This gene product plays a role in vesicular transport of proteins to the Golgi apparatus from the endoplasmic reticulum. The encoded protein is a component of the multisubunit transport protein particle (TRAPP) complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009] See more...

Aliases for TRAPPC1 Gene

Aliases for TRAPPC1 Gene

  • Trafficking Protein Particle Complex Subunit 1 2 3 4
  • Trafficking Protein Particle Complex 1 2 3 5
  • BET5 2 3 4
  • MUM2 2 3 4
  • Multiple Myeloma Protein 2 3 4
  • BET5 Homolog 3 4
  • MUM-2 3 4
  • Melanoma Ubiquitous Mutated 2 3
  • TRAPPC1 5

External Ids for TRAPPC1 Gene

Previous GeneCards Identifiers for TRAPPC1 Gene

  • GC17M007776
  • GC17M008035
  • GC17M008036
  • GC17M007775
  • GC17M007777
  • GC17M007833
  • GC17M007728

Summaries for TRAPPC1 Gene

Entrez Gene Summary for TRAPPC1 Gene

  • This gene product plays a role in vesicular transport of proteins to the Golgi apparatus from the endoplasmic reticulum. The encoded protein is a component of the multisubunit transport protein particle (TRAPP) complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for TRAPPC1 Gene

TRAPPC1 (Trafficking Protein Particle Complex Subunit 1) is a Protein Coding gene. Diseases associated with TRAPPC1 include Spondyloepiphyseal Dysplasia Tarda, X-Linked and Melanoma. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. Gene Ontology (GO) annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is TRAPPC4.

UniProtKB/Swiss-Prot Summary for TRAPPC1 Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRAPPC1 Gene

Genomics for TRAPPC1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRAPPC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRAPPC1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRAPPC1

Top Transcription factor binding sites by QIAGEN in the TRAPPC1 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • E47
  • Elk-1
  • GATA-2
  • Ik-1
  • NCX
  • Sp1
  • Tal-1beta

Genomic Locations for TRAPPC1 Gene

Latest Assembly
chr17:7,930,345-7,932,123
(GRCh38/hg38)
Size:
1,779 bases
Orientation:
Minus strand

Previous Assembly
chr17:7,833,663-7,835,317
(GRCh37/hg19 by Entrez Gene)
Size:
1,655 bases
Orientation:
Minus strand

chr17:7,833,663-7,835,441
(GRCh37/hg19 by Ensembl)
Size:
1,779 bases
Orientation:
Minus strand

Genomic View for TRAPPC1 Gene

Genes around TRAPPC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC1 Gene

Proteins for TRAPPC1 Gene

  • Protein details for TRAPPC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5R8-TPPC1_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 1
    Protein Accession:
    Q9Y5R8
    Secondary Accessions:
    • D3DTR0

    Protein attributes for TRAPPC1 Gene

    Size:
    145 amino acids
    Molecular mass:
    16832 Da
    Quaternary structure:
    • Part of the multisubunit transport protein particle (TRAPP) complex (PubMed:11805826). The heterodimer TRAPPC6B-TRAPPC3 interacts with TRAPPC1 likely providing a core for TRAPP complex formation (PubMed:16828797).

neXtProt entry for TRAPPC1 Gene

Post-translational modifications for TRAPPC1 Gene

  • Ubiquitination at Lys58 and Lys70
  • Modification sites at PhosphoSitePlus

Other Protein References for TRAPPC1 Gene

Antibodies for research

  • Boster Bio Antibodies for TRAPPC1
  • Santa Cruz Biotechnology (SCBT) Antibodies for TRAPPC1

No data available for DME Specific Peptides for TRAPPC1 Gene

Domains & Families for TRAPPC1 Gene

Gene Families for TRAPPC1 Gene

Protein Domains for TRAPPC1 Gene

InterPro:
Blocks:
  • Sybindin-like protein

Suggested Antigen Peptide Sequences for TRAPPC1 Gene

GenScript: Design optimal peptide antigens:
  • Multiple myeloma protein 2 (TPPC1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y5R8

UniProtKB/Swiss-Prot:

TPPC1_HUMAN :
  • Belongs to the TRAPP small subunits family. BET5 subfamily.
Family:
  • Belongs to the TRAPP small subunits family. BET5 subfamily.
genes like me logo Genes that share domains with TRAPPC1: view

Function for TRAPPC1 Gene

Molecular function for TRAPPC1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Phenotypes From GWAS Catalog for TRAPPC1 Gene

Gene Ontology (GO) - Molecular Function for TRAPPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 28514442
genes like me logo Genes that share ontologies with TRAPPC1: view
genes like me logo Genes that share phenotypes with TRAPPC1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRAPPC1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC1 Gene

Localization for TRAPPC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC1 Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAPPC1 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 4
cytosol 4
lysosome 4
golgi apparatus 3
mitochondrion 2
nucleus 2
endosome 2
plasma membrane 1
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRAPPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005576 extracellular region TAS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRAPPC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRAPPC1 Gene

Pathways & Interactions for TRAPPC1 Gene

genes like me logo Genes that share pathways with TRAPPC1: view

Gene Ontology (GO) - Biological Process for TRAPPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IEA,IBA 21873635
GO:0016192 vesicle-mediated transport IEA --
GO:0043312 neutrophil degranulation TAS --
GO:0048208 COPII vesicle coating TAS --
genes like me logo Genes that share ontologies with TRAPPC1: view

No data available for SIGNOR curated interactions for TRAPPC1 Gene

Drugs & Compounds for TRAPPC1 Gene

(1) Drugs for TRAPPC1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-palmitoyl-L-cysteine Experimental Pharma Target 0
genes like me logo Genes that share compounds with TRAPPC1: view

Transcripts for TRAPPC1 Gene

mRNA/cDNA for TRAPPC1 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRAPPC1

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3: - -
SP4: - -
SP5:

Relevant External Links for TRAPPC1 Gene

GeneLoc Exon Structure for
TRAPPC1

Expression for TRAPPC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAPPC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRAPPC1 Gene

This gene is overexpressed in Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for TRAPPC1 Gene

This gene is overexpressed in Breast (19.6), Bone (7.5), and Retina (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRAPPC1 Gene



Protein tissue co-expression partners for TRAPPC1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRAPPC1

SOURCE GeneReport for Unigene cluster for TRAPPC1 Gene:

Hs.24379

Evidence on tissue expression from TISSUES for TRAPPC1 Gene

  • Nervous system(3.8)
  • Kidney(3.1)
  • Muscle(2.8)
  • Intestine(2.8)
  • Skin(2.3)
  • Heart(2.3)
  • Liver(2.2)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with TRAPPC1: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAPPC1 Gene

Orthologs for TRAPPC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRAPPC1 29 30
  • 99.77 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TRAPPC1 30
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia TRAPPC1 29 30
  • 96.09 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TRAPPC1 29 30
  • 94.48 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Trappc1 29 16 30
  • 91.26 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Trappc1 29
  • 90.8 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia TRAPPC1 30
  • 90 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TRAPPC1 30
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia trappc1 29
  • 74.25 (n)
Str.10881 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.2590 29
Zebrafish
(Danio rerio)
Actinopterygii trappc1 29 30
  • 71.49 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000995 29
  • 58.04 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Bet5 29 30
  • 56.41 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea CELE_DC2.8 29
  • 52.8 (n)
trpp-1 30
  • 36 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BET5 30 32
  • 29 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT1G51160 29
  • 53.48 (n)
Rice
(Oryza sativa)
Liliopsida Os01g0513700 29
  • 54.62 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU06176 29
  • 50.91 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes bet5 29
  • 48.91 (n)
Species where no ortholog for TRAPPC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TRAPPC1 Gene

ENSEMBL:
Gene Tree for TRAPPC1 (if available)
TreeFam:
Gene Tree for TRAPPC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRAPPC1: view image
Alliance of Genome Resources:
Additional Orthologs for TRAPPC1

Paralogs for TRAPPC1 Gene

Paralogs for TRAPPC1 Gene

genes like me logo Genes that share paralogs with TRAPPC1: view

Variants for TRAPPC1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRAPPC1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs200476704 A melanoma p.Arg129Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TRAPPC1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC1 Gene

Variant ID Type Subtype PubMed ID
esv2670156 CNV deletion 23128226
nsv457660 CNV loss 19166990
nsv574333 CNV loss 21841781

Variation tolerance for TRAPPC1 Gene

Residual Variation Intolerance Score: 43.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAPPC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAPPC1
Leiden Open Variation Database (LOVD)
TRAPPC1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC1 Gene

Disorders for TRAPPC1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRAPPC1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
spondyloepiphyseal dysplasia tarda, x-linked
  • sedt
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRAPPC1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TRAPPC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAPPC1 Gene

Publications for TRAPPC1 Gene

  1. Two antigens recognized by autologous cytolytic T lymphocytes on a melanoma result from a single point mutation in an essential housekeeping gene. (PMID: 10582700) Chiari R … Coulie PG (Cancer research 1999) 2 3 4 22
  2. Structure of the Bet3-Tpc6B core of TRAPP: two Tpc6 paralogs form trimeric complexes with Bet3 and Mum2. (PMID: 16828797) Kümmel D … Heinemann U (Journal of molecular biology 2006) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Functional organization of the yeast proteome by systematic analysis of protein complexes. (PMID: 11805826) Gavin AC … Superti-Furga G (Nature 2002) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for TRAPPC1 Gene

Sources for TRAPPC1 Gene