T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed... See more...

Aliases for TRAJ18 Gene

Aliases for TRAJ18 Gene

  • T Cell Receptor Alpha Joining 18 2 3 5 13
  • TRAJ18 5

External Ids for TRAJ18 Gene

Previous GeneCards Identifiers for TRAJ18 Gene

  • GC14U990373
  • GC14P020985
  • GC14P021005
  • GC14P022065
  • GC14P023051
  • GC14P023115
  • GC14P023177
  • GC14P023227
  • GC14P023288
  • GC14P023367
  • GC14P023438
  • GC14P023522
  • GC14P023614
  • GC14P023752
  • GC14P022542
  • GC14P022646
  • GC14P024455
  • GC14P024566
  • GC14P024696
  • GC14P024977
  • GC14P022718
  • GC14P022800
  • GC14P022900
  • GC14P023864
  • GC14P023999
  • GC14P024109
  • GC14P024225
  • GC14P024340
  • GC14P025250

Summaries for TRAJ18 Gene

Entrez Gene Summary for TRAJ18 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAJ18 Gene

TRAJ18 (T Cell Receptor Alpha Joining 18) is a Protein Coding gene. Among its related pathways are Immune response Function of MEF2 in T lymphocytes and Th17 cell differentiation.

Additional gene information for TRAJ18 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRAJ18 Gene

Genomics for TRAJ18 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRAJ18 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J022472 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -3.6 -3589 99 SP1 BCL11A MXD4 CEBPA NR2C1 MNT DEK IKZF1 BRCA1 HES1 LOC112267867 TRAJ21 TRAJ22 TRAJ23 LINC02332 ACIN1 RBM23 C14orf93 NGDN ABHD4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRAJ18 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for TRAJ18 Gene

Latest Assembly
chr14:22,525,650-22,525,715
(GRCh38/hg38)
Size:
66 bases
Orientation:
Plus strand

Previous Assembly
chr14:22,994,620-22,994,685
(GRCh37/hg19 by Entrez Gene)
Size:
66 bases
Orientation:
Plus strand

chr14:22,994,620-22,994,685
(GRCh37/hg19 by Ensembl)
Size:
66 bases
Orientation:
Plus strand

Genomic View for TRAJ18 Gene

Genes around TRAJ18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAJ18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAJ18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAJ18 Gene

Proteins for TRAJ18 Gene

  • Protein details for TRAJ18 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A075B6X9-A0A075B6X9_HUMAN
    Recommended name:
    T cell receptor alpha joining 18
    Protein Accession:
    A0A075B6X9

    Protein attributes for TRAJ18 Gene

    Size:
    22 amino acids
    Molecular mass:
    2492 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAJ18 Gene

Post-translational modifications for TRAJ18 Gene

No Post-translational modifications

Other Protein References for TRAJ18 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAJ18 Gene

Domains & Families for TRAJ18 Gene

Gene Families for TRAJ18 Gene

Protein Domains for TRAJ18 Gene

ProtoNet:
genes like me logo Genes that share domains with TRAJ18: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TRAJ18 Gene

Function for TRAJ18 Gene

Phenotypes From GWAS Catalog for TRAJ18 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAJ18 Gene

Localization for TRAJ18 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TRAJ18 Gene

Pathways & Interactions for TRAJ18 Gene

PathCards logo

SuperPathways for TRAJ18 Gene

SuperPathway Contained pathways
1 Immune response NFAT in immune response
.56
.56
.52
.52
2 G-protein signaling N-RAS regulation pathway
.52
.52
3 G-protein signaling_Rap1A regulation pathway
-
4 G-protein signaling_Regulation of RAC1 activity
-
5 Antigen processing-Cross presentation
.51
genes like me logo Genes that share pathways with TRAJ18: view

Pathways by source for TRAJ18 Gene

15 GeneGo (Thomson Reuters) pathways for TRAJ18 Gene
  • G-protein signaling N-RAS regulation pathway
  • G-protein signaling_Rap1A regulation pathway
  • G-protein signaling_Regulation of RAC1 activity
  • Immune response Antigen presentation by MHC class I
  • Immune response Antigen presentation by MHC class II

Interacting Proteins for TRAJ18 Gene

Gene Ontology (GO) - Biological Process for TRAJ18 Gene

None

No data available for SIGNOR curated interactions for TRAJ18 Gene

Drugs & Compounds for TRAJ18 Gene

No Compound Related Data Available

Transcripts for TRAJ18 Gene

mRNA/cDNA for TRAJ18 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRAJ18 Gene

No ASD Table

Relevant External Links for TRAJ18 Gene

GeneLoc Exon Structure for
TRAJ18

Expression for TRAJ18 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAJ18 Gene

Orthologs for TRAJ18 Gene

Evolution for TRAJ18 Gene

ENSEMBL:
Gene Tree for TRAJ18 (if available)
TreeFam:
Gene Tree for TRAJ18 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRAJ18: view image

No data available for Orthologs for TRAJ18 Gene

Paralogs for TRAJ18 Gene

No data available for Paralogs for TRAJ18 Gene

Variants for TRAJ18 Gene

Additional Variant Information for TRAJ18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAJ18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAJ18 Gene

Disorders for TRAJ18 Gene

No disorders were found for TRAJ18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRAJ18 Gene

Publications for TRAJ18 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop BF … Hood L (Genomics 1994) 2 3
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 13

Products for TRAJ18 Gene

Sources for TRAJ18 Gene