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Aliases for TRAV39 Gene

Aliases for TRAV39 Gene

  • T Cell Receptor Alpha Variable 39 2 3
  • T-Cell Receptor Alpha Variable 39 5
  • TCRAV27S1 3
  • TCRAV39S1 3

External Ids for TRAV39 Gene

Previous GeneCards Identifiers for TRAV39 Gene

  • GC14U990279
  • GC14P020762
  • GC14P021841
  • GC14P022773
  • GC14P022809
  • GC14P022860

Summaries for TRAV39 Gene

Entrez Gene Summary for TRAV39 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV39 Gene

TRAV39 (T Cell Receptor Alpha Variable 39) is a Protein Coding gene. An important paralog of this gene is TRAV41.

Additional gene information for TRAV39 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV39 Gene

Genomics for TRAV39 Gene

GeneHancer (GH) Regulatory Elements for TRAV39 Gene

Promoters and enhancers for TRAV39 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I022296 Enhancer 0.8 ENCODE 0.4 -7.2 -7171 0.2 PKNOX1 FOXA2 NEUROD1 FEZF1 RARA ETS1 RCOR1 MIXL1 HMG20B GATAD2B TRAV39 TRAV38-2DV8 TRA
GH14I022289 Enhancer 0.8 FANTOM5 ENCODE 0.4 -14.2 -14228 0.3 ZNF687 CEBPB DPF2 EP300 ZNF592 SREBF1 CTBP1 GATA3 JUND CREB1 TRAV38-2DV8 TRAV39 TRA
GH14I022314 Enhancer 0.7 ENCODE 0.4 +10.3 10320 0.2 SMARCA5 CTCF ZNF654 ATF1 TEAD1 TRIM22 RAD21 ATF2 TEAD3 SMC3 TRAV40 TRAV39 TRA
GH14I022280 Enhancer 0.7 Ensembl ENCODE 0.3 -22.7 -22681 1.6 ATM ZNF512 YBX1 PRDM10 PLRG1 E4F1 TRAV38-2DV8 CDH24 METTL3 SUPT16H RAB2B TRAV39 TRA
GH14I022282 Enhancer 0.3 ENCODE 0.3 -21.4 -21441 0.2 HMBOX1 TRAV38-2DV8 TRAV39 TRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRAV39 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRAV39 Gene

Genomic Locations for TRAV39 Gene
500 bases
Plus strand

Genomic View for TRAV39 Gene

Genes around TRAV39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV39 Gene

Proteins for TRAV39 Gene

  • Protein details for TRAV39 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    T-cell receptor alpha variable 39
    Protein Accession:

    Protein attributes for TRAV39 Gene

    110 amino acids
    Molecular mass:
    12540 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAV39 Gene

Post-translational modifications for TRAV39 Gene

No Post-translational modifications

Other Protein References for TRAV39 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV39 Gene

Domains & Families for TRAV39 Gene

Gene Families for TRAV39 Gene

Protein Domains for TRAV39 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV39: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAV39 Gene

Function for TRAV39 Gene

Animal Model Products

miRNA for TRAV39 Gene

miRTarBase miRNAs that target TRAV39

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAV39 Gene

Localization for TRAV39 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TRAV39 Gene

Pathways & Interactions for TRAV39 Gene

SuperPathways for TRAV39 Gene

No Data Available

Interacting Proteins for TRAV39 Gene

Gene Ontology (GO) - Biological Process for TRAV39 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRAV39 Gene

Drugs & Compounds for TRAV39 Gene

No Compound Related Data Available

Transcripts for TRAV39 Gene

mRNA/cDNA for TRAV39 Gene

(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV39 Gene

No ASD Table

Relevant External Links for TRAV39 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAV39 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAV39 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV39 Gene

This gene is overexpressed in Artery - Coronary (x15.5), Artery - Tibial (x10.4), and Whole Blood (x7.9).

NURSA nuclear receptor signaling pathways regulating expression of TRAV39 Gene:

genes like me logo Genes that share expression patterns with TRAV39: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAV39 Gene

Orthologs for TRAV39 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRAV39 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia TRAV39 34
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia TRAV39 34
  • 45 (a)
Species where no ortholog for TRAV39 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV39 Gene

Gene Tree for TRAV39 (if available)
Gene Tree for TRAV39 (if available)

Paralogs for TRAV39 Gene

Paralogs for TRAV39 Gene

genes like me logo Genes that share paralogs with TRAV39: view

Variants for TRAV39 Gene

Additional Variant Information for TRAV39 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV39 Gene

Disorders for TRAV39 Gene

Additional Disease Information for TRAV39

Human Genome Epidemiology Navigator

No disorders were found for TRAV39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAV39 Gene

Publications for TRAV39 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop BF … Hood L (Genomics 1994) 2 3 58

Products for TRAV39 Gene

Sources for TRAV39 Gene

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