Aliases for TRAM2 Gene
External Ids for TRAM2 Gene
Previous GeneCards Identifiers for TRAM2 Gene
TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004]
GeneCards Summary for TRAM2 Gene
TRAM2 (Translocation Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with TRAM2 include Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease and Epilepsy, Myoclonic Juvenile. Among its related pathways are NF-kB(NFkB) Pathway. An important paralog of this gene is TRAM1.
UniProtKB/Swiss-Prot Summary for TRAM2 Gene
Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) (PubMed:27499293).