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Aliases for TRAV12-2 Gene

Aliases for TRAV12-2 Gene

  • T Cell Receptor Alpha Variable 12-2 2 3
  • T-Cell Receptor Alpha Variable 12-2 5
  • TCRAV12S2 3
  • TCRAV2S1 3
  • TRAV122 3

External Ids for TRAV12-2 Gene

Previous GeneCards Identifiers for TRAV12-2 Gene

  • GC14U990310
  • GC14P020347
  • GC14P020348
  • GC14P021425
  • GC14P022357

Summaries for TRAV12-2 Gene

Entrez Gene Summary for TRAV12-2 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV12-2 Gene

TRAV12-2 (T Cell Receptor Alpha Variable 12-2) is a Protein Coding gene. An important paralog of this gene is TRAV12-3.

Additional gene information for TRAV12-2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV12-2 Gene

Genomics for TRAV12-2 Gene

GeneHancer (GH) Regulatory Elements for TRAV12-2 Gene

Promoters and enhancers for TRAV12-2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I021887 Enhancer 0.8 ENCODE 550.8 +0.1 114 1.2 PKNOX1 FOXA2 ZSCAN4 FEZF1 ZNF335 ZNF302 FOS EGR2 SP3 ZNF280D TRAV12-2 METTL3 TRAV8-5 SUPT16H METTL17 RAB2B LINC00641 ENSG00000258458 MMP14 CHD8
GH14I021894 Enhancer 0.5 ENCODE 0.4 +6.4 6399 0.2 CTCF JUN CREB1 FOS ATF7 ATF2 ZBTB17 TRAV8-4 TRAV12-2 TRA
GH14I021873 Enhancer 0.5 Ensembl ENCODE 0.4 -13.0 -13048 3.1 CBX8 TRAV8-5 TRAV13-1 TRAV12-2 TRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRAV12-2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRAV12-2 Gene

Genomic Locations for TRAV12-2 Gene
646 bases
Plus strand

Genomic View for TRAV12-2 Gene

Genes around TRAV12-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV12-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV12-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV12-2 Gene

Proteins for TRAV12-2 Gene

  • Protein details for TRAV12-2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    T-cell receptor alpha variable 12-2
    Protein Accession:

    Protein attributes for TRAV12-2 Gene

    113 amino acids
    Molecular mass:
    12838 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TRAV12-2 Gene

neXtProt entry for TRAV12-2 Gene

Post-translational modifications for TRAV12-2 Gene

No Post-translational modifications

Other Protein References for TRAV12-2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV12-2 Gene

Domains & Families for TRAV12-2 Gene

Gene Families for TRAV12-2 Gene

Protein Domains for TRAV12-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV12-2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAV12-2 Gene

Function for TRAV12-2 Gene

Animal Model Products

miRNA for TRAV12-2 Gene

miRTarBase miRNAs that target TRAV12-2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAV12-2 Gene

Localization for TRAV12-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TRAV12-2 Gene

Pathways & Interactions for TRAV12-2 Gene

SuperPathways for TRAV12-2 Gene

No Data Available

Interacting Proteins for TRAV12-2 Gene

Gene Ontology (GO) - Biological Process for TRAV12-2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRAV12-2 Gene

Drugs & Compounds for TRAV12-2 Gene

No Compound Related Data Available

Transcripts for TRAV12-2 Gene

mRNA/cDNA for TRAV12-2 Gene

(75) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRAV12-2 Gene

T cell receptor alpha variable 12-2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV12-2 Gene

No ASD Table

Relevant External Links for TRAV12-2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAV12-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAV12-2 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV12-2 Gene

This gene is overexpressed in Whole Blood (x30.4) and Spleen (x5.1).

SOURCE GeneReport for Unigene cluster for TRAV12-2 Gene:

genes like me logo Genes that share expression patterns with TRAV12-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAV12-2 Gene

Orthologs for TRAV12-2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRAV12-2 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Trav7-3 34
  • 69 (a)
Trav7d-3 34
  • 69 (a)
Trav7d-4 34
  • 67 (a)
Trav7-2 34
  • 66 (a)
Trav7-4 34
  • 66 (a)
Trav7d-5 34
  • 63 (a)
Trav7-6 34
  • 60 (a)
Trav7n-6 34
  • 50 (a)
(Bos Taurus)
Mammalia -- 34
  • 66 (a)
-- 34
  • 50 (a)
(Canis familiaris)
Mammalia -- 34
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 40 (a)
Species where no ortholog for TRAV12-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV12-2 Gene

Gene Tree for TRAV12-2 (if available)
Gene Tree for TRAV12-2 (if available)

Paralogs for TRAV12-2 Gene

Paralogs for TRAV12-2 Gene

genes like me logo Genes that share paralogs with TRAV12-2: view

Variants for TRAV12-2 Gene

Additional Variant Information for TRAV12-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV12-2 Gene

Disorders for TRAV12-2 Gene

Additional Disease Information for TRAV12-2

No disorders were found for TRAV12-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAV12-2 Gene

Publications for TRAV12-2 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop BF … Hood L (Genomics 1994) 2 3 58
  2. Comprehensive analysis of the functional TCR repertoire at the single-cell level. (PMID: 18191637) Ozawa T … Muraguchi A (Biochemical and biophysical research communications 2008) 3 58

Products for TRAV12-2 Gene

Sources for TRAV12-2 Gene

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