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T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]
TRAJ18 (T Cell Receptor Alpha Joining 18) is a Protein Coding gene. Among its related pathways are Immune response Function of MEF2 in T lymphocytes and Th17 cell differentiation.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH14J022472 | Promoter/Enhancer | 2.4 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.7 | -3.6 | -3589 | 99 | SP1 BCL11A MXD4 CEBPA NR2C1 MNT DEK IKZF1 BRCA1 HES1 | LOC112267867 TRAJ21 TRAJ22 TRAJ23 LINC02332 ACIN1 RBM23 C14orf93 NGDN ABHD4 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Immune response NFAT in immune response |
Immune response ICOS pathway in T-helper cell
.56
Immune response NFAT in immune response
.56
|
Immune response T cell receptor signaling pathway
.52
Immune response CD28 signaling
.52
|
2 | G-protein signaling N-RAS regulation pathway |
G-protein signaling N-RAS regulation pathway
.52
|
Immune response Antigen presentation by MHC class II
.52
|
3 | G-protein signaling_Rap1A regulation pathway |
G-protein signaling_Rap1A regulation pathway
-
|
|
4 | G-protein signaling_Regulation of RAC1 activity |
G-protein signaling_Regulation of RAC1 activity
-
|
|
5 | Antigen processing-Cross presentation |
Immune response Antigen presentation by MHC class I
.51
|
No disorders were found for TRAJ18 Gene.