Aliases for TRAPPC10 Gene
Aliases for TRAPPC10 Gene
External Ids for TRAPPC10 Gene
- HGNC: 11868
- Entrez Gene: 7109
- Ensembl: ENSG00000160218
- OMIM: 602103
- UniProtKB: P48553
Previous HGNC Symbols for TRAPPC10 Gene
- TMEM1
Previous GeneCards Identifiers for TRAPPC10 Gene
- GC00U913620
- GC21P044257
- GC21P045432
- GC21P030802
Summaries for TRAPPC10 Gene
-
The protein encoded by this gene is a transmembrane protein found in the cis-Golgi complex. The encoded protein is part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport from the endoplasmic reticulum to the Golgi. Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRAPPC10 Gene
TRAPPC10 (Trafficking Protein Particle Complex 10) is a Protein Coding gene. Diseases associated with TRAPPC10 include Progressive Myoclonus Epilepsy and Holoprosencephaly. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include sodium ion transmembrane transporter activity. An important paralog of this gene is LOC102724200.
UniProtKB/Swiss-Prot for TRAPPC10 Gene
-
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Additional gene information for TRAPPC10 Gene
- Monarch Initiative
- Search for TRAPPC10 at DataMed
- Search for TRAPPC10 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC10 Gene
Genomics for TRAPPC10 Gene
GeneHancer (GH) Regulatory Elements for TRAPPC10 Gene
Promoters and enhancers for TRAPPC10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TRAPPC10 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TRAPPC10 Gene
Genomic Locations for TRAPPC10 Gene
- chr21:44,012,319-44,106,552
- (GRCh38/hg38)
- Size:
- 94,234 bases
- Orientation:
- Plus strand
- chr21:45,432,200-45,526,433
- (GRCh37/hg19)
Genomic View for TRAPPC10 Gene
Genes around TRAPPC10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.3 by Ensembl
- 21q22.3 by Entrez Gene
- 21q22.3 by HGNC
TRAPPC10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRAPPC10 Gene
Proteins for TRAPPC10 Gene
-
Protein details for TRAPPC10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P48553-TPC10_HUMAN
- Recommended name:
- Trafficking protein particle complex subunit 10
- Protein Accession:
- P48553
- Q3MIR2
- Q86SI7
- Q9UMD4
- Q9Y4L3
Protein attributes for TRAPPC10 Gene
- Size:
- 1259 amino acids
- Molecular mass:
- 142189 Da
- Quaternary structure:
-
- Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.
- SequenceCaution:
-
- Sequence=AAC50134.1; Type=Frameshift; Positions=1187; Evidence={ECO:0000305};
Protein Expression for TRAPPC10 Gene
Post-translational modifications for TRAPPC10 Gene
No Post-translational modifications
Other Protein References for TRAPPC10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001338638.1
- NP_003265.3
- XP_005261225.1
- XP_011528016.1
- XP_011528017.1
- XP_011528018.1
- XP_011528019.1
- XP_011528020.1
- XP_011528021.1
- XP_011528022.1
- XP_011528023.1
- XP_011528024.1
- XP_011528025.1
- XP_011528027.1
- XP_011528028.1
- XP_011528029.1
- XP_011528030.1
- XP_011528031.1
- XP_011528032.1
- XP_016855322.1
- XP_016855323.1
- XP_016855324.1
- XP_016855325.1
- XP_016855326.1
- XP_016855327.1
- XP_016855328.1
- XP_016855329.1
- XP_016855330.1
- XP_016855331.1
- XP_016855332.1
- XP_016855333.1
- XP_016855334.1
- XP_016855335.1
- XP_016855336.1
- XP_016855337.1
- XP_016855338.1
- XP_016855339.1
- XP_016855340.1
- XP_016855341.1
- XP_016883943.1
- XP_016883944.1
Antibody Products
- Novus Biologicals Antibodies for TRAPPC10
-
Cloud-Clone Corp. Antibodies for TRAPPC10
- Invitrogen Antibodies for TRAPPC10
- Search GeneTex for Antibodies for TRAPPC10
-
Santa Cruz Biotechnology (SCBT) Antibodies for TRAPPC10
Protein Products
-
OriGene Purified Proteins for TRAPPC10
- Search Origene for MassSpec and Protein Over-expression Lysates for TRAPPC10
- Origene Custom Protein Services for TRAPPC10
-
Cloud-Clone Corp. Proteins for TRAPPC10
- antibodies-online: Search results for 6 available TMEM1 Proteins ranked by validation data
- Compare Top TMEM1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for TRAPPC10
-
Abcam proteins for TRAPPC10
Assay Products
No data available for DME Specific Peptides for TRAPPC10 Gene
Domains & Families for TRAPPC10 Gene
Gene Families for TRAPPC10 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for TRAPPC10 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TRAPPC10 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P48553- Family:
-
- Belongs to the TMEM1 family.
Function for TRAPPC10 Gene
Molecular function for TRAPPC10 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Phenotypes From GWAS Catalog for TRAPPC10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 21273506 |
| GO:0015081 | sodium ion transmembrane transporter activity | TAS | 7633421 |
| GO:0017112 | Rab guanyl-nucleotide exchange factor activity | TAS | -- |
Phenotypes for TRAPPC10 Gene
- MGI mutant phenotypes for TRAPPC10:
-
inferred from 3 alleles
- nervous system phenotype
- cardiovascular system phenotype
- immune system phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- hematopoietic system phenotype
- skeleton phenotype
- craniofacial phenotype
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for TRAPPC10:
Animal Models for TRAPPC10 Gene
- MGI Knock Outs for TRAPPC10:
-
- Trappc10 tm1b(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TRAPPC10
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TRAPPC10 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TRAPPC10 gene
- Search ViGene Biosciences for TRAPPC10
CRISPR Products
-
OriGene CRISPR knockouts for TRAPPC10
- genomics-online: gRNA clones - Search results for available TMEM1 gene related products
- Applied Biological Materials CRISPR for TRAPPC10
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRAPPC10
- GenScript: Design CRISPR guide RNA sequences for TRAPPC10
miRNA for TRAPPC10 Gene
- miRTarBase miRNAs that target TRAPPC10
-
- hsa-mir-186-5p (MIRT021083)
- hsa-mir-330-5p (MIRT038240)
- hsa-mir-615-3p (MIRT040102)
- hsa-mir-18a-3p (MIRT040804)
- hsa-mir-193b-3p (MIRT041335)
- hsa-mir-17-5p (MIRT254247)
- hsa-mir-20a-5p (MIRT254248)
- hsa-mir-93-5p (MIRT254250)
- hsa-mir-106b-5p (MIRT254254)
- hsa-mir-20b-5p (MIRT254255)
- hsa-mir-519d-3p (MIRT254260)
- hsa-mir-4713-5p (MIRT621718)
- hsa-mir-2116-3p (MIRT621719)
- hsa-mir-532-3p (MIRT621720)
- hsa-mir-150-5p (MIRT621721)
- hsa-mir-4762-5p (MIRT621722)
- hsa-mir-4753-3p (MIRT652238)
- hsa-mir-130b-5p (MIRT652239)
- hsa-let-7a-5p (MIRT735587)
- hsa-let-7b-5p (MIRT735612)
- hsa-let-7c-5p (MIRT735639)
- hsa-let-7d-5p (MIRT735667)
- hsa-let-7e-5p (MIRT735694)
- hsa-let-7f-5p (MIRT735725)
- hsa-let-7g-5p (MIRT735757)
- hsa-let-7i-5p (MIRT735785)
- hsa-mir-1233-5p (MIRT736273)
- hsa-mir-1249-5p (MIRT736479)
- hsa-mir-1294 (MIRT737185)
- hsa-mir-1321 (MIRT737378)
- hsa-mir-149-3p (MIRT737805)
- hsa-mir-202-3p (MIRT738799)
- hsa-mir-3921 (MIRT742972)
- hsa-mir-4278 (MIRT743694)
- hsa-mir-4316 (MIRT744009)
- hsa-mir-4419a (MIRT744219)
- hsa-mir-4458 (MIRT744773)
- hsa-mir-4468 (MIRT744941)
- hsa-mir-4500 (MIRT745493)
- hsa-mir-4510 (MIRT745659)
- hsa-mir-4653-5p (MIRT746620)
- hsa-mir-4682 (MIRT746930)
- hsa-mir-4685-5p (MIRT746981)
- hsa-mir-4716-3p (MIRT747510)
- hsa-mir-4723-5p (MIRT747679)
- hsa-mir-4728-5p (MIRT747901)
- hsa-mir-4739 (MIRT748095)
- hsa-mir-4756-5p (MIRT748467)
- hsa-mir-503-5p (MIRT749546)
- hsa-mir-5088-5p (MIRT749643)
- hsa-mir-5698 (MIRT751312)
- hsa-mir-6127 (MIRT752133)
- hsa-mir-6129 (MIRT752206)
- hsa-mir-6130 (MIRT752294)
- hsa-mir-6133 (MIRT752398)
- hsa-mir-6732-5p (MIRT754088)
- hsa-mir-6785-5p (MIRT755896)
- hsa-mir-6794-5p (MIRT756110)
- hsa-mir-6797-5p (MIRT756239)
- hsa-mir-6805-5p (MIRT756491)
- hsa-mir-6825-5p (MIRT757026)
- hsa-mir-6837-5p (MIRT757263)
- hsa-mir-6870-5p (MIRT758012)
- hsa-mir-6883-5p (MIRT758481)
- hsa-mir-7111-5p (MIRT759070)
- hsa-mir-760 (MIRT759457)
- hsa-mir-98-5p (MIRT760954)
miRNA Products
- Search ViGene Biosciences for TRAPPC10
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TRAPPC10
- Browse OriGene Inhibitory RNA Products For TRAPPC10
- genomics-online: shRNA clones - Search results for available TMEM1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TRAPPC10 gene
Clone Products
-
OriGene ORF clones in human for TRAPPC10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TRAPPC10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRAPPC10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TRAPPC10
- genomics-online: cdna clones - Search results for available TMEM1 gene related products
- orf clones - Search results for available TMEM1 gene related products
- Applied Biological Materials Clones for TRAPPC10
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TRAPPC10
-
ViGene Biosciences adenoviral particle packaged cDNA for TRAPPC10 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TRAPPC10 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TRAPPC10 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRAPPC10 Gene
Localization for TRAPPC10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC10 Gene
- Golgi apparatus, cis-Golgi network.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| golgi apparatus | 4 |
| endosome | 4 |
| nucleus | 3 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016021 | integral component of membrane | TAS | 9196060 |
| GO:0030008 | TRAPP complex | IDA | 21525244 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRAPPC10 Gene
Pathways & Interactions for TRAPPC10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport to the Golgi and subsequent modification | ||
| 2 | Vesicle-mediated transport | ||
| 3 | Metabolism of proteins | ||
| 4 | RAB GEFs exchange GTP for GDP on RABs | ||
Pathways by source for TRAPPC10 Gene
9 Reactome pathways for TRAPPC10 Gene
Interacting Proteins for TRAPPC10 Gene
Selected Interacting proteins:
ENSP00000291574
P48553-TPC10_HUMAN
for TRAPPC10 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006814 | sodium ion transport | TAS | 7633421 |
| GO:0006891 | intra-Golgi vesicle-mediated transport | IBA | -- |
| GO:0016192 | vesicle-mediated transport | IEA | -- |
| GO:0034498 | early endosome to Golgi transport | IBA | -- |
No data available for SIGNOR curated interactions for TRAPPC10 Gene
Transcripts for TRAPPC10 Gene
mRNA/cDNA for TRAPPC10 Gene
- (42) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (178) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TRAPPC10 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TRAPPC10
- genomics-online: gRNA clones - Search results for available TMEM1 gene related products
- Applied Biological Materials CRISPR for TRAPPC10
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRAPPC10
- GenScript: Design CRISPR guide RNA sequences for TRAPPC10
miRNA Products
- Search ViGene Biosciences for TRAPPC10
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TRAPPC10
- Browse OriGene Inhibitory RNA Products For TRAPPC10
- genomics-online: shRNA clones - Search results for available TMEM1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TRAPPC10 gene
Clone Products
-
OriGene ORF clones in human for TRAPPC10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TRAPPC10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRAPPC10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TRAPPC10
- genomics-online: cdna clones - Search results for available TMEM1 gene related products
- orf clones - Search results for available TMEM1 gene related products
- Applied Biological Materials Clones for TRAPPC10
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | · | 20c | ^ | 21a | · | 21b | ^ | 22 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
| ExUns: | 23 | ^ | 24 | ^ | 25 |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: |
Expression for TRAPPC10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
This gene is overexpressed in Urine (14.7), Peripheral blood mononuclear cells (10.8), and Lymph node (8.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAPPC10 Gene
NURSA nuclear receptor signaling pathways regulating expression of TRAPPC10 Gene:
TRAPPC10SOURCE GeneReport for Unigene cluster for TRAPPC10 Gene:
Hs.126221mRNA Expression by UniProt/SwissProt for TRAPPC10 Gene:
P48553-TPC10_HUMAN
Tissue specificity:
Expressed in all tissues examined.
Evidence on tissue expression from TISSUES for TRAPPC10 Gene
- Nervous system(4.4)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for TRAPPC10
-
OriGene qPCR primer pairs and template standards for TRAPPC10
- genomics-online: primer clones - Search results for available TMEM1 gene related products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAPPC10 Gene
Orthologs for TRAPPC10 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TRAPPC10 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TRAPPC10 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TRAPPC10 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TRAPPC10 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TRAPPC10 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Trappc10 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Trappc10 33 |
|
||
| chicken (Gallus gallus) |
Aves | TRAPPC10 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TRAPPC10 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | trappc10 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | trappc10 33 |
|
||
| TRAPPC10 34 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002242 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | SIDL 33 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | trpp-10 34 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TRS130 36 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for TRAPPC10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TRAPPC10 Gene
Paralogs for TRAPPC10 Gene
Variants for TRAPPC10 Gene
| SNP ID | Clin | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs386352376 | uncertain-significance, not provided | 44,091,981(+) | A/G/T | coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant | |
| rs1000056650 | -- | 44,042,748(+) | G/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000087313 | -- | 44,030,253(+) | G/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000108698 | -- | 44,043,160(+) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000136016 | -- | 44,054,864(+) | G/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv587722 | CNV | loss | 21841781 |
| nsv587721 | CNV | loss | 21841781 |
| nsv1139034 | CNV | deletion | 24896259 |
| nsv1139033 | CNV | deletion | 24896259 |
| nsv1118936 | CNV | deletion | 24896259 |
| nsv1063752 | CNV | gain | 25217958 |
| esv3575397 | CNV | gain | 25503493 |
| esv3557795 | CNV | deletion | 23714750 |
| esv33817 | CNV | loss | 17666407 |
| esv2723627 | CNV | deletion | 23290073 |
| esv25124 | CNV | gain | 19812545 |
Residual Variation Intolerance Score:
15.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.72;
83.09% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TRAPPC10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TRAPPC10
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC10 Gene
Disorders for TRAPPC10 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| progressive myoclonus epilepsy |
|
|
| holoprosencephaly |
|
|
| autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia |
|
|
| holoprosencephaly 1 |
|
|
Search TRAPPC10 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TRAPPC10
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TRAPPC10 Gene
Publications for TRAPPC10 Gene
- Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3. (PMID: 7633421) Yamakawa K … Korenberg JR (Human molecular genetics 1995) 2 3 4 22 58
- Genomic structure of the human GT334 (EHOC-1) gene mapping to 21q22.3. (PMID: 9370297) Lafrenière RG … Rouleau GA (Gene 1997) 3 4 22 58
- Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3. (PMID: 9196060) Nagamine K … Shimizu N (Biochemical and biophysical research communications 1997) 3 4 22 58
- C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens PJ … Sacher M (Molecular biology of the cell 2011) 3 4 58
- L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 44 58
Products for TRAPPC10 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TRAPPC10
- Search Origene for MassSpec and Protein Over-expression Lysates for TRAPPC10
- Origene Custom Protein Services for TRAPPC10
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRAPPC10
- Browse OriGene Inhibitory RNA Products For TRAPPC10
- OriGene qPCR primer pairs and template standards for TRAPPC10
- OriGene qPCR primer pairs for TRAPPC10
- OriGene CRISPR knockouts for TRAPPC10
- OriGene ORF clones in human for TRAPPC10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TRAPPC10
- GenScript: Next-day shipping of latest version cDNA ORF clones for TRAPPC10 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for TRAPPC10
- GenScript Custom Assay Services for TRAPPC10
- GenScript Custom overexpressing Cell Line Services for TRAPPC10
- GenScript: Design CRISPR guide RNA sequences for TRAPPC10
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TRAPPC10
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for TRAPPC10
- Novus Biologicals lysates and proteins for TRAPPC10
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for TRAPPC10
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for TRAPPC10
- Cloud-Clone Corp. Proteins for TRAPPC10
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for TRAPPC10
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for TRAPPC10
- VectorBuilder custom plasmid, inducible vectors for TRAPPC10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRAPPC10
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TRAPPC10
- antibodies-online: Search results for 27 available TMEM1 Antibodies ranked by validation data
- Compare Top TMEM1 Antibodies
- antibodies-online: Search results for available TMEM1 related products ranked by validation data
- antibodies-online: Search results for 6 available TMEM1 Proteins ranked by validation data
- Compare Top TMEM1 Proteins
- Quality Products:
- Search GeneTex for Antibodies for TRAPPC10
- Search GeneTex for Proteins for TRAPPC10
- ViGene Biosciences adenoviral particle packaged cDNA for TRAPPC10 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TRAPPC10 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TRAPPC10 gene
- Search ViGene Biosciences for TRAPPC10
- Santa Cruz Biotechnology (SCBT) Antibodies for TRAPPC10
- Search Santa Cruz Biotechnology (SCBT) for TRAPPC10 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TRAPPC10
- Horizon Cell Lines for TRAPPC10
- genomics-online: cdna clones - Search results for available TMEM1 gene related products
- orf clones - Search results for available TMEM1 gene related products
- genomics-online: gRNA clones - Search results for available TMEM1 gene related products
- genomics-online: primer clones - Search results for available TMEM1 gene related products
- genomics-online: shRNA clones - Search results for available TMEM1 gene related products
Sources for TRAPPC10 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew