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Aliases for TRAPPC1 Gene

Aliases for TRAPPC1 Gene

  • Trafficking Protein Particle Complex 1 2 3 5
  • Multiple Myeloma Protein 2 3 4
  • BET5 Homolog 3 4
  • MUM-2 3 4
  • BET5 3 4
  • MUM2 3 4
  • Trafficking Protein Particle Complex Subunit 1 3
  • Melanoma Ubiquitous Mutated 2 3

External Ids for TRAPPC1 Gene

Previous GeneCards Identifiers for TRAPPC1 Gene

  • GC17M007776
  • GC17M008035
  • GC17M008036
  • GC17M007775
  • GC17M007777
  • GC17M007833
  • GC17M007728

Summaries for TRAPPC1 Gene

Entrez Gene Summary for TRAPPC1 Gene

  • This gene product plays a role in vesicular transport of proteins to the Golgi apparatus from the endoplasmic reticulum. The encoded protein is a component of the multisubunit transport protein particle (TRAPP) complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for TRAPPC1 Gene

TRAPPC1 (Trafficking Protein Particle Complex 1) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include Rab guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for TRAPPC1 Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Additional gene information for TRAPPC1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC1 Gene

Genomics for TRAPPC1 Gene

GeneHancer (GH) Regulatory Elements for TRAPPC1 Gene

Promoters and enhancers for TRAPPC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I007931 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.4 -369 2.8 HDGF PKNOX1 SMAD1 FOXA2 ARID4B NEUROD1 SIN3A ZNF2 ZBTB7B YY1 CNTROB ENSG00000262730 TRAPPC1 PFAS DVL2 CYB5D1 SCARNA21 CHD3 SENP3 CTC1
GH17I007882 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.3 +45.5 45512 7.3 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 NAA38 CHD3 KDM6B NLGN2 WRAP53 CYB5D1 TMEM88 KCNAB3 TRAPPC1 CNTROB
GH17I007625 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.3 +303.9 303900 5.8 FOXA2 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF416 SP3 NFYC MXD4 SAT2 GC17P007715 GC17P007716 GC17P007740 SHBG CHRNB1 DVL2 TP53 WRAP53 EFNB3
GH17I007613 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.3 +317.6 317561 2.9 HDGF PKNOX1 ATF1 ARID4B SIN3A YY1 GTF3C2 POLR2B GLIS2 ARID2 FXR2 SHBG TNFSF12 SNORD10 SOX15 LOC100996842 MPDU1 DVL2 ATP1B2 SNORA48
GH17I008016 Promoter/Enhancer 1.6 Ensembl ENCODE 10.8 -86.3 -86312 4.5 ZNF2 YY1 GLIS2 ZNF143 KLF7 SP3 RXRA YY2 REST GLIS1 KCNAB3 CNTROB NLGN2 ATP1B2 DLG4 VAMP2 ALOX15B TRAPPC1 PFAS NAA38
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRAPPC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRAPPC1 gene promoter:

Genomic Locations for TRAPPC1 Gene

Genomic Locations for TRAPPC1 Gene
1,779 bases
Minus strand

Genomic View for TRAPPC1 Gene

Genes around TRAPPC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC1 Gene

Proteins for TRAPPC1 Gene

  • Protein details for TRAPPC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trafficking protein particle complex subunit 1
    Protein Accession:
    Secondary Accessions:
    • D3DTR0

    Protein attributes for TRAPPC1 Gene

    145 amino acids
    Molecular mass:
    16832 Da
    Quaternary structure:
    • Part of the multisubunit TRAPP (transport protein particle) complex.

neXtProt entry for TRAPPC1 Gene

Post-translational modifications for TRAPPC1 Gene

  • Ubiquitination at posLast=5858 and isoforms=70
  • Modification sites at PhosphoSitePlus

Other Protein References for TRAPPC1 Gene

No data available for DME Specific Peptides for TRAPPC1 Gene

Domains & Families for TRAPPC1 Gene

Gene Families for TRAPPC1 Gene

Protein Domains for TRAPPC1 Gene

Suggested Antigen Peptide Sequences for TRAPPC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAPP small subunits family. BET5 subfamily.
  • Belongs to the TRAPP small subunits family. BET5 subfamily.
genes like me logo Genes that share domains with TRAPPC1: view

Function for TRAPPC1 Gene

Molecular function for TRAPPC1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Phenotypes From GWAS Catalog for TRAPPC1 Gene

Gene Ontology (GO) - Molecular Function for TRAPPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017112 Rab guanyl-nucleotide exchange factor activity IBA,TAS --
genes like me logo Genes that share ontologies with TRAPPC1: view
genes like me logo Genes that share phenotypes with TRAPPC1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC1 Gene

Localization for TRAPPC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC1 Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAPPC1 gene
Compartment Confidence
cytosol 5
extracellular 4
lysosome 4
endoplasmic reticulum 3
golgi apparatus 3
mitochondrion 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRAPPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005576 extracellular region TAS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRAPPC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRAPPC1 Gene

Pathways & Interactions for TRAPPC1 Gene

genes like me logo Genes that share pathways with TRAPPC1: view

Gene Ontology (GO) - Biological Process for TRAPPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0016192 vesicle-mediated transport IEA --
GO:0043312 neutrophil degranulation TAS --
GO:0048208 COPII vesicle coating TAS --
genes like me logo Genes that share ontologies with TRAPPC1: view

No data available for SIGNOR curated interactions for TRAPPC1 Gene

Drugs & Compounds for TRAPPC1 Gene

(1) Drugs for TRAPPC1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-PALMITOYL-L-CYSTEINE Experimental Pharma Target 0
genes like me logo Genes that share compounds with TRAPPC1: view

Transcripts for TRAPPC1 Gene

Unigene Clusters for TRAPPC1 Gene

Trafficking protein particle complex 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for TRAPPC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAPPC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAPPC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRAPPC1 Gene

This gene is overexpressed in Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for TRAPPC1 Gene

This gene is overexpressed in Breast (19.6), Bone (7.5), and Retina (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAPPC1 Gene

Protein tissue co-expression partners for TRAPPC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRAPPC1 Gene:


SOURCE GeneReport for Unigene cluster for TRAPPC1 Gene:


Evidence on tissue expression from TISSUES for TRAPPC1 Gene

  • Nervous system(3.6)
  • Intestine(2.8)
  • Kidney(2.8)
  • Muscle(2.8)
  • Heart(2.3)
  • Liver(2.2)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with TRAPPC1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAPPC1 Gene

Orthologs for TRAPPC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRAPPC1 33 34
  • 99.77 (n)
(Monodelphis domestica)
Mammalia TRAPPC1 34
  • 97 (a)
(Bos Taurus)
Mammalia TRAPPC1 33 34
  • 96.09 (n)
(Canis familiaris)
Mammalia TRAPPC1 33 34
  • 94.48 (n)
(Mus musculus)
Mammalia Trappc1 33 16 34
  • 91.26 (n)
(Rattus norvegicus)
Mammalia Trappc1 33
  • 90.8 (n)
(Ornithorhynchus anatinus)
Mammalia TRAPPC1 34
  • 90 (a)
(Anolis carolinensis)
Reptilia TRAPPC1 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc1 33
  • 74.25 (n)
Str.10881 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.2590 33
(Danio rerio)
Actinopterygii trappc1 33 34
  • 71.49 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000995 33
  • 58.04 (n)
fruit fly
(Drosophila melanogaster)
Insecta Bet5 33 34
  • 56.41 (n)
(Caenorhabditis elegans)
Secernentea CELE_DC2.8 33
  • 52.8 (n)
trpp-1 34
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BET5 34 36
  • 29 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G51160 33
  • 53.48 (n)
(Oryza sativa)
Liliopsida Os01g0513700 33
  • 54.62 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06176 33
  • 50.91 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes bet5 33
  • 48.91 (n)
Species where no ortholog for TRAPPC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC1 Gene

Gene Tree for TRAPPC1 (if available)
Gene Tree for TRAPPC1 (if available)

Paralogs for TRAPPC1 Gene

No data available for Paralogs for TRAPPC1 Gene

Variants for TRAPPC1 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
VAR_013028 A melanoma p.Arg129Gly
rs1000040924 -- 7,933,149(-) C/A/T upstream_transcript_variant
rs1000162751 -- 7,932,392(-) C/T upstream_transcript_variant
rs1000433162 -- 7,932,804(-) G/T upstream_transcript_variant
rs1001142904 -- 7,930,848(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC1 Gene

Variant ID Type Subtype PubMed ID
esv2670156 CNV deletion 23128226
nsv457660 CNV loss 19166990
nsv574333 CNV loss 21841781

Variation tolerance for TRAPPC1 Gene

Residual Variation Intolerance Score: 43.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAPPC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC1 Gene

Disorders for TRAPPC1 Gene

Additional Disease Information for TRAPPC1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TRAPPC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAPPC1 Gene

Publications for TRAPPC1 Gene

  1. Two antigens recognized by autologous cytolytic T lymphocytes on a melanoma result from a single point mutation in an essential housekeeping gene. (PMID: 10582700) Chiari R … Coulie PG (Cancer research 1999) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Functional organization of the yeast proteome by systematic analysis of protein complexes. (PMID: 11805826) Gavin AC … Superti-Furga G (Nature 2002) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58

Products for TRAPPC1 Gene

Sources for TRAPPC1 Gene

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