Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRAPPC13 Gene

Aliases for TRAPPC13 Gene

  • Trafficking Protein Particle Complex 13 2 3 5
  • Trs65-Related 2 3
  • C5orf44 3 4
  • Trafficking Protein Particle Complex Subunit 13 3
  • Chromosome 5 Open Reading Frame 44 2
  • UPF0533 Protein C5orf44 3

External Ids for TRAPPC13 Gene

Previous HGNC Symbols for TRAPPC13 Gene

  • C5orf44

Previous GeneCards Identifiers for TRAPPC13 Gene

  • GC05P064923
  • GC05P064925

Summaries for TRAPPC13 Gene

GeneCards Summary for TRAPPC13 Gene

TRAPPC13 (Trafficking Protein Particle Complex 13) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs.

Additional gene information for TRAPPC13 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC13 Gene

Genomics for TRAPPC13 Gene

GeneHancer (GH) Regulatory Elements for TRAPPC13 Gene

Promoters and enhancers for TRAPPC13 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I065623 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 559.6 +0.1 97 3.2 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B TRAPPC13 ENSG00000253251 TRIM23 PPWD1 CENPK SREK1 RNU6-540P NLN SGTB
GH05I066142 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 25.9 +519.9 519934 4.2 CLOCK FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D GLIS1 SREK1 ENSG00000253744 PPWD1 TRAPPC13 TRIM23 NLN SGTB
GH05I065845 Enhancer 1 Ensembl ENCODE 36.4 +221.2 221212 1.9 ZNF529 ZFP64 RARA ZNF121 ZNF213 ZNF138 ZNF202 ZNF654 ZNF680 SMAD5 PPWD1 SREK1 TRAPPC13 TRIM23 ERBIN ENSG00000272370 ENSG00000272354 CENPK NLN ENSG00000269961
GH05I065923 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 15.1 +302.3 302280 6.3 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF766 ENSG00000269961 GC05M065925 ERBIN PPWD1 TRAPPC13 SREK1 ENSG00000252904 LOC100303749
GH05I064765 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 -857.0 -856958 4.5 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 SREK1IP1 CWC27 PPWD1 TRAPPC13 SHISAL2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRAPPC13 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRAPPC13 Gene

Genomic Locations for TRAPPC13 Gene
41,518 bases
Plus strand

Genomic View for TRAPPC13 Gene

Genes around TRAPPC13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC13 Gene

Proteins for TRAPPC13 Gene

  • Protein details for TRAPPC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trafficking protein particle complex subunit 13
    Protein Accession:
    Secondary Accessions:
    • Q17RZ9
    • Q49A23
    • Q4JHG0
    • Q6MZG4
    • Q8TCM2
    • Q9H8I3

    Protein attributes for TRAPPC13 Gene

    417 amino acids
    Molecular mass:
    46524 Da
    Quaternary structure:
    • Part of the multisubunit TRAPP (transport protein particle) complex.
    • Sequence=AAH47475.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB14633.1; Type=Erroneous termination; Positions=63; Note=Translated as Glu.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAPPC13 Gene


neXtProt entry for TRAPPC13 Gene

Post-translational modifications for TRAPPC13 Gene

  • Ubiquitination at posLast=165165 and isoforms=2, 4, 5, 7264

No data available for DME Specific Peptides for TRAPPC13 Gene

Domains & Families for TRAPPC13 Gene

Gene Families for TRAPPC13 Gene

Protein Domains for TRAPPC13 Gene


Suggested Antigen Peptide Sequences for TRAPPC13 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAPPC13 family.
  • Belongs to the TRAPPC13 family.
genes like me logo Genes that share domains with TRAPPC13: view

Function for TRAPPC13 Gene

Phenotypes From GWAS Catalog for TRAPPC13 Gene

Gene Ontology (GO) - Molecular Function for TRAPPC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21453443
GO:0017112 Rab guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with TRAPPC13: view
genes like me logo Genes that share phenotypes with TRAPPC13: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC13 Gene

Localization for TRAPPC13 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAPPC13 gene
Compartment Confidence
cytosol 5
plasma membrane 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRAPPC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRAPPC13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC13 Gene

Pathways & Interactions for TRAPPC13 Gene

genes like me logo Genes that share pathways with TRAPPC13: view

Pathways by source for TRAPPC13 Gene

Gene Ontology (GO) - Biological Process for TRAPPC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0065009 regulation of molecular function IEA --
genes like me logo Genes that share ontologies with TRAPPC13: view

No data available for SIGNOR curated interactions for TRAPPC13 Gene

Drugs & Compounds for TRAPPC13 Gene

No Compound Related Data Available

Transcripts for TRAPPC13 Gene

Unigene Clusters for TRAPPC13 Gene

Trafficking protein particle complex 13:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC13 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14a · 14b ·
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: -
SP7: -

ExUns: 14c · 14d

Relevant External Links for TRAPPC13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAPPC13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAPPC13 Gene

Protein differential expression in normal tissues from HIPED for TRAPPC13 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRAPPC13 Gene

Protein tissue co-expression partners for TRAPPC13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRAPPC13 Gene:


SOURCE GeneReport for Unigene cluster for TRAPPC13 Gene:


Evidence on tissue expression from TISSUES for TRAPPC13 Gene

  • Nervous system(4.7)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with TRAPPC13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAPPC13 Gene

Orthologs for TRAPPC13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRAPPC13 33
  • 99.6 (n)
C5ORF44 34
  • 99 (a)
(Monodelphis domestica)
Mammalia TRAPPC13 34
  • 94 (a)
(Bos Taurus)
Mammalia TRAPPC13 33 34
  • 93.76 (n)
(Canis familiaris)
Mammalia TRAPPC13 33 34
  • 93.54 (n)
(Rattus norvegicus)
Mammalia Trappc13 33
  • 89.31 (n)
(Mus musculus)
Mammalia Trappc13 33 16 34
  • 89 (n)
(Ornithorhynchus anatinus)
Mammalia TRAPPC13 34
  • 77 (a)
(Gallus gallus)
Aves CZH5ORF44 33 34
  • 82.78 (n)
(Anolis carolinensis)
Reptilia TRAPPC13 34
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc13 33
  • 77.18 (n)
Str.3852 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.2220 33
(Danio rerio)
Actinopterygii trappc13 33 34
  • 72.82 (n)
sbcb318 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005561 33
  • 53.55 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4953 33 34
  • 50.34 (n)
(Caenorhabditis elegans)
Secernentea C56C10.7 33 34
  • 55.38 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G47960 33
  • 47.81 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01664 33
Species where no ortholog for TRAPPC13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC13 Gene

Gene Tree for TRAPPC13 (if available)
Gene Tree for TRAPPC13 (if available)

Paralogs for TRAPPC13 Gene

(1) SIMAP similar genes for TRAPPC13 Gene using alignment to 4 proteins: Pseudogenes for TRAPPC13 Gene

genes like me logo Genes that share paralogs with TRAPPC13: view

No data available for Paralogs for TRAPPC13 Gene

Variants for TRAPPC13 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC13 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000045690 -- 65,632,847(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000077933 -- 65,626,539(+) C/T intron_variant
rs1000103542 -- 65,638,703(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000131004 -- 65,659,439(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000155940 -- 65,626,758(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC13 Gene

Variant ID Type Subtype PubMed ID
esv3894204 CNV loss 25118596
esv3425811 CNV insertion 20981092

Variation tolerance for TRAPPC13 Gene

Residual Variation Intolerance Score: 46.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAPPC13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC13 Gene

Disorders for TRAPPC13 Gene

Additional Disease Information for TRAPPC13

No disorders were found for TRAPPC13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAPPC13 Gene

Publications for TRAPPC13 Gene

  1. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. (PMID: 23394947) Bassik MC … Weissman JS (Cell 2013) 2 3 58
  2. Organization and assembly of the TRAPPII complex. (PMID: 21453443) Choi C … Conibear E (Traffic (Copenhagen, Denmark) 2011) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TRAPPC13 Gene

Sources for TRAPPC13 Gene

Loading form....