain of TRAV38-2DV8*01J31*01C*01/TRBV25-1*01J2S3*01C2*01 alpha-beta T cell receptor (TR) clonotype that displays pan-cancer cell recognition via the invariant MR1 molecule. On CD8-positive T cell clone MC.7.G5, likely recognizes tumor-specific or -associated metabolite(s) essential for cancer cell survival, triggering killing of many cancer cell types including lung, melanoma, leukemia, colon, breast, prostate, bone and ovarian cancer cells. Mediates cancer cell cytotoxicity in an HLA-independent manner. Has no reactivity to healthy cells even stressed or infected by bacteria (PubMed:31959982). Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity).

Additional gene information for TRB Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRB Gene

Genomics for TRB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J142297 Enhancer 0.7 Ensembl dbSUPER 250.7 -0.6 -604 1.2 CTCF YY1 ZNF316 SPI1 NFE2 MAX SP1 RAD21 ZNF143 USF2 TRB TRBV1 lnc-MGAM2-8 PRSS3P3 PRSS58
GH07J142300 Enhancer 0.5 ENCODE dbSUPER 250.7 +1.9 1862 0.2 CTCF ZNF143 HSALNG0061881 HSALNG0061882 TRB TRBV1 TRBV2 lnc-MGAM2-8
GH07J142303 Enhancer 0.7 Ensembl ENCODE dbSUPER 0.7 +4.9 4905 0.6 CTCF RAD21 POLR2A HSALNG0061882 TRY2P HSALNG0061883 TRB TRBV2 TRBV3-1 LOC105375539
GH07J142301 Promoter/Enhancer 0.6 Ensembl dbSUPER 0.7 +2.3 2290 0.2 POLR2A HSALNG0061881 HSALNG0061882 TRBV2 TRB TRBV3-1
GH07J142323 Enhancer 1 Ensembl ENCODE dbSUPER 0.3 +25.2 25190 1.2 CTCF ZIC2 VEZF1 RAD51 ZBTB48 ZNF189 RLF ZNF143 GLIS1 USF2 TRBV5-1 TRBV6-1 LOC105375539 TRB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRB on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for TRB Gene

Latest Assembly
chr7:142,299,011-142,813,287
(GRCh38/hg38)
Size:
514,277 bases
Orientation:
Plus strand

Previous Assembly
chr7:141,998,851-142,510,972
(GRCh37/hg19 by Entrez Gene)
Size:
512,122 bases
Orientation:
Plus strand

Genomic View for TRB Gene

Genes around TRB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRB Gene

Proteins for TRB Gene

  • Protein details for TRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DSE2-TRBR1_HUMAN
    Recommended name:
    M1-specific T cell receptor beta chain
    Protein Accession:
    P0DSE2

    Protein attributes for TRB Gene

    Size:
    310 amino acids
    Molecular mass:
    34792 Da
    Quaternary structure:
    • Disulfide-linked heterodimer with TRAV27*01J42*01C*01 alpha chain. The TR primarily interacts via its CDR3-beta domain with M/matrix protein 1-derived peptide (GILGFVFTL) displayed by HLA-A*02.01 in a 'peg-notch' recognition mode (PubMed:27036003, PubMed:12796775, PubMed:18275829). The alpha-beta TR associates with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octomeric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains (via TM domain), respectively. The association of the CD247 homodimer is the last step of TCR assembly in the endoplasmic reticulum and is required for transport to the cell surface (By similarity).
    Miscellaneous:
    • The JM22 clone described as a variant of the public clonotype differs by one amino acid in the CDR3-beta domain.

    Three dimensional structures from OCA and Proteopedia for TRB Gene

  • Protein details for TRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DTU4-TRBR2_HUMAN
    Recommended name:
    T cell receptor beta chain MC.7.G5
    Protein Accession:
    P0DTU4

    Protein attributes for TRB Gene

    Size:
    315 amino acids
    Molecular mass:
    35490 Da
    Quaternary structure:
    • Disulfide-linked heterodimer with TRAV38-2DV8*01J31*01C*01 alpha chain (PubMed:31959982). The alpha-beta TR associates with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octomeric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains (via TM domain), respectively. The association of the CD247 homodimer is the last step of TCR assembly in the endoplasmic reticulum and is required for transport to the cell surface (By similarity).

neXtProt entry for TRB Gene

Post-translational modifications for TRB Gene

  • Glycosylation at Asn72 and Asn206

Antibodies for research

No data available for DME Specific Peptides for TRB Gene

Domains & Families for TRB Gene

Gene Families for TRB Gene

Protein Domains for TRB Gene

Suggested Antigen Peptide Sequences for TRB Gene

GenScript: Design optimal peptide antigens:
  • T-cell receptor beta chain V region CTL-L17 (TVB2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0DSE2

UniProtKB/Swiss-Prot:

TRBR2_HUMAN :
  • The complementarity-determining region CDR1 confers specificity to the peptide antigen. Assumes a loop structure that recognizes the peptide-HLA-A*02-B2M complex.
Domain:
  • The complementarity-determining region CDR1 confers specificity to the peptide antigen. Assumes a loop structure that recognizes the peptide-HLA-A*02-B2M complex.
  • The complementarity-determining region CDR2 confers specificity to the peptide antigen. Assumes a loop structure that recognizes the peptide-HLA-A*02-B2M complex.
  • The complementarity-determining region CDR3 confers specificity to the peptide antigen. Assumes a loop structure that recognizes the peptide-HLA-A*02-B2M complex. Recognizes M/matrix protein 1-derived peptide mainly via its xRSx motif.
  • The connecting peptide (CP) domain is essential for signal transmission in response to antigenic stimulation, likely downstream from ZAP70 recruitment.
  • The TM domain mediates the interaction with the CD3 subunits.
  • The complementarity-determining region CDR1 confers specificity to the metabolite antigen.
  • The complementarity-determining region CDR2 confers specificity to the metabolite antigen.
  • The complementarity-determining region CDR3 confers specificity to the metabolite antigen.
genes like me logo Genes that share domains with TRB: view

Function for TRB Gene

Molecular function for TRB Gene

UniProtKB/Swiss-Prot Function:
The beta chain of TRAV27*01J42*01C*01/TRBV19*01J2S7*01C*02 alpha-beta T cell receptor (TR) clonotype that is specific for HLA-A*02:01-restricted M/matrix protein 1 immunodominant epitope GILGFVFTL of influenza A virus (IAV). Classified as a public TCR clonotype, it is preferentially selected in effector memory CD8-positive T cells among multiple HLA-A*02:01 carriers/individuals and confers long-lived immunity against IAV infection. Can cross-recognize sporadically emerging IAV variants by molecular mimicry, inducing immunity toward different influenza strains (PubMed:1833769, PubMed:7807026, PubMed:29997621, PubMed:27036003, PubMed:12796775, PubMed:18275829). Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity).
UniProtKB/Swiss-Prot Function:
The beta chain of TRAV38-2DV8*01J31*01C*01/TRBV25-1*01J2S3*01C2*01 alpha-beta T cell receptor (TR) clonotype that displays pan-cancer cell recognition via the invariant MR1 molecule. On CD8-positive T cell clone MC.7.G5, likely recognizes tumor-specific or -associated metabolite(s) essential for cancer cell survival, triggering killing of many cancer cell types including lung, melanoma, leukemia, colon, breast, prostate, bone and ovarian cancer cells. Mediates cancer cell cytotoxicity in an HLA-independent manner. Has no reactivity to healthy cells even stressed or infected by bacteria (PubMed:31959982). Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity).

Phenotypes From GWAS Catalog for TRB Gene

Gene Ontology (GO) - Molecular Function for TRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038023 signaling receptor activity IDA 31959982
genes like me logo Genes that share ontologies with TRB: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRB Gene

Localization for TRB Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRB Gene

Gene Ontology (GO) - Cellular Components for TRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0042105 alpha-beta T cell receptor complex IDA 31959982
genes like me logo Genes that share ontologies with TRB: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TRB Gene

Pathways & Interactions for TRB Gene

PathCards logo

SuperPathways for TRB Gene

SuperPathway Contained pathways
1 Immune response NFAT in immune response
.56
.56
.52
.52
2 G-protein signaling N-RAS regulation pathway
.52
.52
3 G-protein signaling_Rap1A regulation pathway
-
4 G-protein signaling_Regulation of RAC1 activity
-
5 Antigen processing-Cross presentation
.51
genes like me logo Genes that share pathways with TRB: view

Pathways by source for TRB Gene

15 GeneGo (Thomson Reuters) pathways for TRB Gene
  • G-protein signaling N-RAS regulation pathway
  • G-protein signaling_Rap1A regulation pathway
  • G-protein signaling_Regulation of RAC1 activity
  • Immune response Antigen presentation by MHC class I
  • Immune response Antigen presentation by MHC class II

Interacting Proteins for TRB Gene

Gene Ontology (GO) - Biological Process for TRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002355 detection of tumor cell IDA 31959982
GO:0002419 T cell mediated cytotoxicity directed against tumor cell target IDA 31959982
genes like me logo Genes that share ontologies with TRB: view

No data available for SIGNOR curated interactions for TRB Gene

Drugs & Compounds for TRB Gene

(5) Drugs for TRB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for TRB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRB: view

Transcripts for TRB Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRB Gene

No ASD Table

Relevant External Links for TRB Gene

GeneLoc Exon Structure for
TRB

No data available for mRNA/cDNA for TRB Gene

Expression for TRB Gene

mRNA Expression by UniProt/SwissProt for TRB Gene:

P0DSE2-TRBR1_HUMAN
Tissue specificity: Expressed in M/matrix protein 1-specific effector memory CD8-positive T cells readily detectable in the peripheral blood, secondary lymphoid organs and lung (primary site of infection) of IAV infected individuals.

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRB Gene

Orthologs for TRB Gene

No data available for Orthologs and Evolution for TRB Gene

Paralogs for TRB Gene

No data available for Paralogs for TRB Gene

Variants for TRB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRB Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
653067 Uncertain Significance: Hereditary pancreatitis 142,752,462(+) TG/CA
NM_002769.5(PRSS1):c.486_487inv (p.Ala163Thr)
MISSENSE
835637 Uncertain Significance: Hereditary pancreatitis 142,751,968(+) C/A
NM_002769.5(PRSS1):c.395C>A (p.Pro132His)
MISSENSE
835873 Uncertain Significance: Hereditary pancreatitis 142,751,812(+) T/G
NM_002769.5(PRSS1):c.239T>G (p.Val80Gly)
MISSENSE
836237 Uncertain Significance: Hereditary pancreatitis 142,751,776(+) G/A
NM_002769.5(PRSS1):c.203G>A (p.Arg68His)
MISSENSE
843019 Uncertain Significance: Hereditary pancreatitis 142,750,594(+) G/A
NM_002769.5(PRSS1):c.80G>A (p.Gly27Asp)
MISSENSE

Additional Variant Information for TRB Gene

Human Gene Mutation Database (HGMD)
TRB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRB Gene

Disorders for TRB Gene

MalaCards: The human disease database

(11) MalaCards diseases for TRB Gene - From: CVR, ORP, and GCD

Disorder Aliases PubMed IDs
trypsinogen deficiency
  • pancreatic trypsinogen deficiency
prss1-related hereditary pancreatitis
pancreatitis, hereditary
  • pctt
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
red cell aplasia
- elite association - COSMIC cancer census association via MalaCards
Search TRB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TRB

genes like me logo Genes that share disorders with TRB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRB Gene

Publications for TRB Gene

  1. Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. (PMID: 31959982) Crowther MD … Sewell AK (Nature immunology 2020) 3 4
  2. The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain. (PMID: 18275829) Ishizuka J … Jones EY (Immunity 2008) 3 4
  3. Molecular analysis of T-cell receptor beta genes in cutaneous T-cell lymphoma reveals Jbeta1 bias. (PMID: 16741518) Morgan SM … Smith JL (The Journal of investigative dermatology 2006) 3 23
  4. Protein displays of the human T cell receptor alpha, beta, gamma and delta variable and joining regions. (PMID: 11096259) Folch G … Lefranc MP (Experimental and clinical immunogenetics 2000) 3 4
  5. Identification and functional characterization of the human T-cell receptor beta gene transcriptional enhancer: common nuclear proteins interact with the transcriptional regulatory elements of the T-cell receptor alpha and beta genes. (PMID: 2144610) Gottschalk LR … Leiden JM (Molecular and cellular biology 1990) 3 23

Products for TRB Gene

Sources for TRB Gene