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Aliases for TRAPPC3L Gene

Aliases for TRAPPC3L Gene

  • Trafficking Protein Particle Complex 3 Like 2 3 5
  • TRAPPC3-Like Protein 3 4
  • BET3-Like Protein 3 4
  • BET3L 3 4
  • Trafficking Protein Particle Complex Subunit 3-Like Protein 3
  • Trafficking Protein Particle Complex 3-Like 2
  • BET3 Like (S. Cerevisiae) 2
  • BA259P20.2 3

External Ids for TRAPPC3L Gene

Previous HGNC Symbols for TRAPPC3L Gene

  • BET3L

Previous GeneCards Identifiers for TRAPPC3L Gene

  • GC06M116817

Summaries for TRAPPC3L Gene

GeneCards Summary for TRAPPC3L Gene

TRAPPC3L (Trafficking Protein Particle Complex 3 Like) is a Protein Coding gene. An important paralog of this gene is TRAPPC3.

UniProtKB/Swiss-Prot for TRAPPC3L Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Additional gene information for TRAPPC3L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC3L Gene

Genomics for TRAPPC3L Gene

GeneHancer (GH) Regulatory Elements for TRAPPC3L Gene

Promoters and enhancers for TRAPPC3L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I116545 Promoter/Enhancer 0.9 EPDnew Ensembl 550.8 -0.1 -91 0.2 RNF2 TCF7L2 TRAPPC3L CALHM6 CALHM4 RWDD1
GH06I116276 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.4 +266.4 266425 5.6 HDGF FOXA2 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 TSPYL1 ENSG00000240050 PIR59102 DSE CALHM6 TSPYL4 CALHM4 TRAPPC3L KRT18P22 CBX3P9
GH06I116461 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 10.7 +82.0 81956 4.5 MXI1 MAX BACH1 BMI1 E2F1 CTBP1 ZNF316 POLR2A SCRT2 IKZF2 CALHM6 ENSG00000244158 DSE ENSG00000234117 TRAPPC3L RWDD1 TSPYL1 ZUFSP
GH06I116510 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 10.6 +33.4 33364 2.6 PKNOX1 ATF1 ZNF2 IRF4 RAD21 ZBTB40 YY1 CHAMP1 ZNF335 ZNF213 CALHM5 TRAPPC3L CALHM6 RWDD1 CALHM4
GH06I116384 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +156.2 156154 9.7 PKNOX1 MZF1 BATF IRF4 ZNF366 ATF7 ETV6 FOS BCLAF1 IKZF2 DSE CALHM6 CALHM4 CBX3P9 KRT18P22 ENSG00000244158 ENSG00000234117 TRAPPC3L ENSG00000240050 TSPYL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRAPPC3L on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRAPPC3L Gene

Genomic Locations for TRAPPC3L Gene
50,622 bases
Minus strand

Genomic View for TRAPPC3L Gene

Genes around TRAPPC3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC3L Gene

Proteins for TRAPPC3L Gene

  • Protein details for TRAPPC3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trafficking protein particle complex subunit 3-like protein
    Protein Accession:
    Secondary Accessions:
    • Q5T213
    • Q5T214

    Protein attributes for TRAPPC3L Gene

    181 amino acids
    Molecular mass:
    20566 Da
    Quaternary structure:
    • Homodimer. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.

    Alternative splice isoforms for TRAPPC3L Gene


neXtProt entry for TRAPPC3L Gene

Post-translational modifications for TRAPPC3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAPPC3L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRAPPC3L Gene

Domains & Families for TRAPPC3L Gene

Gene Families for TRAPPC3L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TRAPPC3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAPP small subunits family. BET3 subfamily.
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
genes like me logo Genes that share domains with TRAPPC3L: view

Function for TRAPPC3L Gene

Molecular function for TRAPPC3L Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Gene Ontology (GO) - Molecular Function for TRAPPC3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21525244
genes like me logo Genes that share ontologies with TRAPPC3L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC3L Gene

Localization for TRAPPC3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC3L Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAPPC3L gene
Compartment Confidence
endoplasmic reticulum 3
golgi apparatus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TRAPPC3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0030008 TRAPP complex IDA 21525244
genes like me logo Genes that share ontologies with TRAPPC3L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRAPPC3L Gene

Pathways & Interactions for TRAPPC3L Gene

SuperPathways for TRAPPC3L Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAPPC3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008150 biological_process ND --
GO:0016192 vesicle-mediated transport IEA --
GO:0048193 Golgi vesicle transport IEA --
genes like me logo Genes that share ontologies with TRAPPC3L: view

No data available for Pathways by source and SIGNOR curated interactions for TRAPPC3L Gene

Drugs & Compounds for TRAPPC3L Gene

No Compound Related Data Available

Transcripts for TRAPPC3L Gene


(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC3L Gene

No ASD Table

Relevant External Links for TRAPPC3L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAPPC3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAPPC3L Gene

mRNA differential expression in normal tissues according to GTEx for TRAPPC3L Gene

This gene is overexpressed in Spleen (x11.0).

NURSA nuclear receptor signaling pathways regulating expression of TRAPPC3L Gene:

genes like me logo Genes that share expression patterns with TRAPPC3L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAPPC3L Gene

Orthologs for TRAPPC3L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRAPPC3L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BET3L 33
  • 99.63 (n)
  • 99 (a)
(Bos Taurus)
Mammalia TRAPPC3L 34
  • 94 (a)
BET3L 33
  • 92.27 (n)
(Canis familiaris)
Mammalia TRAPPC3L 33 34
  • 91.16 (n)
(Mus musculus)
Mammalia Trappc3l 33 16 34
  • 89.5 (n)
(Rattus norvegicus)
Mammalia Trappc3l 33
  • 88.58 (n)
(Monodelphis domestica)
Mammalia TRAPPC3L 34
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia TRAPPC3L 34
  • 81 (a)
(Gallus gallus)
Aves TRAPPC3L 34
  • 77 (a)
BET3L 33
  • 72.04 (n)
(Anolis carolinensis)
Reptilia TRAPPC3L 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488207 33
  • 64.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta Bet3 34
  • 47 (a)
(Caenorhabditis elegans)
Secernentea trpp-3 34
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BET3 34
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8333 34
  • 53 (a)
Species where no ortholog for TRAPPC3L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TRAPPC3L Gene

Gene Tree for TRAPPC3L (if available)
Gene Tree for TRAPPC3L (if available)

Paralogs for TRAPPC3L Gene

Paralogs for TRAPPC3L Gene

(1) SIMAP similar genes for TRAPPC3L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRAPPC3L: view

Variants for TRAPPC3L Gene

Sequence variations from dbSNP and Humsavar for TRAPPC3L Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000057975 -- 116,528,385(-) G/A intron_variant
rs1000082814 -- 116,508,554(-) T/C intron_variant
rs1000148544 -- 116,517,635(-) G/T intron_variant
rs1000343394 -- 116,521,338(-) G/T intron_variant
rs1000354362 -- 116,497,095(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC3L Gene

Variant ID Type Subtype PubMed ID
esv2663254 CNV deletion 23128226
esv3326453 CNV insertion 20981092
esv3340874 CNV insertion 20981092
esv3364800 CNV insertion 20981092
esv3610471 CNV loss 21293372
nsv523972 CNV gain 19592680
nsv830783 CNV gain 17160897

Variation tolerance for TRAPPC3L Gene

Gene Damage Index Score: 1.81; 34.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAPPC3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC3L Gene

Disorders for TRAPPC3L Gene

Additional Disease Information for TRAPPC3L

No disorders were found for TRAPPC3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAPPC3L Gene

Publications for TRAPPC3L Gene

  1. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens PJ … Sacher M (Molecular biology of the cell 2011) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for TRAPPC3L Gene

Sources for TRAPPC3L Gene

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