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Aliases for TRAM1L1 Gene

Aliases for TRAM1L1 Gene

  • Translocation Associated Membrane Protein 1 Like 1 2 3
  • Translocation Associated Membrane Protein 1-Like 1 5

External Ids for TRAM1L1 Gene

Previous GeneCards Identifiers for TRAM1L1 Gene

  • GC04M118463
  • GC04M118362
  • GC04M118224
  • GC04M118004
  • GC04M113738

Summaries for TRAM1L1 Gene

GeneCards Summary for TRAM1L1 Gene

TRAM1L1 (Translocation Associated Membrane Protein 1 Like 1) is a Protein Coding gene. Among its related pathways are NF-kB (NFkB) Pathway. An important paralog of this gene is TRAM1.

UniProtKB/Swiss-Prot for TRAM1L1 Gene

  • Stimulatory or required for the translocation of secretory proteins across the ER membrane.

Additional gene information for TRAM1L1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAM1L1 Gene

Genomics for TRAM1L1 Gene

GeneHancer (GH) Regulatory Elements for TRAM1L1 Gene

Promoters and enhancers for TRAM1L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I117084 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 +0.1 123 1.3 CTCF MXI1 PKNOX1 ZNF362 L3MBTL2 NRF1 ZIC2 POLR2A ZNF341 PRDM10 TRAM1L1 LOC105377388
GH04I117134 Enhancer 0.7 Ensembl ENCODE 0.2 -49.0 -49013 0.5 CTCF ZNF654 USF1 RAD21 PRDM1 TRAM1L1 ENSG00000223605
GH04I117137 Enhancer 0.6 ENCODE 0.2 -51.8 -51760 0.2 ZNF280D ZBTB21 JUN ATF2 OSR2 JUND ZNF629 CREB1 FOS SP7 TRAM1L1 ENSG00000223605
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRAM1L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRAM1L1 gene promoter:

Genomic Locations for TRAM1L1 Gene

Genomic Locations for TRAM1L1 Gene
chr4:117,083,554-117,085,580
(GRCh38/hg38)
Size:
2,027 bases
Orientation:
Minus strand
chr4:118,004,710-118,006,736
(GRCh37/hg19)

Genomic View for TRAM1L1 Gene

Genes around TRAM1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAM1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAM1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAM1L1 Gene

Proteins for TRAM1L1 Gene

  • Protein details for TRAM1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N609-TR1L1_HUMAN
    Recommended name:
    Translocating chain-associated membrane protein 1-like 1
    Protein Accession:
    Q8N609
    Secondary Accessions:
    • Q8N2L7

    Protein attributes for TRAM1L1 Gene

    Size:
    369 amino acids
    Molecular mass:
    42162 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAM1L1 Gene

Post-translational modifications for TRAM1L1 Gene

No Post-translational modifications

Other Protein References for TRAM1L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRAM1L1 Gene

Domains & Families for TRAM1L1 Gene

Gene Families for TRAM1L1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TRAM1L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N609

UniProtKB/Swiss-Prot:

TR1L1_HUMAN :
  • Belongs to the TRAM family.
Family:
  • Belongs to the TRAM family.
genes like me logo Genes that share domains with TRAM1L1: view

Function for TRAM1L1 Gene

Molecular function for TRAM1L1 Gene

UniProtKB/Swiss-Prot Function:
Stimulatory or required for the translocation of secretory proteins across the ER membrane.

Phenotypes From GWAS Catalog for TRAM1L1 Gene

genes like me logo Genes that share phenotypes with TRAM1L1: view

Animal Model Products

miRNA for TRAM1L1 Gene

miRTarBase miRNAs that target TRAM1L1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAM1L1 Gene

Localization for TRAM1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAM1L1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAM1L1 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3
mitochondrion 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRAM1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TRAM1L1: view

Pathways & Interactions for TRAM1L1 Gene

SuperPathways for TRAM1L1 Gene

SuperPathway Contained pathways
1 NF-kB (NFkB) Pathway
genes like me logo Genes that share pathways with TRAM1L1: view

Pathways by source for TRAM1L1 Gene

1 Sino Biological pathway for TRAM1L1 Gene

Interacting Proteins for TRAM1L1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309402%0d%0a9606.ENSP00000223641%0d%0a9606.ENSP00000273963%0d%0a9606.ENSP00000365370%0d%0a
Selected Interacting proteins: Q8N609-TR1L1_HUMAN ENSP00000309402 for TRAM1L1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for TRAM1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with TRAM1L1: view

No data available for SIGNOR curated interactions for TRAM1L1 Gene

Drugs & Compounds for TRAM1L1 Gene

No Compound Related Data Available

Transcripts for TRAM1L1 Gene

mRNA/cDNA for TRAM1L1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRAM1L1 Gene

Translocation associated membrane protein 1-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAM1L1 Gene

No ASD Table

Relevant External Links for TRAM1L1 Gene

GeneLoc Exon Structure for
TRAM1L1
ECgene alternative splicing isoforms for
TRAM1L1

Expression for TRAM1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAM1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRAM1L1 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRAM1L1 Gene



Protein tissue co-expression partners for TRAM1L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRAM1L1 Gene:

TRAM1L1

SOURCE GeneReport for Unigene cluster for TRAM1L1 Gene:

Hs.570737

Evidence on tissue expression from TISSUES for TRAM1L1 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with TRAM1L1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAM1L1 Gene

Orthologs for TRAM1L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAM1L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAM1L1 33
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia TRAM1L1 33 34
  • 81.02 (n)
rat
(Rattus norvegicus)
Mammalia Tram1l1 33
  • 77.44 (n)
dog
(Canis familiaris)
Mammalia TRAM1L1 33 34
  • 77.2 (n)
mouse
(Mus musculus)
Mammalia Tram1l1 33 16 34
  • 76.43 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 38 (a)
OneToMany
chicken
(Gallus gallus)
Aves TRAM1 34
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 64 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tram1 34
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta TRAM 34
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tram-1 34
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
OneToMany
Species where no ortholog for TRAM1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRAM1L1 Gene

ENSEMBL:
Gene Tree for TRAM1L1 (if available)
TreeFam:
Gene Tree for TRAM1L1 (if available)

Paralogs for TRAM1L1 Gene

Paralogs for TRAM1L1 Gene

(2) SIMAP similar genes for TRAM1L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRAM1L1: view

Variants for TRAM1L1 Gene

Sequence variations from dbSNP and Humsavar for TRAM1L1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000472812 -- 117,085,781(-) C/T upstream_transcript_variant
rs1000988899 -- 117,083,991(-) C/A 3_prime_UTR_variant
rs1001298765 -- 117,086,696(-) T/C upstream_transcript_variant
rs1001718299 -- 117,083,310(-) A/G downstream_transcript_variant
rs1002252107 -- 117,085,614(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TRAM1L1 Gene

Variant ID Type Subtype PubMed ID
nsv1008744 CNV loss 25217958
esv3569670 CNV loss 25503493

Variation tolerance for TRAM1L1 Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAM1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAM1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAM1L1 Gene

Disorders for TRAM1L1 Gene

Additional Disease Information for TRAM1L1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TRAM1L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAM1L1 Gene

Publications for TRAM1L1 Gene

  1. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G … Riley BP (Human molecular genetics 2010) 3 44 58
  2. Common body mass index-associated variants confer risk of extreme obesity. (PMID: 19553259) Cotsapas C … GIANT Consortium (Human molecular genetics 2009) 3 44 58
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. A genome-wide association study (GWAS) for bronchopulmonary dysplasia. (PMID: 23897914) Wang H … O'Brodovich HM (Pediatrics 2013) 3 58

Products for TRAM1L1 Gene

Sources for TRAM1L1 Gene

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