Aliases for TRAF7 Gene
External Ids for TRAF7 Gene
Previous HGNC Symbols for TRAF7 Gene
Previous GeneCards Identifiers for TRAF7 Gene
Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]
GeneCards Summary for TRAF7 Gene
TRAF7 (TNF Receptor Associated Factor 7) is a Protein Coding gene. Diseases associated with TRAF7 include Cardiac, Facial, And Digital Anomalies With Developmental Delay and Aortic Coarctation. Among its related pathways are Class I MHC mediated antigen processing and presentation and SMAD Signaling Network. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is FBXW7.
UniProtKB/Swiss-Prot Summary for TRAF7 Gene
E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MAP3K3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators (PubMed:14743216). Induces apoptosis when overexpressed (PubMed:15001576). Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3.