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Aliases for TRAV24 Gene

Aliases for TRAV24 Gene

  • T Cell Receptor Alpha Variable 24 2 3
  • T-Cell Receptor Alpha Variable 24 5
  • TCRAV24S1 3
  • TCRAV18S1 3

External Ids for TRAV24 Gene

Previous GeneCards Identifiers for TRAV24 Gene

  • GC14U990296
  • GC14P020563
  • GC14P021643
  • GC14P022575
  • GC14P022576
  • GC14P022605
  • GC14P022732
  • GC14P022831

Summaries for TRAV24 Gene

Entrez Gene Summary for TRAV24 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV24 Gene

TRAV24 (T Cell Receptor Alpha Variable 24) is a Protein Coding gene. Among its related pathways are G-protein signaling N-RAS regulation pathway and G-protein signaling_Regulation of RAC1 activity. An important paralog of this gene is TRAV36DV7.

Additional gene information for TRAV24 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV24 Gene

Genomics for TRAV24 Gene

GeneHancer (GH) Regulatory Elements for TRAV24 Gene

Promoters and enhancers for TRAV24 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I022104 Enhancer 0.4 ENCODE dbSUPER 550.8 -0.2 -162 1.1 TRAV24 RBM23 TRAV8-4 TRDV1 TRA
GH14I022100 Enhancer 0.8 ENCODE 0.8 -4.9 -4934 0.2 ELF3 ARID4B ZNF48 ZSCAN9 RAD21 ZNF143 THAP11 MIXL1 SMARCA5 MXD4 TRAV24 TRDV1 TRA
GH14I022095 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.4 -8.3 -8269 3.2 ZBED1 ZFP64 FOXP2 MNT RFX5 ZNF7 TRDV1 TRAV24 TRA
GH14I022112 Enhancer 0.7 ENCODE dbSUPER 0.4 +6.9 6870 0.1 CTCF GATA3 ZNF143 RAD21 TRAV25 TRAV24 TRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRAV24 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRAV24 Gene

Genomic Locations for TRAV24 Gene
504 bases
Plus strand

Genomic View for TRAV24 Gene

Genes around TRAV24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV24 Gene

Proteins for TRAV24 Gene

  • Protein details for TRAV24 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    T-cell receptor alpha variable 24
    Protein Accession:

    Protein attributes for TRAV24 Gene

    114 amino acids
    Molecular mass:
    12919 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAV24 Gene

Post-translational modifications for TRAV24 Gene

No Post-translational modifications

Other Protein References for TRAV24 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV24 Gene

Domains & Families for TRAV24 Gene

Gene Families for TRAV24 Gene

Protein Domains for TRAV24 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV24: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAV24 Gene

Function for TRAV24 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV24 Gene

Localization for TRAV24 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TRAV24 Gene

Drugs & Compounds for TRAV24 Gene

No Compound Related Data Available

Transcripts for TRAV24 Gene

mRNA/cDNA for TRAV24 Gene

(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV24 Gene

No ASD Table

Relevant External Links for TRAV24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAV24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAV24 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV24 Gene

This gene is overexpressed in Whole Blood (x32.5).

NURSA nuclear receptor signaling pathways regulating expression of TRAV24 Gene:

genes like me logo Genes that share expression patterns with TRAV24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAV24 Gene

Orthologs for TRAV24 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRAV24 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 34
  • 66 (a)
-- 34
  • 61 (a)
(Canis familiaris)
Mammalia TRAV24 34
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 50 (a)
-- 34
  • 48 (a)
-- 34
  • 46 (a)
-- 34
  • 44 (a)
-- 34
  • 44 (a)
-- 34
  • 44 (a)
-- 34
  • 43 (a)
-- 34
  • 41 (a)
-- 34
  • 35 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 37 (a)
Species where no ortholog for TRAV24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV24 Gene

Gene Tree for TRAV24 (if available)
Gene Tree for TRAV24 (if available)

Paralogs for TRAV24 Gene

Paralogs for TRAV24 Gene

genes like me logo Genes that share paralogs with TRAV24: view

Variants for TRAV24 Gene

Additional Variant Information for TRAV24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV24 Gene

Disorders for TRAV24 Gene

Additional Disease Information for TRAV24

No disorders were found for TRAV24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAV24 Gene

Publications for TRAV24 Gene

  1. Human invariant V alpha 24-J alpha Q TCR supports the development of CD1d-dependent NK1.1+ and NK1.1- T cells in transgenic mice. (PMID: 12594262) Capone M … Casorati G (Journal of immunology (Baltimore, Md. : 1950) 2003) 2 3 58
  2. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop BF … Hood L (Genomics 1994) 2 3 58
  3. Invariant TCR rather than CD1d shapes the preferential activities of C-glycoside analogues against human versus murine invariant NKT cells. (PMID: 19734232) Li X … Tsuji M (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 58
  4. Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages. (PMID: 19411762) Song L … Metelitsa LS (The Journal of clinical investigation 2009) 3 58

Products for TRAV24 Gene

Sources for TRAV24 Gene

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