Aliases for TRANK1 Gene

Aliases for TRANK1 Gene

  • Tetratricopeptide Repeat And Ankyrin Repeat Containing 1 2 3 5
  • KIAA0342 2 2 4
  • LBA1 2 3 4
  • TPR And Ankyrin Repeat-Containing Protein 1 3 4
  • Lupus Brain Antigen 1 Homolog 3 4
  • Lupus Brain Antigen 1 2
  • TRANK1 5

External Ids for TRANK1 Gene

Summaries for TRANK1 Gene

GeneCards Summary for TRANK1 Gene

TRANK1 (Tetratricopeptide Repeat And Ankyrin Repeat Containing 1) is a Protein Coding gene. Diseases associated with TRANK1 include Kohlschutter-Tonz Syndrome and Epileptic Encephalopathy, Early Infantile, 2. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is FAM89A.

Additional gene information for TRANK1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRANK1 Gene

Genomics for TRANK1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRANK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRANK1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRANK1

Genomic Locations for TRANK1 Gene

Genomic Locations for TRANK1 Gene
chr3:36,826,817-36,945,662
(GRCh38/hg38)
Size:
118,846 bases
Orientation:
Minus strand
chr3:36,868,308-36,986,548
(GRCh37/hg19)
Size:
118,241 bases
Orientation:
Minus strand

Genomic View for TRANK1 Gene

Genes around TRANK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRANK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRANK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRANK1 Gene

Proteins for TRANK1 Gene

  • Protein details for TRANK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15050-TRNK1_HUMAN
    Recommended name:
    TPR and ankyrin repeat-containing protein 1
    Protein Accession:
    O15050
    Secondary Accessions:
    • Q8N8K0

    Protein attributes for TRANK1 Gene

    Size:
    2925 amino acids
    Molecular mass:
    336221 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04838.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for TRANK1 Gene

Post-translational modifications for TRANK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRANK1 Gene

Domains & Families for TRANK1 Gene

Gene Families for TRANK1 Gene

Protein Domains for TRANK1 Gene

InterPro:
Blocks:
  • Binding-protein-dependent transport systems inner membrane component
ProtoNet:

Suggested Antigen Peptide Sequences for TRANK1 Gene

GenScript: Design optimal peptide antigens:
  • Lupus brain antigen 1 homolog (TRNK1_HUMAN)
genes like me logo Genes that share domains with TRANK1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TRANK1 Gene

Function for TRANK1 Gene

Phenotypes From GWAS Catalog for TRANK1 Gene

Gene Ontology (GO) - Molecular Function for TRANK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TRANK1: view

Phenotypes for TRANK1 Gene

genes like me logo Genes that share phenotypes with TRANK1: view

Animal Model Products

CRISPR Products

miRNA for TRANK1 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRANK1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRANK1 Gene

Localization for TRANK1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRANK1 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRANK1 Gene

Pathways & Interactions for TRANK1 Gene

PathCards logo

SuperPathways for TRANK1 Gene

No Data Available

Interacting Proteins for TRANK1 Gene

Selected Interacting proteins: O15050-TRNK1_HUMAN for TRANK1 Gene via IID

Gene Ontology (GO) - Biological Process for TRANK1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRANK1 Gene

Drugs & Compounds for TRANK1 Gene

No Compound Related Data Available

Transcripts for TRANK1 Gene

mRNA/cDNA for TRANK1 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRANK1

Alternative Splicing Database (ASD) splice patterns (SP) for TRANK1 Gene

No ASD Table

Relevant External Links for TRANK1 Gene

GeneLoc Exon Structure for
TRANK1

Expression for TRANK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRANK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRANK1 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3).

Protein differential expression in normal tissues from HIPED for TRANK1 Gene

This gene is overexpressed in Heart (46.3) and Plasma (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRANK1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRANK1

SOURCE GeneReport for Unigene cluster for TRANK1 Gene:

Hs.170999

Evidence on tissue expression from TISSUES for TRANK1 Gene

  • Nervous system(2.6)
  • Blood(2)
genes like me logo Genes that share expression patterns with TRANK1: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRANK1 Gene

Orthologs for TRANK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRANK1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRANK1 30 31
  • 99.66 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TRANK1 30 31
  • 87.69 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Trank1 30 17 31
  • 84.12 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Trank1 30
  • 83.91 (n)
Cow
(Bos Taurus)
Mammalia TRANK1 30 31
  • 83.75 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TRANK1 31
  • 81 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TRANK1 31
  • 57 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TRANK1 30 31
  • 63.26 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TRANK1 31
  • 55 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia trank1 30
  • 56.2 (n)
Species where no ortholog for TRANK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TRANK1 Gene

ENSEMBL:
Gene Tree for TRANK1 (if available)
TreeFam:
Gene Tree for TRANK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRANK1: view image

Paralogs for TRANK1 Gene

Paralogs for TRANK1 Gene

genes like me logo Genes that share paralogs with TRANK1: view

Variants for TRANK1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRANK1 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs17201603 -. - p.Pro703Leup.Pro153Leu
rs11712950 - p.Glu1090Gly

Additional dbSNP identifiers (rs#s) for TRANK1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRANK1 Gene

Variant ID Type Subtype PubMed ID
esv1503716 CNV insertion 17803354
esv2725156 CNV deletion 23290073
nsv1112382 CNV deletion 24896259
nsv1152078 CNV deletion 26484159
nsv3762 CNV insertion 18451855
nsv473639 CNV novel sequence insertion 20440878
nsv590067 CNV loss 21841781
nsv834660 CNV loss 17160897
nsv834661 CNV loss 17160897
nsv834662 CNV loss 17160897
nsv998118 CNV loss 25217958

Variation tolerance for TRANK1 Gene

Residual Variation Intolerance Score: 0.572% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.50; 82.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRANK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRANK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRANK1 Gene

Disorders for TRANK1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TRANK1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
kohlschutter-tonz syndrome
  • ktzs
epileptic encephalopathy, early infantile, 2
  • eiee2
bipolar disorder
  • major affective disorder 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRANK1

genes like me logo Genes that share disorders with TRANK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRANK1 Gene

Publications for TRANK1 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3
  4. Genome-wide association study reveals two new risk loci for bipolar disorder. (PMID: 24618891) Mühleisen TW … Cichon S (Nature communications 2014) 3
  5. Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. (PMID: 24280982) Ruderfer DM … Kendler KS (Molecular psychiatry 2014) 3

Products for TRANK1 Gene

Sources for TRANK1 Gene