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Aliases for TRAV8-5 Gene

Aliases for TRAV8-5 Gene

  • T Cell Receptor Alpha Variable 8-5 (Pseudogene) 2 3
  • T-Cell Receptor Alpha Variable 8-5 (Pseudogene) 5
  • TCRAV8S5 3
  • TRAV85 3

External Ids for TRAV8-5 Gene

Previous GeneCards Identifiers for TRAV8-5 Gene

  • GC14U990318
  • GC14P020361
  • GC14P021441
  • GC14P022371
  • GC14P002489

Summaries for TRAV8-5 Gene

Entrez Gene Summary for TRAV8-5 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV8-5 Gene

TRAV8-5 (T Cell Receptor Alpha Variable 8-5 (Pseudogene)) is a Pseudogene.

Additional gene information for TRAV8-5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV8-5 Gene

Genomics for TRAV8-5 Gene

GeneHancer (GH) Regulatory Elements for TRAV8-5 Gene

Promoters and enhancers for TRAV8-5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I021902 Enhancer 0.3 Ensembl 589.8 -0.1 -76 0.4 CTCF TRAV8-5 TRAV8-4 TRA
GH14I021903 Enhancer 0.3 ENCODE 589.8 -0.4 -361 0.2 CTCF TRAV8-5 TRAV8-4 TRA
GH14I021887 Enhancer 0.8 ENCODE 29.4 -15.1 -15106 1.2 PKNOX1 FOXA2 ZSCAN4 FEZF1 ZNF335 ZNF302 FOS EGR2 SP3 ZNF280D TRAV12-2 METTL3 TRAV8-5 SUPT16H METTL17 RAB2B LINC00641 ENSG00000258458 MMP14 CHD8
GH14I021263 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 5.6 -636.0 -636023 7.6 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 HNRNPC SUPT16H METTL3 CHD8 METTL17 ENSG00000258515 PIP4P1 RAB2B APEX1 TRAV8-5
GH14I022472 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.2 +585.5 585471 32 HDGF PKNOX1 SMAD1 YBX1 IRF4 TCF12 ZNF207 ZNF143 ATF7 RUNX3 GC14P024192 GC14P024203 TRAJ48 TRAJ49 TRAJ50 TRAJ51 PRMT5-AS1 ABHD4 MMP14 MRPL52
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRAV8-5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRAV8-5 Gene

Genomic Locations for TRAV8-5 Gene
1,522 bases
Plus strand

Genomic View for TRAV8-5 Gene

Genes around TRAV8-5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV8-5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV8-5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV8-5 Gene

Proteins for TRAV8-5 Gene

Post-translational modifications for TRAV8-5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRAV8-5 Gene

Domains & Families for TRAV8-5 Gene

Gene Families for TRAV8-5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV8-5: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAV8-5 Gene

Function for TRAV8-5 Gene

Phenotypes From GWAS Catalog for TRAV8-5 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV8-5 Gene

Localization for TRAV8-5 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TRAV8-5 Gene

Pathways & Interactions for TRAV8-5 Gene

SuperPathways for TRAV8-5 Gene

No Data Available

Interacting Proteins for TRAV8-5 Gene

Gene Ontology (GO) - Biological Process for TRAV8-5 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRAV8-5 Gene

Drugs & Compounds for TRAV8-5 Gene

No Compound Related Data Available

Transcripts for TRAV8-5 Gene

mRNA/cDNA for TRAV8-5 Gene

(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV8-5 Gene

No ASD Table

Relevant External Links for TRAV8-5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAV8-5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAV8-5 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV8-5 Gene

This gene is overexpressed in Nerve - Tibial (x11.0), Brain - Spinal cord (cervical c-1) (x7.8), Whole Blood (x5.4), and Colon - Sigmoid (x5.2).
genes like me logo Genes that share expression patterns with TRAV8-5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAV8-5 Gene

Orthologs for TRAV8-5 Gene

Evolution for TRAV8-5 Gene

Gene Tree for TRAV8-5 (if available)
Gene Tree for TRAV8-5 (if available)

No data available for Orthologs for TRAV8-5 Gene

Paralogs for TRAV8-5 Gene

No data available for Paralogs for TRAV8-5 Gene

Variants for TRAV8-5 Gene

Additional Variant Information for TRAV8-5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV8-5 Gene

Disorders for TRAV8-5 Gene

Additional Disease Information for TRAV8-5

No disorders were found for TRAV8-5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAV8-5 Gene

Publications for TRAV8-5 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop BF … Hood L (Genomics 1994) 2 3 58
  2. Comprehensive analysis of the functional TCR repertoire at the single-cell level. (PMID: 18191637) Ozawa T … Muraguchi A (Biochemical and biophysical research communications 2008) 3 58

Products for TRAV8-5 Gene

Sources for TRAV8-5 Gene

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