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TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004]
TRAM2 (Translocation Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with TRAM2 include Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease and Epilepsy, Myoclonic Juvenile. Among its related pathways are NF-kB(NFkB) Pathway. An important paralog of this gene is TRAM1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 14749390 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005791 | rough endoplasmic reticulum | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | NF-kB(NFkB) Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006616 | SRP-dependent cotranslational protein targeting to membrane, translocation | IEA | -- |
GO:0015031 | protein transport | IEA | -- |
GO:0032964 | collagen biosynthetic process | IMP | 14749390 |
GO:0045048 | protein insertion into ER membrane | IDA | 27499293 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TRAM2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TRAM2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TRAM2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tram2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | LOC100361830 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | TRAM2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TRAM2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TRAM2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TRAM2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tram2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tram2 30 31 |
|
OneToOne | |
Dr.4811 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | TRAM 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | tram-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2732081 | CNV | deletion | 23290073 |
esv2732082 | CNV | deletion | 23290073 |
esv3608999 | CNV | loss | 21293372 |
nsv518713 | CNV | loss | 19592680 |
nsv522674 | CNV | loss | 19592680 |
nsv527895 | CNV | loss | 19592680 |
nsv830663 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
polycystic kidney disease 4 with or without polycystic liver disease |
|
|
epilepsy, myoclonic juvenile |
|
|