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Aliases for TRAPPC12 Gene

Aliases for TRAPPC12 Gene

  • Trafficking Protein Particle Complex 12 2 3 5
  • Trafficking Of Membranes And Mitosis 3 4
  • Tetratricopeptide Repeat Protein 15 3 4
  • Tetratricopeptide Repeat Domain 15 2 3
  • TPR Repeat Protein 15 3 4
  • TTC-15 3 4
  • TTC15 3 4
  • Trafficking Protein Particle Complex Subunit 12 3
  • CGI-87 3
  • PEBAS 3
  • TRAMM 4

External Ids for TRAPPC12 Gene

Previous HGNC Symbols for TRAPPC12 Gene

  • TTC15

Summaries for TRAPPC12 Gene

GeneCards Summary for TRAPPC12 Gene

TRAPPC12 (Trafficking Protein Particle Complex 12) is a Protein Coding gene. Diseases associated with TRAPPC12 include Encephalopathy, Progressive, Early-Onset, With Brain Atrophy And Spasticity. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. Gene Ontology (GO) annotations related to this gene include structural molecule activity and endopeptidase activity.

UniProtKB/Swiss-Prot for TRAPPC12 Gene

  • Plays an important role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224). May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244).

Additional gene information for TRAPPC12 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC12 Gene

Genomics for TRAPPC12 Gene

GeneHancer (GH) Regulatory Elements for TRAPPC12 Gene

Promoters and enhancers for TRAPPC12 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I003376 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 571.5 -0.7 -663 4.6 MLX DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC GLIS1 TRAPPC12 EIPR1 TRAPPC12-AS1
GH02I003574 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE 53.3 +196.7 196680 3.6 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 RPS7 TRAPPC12 RNASEH1 COLEC11 RNASEH1-AS1
GH02I003482 Enhancer 1 FANTOM5 Ensembl ENCODE 22.6 +103.8 103775 1.1 PKNOX1 USF1 NFIB DDX20 NFYC REST SP1 CTBP1 ZNF316 ZNF143 TRAPPC12-AS1 TRAPPC12 ENSG00000271868
GH02I003368 Enhancer 1 ENCODE dbSUPER 14.5 -10.8 -10785 1.7 ELF3 FOXA2 NFRKB ARID4B SIN3A DNMT3B ZNF48 ZSCAN9 RARA SLC30A9 TRAPPC12 EIPR1 GC02M003336
GH02I003464 Enhancer 1.3 Ensembl ENCODE dbSUPER 9.4 +86.3 86252 2.6 FOXA2 MLX ARID4B DMAP1 ETS1 TCF12 ATF7 FOS SP5 NFYC TRAPPC12-AS1 TRAPPC12 PIR36101 GC02P003451
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRAPPC12 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRAPPC12 Gene

Genomic Locations for TRAPPC12 Gene
105,423 bases
Plus strand

Genomic View for TRAPPC12 Gene

Genes around TRAPPC12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC12 Gene

Proteins for TRAPPC12 Gene

  • Protein details for TRAPPC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trafficking protein particle complex subunit 12
    Protein Accession:
    Secondary Accessions:
    • B3KV01
    • D6W4Y2
    • Q8WVW1
    • Q9Y395

    Protein attributes for TRAPPC12 Gene

    735 amino acids
    Molecular mass:
    79375 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12 (PubMed:21525244). Interacts with CENPE (PubMed:25918224).
    • Sequence=AAD34082.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TRAPPC12 Gene

Post-translational modifications for TRAPPC12 Gene

  • Phosphorylated as the cells enter mitosis but is dephosphorylated at or before the onset of anaphase. The phosphorylated form recruits CENPE to kinetochores more efficiently than the non-phosphorylated form.
  • Ubiquitination at posLast=354354, isoforms=364, isoforms=385, isoforms=510, and isoforms=601
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRAPPC12 Gene

Domains & Families for TRAPPC12 Gene

Gene Families for TRAPPC12 Gene

Protein Domains for TRAPPC12 Gene

Suggested Antigen Peptide Sequences for TRAPPC12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAPPC12: view

No data available for UniProtKB/Swiss-Prot for TRAPPC12 Gene

Function for TRAPPC12 Gene

Molecular function for TRAPPC12 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224). May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244).

Phenotypes From GWAS Catalog for TRAPPC12 Gene

Gene Ontology (GO) - Molecular Function for TRAPPC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IBA --
GO:0005515 protein binding IPI 21525244
GO:0017112 Rab guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with TRAPPC12: view

Phenotypes for TRAPPC12 Gene

genes like me logo Genes that share phenotypes with TRAPPC12: view

Animal Model Products

CRISPR Products

miRNA for TRAPPC12 Gene

miRTarBase miRNAs that target TRAPPC12

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC12 Gene

Localization for TRAPPC12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC12 Gene

Endoplasmic reticulum-Golgi intermediate compartment. Nucleus. Note=Mainly localizes to structures resembling the Golgi and a small amount is found in the nucleus. {ECO:0000269 PubMed:25918224}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAPPC12 gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TRAPPC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 25918224
GO:0005634 nucleus IDA,IEA 25918224
GO:0005793 colocalizes_with endoplasmic reticulum-Golgi intermediate compartment IMP 21525244
GO:0005829 cytosol TAS --
GO:0030008 TRAPP complex IDA 21525244
genes like me logo Genes that share ontologies with TRAPPC12: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRAPPC12 Gene

Pathways & Interactions for TRAPPC12 Gene

genes like me logo Genes that share pathways with TRAPPC12: view

Pathways by source for TRAPPC12 Gene

Gene Ontology (GO) - Biological Process for TRAPPC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IMP 21525244
GO:0007030 Golgi organization IMP 21525244
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with TRAPPC12: view

No data available for SIGNOR curated interactions for TRAPPC12 Gene

Drugs & Compounds for TRAPPC12 Gene

No Compound Related Data Available

Transcripts for TRAPPC12 Gene

Unigene Clusters for TRAPPC12 Gene

Trafficking protein particle complex 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC12 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - -
SP6: - -
SP7: - - - - - -
SP9: -
SP10: - - - - -
SP12: -

ExUns: 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20
SP1: - -
SP2: - -
SP3: - - -
SP4: - -
SP8: -

Relevant External Links for TRAPPC12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAPPC12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAPPC12 Gene

Protein differential expression in normal tissues from HIPED for TRAPPC12 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.7), Liver (9.1), and Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAPPC12 Gene

Protein tissue co-expression partners for TRAPPC12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRAPPC12 Gene:


SOURCE GeneReport for Unigene cluster for TRAPPC12 Gene:


Evidence on tissue expression from TISSUES for TRAPPC12 Gene

  • Lung(4.3)
  • Muscle(4.3)
  • Liver(4.2)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with TRAPPC12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAPPC12 Gene

Orthologs for TRAPPC12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TTC15 34 33
  • 99.14 (n)
(Ornithorhynchus anatinus)
Mammalia TRAPPC12 34
  • 85 (a)
(Bos Taurus)
Mammalia TTC15 34 33
  • 78.54 (n)
(Canis familiaris)
Mammalia TRAPPC12 33 34
  • 78.37 (n)
(Rattus norvegicus)
Mammalia Trappc12 33
  • 77.88 (n)
(Mus musculus)
Mammalia Trappc12 33 16 34
  • 76.64 (n)
(Monodelphis domestica)
Mammalia TRAPPC12 34
  • 69 (a)
(Gallus gallus)
Aves TRAPPC12 33 34
  • 69.65 (n)
(Anolis carolinensis)
Reptilia TRAPPC12 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc12 33
  • 67 (n)
Str.4089 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25574 33
(Danio rerio)
Actinopterygii trappc12 33 34
  • 64.27 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11396 33 34
  • 50.13 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011533 33
  • 24.04 (n)
(Caenorhabditis elegans)
Secernentea trpp-12 34
  • 25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G39820 33
  • 46.03 (n)
(Oryza sativa)
Liliopsida Os02g0550400 33
  • 46.01 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.736 34
  • 42 (a)
-- 34
  • 21 (a)
Species where no ortholog for TRAPPC12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC12 Gene

Gene Tree for TRAPPC12 (if available)
Gene Tree for TRAPPC12 (if available)

Paralogs for TRAPPC12 Gene Pseudogenes for TRAPPC12 Gene

genes like me logo Genes that share paralogs with TRAPPC12: view

No data available for Paralogs for TRAPPC12 Gene

Variants for TRAPPC12 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC12 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs768950892 pathogenic, Progressive childhood encephalopathy, ENCEPHALOPATHY, PROGRESSIVE, EARLY-ONSET, WITH BRAIN ATROPHY AND SPASTICITY 3,478,848(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
VAR_035869 A breast cancer sample p.Glu717Gln
rs1000000388 -- 3,408,563(+) G/T intron_variant
rs1000032831 -- 3,447,623(+) C/T intron_variant
rs1000065401 -- 3,433,288(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC12 Gene

Variant ID Type Subtype PubMed ID
dgv1848n106 CNV deletion 24896259
dgv3702n100 CNV gain 25217958
dgv6655n54 CNV gain 21841781
dgv6656n54 CNV gain+loss 21841781
dgv6657n54 CNV gain+loss 21841781
dgv6658n54 CNV gain 21841781
dgv6659n54 CNV gain 21841781
dgv6660n54 CNV gain+loss 21841781
dgv6661n54 CNV loss 21841781
dgv6662n54 CNV loss 21841781
esv1396860 CNV deletion 17803354
esv2392388 CNV deletion 18987734
esv25165 CNV gain+loss 19812545
esv2656713 CNV deletion 23128226
esv2660858 CNV deletion 23128226
esv2719515 CNV deletion 23290073
esv3589655 CNV gain 21293372
esv3589656 CNV loss 21293372
esv997718 CNV insertion 20482838
nsv1003355 CNV gain 25217958
nsv1006526 CNV loss 25217958
nsv1011656 CNV gain 25217958
nsv1071566 CNV deletion 25765185
nsv1118847 CNV deletion 24896259
nsv1149598 CNV insertion 26484159
nsv214768 CNV insertion 16902084
nsv2584 CNV insertion 18451855
nsv520390 CNV gain 19592680
nsv580773 CNV loss 21841781
nsv580774 CNV gain 21841781
nsv580776 CNV loss 21841781
nsv580796 CNV loss 21841781
nsv580802 CNV loss 21841781
nsv580803 CNV loss 21841781
nsv580807 CNV loss 21841781
nsv580810 CNV loss 21841781
nsv580817 CNV loss 21841781
nsv580818 CNV loss 21841781
nsv580819 CNV loss 21841781
nsv580820 CNV loss 21841781
nsv580821 CNV loss 21841781
nsv821316 CNV deletion 20802225
nsv953388 CNV deletion 24416366

Variation tolerance for TRAPPC12 Gene

Residual Variation Intolerance Score: 10.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.56; 97.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAPPC12 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC12 Gene

Disorders for TRAPPC12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRAPPC12 Gene - From: OMIM and ClinVar

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRAPPC12

genes like me logo Genes that share disorders with TRAPPC12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAPPC12 Gene

Publications for TRAPPC12 Gene

  1. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens PJ … Sacher M (Molecular biology of the cell 2011) 2 3 4 58
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  3. TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment. (PMID: 25918224) Milev MP … Sacher M (The Journal of cell biology 2015) 3 4 58
  4. Network organization of the human autophagy system. (PMID: 20562859) Behrends C … Harper JW (Nature 2010) 2 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for TRAPPC12 Gene

Sources for TRAPPC12 Gene

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