Aliases for TRAP1 Gene
External Ids for TRAP1 Gene
Previous GeneCards Identifiers for TRAP1 Gene
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
GeneCards Summary for TRAP1 Gene
TRAP1 (TNF Receptor Associated Protein 1) is a Protein Coding gene. Diseases associated with TRAP1 include Hereditary Multiple Exostoses and Vacterl Association. Among its related pathways are Development_Glucocorticoid receptor signaling and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include unfolded protein binding. An important paralog of this gene is HSP90B1.
UniProtKB/Swiss-Prot Summary for TRAP1 Gene
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.