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Aliases for TRAPPC5 Gene

Aliases for TRAPPC5 Gene

  • Trafficking Protein Particle Complex 5 2 3 5
  • Trafficking Protein Particle Complex Subunit 5 3 4
  • TRS31 3

External Ids for TRAPPC5 Gene

Previous GeneCards Identifiers for TRAPPC5 Gene

  • GC19P007640
  • GC19P007651
  • GC19U900665
  • GC19P007745
  • GC19P007415

Summaries for TRAPPC5 Gene

GeneCards Summary for TRAPPC5 Gene

TRAPPC5 (Trafficking Protein Particle Complex 5) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Transport to the Golgi and subsequent modification.

UniProtKB/Swiss-Prot for TRAPPC5 Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Additional gene information for TRAPPC5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC5 Gene

Genomics for TRAPPC5 Gene

GeneHancer (GH) Regulatory Elements for TRAPPC5 Gene

Promoters and enhancers for TRAPPC5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J007678 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 600.7 -0.1 -126 3.6 SP1 ZFX CTCF ELF3 MNT ZNF148 POLR2A ZNF121 CEBPG ZNF687 MCEMP1 TRAPPC5 HNRNPM ELAVL1 XAB2 MAP2K7 ZNF557 ZNF414 STXBP2 PEX11G
GH19J007807 Enhancer 1.1 Ensembl ENCODE 11.9 +127.3 127280 2.2 SP1 RELA CREM MLLT1 ZNF680 ZNF560 ZBED1 IKZF1 ZBTB8A BACH1 HNRNPM ELAVL1 XAB2 ZNF557 ZNF414 MAP2K7 TRAPPC5 MCEMP1 RPL21P129 CD209
GH19J007714 Promoter/Enhancer 0.9 Ensembl ENCODE dbSUPER 13.2 +34.0 33986 1.3 CD209 TRAPPC5 MCEMP1 RPL21P129 CAMSAP3 CLEC4G FCER2 XAB2 LOC105372262
GH19J007799 Enhancer 0.8 ENCODE 12 +119.1 119142 0.7 CC2D1A CTCF ZNF148 YY1 SP7 RELA PPARG MZF1 RAD21 IKZF1 CLEC4G TRAPPC5 MCEMP1 XAB2 PET100 LRRC8E PRR36 EXOSC3P2 CLEC4GP1
GH19J007801 Enhancer 0.7 ENCODE 12 +120.6 120599 0.1 CBFA2T2 TRIM24 IKZF1 REST PKNOX1 HDAC1 NR2C1 NCOR1 NFIC TCF12 CLEC4G MCEMP1 TRAPPC5 XAB2 PET100 CLEC4GP1 EXOSC3P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRAPPC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRAPPC5 gene promoter:
  • AP-2alpha
  • ATF-2
  • c-Jun
  • p300

Genomic Locations for TRAPPC5 Gene

Genomic Locations for TRAPPC5 Gene
chr19:7,680,821-7,687,703
(GRCh38/hg38)
Size:
6,883 bases
Orientation:
Plus strand
chr19:7,745,707-7,747,748
(GRCh37/hg19)
Size:
2,042 bases
Orientation:
Plus strand

Genomic View for TRAPPC5 Gene

Genes around TRAPPC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC5 Gene

Proteins for TRAPPC5 Gene

  • Protein details for TRAPPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUR0-TPPC5_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 5
    Protein Accession:
    Q8IUR0
    Secondary Accessions:
    • A8K7I6

    Protein attributes for TRAPPC5 Gene

    Size:
    188 amino acids
    Molecular mass:
    20783 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.

neXtProt entry for TRAPPC5 Gene

Post-translational modifications for TRAPPC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAPPC5 Gene

No data available for DME Specific Peptides for TRAPPC5 Gene

Domains & Families for TRAPPC5 Gene

Gene Families for TRAPPC5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TRAPPC5 Gene

GenScript: Design optimal peptide antigens:
  • Trafficking protein particle complex subunit 5 (TPPC5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IUR0

UniProtKB/Swiss-Prot:

TPPC5_HUMAN :
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
Family:
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
genes like me logo Genes that share domains with TRAPPC5: view

Function for TRAPPC5 Gene

Molecular function for TRAPPC5 Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Phenotypes From GWAS Catalog for TRAPPC5 Gene

Gene Ontology (GO) - Molecular Function for TRAPPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0017112 contributes_to Rab guanyl-nucleotide exchange factor activity IBA 21873635
genes like me logo Genes that share ontologies with TRAPPC5: view
genes like me logo Genes that share phenotypes with TRAPPC5: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TRAPPC5 - Now 50% OFF >
  • * TRAPPC5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TRAPPC5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAPPC5 Gene

Localization for TRAPPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC5 Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAPPC5 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 3
endosome 3
golgi apparatus 3
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRAPPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0030008 TRAPP complex IDA,IEA 21525244
genes like me logo Genes that share ontologies with TRAPPC5: view

Pathways & Interactions for TRAPPC5 Gene

genes like me logo Genes that share pathways with TRAPPC5: view

Gene Ontology (GO) - Biological Process for TRAPPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IBA 21873635
GO:0016192 vesicle-mediated transport IEA --
GO:0048193 Golgi vesicle transport IEA --
GO:0048208 COPII vesicle coating TAS --
genes like me logo Genes that share ontologies with TRAPPC5: view

No data available for SIGNOR curated interactions for TRAPPC5 Gene

Drugs & Compounds for TRAPPC5 Gene

(1) Drugs for TRAPPC5 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-PALMITOYL-L-CYSTEINE Experimental Pharma Target 0
genes like me logo Genes that share compounds with TRAPPC5: view

Transcripts for TRAPPC5 Gene

mRNA/cDNA for TRAPPC5 Gene

Unigene Clusters for TRAPPC5 Gene

Trafficking protein particle complex 5:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TRAPPC5 - Now 50% OFF >
  • * TRAPPC5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TRAPPC5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: - -
SP2:
SP3: -
SP4:

Relevant External Links for TRAPPC5 Gene

GeneLoc Exon Structure for
TRAPPC5
ECgene alternative splicing isoforms for
TRAPPC5

Expression for TRAPPC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAPPC5 Gene

mRNA differential expression in normal tissues according to GTEx for TRAPPC5 Gene

This gene is overexpressed in Testis (x11.8) and Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for TRAPPC5 Gene

This gene is overexpressed in Nasal epithelium (35.9) and Bone (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRAPPC5 Gene



Protein tissue co-expression partners for TRAPPC5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRAPPC5 Gene:

TRAPPC5

SOURCE GeneReport for Unigene cluster for TRAPPC5 Gene:

Hs.432413

Evidence on tissue expression from TISSUES for TRAPPC5 Gene

  • Intestine(4.2)
  • Skin(4.2)
  • Lung(3.5)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with TRAPPC5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAPPC5 Gene

Orthologs for TRAPPC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAPPC5 34 35
  • 99.47 (n)
cow
(Bos Taurus)
Mammalia TRAPPC5 35 34
  • 94.15 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TRAPPC5 35 34
  • 93.97 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Trappc5 17 34 35
  • 89.18 (n)
rat
(Rattus norvegicus)
Mammalia Trappc5 34
  • 88.48 (n)
oppossum
(Monodelphis domestica)
Mammalia TRAPPC5 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRAPPC5 34 35
  • 79.79 (n)
lizard
(Anolis carolinensis)
Reptilia TRAPPC5 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc5 34
  • 67.38 (n)
Str.2195 34
zebrafish
(Danio rerio)
Actinopterygii trappc5 34 35
  • 73.4 (n)
wufc34a11 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4571 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012083 34
  • 64.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10153 34 35
  • 63 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y57A10A.16 34
  • 53.79 (n)
trpp-5 35
  • 51 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR408C 34
  • 53.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRS31 34 35 37
  • 41.83 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03345g 34
  • 38.86 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G58030 34
  • 51.64 (n)
rice
(Oryza sativa)
Liliopsida Os01g0708600 34
  • 52.83 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 62 (a)
OneToOne
Cin.4272 34
bread mold
(Neurospora crassa)
Ascomycetes NCU08874 34
  • 52.33 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trs31 34
  • 44.82 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4272 34
Species where no ortholog for TRAPPC5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC5 Gene

ENSEMBL:
Gene Tree for TRAPPC5 (if available)
TreeFam:
Gene Tree for TRAPPC5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRAPPC5: view image

Paralogs for TRAPPC5 Gene

No data available for Paralogs for TRAPPC5 Gene

Variants for TRAPPC5 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs398122420 uncertain-significance, not provided 7,682,801(+) G/A/C coding_sequence_variant, missense_variant
rs1000083785 -- 7,680,485(+) C/T upstream_transcript_variant
rs1000136938 -- 7,681,974(+) G/C/T intron_variant
rs1000464639 -- 7,682,298(+) C/T coding_sequence_variant, synonymous_variant
rs1001094088 -- 7,679,302(+) GTGTGTGTG/GTGTG upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC5 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV gain 17911159
nsv1060887 CNV gain 25217958
nsv1061452 CNV gain 25217958
nsv833731 CNV loss 17160897
nsv833732 CNV gain 17160897
nsv953959 CNV deletion 24416366

Variation tolerance for TRAPPC5 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.78; 91.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAPPC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAPPC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC5 Gene

Disorders for TRAPPC5 Gene

Additional Disease Information for TRAPPC5

No disorders were found for TRAPPC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAPPC5 Gene

Publications for TRAPPC5 Gene

  1. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens PJ … Sacher M (Molecular biology of the cell 2011) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions. (PMID: 28319085) Han K … Bassik MC (Nature biotechnology 2017) 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair. (PMID: 29229926) Lu H … Bohr VA (Nature communications 2017) 3 58

Products for TRAPPC5 Gene

Sources for TRAPPC5 Gene

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