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Aliases for TRAPPC5 Gene

Aliases for TRAPPC5 Gene

  • Trafficking Protein Particle Complex 5 2 3 5
  • Trafficking Protein Particle Complex Subunit 5 3
  • TRS31 3

External Ids for TRAPPC5 Gene

Previous GeneCards Identifiers for TRAPPC5 Gene

  • GC19P007640
  • GC19P007651
  • GC19U900665
  • GC19P007745
  • GC19P007415

Summaries for TRAPPC5 Gene

GeneCards Summary for TRAPPC5 Gene

TRAPPC5 (Trafficking Protein Particle Complex 5) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification.

UniProtKB/Swiss-Prot for TRAPPC5 Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Additional gene information for TRAPPC5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC5 Gene

Genomics for TRAPPC5 Gene

GeneHancer (GH) Regulatory Elements for TRAPPC5 Gene

Promoters and enhancers for TRAPPC5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I007678 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 550.8 -0.1 -126 3.6 PKNOX1 ARNT ARID4B SIN3A YY1 ZNF207 ZNF143 SP3 SP5 REST TRAPPC5 HNRNPM ELAVL1 XAB2 ZNF557 MAP2K7 STXBP2 ZNF414 MCEMP1 PEX11G
GH19I007799 Enhancer 1 Ensembl ENCODE 12.3 +119.1 119080 1.4 KLF17 MZF1 RAD21 RFX5 ZNF335 ZNF143 IKZF2 MIXL1 ZNF654 CEBPB TRAPPC5 MCEMP1 CLEC4G RPL21P129 CD209 XAB2 PET100 LRRC8E PRR36 CLEC4GP1
GH19I007714 Enhancer 0.7 Ensembl ENCODE dbSUPER 13.2 +34.0 33986 1.3 SRF CD209 TRAPPC5 MCEMP1 RPL21P129 CAMSAP3 CLEC4G FCER2 XAB2 LOC105372262
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRAPPC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRAPPC5 gene promoter:

Genomic Locations for TRAPPC5 Gene

Genomic Locations for TRAPPC5 Gene
6,883 bases
Plus strand

Genomic View for TRAPPC5 Gene

Genes around TRAPPC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC5 Gene

Proteins for TRAPPC5 Gene

  • Protein details for TRAPPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trafficking protein particle complex subunit 5
    Protein Accession:
    Secondary Accessions:
    • A8K7I6

    Protein attributes for TRAPPC5 Gene

    188 amino acids
    Molecular mass:
    20783 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.

neXtProt entry for TRAPPC5 Gene

Post-translational modifications for TRAPPC5 Gene

No Post-translational modifications

Other Protein References for TRAPPC5 Gene

No data available for DME Specific Peptides for TRAPPC5 Gene

Domains & Families for TRAPPC5 Gene

Gene Families for TRAPPC5 Gene

Suggested Antigen Peptide Sequences for TRAPPC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAPP small subunits family. BET3 subfamily.
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
genes like me logo Genes that share domains with TRAPPC5: view

Function for TRAPPC5 Gene

Molecular function for TRAPPC5 Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Phenotypes From GWAS Catalog for TRAPPC5 Gene

Gene Ontology (GO) - Molecular Function for TRAPPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0017112 Rab guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with TRAPPC5: view
genes like me logo Genes that share phenotypes with TRAPPC5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAPPC5 Gene

Localization for TRAPPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC5 Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAPPC5 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 3
mitochondrion 2
golgi apparatus 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRAPPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0030008 TRAPP complex IDA,IEA 21525244
genes like me logo Genes that share ontologies with TRAPPC5: view

Pathways & Interactions for TRAPPC5 Gene

genes like me logo Genes that share pathways with TRAPPC5: view

Gene Ontology (GO) - Biological Process for TRAPPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0048193 Golgi vesicle transport IEA --
GO:0048208 COPII vesicle coating TAS --
GO:0065009 regulation of molecular function IEA --
genes like me logo Genes that share ontologies with TRAPPC5: view

No data available for SIGNOR curated interactions for TRAPPC5 Gene

Drugs & Compounds for TRAPPC5 Gene

(1) Drugs for TRAPPC5 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-PALMITOYL-L-CYSTEINE Experimental Pharma Target 0
genes like me logo Genes that share compounds with TRAPPC5: view

Transcripts for TRAPPC5 Gene

Unigene Clusters for TRAPPC5 Gene

Trafficking protein particle complex 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: - -
SP3: -

Relevant External Links for TRAPPC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAPPC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAPPC5 Gene

mRNA differential expression in normal tissues according to GTEx for TRAPPC5 Gene

This gene is overexpressed in Testis (x11.8) and Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for TRAPPC5 Gene

This gene is overexpressed in Nasal epithelium (35.9) and Bone (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAPPC5 Gene

Protein tissue co-expression partners for TRAPPC5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRAPPC5 Gene:


SOURCE GeneReport for Unigene cluster for TRAPPC5 Gene:


Evidence on tissue expression from TISSUES for TRAPPC5 Gene

  • Intestine(4.2)
  • Skin(4.2)
  • Lung(3.5)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with TRAPPC5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAPPC5 Gene

Orthologs for TRAPPC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRAPPC5 33 34
  • 99.47 (n)
(Bos Taurus)
Mammalia TRAPPC5 33 34
  • 94.15 (n)
(Canis familiaris)
Mammalia TRAPPC5 33 34
  • 93.97 (n)
(Mus musculus)
Mammalia Trappc5 33 16 34
  • 89.18 (n)
(Rattus norvegicus)
Mammalia Trappc5 33
  • 88.48 (n)
(Monodelphis domestica)
Mammalia TRAPPC5 34
  • 88 (a)
(Gallus gallus)
Aves TRAPPC5 33 34
  • 79.79 (n)
(Anolis carolinensis)
Reptilia TRAPPC5 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc5 33
  • 67.38 (n)
Str.2195 33
(Danio rerio)
Actinopterygii trappc5 33 34
  • 73.4 (n)
wufc34a11 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4571 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012083 33
  • 64.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10153 33 34
  • 63 (n)
(Caenorhabditis elegans)
Secernentea CELE_Y57A10A.16 33
  • 53.79 (n)
trpp-5 34
  • 51 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR408C 33
  • 53.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRS31 33 34 36
  • 41.83 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03345g 33
  • 38.86 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G58030 33
  • 51.64 (n)
(Oryza sativa)
Liliopsida Os01g0708600 33
  • 52.83 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 62 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08874 33
  • 52.33 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trs31 33
  • 44.82 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4272 33
Species where no ortholog for TRAPPC5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC5 Gene

Gene Tree for TRAPPC5 (if available)
Gene Tree for TRAPPC5 (if available)

Paralogs for TRAPPC5 Gene

No data available for Paralogs for TRAPPC5 Gene

Variants for TRAPPC5 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs398122420 uncertain-significance, not provided 7,682,801(+) G/A/C coding_sequence_variant, missense_variant
rs1000083785 -- 7,680,485(+) C/T upstream_transcript_variant
rs1000136938 -- 7,681,974(+) G/C/T intron_variant
rs1000464639 -- 7,682,298(+) C/T coding_sequence_variant, synonymous_variant
rs1001094088 -- 7,679,302(+) GTGTGTGTG/GTGTG upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC5 Gene

Variant ID Type Subtype PubMed ID
nsv953959 CNV deletion 24416366
nsv833732 CNV gain 17160897
nsv833731 CNV loss 17160897
nsv1061452 CNV gain 25217958
nsv1060887 CNV gain 25217958
esv2751809 CNV gain 17911159

Variation tolerance for TRAPPC5 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.78; 91.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAPPC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC5 Gene

Disorders for TRAPPC5 Gene

Additional Disease Information for TRAPPC5

No disorders were found for TRAPPC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAPPC5 Gene

Publications for TRAPPC5 Gene

  1. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens PJ … Sacher M (Molecular biology of the cell 2011) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert JP … Gingras AC (Journal of proteomics 2015) 3 58
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58

Products for TRAPPC5 Gene

Sources for TRAPPC5 Gene

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