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Aliases for TRAV2 Gene

Aliases for TRAV2 Gene

  • T Cell Receptor Alpha Variable 2 2 3
  • T-Cell Receptor Alpha Variable 2 5
  • TCRAV11S1 3
  • TCRAV2S1 3

External Ids for TRAV2 Gene

Previous GeneCards Identifiers for TRAV2 Gene

  • GC14U990327
  • GC14P020171
  • GC14P020172
  • GC14P021250
  • GC14P022181

Summaries for TRAV2 Gene

Entrez Gene Summary for TRAV2 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV2 Gene

TRAV2 (T Cell Receptor Alpha Variable 2) is a Protein Coding gene.

Additional gene information for TRAV2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV2 Gene

Genomics for TRAV2 Gene

GeneHancer (GH) Regulatory Elements for TRAV2 Gene

Promoters and enhancers for TRAV2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I021711 Enhancer 0.6 ENCODE 550.8 -0.7 -748 0.2 CTCF FOXA2 FOXA3 HLF TRIM22 CEBPB CEBPG RAD21 NFIL3 CEBPA TRAV2 ENSG00000256350 TRA
GH14I021712 Enhancer 0.5 ENCODE 550.8 -0.1 -108 0.2 CTCF ATF1 ZNF629 CREB1 ATF7 ATF2 TRAV2 ENSG00000256350 TRA
GH14I021703 Enhancer 0.8 VISTA 0.4 -8.3 -8258 2 PKNOX1 FOXA2 EBF1 FEZF1 ZNF217 GATA3 MYNN WT1 OR10G3 ENSG00000256350 TRAV2 TRA
GH14I021714 Enhancer 0.2 ENCODE 0.8 +2.4 2372 0.2 ENSG00000248358 OR10G2 TRAV2 TRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRAV2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRAV2 Gene

Genomic Locations for TRAV2 Gene
523 bases
Plus strand

Genomic View for TRAV2 Gene

Genes around TRAV2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV2 Gene

Proteins for TRAV2 Gene

  • Protein details for TRAV2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    T-cell receptor alpha variable 2
    Protein Accession:

    Protein attributes for TRAV2 Gene

    112 amino acids
    Molecular mass:
    12502 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAV2 Gene

Post-translational modifications for TRAV2 Gene

No Post-translational modifications

Other Protein References for TRAV2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV2 Gene

Domains & Families for TRAV2 Gene

Gene Families for TRAV2 Gene

Protein Domains for TRAV2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAV2 Gene

Function for TRAV2 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV2 Gene

Localization for TRAV2 Gene

Gene Ontology (GO) - Cellular Components for TRAV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with TRAV2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TRAV2 Gene

Pathways & Interactions for TRAV2 Gene

SuperPathways for TRAV2 Gene

No Data Available

Interacting Proteins for TRAV2 Gene

Gene Ontology (GO) - Biological Process for TRAV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with TRAV2: view

No data available for Pathways by source and SIGNOR curated interactions for TRAV2 Gene

Drugs & Compounds for TRAV2 Gene

No Compound Related Data Available

Transcripts for TRAV2 Gene

mRNA/cDNA for TRAV2 Gene

(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV2 Gene

No ASD Table

Relevant External Links for TRAV2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAV2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAV2 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV2 Gene

This gene is overexpressed in Whole Blood (x31.0) and Small Intestine - Terminal Ileum (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of TRAV2 Gene:

genes like me logo Genes that share expression patterns with TRAV2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAV2 Gene

Orthologs for TRAV2 Gene

Evolution for TRAV2 Gene

Gene Tree for TRAV2 (if available)
Gene Tree for TRAV2 (if available)

No data available for Orthologs for TRAV2 Gene

Paralogs for TRAV2 Gene

No data available for Paralogs for TRAV2 Gene

Variants for TRAV2 Gene

Additional Variant Information for TRAV2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV2 Gene

Disorders for TRAV2 Gene

No disorders were found for TRAV2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRAV2 Gene

Publications for TRAV2 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop BF … Hood L (Genomics 1994) 2 3 58

Products for TRAV2 Gene

Sources for TRAV2 Gene

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