Aliases for TRAPPC5 Gene

Aliases for TRAPPC5 Gene

  • Trafficking Protein Particle Complex Subunit 5 2 3 4
  • Trafficking Protein Particle Complex 5 2 3 5
  • TRS31 2 3
  • MGC52424 2
  • TRAPPC5 5

External Ids for TRAPPC5 Gene

Previous GeneCards Identifiers for TRAPPC5 Gene

  • GC19P007640
  • GC19P007651
  • GC19U900665
  • GC19P007745
  • GC19P007415

Summaries for TRAPPC5 Gene

GeneCards Summary for TRAPPC5 Gene

TRAPPC5 (Trafficking Protein Particle Complex Subunit 5) is a Protein Coding gene. Diseases associated with TRAPPC5 include Spondyloepiphyseal Dysplasia Tarda, X-Linked and Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs.

UniProtKB/Swiss-Prot Summary for TRAPPC5 Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRAPPC5 Gene

Genomics for TRAPPC5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRAPPC5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRAPPC5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRAPPC5

Top Transcription factor binding sites by QIAGEN in the TRAPPC5 gene promoter:
  • AP-2alpha
  • ATF-2
  • c-Jun
  • p300

Genomic Locations for TRAPPC5 Gene

Latest Assembly
chr19:7,680,833-7,687,703
(GRCh38/hg38)
Size:
6,871 bases
Orientation:
Plus strand

Previous Assembly
chr19:7,745,719-7,752,589
(GRCh37/hg19 by Entrez Gene)
Size:
6,871 bases
Orientation:
Plus strand

chr19:7,745,729-7,747,744
(GRCh37/hg19 by Ensembl)
Size:
2,016 bases
Orientation:
Plus strand

Genomic View for TRAPPC5 Gene

Genes around TRAPPC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC5 Gene

Proteins for TRAPPC5 Gene

  • Protein details for TRAPPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUR0-TPPC5_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 5
    Protein Accession:
    Q8IUR0
    Secondary Accessions:
    • A8K7I6

    Protein attributes for TRAPPC5 Gene

    Size:
    188 amino acids
    Molecular mass:
    20783 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.

neXtProt entry for TRAPPC5 Gene

Post-translational modifications for TRAPPC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAPPC5 Gene

No data available for DME Specific Peptides for TRAPPC5 Gene

Domains & Families for TRAPPC5 Gene

Gene Families for TRAPPC5 Gene

Protein Domains for TRAPPC5 Gene

InterPro:
Blocks:
  • Transport protein particle (TRAPP) component, Bet3

Suggested Antigen Peptide Sequences for TRAPPC5 Gene

GenScript: Design optimal peptide antigens:
  • Trafficking protein particle complex subunit 5 (TPPC5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IUR0

UniProtKB/Swiss-Prot:

TPPC5_HUMAN :
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
Family:
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
genes like me logo Genes that share domains with TRAPPC5: view

Function for TRAPPC5 Gene

Molecular function for TRAPPC5 Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Phenotypes From GWAS Catalog for TRAPPC5 Gene

Gene Ontology (GO) - Molecular Function for TRAPPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TRAPPC5: view
genes like me logo Genes that share phenotypes with TRAPPC5: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRAPPC5

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAPPC5 Gene

Localization for TRAPPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC5 Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAPPC5 gene
Compartment Confidence
endoplasmic reticulum 4
endosome 4
cytosol 4
golgi apparatus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRAPPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0030008 TRAPP complex IEA,IDA 21525244
genes like me logo Genes that share ontologies with TRAPPC5: view

Pathways & Interactions for TRAPPC5 Gene

genes like me logo Genes that share pathways with TRAPPC5: view

Gene Ontology (GO) - Biological Process for TRAPPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IBA 21873635
GO:0016192 vesicle-mediated transport IEA --
GO:0048193 Golgi vesicle transport IEA --
GO:0048208 COPII vesicle coating TAS --
genes like me logo Genes that share ontologies with TRAPPC5: view

No data available for SIGNOR curated interactions for TRAPPC5 Gene

Drugs & Compounds for TRAPPC5 Gene

(1) Drugs for TRAPPC5 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-palmitoyl-L-cysteine Experimental Pharma Target 0
genes like me logo Genes that share compounds with TRAPPC5: view

Transcripts for TRAPPC5 Gene

mRNA/cDNA for TRAPPC5 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRAPPC5

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: - -
SP2:
SP3: -
SP4:

Relevant External Links for TRAPPC5 Gene

GeneLoc Exon Structure for
TRAPPC5

Expression for TRAPPC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAPPC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for TRAPPC5 Gene

This gene is overexpressed in Testis (x11.8) and Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for TRAPPC5 Gene

This gene is overexpressed in Nasal epithelium (35.9) and Bone (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRAPPC5 Gene



Protein tissue co-expression partners for TRAPPC5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRAPPC5

SOURCE GeneReport for Unigene cluster for TRAPPC5 Gene:

Hs.432413

Evidence on tissue expression from TISSUES for TRAPPC5 Gene

  • Skin(4.4)
  • Intestine(4.2)
  • Lung(3.5)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with TRAPPC5: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAPPC5 Gene

Orthologs for TRAPPC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRAPPC5 29 30
  • 99.47 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TRAPPC5 29 30
  • 94.15 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TRAPPC5 29 30
  • 93.97 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Trappc5 29 16 30
  • 89.18 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Trappc5 29
  • 88.48 (n)
Oppossum
(Monodelphis domestica)
Mammalia TRAPPC5 30
  • 88 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TRAPPC5 29 30
  • 79.79 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TRAPPC5 30
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia trappc5 29
  • 67.38 (n)
Str.2195 29
Zebrafish
(Danio rerio)
Actinopterygii trappc5 29 30
  • 73.4 (n)
OneToOne
wufc34a11 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4571 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012083 29
  • 64.76 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG10153 29 30
  • 63 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea CELE_Y57A10A.16 29
  • 53.79 (n)
trpp-5 30
  • 51 (a)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFR408C 29
  • 53.45 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRS31 29 30 32
  • 41.83 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03345g 29
  • 38.86 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G58030 29
  • 51.64 (n)
Rice
(Oryza sativa)
Liliopsida Os01g0708600 29
  • 52.83 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 62 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU08874 29
  • 52.33 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trs31 29
  • 44.82 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4272 29
Species where no ortholog for TRAPPC5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TRAPPC5 Gene

ENSEMBL:
Gene Tree for TRAPPC5 (if available)
TreeFam:
Gene Tree for TRAPPC5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRAPPC5: view image
Alliance of Genome Resources:
Additional Orthologs for TRAPPC5

Paralogs for TRAPPC5 Gene

No data available for Paralogs for TRAPPC5 Gene

Variants for TRAPPC5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRAPPC5 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs398122420 Uncertain Significance: not provided 7,682,801(+) G/C
NM_001042462.2(TRAPPC5):c.548G>C (p.Arg183Pro)
MISSENSE
rs6952 -- p.Ser52Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TRAPPC5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC5 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV gain 17911159
nsv1060887 CNV gain 25217958
nsv1061452 CNV gain 25217958
nsv833731 CNV loss 17160897
nsv833732 CNV gain 17160897
nsv953959 CNV deletion 24416366

Variation tolerance for TRAPPC5 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.78; 91.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAPPC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAPPC5
Leiden Open Variation Database (LOVD)
TRAPPC5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC5 Gene

Disorders for TRAPPC5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRAPPC5 Gene - From: COP

Disorder Aliases PubMed IDs
spondyloepiphyseal dysplasia tarda, x-linked
  • sedt
autosomal recessive non-syndromic intellectual disability
  • autosomal recessive mental retardation
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRAPPC5

genes like me logo Genes that share disorders with TRAPPC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAPPC5 Gene

Publications for TRAPPC5 Gene

  1. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens PJ … Sacher M (Molecular biology of the cell 2011) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. (PMID: 33060197) Gordon DE … Krogan NJ (Science (New York, N.Y.) 2020) 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3

Products for TRAPPC5 Gene

Sources for TRAPPC5 Gene