Aliases for TRAFD1 Gene
External Ids for TRAFD1 Gene
Previous GeneCards Identifiers for TRAFD1 Gene
The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009]
GeneCards Summary for TRAFD1 Gene
TRAFD1 (TRAF-Type Zinc Finger Domain Containing 1) is a Protein Coding gene. Diseases associated with TRAFD1 include Choroid Plexus Meningioma and Diabetes Mellitus, Insulin-Dependent, 19. Among its related pathways are Toll-like Receptor Signaling Pathway. An important paralog of this gene is XAF1.
UniProtKB/Swiss-Prot Summary for TRAFD1 Gene
Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity).