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Aliases for TRAV38-2DV8 Gene

Aliases for TRAV38-2DV8 Gene

  • T Cell Receptor Alpha Variable 38-2/Delta Variable 8 2 3
  • T Cell Receptor Alpha/Delta Variable 38-2/DV8 2 3
  • T-Cell Receptor Alpha Variable 38-2/Delta Variable 8 5
  • TRAV38-2/DV8 3
  • TRAV382DV8 3
  • TCRAV14S1 3
  • HADV38S2 3

External Ids for TRAV38-2DV8 Gene

Previous GeneCards Identifiers for TRAV38-2DV8 Gene

  • GC14U990280
  • GC14P020739
  • GC14P021818
  • GC14P022750
  • GC14P022786
  • GC14P022856

Summaries for TRAV38-2DV8 Gene

Entrez Gene Summary for TRAV38-2DV8 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV38-2DV8 Gene

TRAV38-2DV8 (T Cell Receptor Alpha Variable 38-2/Delta Variable 8) is a Protein Coding gene. An important paralog of this gene is TRAV38-1.

Additional gene information for TRAV38-2DV8 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV38-2DV8 Gene

Genomics for TRAV38-2DV8 Gene

GeneHancer (GH) Regulatory Elements for TRAV38-2DV8 Gene

Promoters and enhancers for TRAV38-2DV8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I022280 Enhancer 0.7 Ensembl ENCODE 550.8 +0.3 268 1.6 ATM ZNF512 YBX1 PRDM10 PLRG1 E4F1 TRAV38-2DV8 CDH24 METTL3 SUPT16H RAB2B TRAV39 TRA
GH14I022282 Enhancer 0.3 ENCODE 550.8 +1.5 1508 0.2 HMBOX1 TRAV38-2DV8 TRAV39 TRA
GH14I022332 Enhancer 1.2 Ensembl ENCODE 4.7 +52.9 52865 2.5 PKNOX1 FOXA2 ARID4B NEUROD1 SIN3A FEZF1 ZNF2 IRF4 ZNF766 FOS LOC100420343 METTL3 SUPT16H ACIN1 CHD8 RBM23 PRMT5-AS1 TRAV38-2DV8 TRAV41 TRA
GH14I022382 Enhancer 0.8 ENCODE 4.5 +103.1 103139 4 HDGF PKNOX1 SMAD1 RB1 BMI1 BATF KLF5 ATF7 ETV6 BCLAF1 MMP14 OR6J1 MRPL52 SLC7A7 TRAV38-2DV8 ENSG00000259042 LOC100420343 ENSG00000251002 TRA
GH14I022392 Enhancer 0.6 ENCODE 4.5 +110.2 110233 0.3 HDGF SMARCA5 NR2F1 DPF2 ZNF217 NFATC1 IKZF1 NBN ATF7 ETV6 TRAV38-2DV8 ENSG00000259042 LOC100420343 ENSG00000251002 TRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRAV38-2DV8 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRAV38-2DV8 Gene

Genomic Locations for TRAV38-2DV8 Gene
644 bases
Plus strand

Genomic View for TRAV38-2DV8 Gene

Genes around TRAV38-2DV8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV38-2DV8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV38-2DV8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV38-2DV8 Gene

Proteins for TRAV38-2DV8 Gene

  • Protein details for TRAV38-2DV8 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for TRAV38-2DV8 Gene

    116 amino acids
    Molecular mass:
    13278 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAV38-2DV8 Gene

Post-translational modifications for TRAV38-2DV8 Gene

No Post-translational modifications

Other Protein References for TRAV38-2DV8 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV38-2DV8 Gene

Domains & Families for TRAV38-2DV8 Gene

Gene Families for TRAV38-2DV8 Gene

Protein Domains for TRAV38-2DV8 Gene

Suggested Antigen Peptide Sequences for TRAV38-2DV8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV38-2DV8: view

No data available for UniProtKB/Swiss-Prot for TRAV38-2DV8 Gene

Function for TRAV38-2DV8 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV38-2DV8 Gene

Localization for TRAV38-2DV8 Gene

Gene Ontology (GO) - Cellular Components for TRAV38-2DV8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with TRAV38-2DV8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TRAV38-2DV8 Gene

Pathways & Interactions for TRAV38-2DV8 Gene

SuperPathways for TRAV38-2DV8 Gene

No Data Available

Interacting Proteins for TRAV38-2DV8 Gene

Gene Ontology (GO) - Biological Process for TRAV38-2DV8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with TRAV38-2DV8: view

No data available for Pathways by source and SIGNOR curated interactions for TRAV38-2DV8 Gene

Drugs & Compounds for TRAV38-2DV8 Gene

No Compound Related Data Available

Transcripts for TRAV38-2DV8 Gene

mRNA/cDNA for TRAV38-2DV8 Gene

(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV38-2DV8 Gene

No ASD Table

Relevant External Links for TRAV38-2DV8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAV38-2DV8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAV38-2DV8 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV38-2DV8 Gene

This gene is overexpressed in Whole Blood (x21.3), Artery - Tibial (x5.3), and Artery - Coronary (x5.1).
genes like me logo Genes that share expression patterns with TRAV38-2DV8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAV38-2DV8 Gene

Orthologs for TRAV38-2DV8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRAV38-2DV8 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia -- 34
  • 75 (a)
-- 34
  • 67 (a)
(Bos Taurus)
Mammalia -- 34
  • 63 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 52 (a)
-- 34
  • 50 (a)
-- 34
  • 48 (a)
-- 34
  • 46 (a)
-- 34
  • 45 (a)
-- 34
  • 45 (a)
-- 34
  • 44 (a)
-- 34
  • 44 (a)
-- 34
  • 36 (a)
-- 34
  • 32 (a)
Species where no ortholog for TRAV38-2DV8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV38-2DV8 Gene

Gene Tree for TRAV38-2DV8 (if available)
Gene Tree for TRAV38-2DV8 (if available)

Paralogs for TRAV38-2DV8 Gene

Paralogs for TRAV38-2DV8 Gene

genes like me logo Genes that share paralogs with TRAV38-2DV8: view

Variants for TRAV38-2DV8 Gene

Additional Variant Information for TRAV38-2DV8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV38-2DV8 Gene

Disorders for TRAV38-2DV8 Gene

No disorders were found for TRAV38-2DV8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRAV38-2DV8 Gene

Publications for TRAV38-2DV8 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop BF … Hood L (Genomics 1994) 2 3 58

Products for TRAV38-2DV8 Gene

Sources for TRAV38-2DV8 Gene

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