Aliases for TRAM1L1 Gene

Aliases for TRAM1L1 Gene

  • Translocation Associated Membrane Protein 1 Like 1 2 3 5
  • Translocating Chain-Associated Membrane Protein 1-Like 1 3 4
  • MGC26568 2
  • TRAM1L1 5

External Ids for TRAM1L1 Gene

Previous GeneCards Identifiers for TRAM1L1 Gene

  • GC04M118463
  • GC04M118362
  • GC04M118224
  • GC04M118004
  • GC04M113738

Summaries for TRAM1L1 Gene

GeneCards Summary for TRAM1L1 Gene

TRAM1L1 (Translocation Associated Membrane Protein 1 Like 1) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum. An important paralog of this gene is TRAM1.

UniProtKB/Swiss-Prot Summary for TRAM1L1 Gene

  • Stimulatory or required for the translocation of secretory proteins across the ER membrane.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRAM1L1 Gene

Genomics for TRAM1L1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRAM1L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J117084 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 250.7 +0.3 276 1.8 POLR2A ZIC2 ZNF341 YY1 GABPB1 CTCF MAFK NRF1 TAF1 ZNF362 TRAM1L1 HSALNG0036626 LOC105377388
GH04J117137 Enhancer 0.6 ENCODE 0.2 -51.8 -51764 0.2 ATF2 JUND ZBTB21 BHLHE40 SP7 CREB1 ZNF280D ATF3 ZNF629 OSR2 HSALNG0036628-001 TRAM1L1 NDST3
GH04J117134 Enhancer 0.5 ENCODE 0.3 -48.9 -48944 0.2 ZNF654 CTCF RAD21 SMC3 USF1 PRDM1 HSALNG0036628-001 TRAM1L1 NDST3
GH04J117156 Enhancer 0.4 Ensembl 0.2 -71.6 -71625 0.8 MAFF ZNF316 MAFK HSALNG0036628-001 TRAM1L1 NDST3
GH04J117070 Enhancer 0.2 Ensembl 0.4 +15.0 14975 0.4 LOC105377388 TRAM1L1 LOC105377387 HSALNG0036625
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRAM1L1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRAM1L1

Top Transcription factor binding sites by QIAGEN in the TRAM1L1 gene promoter:
  • FAC1
  • HFH-1
  • IRF-7A
  • p53
  • POU3F2
  • S8
  • STAT1
  • STAT1alpha
  • STAT1beta
  • TBP

Genomic Locations for TRAM1L1 Gene

Latest Assembly
chr4:117,083,554-117,085,576
(GRCh38/hg38)
Size:
2,023 bases
Orientation:
Minus strand

Previous Assembly
chr4:118,004,710-118,006,732
(GRCh37/hg19 by Entrez Gene)
Size:
2,023 bases
Orientation:
Minus strand

chr4:118,004,718-118,006,736
(GRCh37/hg19 by Ensembl)
Size:
2,019 bases
Orientation:
Minus strand

Genomic View for TRAM1L1 Gene

Genes around TRAM1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAM1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAM1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAM1L1 Gene

Proteins for TRAM1L1 Gene

  • Protein details for TRAM1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N609-TR1L1_HUMAN
    Recommended name:
    Translocating chain-associated membrane protein 1-like 1
    Protein Accession:
    Q8N609
    Secondary Accessions:
    • Q8N2L7

    Protein attributes for TRAM1L1 Gene

    Size:
    369 amino acids
    Molecular mass:
    42162 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAM1L1 Gene

Post-translational modifications for TRAM1L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAM1L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRAM1L1 Gene

Domains & Families for TRAM1L1 Gene

Gene Families for TRAM1L1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TRAM1L1 Gene

InterPro:
Blocks:
  • Longevity-assurance protein (LAG1)
  • TRAM, LAG1 and CLN8 homology
  • TRAM1-like protein
  • Tetracyclin repressor-like, C-terminal

Suggested Antigen Peptide Sequences for TRAM1L1 Gene

GenScript: Design optimal peptide antigens:
  • Translocating chain-associated membrane protein 1-like 1 (TR1L1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N609

UniProtKB/Swiss-Prot:

TR1L1_HUMAN :
  • Belongs to the TRAM family.
Family:
  • Belongs to the TRAM family.
genes like me logo Genes that share domains with TRAM1L1: view

Function for TRAM1L1 Gene

Molecular function for TRAM1L1 Gene

UniProtKB/Swiss-Prot Function:
Stimulatory or required for the translocation of secretory proteins across the ER membrane.

Phenotypes From GWAS Catalog for TRAM1L1 Gene

Gene Ontology (GO) - Molecular Function for TRAM1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with TRAM1L1: view
genes like me logo Genes that share phenotypes with TRAM1L1: view

miRNA for TRAM1L1 Gene

miRTarBase miRNAs that target TRAM1L1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRAM1L1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAM1L1 Gene

Localization for TRAM1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAM1L1 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAM1L1 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3
mitochondrion 2
nucleus 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRAM1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane IBA 21873635
genes like me logo Genes that share ontologies with TRAM1L1: view

Pathways & Interactions for TRAM1L1 Gene

PathCards logo

SuperPathways for TRAM1L1 Gene

genes like me logo Genes that share pathways with TRAM1L1: view

Pathways by source for TRAM1L1 Gene

1 KEGG pathway for TRAM1L1 Gene

Interacting Proteins for TRAM1L1 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q8N609-TR1L1_HUMAN ENSP00000309402 for TRAM1L1 Gene via UniProtKB STRING IID

Gene Ontology (GO) - Biological Process for TRAM1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation IEA --
GO:0015031 protein transport IEA --
GO:0045048 protein insertion into ER membrane IBA 21873635
genes like me logo Genes that share ontologies with TRAM1L1: view

No data available for SIGNOR curated interactions for TRAM1L1 Gene

Drugs & Compounds for TRAM1L1 Gene

No Compound Related Data Available

Transcripts for TRAM1L1 Gene

mRNA/cDNA for TRAM1L1 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRAM1L1

Alternative Splicing Database (ASD) splice patterns (SP) for TRAM1L1 Gene

No ASD Table

Relevant External Links for TRAM1L1 Gene

GeneLoc Exon Structure for
TRAM1L1

Expression for TRAM1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAM1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRAM1L1 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRAM1L1 Gene



Protein tissue co-expression partners for TRAM1L1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRAM1L1

SOURCE GeneReport for Unigene cluster for TRAM1L1 Gene:

Hs.570737

Evidence on tissue expression from TISSUES for TRAM1L1 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with TRAM1L1: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAM1L1 Gene

Orthologs for TRAM1L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAM1L1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRAM1L1 29
  • 99.55 (n)
Cow
(Bos Taurus)
Mammalia TRAM1L1 29 30
  • 81.02 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tram1l1 29
  • 77.44 (n)
Dog
(Canis familiaris)
Mammalia TRAM1L1 29 30
  • 77.2 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tram1l1 29 16 30
  • 76.43 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 68 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 38 (a)
OneToMany
Chicken
(Gallus gallus)
Aves TRAM1 30
  • 63 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 64 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii tram1 30
  • 57 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta TRAM 30
  • 36 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea tram-1 30
  • 29 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 32 (a)
OneToMany
Species where no ortholog for TRAM1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for TRAM1L1 Gene

ENSEMBL:
Gene Tree for TRAM1L1 (if available)
TreeFam:
Gene Tree for TRAM1L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRAM1L1: view image
Alliance of Genome Resources:
Additional Orthologs for TRAM1L1

Paralogs for TRAM1L1 Gene

Paralogs for TRAM1L1 Gene

(2) SIMAP similar genes for TRAM1L1 Gene using alignment to 1 proteins:

  • TR1L1_HUMAN
genes like me logo Genes that share paralogs with TRAM1L1: view

Variants for TRAM1L1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRAM1L1 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs35809332 Benign: not provided 117,084,302(-) C/T
NM_152402.3(TRAM1L1):c.1092G>A (p.Arg364=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TRAM1L1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TRAM1L1 Gene

Variant ID Type Subtype PubMed ID
esv3569670 CNV loss 25503493
nsv1008744 CNV loss 25217958

Variation tolerance for TRAM1L1 Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAM1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAM1L1
Leiden Open Variation Database (LOVD)
TRAM1L1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAM1L1 Gene

Disorders for TRAM1L1 Gene

Additional Disease Information for TRAM1L1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for TRAM1L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAM1L1 Gene

Publications for TRAM1L1 Gene

  1. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G … Riley BP (Human molecular genetics 2010) 3 40
  2. Common body mass index-associated variants confer risk of extreme obesity. (PMID: 19553259) Cotsapas C … GIANT Consortium (Human molecular genetics 2009) 3 40
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for TRAM1L1 Gene

Sources for TRAM1L1 Gene