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Aliases for TRAPPC8 Gene

Aliases for TRAPPC8 Gene

  • Trafficking Protein Particle Complex 8 2 3 5
  • KIAA1012 2 3 4
  • Protein TRS85 Homolog 3 4
  • General Sporulation Gene 1 Homolog (S. Cerevisiae) 2
  • Trafficking Protein Particle Complex Subunit 8 3
  • General Sporulation Gene 1 Homolog 3
  • HsT2706 3
  • TRS85 3
  • GSG1 3

External Ids for TRAPPC8 Gene

Previous HGNC Symbols for TRAPPC8 Gene

  • KIAA1012

Previous GeneCards Identifiers for TRAPPC8 Gene

  • GC00U913618
  • GC18M029409
  • GC18M026266

Summaries for TRAPPC8 Gene

GeneCards Summary for TRAPPC8 Gene

TRAPPC8 (Trafficking Protein Particle Complex 8) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs.

UniProtKB/Swiss-Prot for TRAPPC8 Gene

  • May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.

Gene Wiki entry for TRAPPC8 Gene

Additional gene information for TRAPPC8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC8 Gene

Genomics for TRAPPC8 Gene

GeneHancer (GH) Regulatory Elements for TRAPPC8 Gene

Promoters and enhancers for TRAPPC8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I031941 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.4 +9.9 9939 3.4 PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000263823 TRAPPC8 ENSG00000263393 HNRNPA1P7 ENSG00000263924 SLC25A52 GC18P031876
GH18I031955 Enhancer 0.8 ENCODE 550.8 -1.4 -1417 0.6 FOXA2 FEZF1 RAD21 YY1 ZNF366 RCOR1 THAP11 RXRA USF2 CEBPB TRAPPC8 GC18P031960 GC18P031876
GH18I031954 Enhancer 0.3 ENCODE 550.8 -1.8 -1837 0.2 YY1 TRAPPC8 SLC25A52 GC18P031960 GC18P031876
GH18I032091 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.6 -139.9 -139934 4 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 RNF138 LOC107985133 ENSG00000263924 ENSG00000263393 HNRNPA1P7 TRAPPC8 RNF125 B4GALT6 ENSG00000263917
GH18I032084 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 13.8 -132.8 -132765 3.4 HDGF ZNF529 INSM2 KLF17 FEZF1 ZNF2 IRF4 ZEB1 ZNF213 ZSCAN5C TRAPPC8 RNF138 HNRNPA1P7 RPS15AP35 RNF125 ENSG00000263917
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRAPPC8 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRAPPC8 Gene

Genomic Locations for TRAPPC8 Gene
123,964 bases
Minus strand

Genomic View for TRAPPC8 Gene

Genes around TRAPPC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC8 Gene

Proteins for TRAPPC8 Gene

  • Protein details for TRAPPC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trafficking protein particle complex subunit 8
    Protein Accession:
    Secondary Accessions:
    • A0JP15
    • B3KME5
    • Q9H0L2

    Protein attributes for TRAPPC8 Gene

    1435 amino acids
    Molecular mass:
    160997 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.
    • Sequence=AAI27110.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI27111.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA76856.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG50957.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAPPC8 Gene


neXtProt entry for TRAPPC8 Gene

Post-translational modifications for TRAPPC8 Gene

  • Ubiquitination at posLast=12881288
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRAPPC8 Gene

Domains & Families for TRAPPC8 Gene

Gene Families for TRAPPC8 Gene

Protein Domains for TRAPPC8 Gene

Suggested Antigen Peptide Sequences for TRAPPC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRS85 family.
  • Belongs to the TRS85 family.
genes like me logo Genes that share domains with TRAPPC8: view

Function for TRAPPC8 Gene

Molecular function for TRAPPC8 Gene

UniProtKB/Swiss-Prot Function:
May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.

Phenotypes From GWAS Catalog for TRAPPC8 Gene

Gene Ontology (GO) - Molecular Function for TRAPPC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21453443
GO:0017112 Rab guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with TRAPPC8: view
genes like me logo Genes that share phenotypes with TRAPPC8: view

Animal Model Products

CRISPR Products

miRNA for TRAPPC8 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC8 Gene

Localization for TRAPPC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC8 Gene

Golgi apparatus, cis-Golgi network.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAPPC8 gene
Compartment Confidence
cytosol 5
golgi apparatus 4
cytoskeleton 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRAPPC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 phagophore assembly site IBA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0030008 TRAPP complex IDA 21525244
GO:0031410 cytoplasmic vesicle IBA --
genes like me logo Genes that share ontologies with TRAPPC8: view

Pathways & Interactions for TRAPPC8 Gene

genes like me logo Genes that share pathways with TRAPPC8: view

Pathways by source for TRAPPC8 Gene

Gene Ontology (GO) - Biological Process for TRAPPC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0007030 Golgi organization IMP 21525244
GO:0016192 vesicle-mediated transport IEA --
GO:0030242 autophagy of peroxisome IBA --
genes like me logo Genes that share ontologies with TRAPPC8: view

No data available for SIGNOR curated interactions for TRAPPC8 Gene

Drugs & Compounds for TRAPPC8 Gene

No Compound Related Data Available

Transcripts for TRAPPC8 Gene

Unigene Clusters for TRAPPC8 Gene

Trafficking protein particle complex 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP2: - -
SP7: -

ExUns: 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b · 32c · 32d
SP1: - - -
SP5: -

Relevant External Links for TRAPPC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAPPC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAPPC8 Gene

Protein differential expression in normal tissues from HIPED for TRAPPC8 Gene

This gene is overexpressed in Breast (26.2), Peripheral blood mononuclear cells (11.4), and Lymph node (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAPPC8 Gene

Protein tissue co-expression partners for TRAPPC8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRAPPC8 Gene:


SOURCE GeneReport for Unigene cluster for TRAPPC8 Gene:


Evidence on tissue expression from TISSUES for TRAPPC8 Gene

  • Nervous system(4.4)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with TRAPPC8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAPPC8 Gene

Orthologs for TRAPPC8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRAPPC8 33 34
  • 99.7 (n)
(Bos Taurus)
Mammalia -- 34
  • 95 (a)
  • 91.89 (n)
-- 34
  • 87 (a)
(Canis familiaris)
Mammalia TRAPPC8 33 34
  • 94.35 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 93 (a)
-- 34
  • 88 (a)
-- 34
  • 80 (a)
(Monodelphis domestica)
Mammalia TRAPPC8 34
  • 89 (a)
(Mus musculus)
Mammalia Trappc8 33 16 34
  • 88.63 (n)
(Rattus norvegicus)
Mammalia Trappc8 33
  • 87.65 (n)
(Gallus gallus)
Aves TRAPPC8 33 34
  • 80.97 (n)
(Anolis carolinensis)
Reptilia TRAPPC8 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc8 33
  • 73.66 (n)
(Danio rerio)
Actinopterygii TRAPPC8 34
  • 66 (a)
trappc8 33
  • 63.69 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(3)76BDm 33 34
  • 44.64 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006965 33
  • 41.92 (n)
(Caenorhabditis elegans)
Secernentea trpp-8 34
  • 22 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G16280 33
  • 44.74 (n)
(Oryza sativa)
Liliopsida Os03g0786900 33
  • 45.31 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
Species where no ortholog for TRAPPC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC8 Gene

Gene Tree for TRAPPC8 (if available)
Gene Tree for TRAPPC8 (if available)

Paralogs for TRAPPC8 Gene

(1) SIMAP similar genes for TRAPPC8 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TRAPPC8: view

No data available for Paralogs for TRAPPC8 Gene

Variants for TRAPPC8 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC8 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs754569032 A breast cancer sample 31,890,853(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000001596 -- 31,834,921(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000002891 -- 31,910,586(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000029841 -- 31,920,504(-) ATAAAA/A genic_upstream_transcript_variant, intron_variant
rs1000039731 -- 31,928,294(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC8 Gene

Variant ID Type Subtype PubMed ID
esv1720728 CNV insertion 17803354
esv2855347 CNV duplication 24192839
esv3642135 CNV gain 21293372
esv3642136 CNV gain 21293372
esv3642140 CNV gain 21293372
esv3642141 CNV loss 21293372
esv3893086 CNV gain 25118596
esv990849 CNV deletion 20482838
nsv1057229 CNV gain 25217958
nsv1067252 CNV gain 25217958
nsv1117196 CNV tandem duplication 24896259
nsv1138617 CNV deletion 24896259
nsv131072 CNV deletion 16902084
nsv2247 CNV deletion 18451855
nsv820095 CNV loss 19587683

Variation tolerance for TRAPPC8 Gene

Residual Variation Intolerance Score: 8.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.04; 93.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAPPC8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC8 Gene

Disorders for TRAPPC8 Gene

Additional Disease Information for TRAPPC8

No disorders were found for TRAPPC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAPPC8 Gene

Publications for TRAPPC8 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  3. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens PJ … Sacher M (Molecular biology of the cell 2011) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Functional organization of the yeast proteome by systematic analysis of protein complexes. (PMID: 11805826) Gavin AC … Superti-Furga G (Nature 2002) 3 4 58

Products for TRAPPC8 Gene

Sources for TRAPPC8 Gene

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