This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. [provided by Ref... See more...

Aliases for TRAM1 Gene

Aliases for TRAM1 Gene

  • Translocation Associated Membrane Protein 1 2 3 5
  • TRAM 2 3 4
  • Translocating Chain-Associated Membrane Protein 1 3 4
  • TRAMP 2 3
  • Translocating Chain-Associating Membrane Protein 3
  • Translocation-Associating Membrane Protein 1 3
  • PNAS8 3
  • TRAM1 5

External Ids for TRAM1 Gene

Previous GeneCards Identifiers for TRAM1 Gene

  • GC08M071426
  • GC08M071208
  • GC08M071535
  • GC08M071648
  • GC08M066978

Summaries for TRAM1 Gene

Entrez Gene Summary for TRAM1 Gene

  • This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. [provided by RefSeq, Oct 2009]

GeneCards Summary for TRAM1 Gene

TRAM1 (Translocation Associated Membrane Protein 1) is a Protein Coding gene. Diseases associated with TRAM1 include Ceroid Lipofuscinosis, Neuronal, 8, Northern Epilepsy Variant and Orofaciodigital Syndrome Vi. Among its related pathways are Viral mRNA Translation and Diseases associated with the TLR signaling cascade. An important paralog of this gene is TRAM1L1.

UniProtKB/Swiss-Prot Summary for TRAM1 Gene

  • Stimulatory or required for the translocation of secretory proteins across the ER membrane.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRAM1 Gene

Genomics for TRAM1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRAM1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRAM1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRAM1

Top Transcription factor binding sites by QIAGEN in the TRAM1 gene promoter:
  • AREB6
  • FOXO4
  • HOXA3
  • HOXA9
  • HOXA9B
  • Lmo2
  • Meis-1
  • Meis-1b
  • Pax-4a
  • S8

Genomic Locations for TRAM1 Gene

Latest Assembly
chr8:70,573,218-70,608,453
(GRCh38/hg38)
Size:
35,236 bases
Orientation:
Minus strand

Previous Assembly
chr8:71,485,453-71,520,651
(GRCh37/hg19 by Entrez Gene)
Size:
35,199 bases
Orientation:
Minus strand

chr8:71,485,677-71,520,622
(GRCh37/hg19 by Ensembl)
Size:
34,946 bases
Orientation:
Minus strand

Genomic View for TRAM1 Gene

Genes around TRAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAM1 Gene

Proteins for TRAM1 Gene

  • Protein details for TRAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15629-TRAM1_HUMAN
    Recommended name:
    Translocating chain-associated membrane protein 1
    Protein Accession:
    Q15629
    Secondary Accessions:
    • B4E0K2

    Protein attributes for TRAM1 Gene

    Size:
    374 amino acids
    Molecular mass:
    43072 Da
    Quaternary structure:
    • (Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein US2.

    Alternative splice isoforms for TRAM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAM1 Gene

Post-translational modifications for TRAM1 Gene

  • Glycosylation at Asn56 and Asn355
  • Ubiquitination at Lys283
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • TRAM1_HUMAN (1838)

Other Protein References for TRAM1 Gene

Antibodies for research

  • Abcam antibodies for TRAM1
  • Boster Bio Antibodies for TRAM1

No data available for DME Specific Peptides for TRAM1 Gene

Domains & Families for TRAM1 Gene

Gene Families for TRAM1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for TRAM1 Gene

InterPro:
Blocks:
  • Longevity-assurance protein (LAG1)
  • TRAM, LAG1 and CLN8 homology
  • TRAM1-like protein

Suggested Antigen Peptide Sequences for TRAM1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53588, highly similar to Translocation-associated membrane protein 1 (B4E0K2_HUMAN)
  • cDNA FLJ78414, highly similar to Homo sapiens translocation associated membrane protein 1 (TRAM1), mRNA (Q6FHL3_HUMAN)
  • TRAM1 protein (Q6FHU7_HUMAN)
  • Translocating chain-associated membrane protein 1 (TRAM1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15629

UniProtKB/Swiss-Prot:

TRAM1_HUMAN :
  • Belongs to the TRAM family.
Family:
  • Belongs to the TRAM family.
genes like me logo Genes that share domains with TRAM1: view

Function for TRAM1 Gene

Molecular function for TRAM1 Gene

UniProtKB/Swiss-Prot Function:
Stimulatory or required for the translocation of secretory proteins across the ER membrane.

Phenotypes From GWAS Catalog for TRAM1 Gene

Gene Ontology (GO) - Molecular Function for TRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18555783
GO:0038023 signaling receptor activity TAS 1315422
genes like me logo Genes that share ontologies with TRAM1: view
genes like me logo Genes that share phenotypes with TRAM1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRAM1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAM1 Gene

Localization for TRAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAM1 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAM1 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endosome 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS,IDA 18555783
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS 1315422
GO:0030176 integral component of endoplasmic reticulum membrane IEA,ISS --
genes like me logo Genes that share ontologies with TRAM1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRAM1 Gene

Pathways & Interactions for TRAM1 Gene

genes like me logo Genes that share pathways with TRAM1: view

Pathways by source for TRAM1 Gene

Gene Ontology (GO) - Biological Process for TRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006613 cotranslational protein targeting to membrane TAS 1315422
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation IEA --
GO:0015031 protein transport IEA --
GO:0016032 viral process IEA --
GO:0045048 protein insertion into ER membrane IBA 21873635
genes like me logo Genes that share ontologies with TRAM1: view

No data available for SIGNOR curated interactions for TRAM1 Gene

Drugs & Compounds for TRAM1 Gene

No Compound Related Data Available

Transcripts for TRAM1 Gene

mRNA/cDNA for TRAM1 Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRAM1

Alternative Splicing Database (ASD) splice patterns (SP) for TRAM1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2:
SP3: -
SP4: - -

Relevant External Links for TRAM1 Gene

GeneLoc Exon Structure for
TRAM1

Expression for TRAM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRAM1 Gene

This gene is overexpressed in Nasal epithelium (50.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRAM1 Gene



Protein tissue co-expression partners for TRAM1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRAM1

SOURCE GeneReport for Unigene cluster for TRAM1 Gene:

Hs.491988

Evidence on tissue expression from TISSUES for TRAM1 Gene

  • Nervous system(4.7)
  • Kidney(4.6)
  • Lung(2.7)
  • Liver(2.5)
  • Pancreas(2.3)
  • Thyroid gland(2.1)
  • Stomach(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with TRAM1: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAM1 Gene

Orthologs for TRAM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAM1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRAM1 29 30
  • 99.47 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TRAM1 29 30
  • 94.03 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TRAM1 29 30
  • 93.58 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 89 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Tram1 29
  • 87.52 (n)
Mouse
(Mus musculus)
Mammalia Tram1 29 16 30
  • 87.34 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 49 (a)
OneToMany
Chicken
(Gallus gallus)
Aves TRAM1 29 30
  • 80.57 (n)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 85 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tram1 29
  • 75.25 (n)
Str.6518 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.20545 29
Zebrafish
(Danio rerio)
Actinopterygii tram1 29 30
  • 69.56 (n)
OneToMany
tram 29
Fruit Fly
(Drosophila melanogaster)
Insecta TRAM 30
  • 38 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea tram-1 29 30
  • 50.34 (n)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 38 (a)
OneToMany
Species where no ortholog for TRAM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TRAM1 Gene

ENSEMBL:
Gene Tree for TRAM1 (if available)
TreeFam:
Gene Tree for TRAM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRAM1: view image
Alliance of Genome Resources:
Additional Orthologs for TRAM1

Paralogs for TRAM1 Gene

Paralogs for TRAM1 Gene

(2) SIMAP similar genes for TRAM1 Gene using alignment to 6 proteins:

  • TRAM1_HUMAN
  • B4E0K2_HUMAN
  • E5RFP8_HUMAN
  • G3XAN4_HUMAN
  • Q6FHL3_HUMAN
  • Q6FHU7_HUMAN
genes like me logo Genes that share paralogs with TRAM1: view

Variants for TRAM1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRAM1 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs34159261 Benign: not provided 70,596,318(-) T/C
NM_014294.6(TRAM1):c.430A>G (p.Asn144Asp)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TRAM1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TRAM1 Gene

Variant ID Type Subtype PubMed ID
nsv1068714 OTHER inversion 25765185

Variation tolerance for TRAM1 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAM1
Leiden Open Variation Database (LOVD)
TRAM1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAM1 Gene

Disorders for TRAM1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRAM1 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search TRAM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TRAM1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TRAM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAM1 Gene

Publications for TRAM1 Gene

  1. TRAM1 participates in human cytomegalovirus US2- and US11-mediated dislocation of an endoplasmic reticulum membrane glycoprotein. (PMID: 19121997) Oresic K … Tortorella D (The Journal of biological chemistry 2009) 3 4 22
  2. A protein of the endoplasmic reticulum involved early in polypeptide translocation. (PMID: 1315422) Görlich D … Rapoport TA (Nature 1992) 2 3 4
  3. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 40
  4. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 40
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 40

Products for TRAM1 Gene

Sources for TRAM1 Gene