This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] See more...

Aliases for TRAP1 Gene

Aliases for TRAP1 Gene

  • TNF Receptor Associated Protein 1 2 3 5
  • HSP75 2 3 4
  • Tumor Necrosis Factor Type 1 Receptor-Associated Protein 3 4
  • Heat Shock Protein 75 KDa, Mitochondrial 3 4
  • TNFR-Associated Protein 1 3 4
  • HSP 75 3 4
  • HSP90L 2 3
  • TRAP-1 3 4
  • TNF Receptor-Associated Protein 1 2
  • Testicular Tissue Protein Li 209 3
  • TRAP1 5

External Ids for TRAP1 Gene

Previous GeneCards Identifiers for TRAP1 Gene

  • GC15U990048
  • GC16M003648
  • GC16M003709
  • GC16M003677
  • GC16M003710

Summaries for TRAP1 Gene

Entrez Gene Summary for TRAP1 Gene

  • This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for TRAP1 Gene

TRAP1 (TNF Receptor Associated Protein 1) is a Protein Coding gene. Diseases associated with TRAP1 include Vacterl Association and Vacterl Association, X-Linked, With Or Without Hydrocephalus. Among its related pathways are Neuroscience and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include unfolded protein binding. An important paralog of this gene is HSP90B1.

UniProtKB/Swiss-Prot Summary for TRAP1 Gene

  • Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.

Gene Wiki entry for TRAP1 Gene

Additional gene information for TRAP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRAP1 Gene

Genomics for TRAP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRAP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J003716 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 0.0 -47 2.8 SP1 HNRNPL CREB1 TEAD4 PRDM10 ZNF629 TFE3 RFX1 NFKBIZ POLR2A TRAP1 ZNF263 CREBBP ENSG00000261938 lnc-TRAP1-2
GH16J003694 Enhancer 1 ENCODE 39.8 +21.4 21363 3.1 GATAD2A ATF7 ZNF629 REST TFE3 RFX1 SOX13 IKZF1 NFKBIZ RCOR2 TRAP1 CLUAP1 DNASE1 ENSG00000262370 piR-53362-001 RF00017-1939
GH16J003636 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 14.3 +77.5 77453 7.4 PRDM10 TFE3 KDM1A RCOR2 TARDBP JUND ZIC2 ZSCAN4 RXRB IRF2 DNASE1 piR-40322 CLUAP1 ZNF75A TIGD7 ZNF213-AS1 TRAP1 ZSCAN32 ZNF174 FLYWCH2
GH16J003609 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.5 +105.8 105848 4.2 ZNF629 TFE3 NFKBIZ KDM1A POLR2A BACH1 ETV6 FOXA1 LARP7 PRDM1 DNASE1 MN297347 SLX4 lnc-CLUAP1-8 CLUAP1 NLRC3 TRAP1
GH16J003836 Enhancer 1.1 Ensembl ENCODE 18.9 -124.7 -124726 11.4 PRDM10 ZNF512 LEF1 IKZF1 JUND PRDM1 MTA2 PKNOX1 POLR2A BRD9 ENSG00000262516 L13714-164 TRAP1 CREBBP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRAP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRAP1

Top Transcription factor binding sites by QIAGEN in the TRAP1 gene promoter:
  • aMEF-2
  • c-Myb
  • CREB
  • CUTL1
  • deltaCREB
  • MEF-2A
  • MyoD
  • NRSF form 1
  • NRSF form 2

Genomic Locations for TRAP1 Gene

Genomic Locations for TRAP1 Gene
chr16:3,651,639-3,717,553
(GRCh38/hg38)
Size:
65,915 bases
Orientation:
Minus strand
chr16:3,701,640-3,767,598
(GRCh37/hg19)
Size:
65,959 bases
Orientation:
Minus strand

Genomic View for TRAP1 Gene

Genes around TRAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAP1 Gene

Proteins for TRAP1 Gene

  • Protein details for TRAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12931-TRAP1_HUMAN
    Recommended name:
    Heat shock protein 75 kDa, mitochondrial
    Protein Accession:
    Q12931
    Secondary Accessions:
    • B4DR68
    • D3DUC8
    • F5H897
    • O43642
    • O75235
    • Q9UHL5

    Protein attributes for TRAP1 Gene

    Size:
    704 amino acids
    Molecular mass:
    80110 Da
    Quaternary structure:
    • Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1. Interacts with SRC. Interacts with SDHA.
    SequenceCaution:
    • Sequence=AAA87704.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRAP1 Gene

    Alternative splice isoforms for TRAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAP1 Gene

Post-translational modifications for TRAP1 Gene

  • Ubiquitination at Lys109 and Lys699
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRAP1 Gene

Domains & Families for TRAP1 Gene

Gene Families for TRAP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TRAP1 Gene

InterPro:
Blocks:
  • Heat shock protein Hsp90
ProtoNet:

Suggested Antigen Peptide Sequences for TRAP1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ33058 fis, clone TRACH1000181, highly similar to Heat shock protein 75 kDa, mitochondrial (Q5CAQ4_HUMAN)
  • TRAP1 protein (Q9BV61_HUMAN)
  • Tumor necrosis factor type 1 receptor-associated protein (TRAP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q12931

UniProtKB/Swiss-Prot:

TRAP1_HUMAN :
  • Belongs to the heat shock protein 90 family.
Family:
  • Belongs to the heat shock protein 90 family.
genes like me logo Genes that share domains with TRAP1: view

Function for TRAP1 Gene

Molecular function for TRAP1 Gene

UniProtKB/Swiss-Prot Function:
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
GENATLAS Biochemistry:
tumor rejection antigen (gp96),pseudogene 1

Phenotypes From GWAS Catalog for TRAP1 Gene

Gene Ontology (GO) - Molecular Function for TRAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0005164 tumor necrosis factor receptor binding NAS 7876093
GO:0005515 protein binding IPI 17579517
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TRAP1: view
genes like me logo Genes that share phenotypes with TRAP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRAP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAP1 Gene

Localization for TRAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAP1 Gene

Mitochondrion. Mitochondrion inner membrane. Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAP1 gene
Compartment Confidence
mitochondrion 5
nucleus 4
cytosol 3
endoplasmic reticulum 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IBA,IDA 17579517
GO:0005743 mitochondrial inner membrane IBA,IDA 23564345
GO:0005758 mitochondrial intermembrane space ISS 17579517
GO:0005759 mitochondrial matrix IEA,IDA 23564345
genes like me logo Genes that share ontologies with TRAP1: view

Pathways & Interactions for TRAP1 Gene

genes like me logo Genes that share pathways with TRAP1: view

Pathways by source for TRAP1 Gene

5 GeneGo (Thomson Reuters) pathways for TRAP1 Gene
  • Development VEGF signaling via VEGFR2 - generic cascades
  • Development_Glucocorticoid receptor signaling
  • Immune response Antigen presentation by MHC class I
  • Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
  • Signal transduction AKT signaling
1 Cell Signaling Technology pathway for TRAP1 Gene

Gene Ontology (GO) - Biological Process for TRAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA,IBA 21873635
GO:0009386 translational attenuation IMP 24113185
GO:0061077 chaperone-mediated protein folding TAS 24522549
GO:1901856 negative regulation of cellular respiration IMP 23564345
GO:1903427 negative regulation of reactive oxygen species biosynthetic process TAS 18221368
genes like me logo Genes that share ontologies with TRAP1: view

No data available for SIGNOR curated interactions for TRAP1 Gene

Drugs & Compounds for TRAP1 Gene

(2) Drugs for TRAP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TRAP1: view

Transcripts for TRAP1 Gene

mRNA/cDNA for TRAP1 Gene

2 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRAP1

Alternative Splicing Database (ASD) splice patterns (SP) for TRAP1 Gene

No ASD Table

Relevant External Links for TRAP1 Gene

GeneLoc Exon Structure for
TRAP1

Expression for TRAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAP1 Gene

Protein differential expression in normal tissues from HIPED for TRAP1 Gene

This gene is overexpressed in Lymph node (7.6) and Brain (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRAP1 Gene



Protein tissue co-expression partners for TRAP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRAP1

SOURCE GeneReport for Unigene cluster for TRAP1 Gene:

Hs.30345

mRNA Expression by UniProt/SwissProt for TRAP1 Gene:

Q12931-TRAP1_HUMAN
Tissue specificity: Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is highly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors.

Evidence on tissue expression from TISSUES for TRAP1 Gene

  • Nervous system(5)
  • Eye(4.7)
  • Liver(4.6)
  • Skin(4)
  • Lung(3.9)
  • Intestine(3.6)
  • Kidney(3.5)
  • Muscle(3.4)
  • Heart(3.4)
  • Adrenal gland(3.2)
  • Pancreas(3.2)
  • Thyroid gland(3.1)
  • Bone marrow(2.8)
  • Gall bladder(2.8)
  • Stomach(2.8)
  • Blood(2.5)
  • Spleen(2.4)
genes like me logo Genes that share expression patterns with TRAP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAP1 Gene

Orthologs for TRAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRAP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRAP1 30 31
  • 98.86 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 92 (a)
OneToMany
-- 31
  • 85 (a)
OneToMany
-- 31
  • 84 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia TRAP1 30 31
  • 87.81 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TRAP1 30 31
  • 86.57 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Trap1 30
  • 84.8 (n)
Mouse
(Mus musculus)
Mammalia Trap1 30 17 31
  • 84.37 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TRAP1 31
  • 79 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TRAP1 30 31
  • 78.44 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TRAP1 31
  • 73 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia trap1 30
  • 73.5 (n)
Str.16680 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.9148 30
Zebrafish
(Danio rerio)
Actinopterygii LOC101884569 30
  • 74.85 (n)
trap1 31 31
  • 67 (a)
OneToMany
wufc85a11 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.291 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010691 30
  • 59.43 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Trap1 30 31 32
  • 57.6 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea R151.7 30 31
  • 52.37 (n)
OneToOne
R151.7b 32
  • 48 (a)
R151.7a 32
  • 46 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSC82 31
  • 29 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 48 (a)
OneToOne
Species where no ortholog for TRAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TRAP1 Gene

ENSEMBL:
Gene Tree for TRAP1 (if available)
TreeFam:
Gene Tree for TRAP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRAP1: view image

Paralogs for TRAP1 Gene

Paralogs for TRAP1 Gene

(6) SIMAP similar genes for TRAP1 Gene using alignment to 12 proteins:

  • TRAP1_HUMAN
  • F5H897_HUMAN
  • I3L0K7_HUMAN
  • I3L0P6_HUMAN
  • I3L239_HUMAN
  • I3L253_HUMAN
  • I3L2D5_HUMAN
  • I3L3L4_HUMAN
  • I3L4L7_HUMAN
  • K0A7K7_HUMAN
  • Q5CAQ4_HUMAN
  • Q9BV61_HUMAN
genes like me logo Genes that share paralogs with TRAP1: view

Variants for TRAP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRAP1 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
717741 Likely Benign: not provided 3,664,382(-) G/A SYNONYMOUS_VARIANT
719777 Benign: not provided 3,664,371(-) C/T MISSENSE_VARIANT
719778 Benign: not provided 3,677,536(-) T/C SYNONYMOUS_VARIANT
720753 Benign: not provided 3,658,129(-) T/G STOP_LOST
720754 Benign: not provided 3,674,329(-) A/G INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for TRAP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRAP1 Gene

Variant ID Type Subtype PubMed ID
dgv4876n54 CNV loss 21841781
esv2659167 CNV deletion 23128226
esv2666403 CNV deletion 23128226
esv2761892 CNV loss 21179565
esv3570165 CNV gain 25503493
esv3581942 CNV loss 25503493
esv3637673 CNV loss 21293372
esv3637674 CNV loss 21293372
nsv1051657 CNV gain 25217958
nsv1717 CNV insertion 18451855
nsv457359 CNV loss 19166990
nsv516876 CNV loss 19592680
nsv518509 CNV gain 19592680
nsv525301 CNV loss 19592680
nsv833128 CNV loss 17160897

Variation tolerance for TRAP1 Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.80; 86.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAP1 Gene

Human Gene Mutation Database (HGMD)
TRAP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAP1 Gene

Disorders for TRAP1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for TRAP1 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TRAP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TRAP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TRAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAP1 Gene

Publications for TRAP1 Gene

  1. The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. (PMID: 10652318) Felts SJ … Toft DO (The Journal of biological chemistry 2000) 2 3 4 23
  2. Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor. (PMID: 7876093) Song HY … Donner DB (The Journal of biological chemistry 1995) 2 3 4 23
  3. Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis. (PMID: 23564345) Yoshida S … Neckers L (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4
  4. The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase. (PMID: 23747254) Sciacovelli M … Rasola A (Cell metabolism 2013) 3 4
  5. TRAP1 rescues PINK1 loss-of-function phenotypes. (PMID: 23525905) Zhang L … Voigt A (Human molecular genetics 2013) 3 4

Products for TRAP1 Gene

Sources for TRAP1 Gene