T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed... See more...

Aliases for TRAV24 Gene

Aliases for TRAV24 Gene

  • T Cell Receptor Alpha Variable 24 2 3 4 5
  • TCRAV18S1 3
  • TCRAV24S1 3
  • TRAV24 5

External Ids for TRAV24 Gene

Previous GeneCards Identifiers for TRAV24 Gene

  • GC14U990296
  • GC14P020563
  • GC14P021643
  • GC14P022575
  • GC14P022576
  • GC14P022605
  • GC14P022732
  • GC14P022831

Summaries for TRAV24 Gene

Entrez Gene Summary for TRAV24 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV24 Gene

TRAV24 (T Cell Receptor Alpha Variable 24) is a Protein Coding gene. Among its related pathways are Immune response Function of MEF2 in T lymphocytes and Th17 cell differentiation. An important paralog of this gene is TRAV36DV7.

UniProtKB/Swiss-Prot Summary for TRAV24 Gene

  • V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRAV24 Gene

Genomics for TRAV24 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRAV24 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J022104 Enhancer 0.5 Ensembl ENCODE dbSUPER 250.7 -0.2 -162 1.1 TRAV24 RBM23 TRAV8-4 TRDV1 HSALNG0099933 lnc-ABHD4-12 TRA
GH14J022100 Enhancer 0.8 ENCODE 0.7 -4.9 -4934 0.2 MXD4 CTCF HOMEZ THAP11 REST ZNF511 SAP130 ZSCAN9 SMC3 RAD21 TRAV24 TRDV1 HSALNG0099933 lnc-ABHD4-12 TRA
GH14J022095 Promoter/Enhancer 1 Ensembl ENCODE dbSUPER 0.4 -8.3 -8269 3.2 CBX2 ZFP64 RFX5 ZBED1 ZNF7 MNT NONHSAG014446.2 TRDV1 lnc-OR4E1-10 TRAV24 HSALNG0099933 lnc-ABHD4-12 TRA
GH14J022112 Enhancer 0.6 ENCODE dbSUPER 0.4 +6.9 6870 0.1 CTCF SMC3 RAD21 ARID3A ZNF143 TRAV25 TRAV24 HSALNG0099933 lnc-ABHD4-12 TRA
GH14J022107 Enhancer 0.3 Ensembl dbSUPER 0.7 +2.2 2158 0.2 TRAV24 TRAV25 HSALNG0099933 lnc-ABHD4-12 TRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRAV24 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for TRAV24 Gene

Latest Assembly
chr14:22,105,343-22,105,846
(GRCh38/hg38)
Size:
504 bases
Orientation:
Plus strand

Previous Assembly
chr14:22,573,620-22,574,123
(GRCh37/hg19 by Entrez Gene)
Size:
504 bases
Orientation:
Plus strand

chr14:22,573,620-22,574,123
(GRCh37/hg19 by Ensembl)
Size:
504 bases
Orientation:
Plus strand

Genomic View for TRAV24 Gene

Genes around TRAV24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV24 Gene

Proteins for TRAV24 Gene

  • Protein details for TRAV24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A0B4J272-TVA24_HUMAN
    Recommended name:
    T cell receptor alpha variable 24
    Protein Accession:
    A0A0B4J272

    Protein attributes for TRAV24 Gene

    Size:
    114 amino acids
    Molecular mass:
    12919 Da
    Quaternary structure:
    • Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octomeric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.

    Three dimensional structures from OCA and Proteopedia for TRAV24 Gene

neXtProt entry for TRAV24 Gene

Post-translational modifications for TRAV24 Gene

Other Protein References for TRAV24 Gene

ENSEMBL proteins:

Antibodies for research

No data available for DME Specific Peptides for TRAV24 Gene

Domains & Families for TRAV24 Gene

Gene Families for TRAV24 Gene

Protein Domains for TRAV24 Gene

genes like me logo Genes that share domains with TRAV24: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TRAV24 Gene

Function for TRAV24 Gene

Molecular function for TRAV24 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV24 Gene

Localization for TRAV24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAV24 Gene

Cell membrane.

Gene Ontology (GO) - Cellular Components for TRAV24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0042101 T cell receptor complex IEA --
genes like me logo Genes that share ontologies with TRAV24: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TRAV24 Gene

Pathways & Interactions for TRAV24 Gene

PathCards logo

SuperPathways for TRAV24 Gene

SuperPathway Contained pathways
1 Immune response NFAT in immune response
.56
.56
.52
.52
2 G-protein signaling N-RAS regulation pathway
.52
.52
3 G-protein signaling_Rap1A regulation pathway
-
4 G-protein signaling_Regulation of RAC1 activity
-
5 Antigen processing-Cross presentation
.51
genes like me logo Genes that share pathways with TRAV24: view

Pathways by source for TRAV24 Gene

15 GeneGo (Thomson Reuters) pathways for TRAV24 Gene
  • G-protein signaling N-RAS regulation pathway
  • G-protein signaling_Rap1A regulation pathway
  • G-protein signaling_Regulation of RAC1 activity
  • Immune response Antigen presentation by MHC class I
  • Immune response Antigen presentation by MHC class II

Interacting Proteins for TRAV24 Gene

Gene Ontology (GO) - Biological Process for TRAV24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0009617 response to bacterium IBA 21873635
genes like me logo Genes that share ontologies with TRAV24: view

No data available for SIGNOR curated interactions for TRAV24 Gene

Drugs & Compounds for TRAV24 Gene

No Compound Related Data Available

Transcripts for TRAV24 Gene

mRNA/cDNA for TRAV24 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV24 Gene

No ASD Table

Relevant External Links for TRAV24 Gene

GeneLoc Exon Structure for
TRAV24

Expression for TRAV24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAV24 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV24 Gene

This gene is overexpressed in Whole Blood (x32.5).
genes like me logo Genes that share expression patterns with TRAV24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAV24 Gene

Orthologs for TRAV24 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRAV24 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia -- 31
  • 66 (a)
OneToMany
-- 31
  • 61 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia TRAV24 31
  • 64 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 50 (a)
ManyToMany
-- 31
  • 48 (a)
ManyToMany
-- 31
  • 46 (a)
ManyToMany
-- 31
  • 44 (a)
ManyToMany
-- 31
  • 44 (a)
ManyToMany
-- 31
  • 44 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 37 (a)
OneToMany
Species where no ortholog for TRAV24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TRAV24 Gene

ENSEMBL:
Gene Tree for TRAV24 (if available)
TreeFam:
Gene Tree for TRAV24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRAV24: view image

Paralogs for TRAV24 Gene

Variants for TRAV24 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TRAV24 Gene

TVA24_HUMAN-A0A0B4J272
There are several alleles. The sequence shown is that of IMGT allele TRAV24*01.

Additional Variant Information for TRAV24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAV24

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV24 Gene

Disorders for TRAV24 Gene

Additional Disease Information for TRAV24

No disorders were found for TRAV24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAV24 Gene

Publications for TRAV24 Gene

  1. Human invariant V alpha 24-J alpha Q TCR supports the development of CD1d-dependent NK1.1+ and NK1.1- T cells in transgenic mice. (PMID: 12594262) Capone M … Casorati G (Journal of immunology (Baltimore, Md. : 1950) 2003) 2 3
  2. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop BF … Hood L (Genomics 1994) 2 3
  3. Invariant natural killer T infiltration in neuroblastoma with favorable outcome. (PMID: 29018959) Hishiki T … Motohashi S (Pediatric surgery international 2018) 3
  4. T cell antigen receptor recognition of antigen-presenting molecules. (PMID: 25493333) Rossjohn J … McCluskey J (Annual review of immunology 2015) 4
  5. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4

Products for TRAV24 Gene

Sources for TRAV24 Gene