The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE... See more...

Aliases for TRAF6 Gene

Aliases for TRAF6 Gene

  • TNF Receptor Associated Factor 6 2 3 5
  • RNF85 2 3 4
  • TNF Receptor-Associated Factor 6, E3 Ubiquitin Protein Ligase 2 3
  • RING-Type E3 Ubiquitin Transferase TRAF6 3 4
  • E3 Ubiquitin-Protein Ligase TRAF6 3 4
  • TNF Receptor-Associated Factor 6 3 4
  • Interleukin-1 Signal Transducer 3 4
  • RING Finger Protein 85 3 4
  • EC 2.3.2.27 4
  • MGC:3310 3
  • TRAF6 5

External Ids for TRAF6 Gene

Previous GeneCards Identifiers for TRAF6 Gene

  • GC11M038067
  • GC11M037188
  • GC11M036549
  • GC11M036475
  • GC11M036212

Summaries for TRAF6 Gene

Entrez Gene Summary for TRAF6 Gene

  • The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012]

GeneCards Summary for TRAF6 Gene

TRAF6 (TNF Receptor Associated Factor 6) is a Protein Coding gene. Diseases associated with TRAF6 include Ectodermal Dysplasia 10A, Hypohidrotic/Hair/Nail Type, Autosomal Dominant and Streptococcus Pneumonia. Among its related pathways are Toll-Like receptor Signaling Pathways and IL-17 Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include identical protein binding and ligase activity. An important paralog of this gene is TRAF5.

UniProtKB/Swiss-Prot Summary for TRAF6 Gene

  • E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

Gene Wiki entry for TRAF6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRAF6 Gene

Genomics for TRAF6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRAF6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J036507 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 280.7 -0.2 -151 5.2 BCLAF1 SP1 ZNF207 MYC ZNF600 IKZF1 SSRP1 ZNF580 ZMYM3 KLF9 TRAF6 ENSG00000280331 RAG1 lnc-RAG1-1 PRR5L COMMD9 IFTAP
GH11J035661 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 22.6 +846.6 846612 4.2 NCOR1 ZNF207 IKZF1 MYC ZNF600 ZNF580 ZNF592 KLF9 CEBPA BRCA1 TRIM44 MK280045 TRAF6 ENSG00000251194 CD44-AS1 LDLRAD3
GH11J036103 Enhancer 1.3 Ensembl ENCODE dbSUPER 27.4 +404.9 404886 3 NCOR1 IKZF1 ZNF592 POLR2A NFIC REST SMAD5 HES1 MBD2 TBP TRAF6 LOC101928510 piR-33287 LDLRAD3 COMMD9
GH11J036593 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 13.7 -84.6 -84611 2.2 BCLAF1 MYC ZNF600 IKZF1 SIX5 JUND ZNF580 ZNF592 CEBPA ATF3 IFTAP TRAF6 PRR5L RAG2 lnc-RAG2-1 HSALNG0083672
GH11J035617 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.9 +889.3 889269 7.3 ZNF600 JUND ZNF580 ZIC2 ZBTB10 SMAD5 FEZF1 ZNF341 MAX SIN3A TRAF6 TRIM44 FJX1 PAMR1 HSALNG0083631 HSALNG0083634-001 HSALNG0083634-002
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRAF6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRAF6

Top Transcription factor binding sites by QIAGEN in the TRAF6 gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • NF-kappaB
  • NF-kappaB1
  • STAT3
  • USF-1
  • USF1

Genomic Locations for TRAF6 Gene

Latest Assembly
chr11:36,483,769-36,510,313
(GRCh38/hg38)
Size:
26,545 bases
Orientation:
Minus strand

Previous Assembly
chr11:36,505,319-36,531,822
(GRCh37/hg19 by Entrez Gene)
Size:
26,504 bases
Orientation:
Minus strand

chr11:36,508,577-36,531,822
(GRCh37/hg19 by Ensembl)
Size:
23,246 bases
Orientation:
Minus strand

Genomic View for TRAF6 Gene

Genes around TRAF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF6 Gene

Proteins for TRAF6 Gene

  • Protein details for TRAF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4K3-TRAF6_HUMAN
    Recommended name:
    TNF receptor-associated factor 6
    Protein Accession:
    Q9Y4K3
    Secondary Accessions:
    • A6NKI7
    • A8KAB3
    • D3DR16
    • Q8NEH5

    Protein attributes for TRAF6 Gene

    Size:
    522 amino acids
    Molecular mass:
    59573 Da
    Quaternary structure:
    • Homotrimer. Homooligomer. N-terminal region is dimeric while C-terminal region is trimeric; maybe providing a mode of oligomerization. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and MYD88; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. Binds to TNFRSF5/CD40 and TNFRSF11A/RANK. Associates with NGFR, TNFRSF17, IRAK2, IRAK3, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, TRAF, TRAF-interacting protein TRIP and TNF receptor associated protein TDP2. Interacts with IL17R. Interacts with SQSTM1 bridging NTRK1 and NGFR. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity). Interacts with PELI2 and PELI3. Binds UBE2V1. Interacts with TAX1BP1. Interacts with ZNF675. Interacts with ARRB1 and ARRB2. Interacts with MAP3K7 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with UBE2N. Interacts with TGFBR1, HDAC1 and RANGAP1. Interacts with AKT1, AKT2 and AKT3. Interacts (via TRAF domains) with NUMBL (via C-terminal). Interacts with RBCK1. Interacts with LIMD1 (via LIM domains) (By similarity). Interacts with RSAD2/viperin (By similarity). Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain) (By similarity). Interacts with ZFAND5. Interacts with IL1RL1. Interacts with TRAFD1. Interacts with AJUBA. Interacts with MAVS/IPS1. Interacts (via TRAF domains) with DYNC2I2 (via WD domains). Interacts with IFIT3 (via N-terminus). Interacts with TICAM2. Interacts with CARD14. Interacts with CD40 and MAP3K8; the interaction is required for ERK activation (By similarity). Interacts with TICAM1 and this interaction is enhanced in the presence of WDFY1 (PubMed:25736436). Interacts with TANK; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with USP10; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with ZC3H12A; this interaction increases in response to DNA damage and is stimulated by TANK (PubMed:25861989). Interacts with WDFY3 (By similarity). Interacts with TRIM13 (PubMed:28087809). Interacts with GPS2 (By similarity). Interacts (via C-terminus) with SASH1 (PubMed:23776175). Interacts with LRRC19 (PubMed:25026888). Interacts with IL17RA AND TRAF3IP2. Interacts with TOMM70 (PubMed:20628368).

    Three dimensional structures from OCA and Proteopedia for TRAF6 Gene

neXtProt entry for TRAF6 Gene

Post-translational modifications for TRAF6 Gene

  • Sumoylated on Lys-124, Lys-142 and Lys-453 with SUMO1.
  • Polyubiquitinated on Lys-124 by TRAF3IP2; after cell stimulation with IL17A (PubMed:19825828). Polyubiquitinated on Lys-124; after cell stimulation with IL1B or TGFB. This ligand-induced cell stimulation leads to dimerization/oligomerization of TRAF6 molecules, followed by auto-ubiquitination which involves UBE2N and UBE2V1 and leads to TRAF6 activation. This 'Lys-63' site-specific poly-ubiquitination appears to be associated with the activation of signaling molecules. Endogenous autoubiquitination occurs only for the cytoplasmic form. Deubiquitinated by USP10 in a TANK-dependent manner, leading to the negative regulation of NF-kappaB signaling upon DNA damage (PubMed:25861989). LRRC19 induces 'Lys-63' ubiquitination (PubMed:25026888).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAF6 Gene

No data available for DME Specific Peptides for TRAF6 Gene

Domains & Families for TRAF6 Gene

Gene Families for TRAF6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TRAF6 Gene

InterPro:
Blocks:
  • Zn-finger, RING
  • Meprin/TRAF-like MATH
  • Zn-finger, TRAF type

Suggested Antigen Peptide Sequences for TRAF6 Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 85 (TRAF6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y4K3

UniProtKB/Swiss-Prot:

TRAF6_HUMAN :
  • The coiled coil domain mediates homo- and hetero-oligomerization.
  • Belongs to the TNF receptor-associated factor family. A subfamily.
Domain:
  • The coiled coil domain mediates homo- and hetero-oligomerization.
  • The MATH/TRAF domain binds to receptor cytoplasmic domains.
Family:
  • Belongs to the TNF receptor-associated factor family. A subfamily.
genes like me logo Genes that share domains with TRAF6: view

Function for TRAF6 Gene

Molecular function for TRAF6 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.
GENATLAS Biochemistry:
tumor necrosis factor (TNF)-receptor-associated factor 6,cytoplasmic,involved in the activation of NFKB by TNFRSFs,associating with IRAK1 after stimulation by IL1B,also associating with TNFRSF11 and SRC and,in turn activating the kinase activity of SRC

Enzyme Numbers (IUBMB) for TRAF6 Gene

Phenotypes From GWAS Catalog for TRAF6 Gene

Gene Ontology (GO) - Molecular Function for TRAF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005164 tumor necrosis factor receptor binding IBA,IPI 11728344
GO:0005515 protein binding IPI 10094049
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with TRAF6: view
genes like me logo Genes that share phenotypes with TRAF6: view

Human Phenotype Ontology for TRAF6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TRAF6 Gene

MGI Knock Outs for TRAF6:

miRNA for TRAF6 Gene

miRTarBase miRNAs that target TRAF6

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRAF6

No data available for Transcription Factor Targets and HOMER Transcription for TRAF6 Gene

Localization for TRAF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAF6 Gene

Cytoplasm. Cytoplasm, cell cortex. Nucleus. Lipid droplet. Note=Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAF6 gene
Compartment Confidence
plasma membrane 5
nucleus 5
endosome 5
cytosol 5
extracellular 3
mitochondrion 3
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (1)
  • Nucleoli (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRAF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 18093978
GO:0005737 cytoplasm IEA,IDA 16378096
GO:0005811 lipid droplet ISS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with TRAF6: view

Pathways & Interactions for TRAF6 Gene

PathCards logo

SuperPathways for TRAF6 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 Toll-like Receptor Signaling Pathway
3 p75 NTR receptor-mediated signalling
4 RANK Signaling in Osteoclasts
.92
.92
.45
.39
.38
5 Diseases associated with the TLR signaling cascade
genes like me logo Genes that share pathways with TRAF6: view

Pathways by source for TRAF6 Gene

3 Sino Biological pathways for TRAF6 Gene
17 GeneGo (Thomson Reuters) pathways for TRAF6 Gene
  • Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
  • Apoptosis and survival APRIL and BAFF signaling
  • Bacterial infections in CF airways
  • Cytokine production by Th17 cells in CF
  • Cytokine production by Th17 cells in CF (Mouse model)
21 Qiagen pathways for TRAF6 Gene
  • 14-3-3 Induced Apoptosis
  • APRIL Pathway
  • BAFF in B-Cell Signaling
  • CD40 Signaling
  • IL-1 Pathway
2 Cell Signaling Technology pathways for TRAF6 Gene
1 GeneTex pathway for TRAF6 Gene

UniProtKB/Swiss-Prot Q9Y4K3-TRAF6_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for TRAF6 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TRAF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 18093978
GO:0000187 activation of MAPK activity TAS --
GO:0000209 protein polyubiquitination IDA 15125833
GO:0001503 ossification IEA --
GO:0001701 in utero embryonic development IEA --
genes like me logo Genes that share ontologies with TRAF6: view

Drugs & Compounds for TRAF6 Gene

(8) Drugs for TRAF6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for TRAF6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRAF6: view

Transcripts for TRAF6 Gene

mRNA/cDNA for TRAF6 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRAF6

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3: - -

Relevant External Links for TRAF6 Gene

GeneLoc Exon Structure for
TRAF6

Expression for TRAF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRAF6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.9), Heart (7.5), and Testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRAF6 Gene



Protein tissue co-expression partners for TRAF6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRAF6

SOURCE GeneReport for Unigene cluster for TRAF6 Gene:

Hs.444172

mRNA Expression by UniProt/SwissProt for TRAF6 Gene:

Q9Y4K3-TRAF6_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for TRAF6 Gene

  • Blood(3)
  • Spleen(3)
  • Bone marrow(2.8)
  • Lymph node(2.7)
  • Kidney(2.7)
  • Nervous system(2.7)
  • Liver(2.6)
  • Heart(2.6)
  • Intestine(2.5)
  • Muscle(2.5)
  • Lung(2.5)
  • Bone(2.5)
  • Skin(2.4)
  • Stomach(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAF6 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • immune
  • integumentary
  • nervous
  • skeleton
Regions:
Head and neck:
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • scalp
  • skull
  • tooth
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • hair
  • skin
  • sweat gland
genes like me logo Genes that share expression patterns with TRAF6: view

No data available for mRNA differential expression in normal tissues for TRAF6 Gene

Orthologs for TRAF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAF6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRAF6 29 30
  • 99.74 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TRAF6 29 30
  • 90.29 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TRAF6 29 30
  • 89.21 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Traf6 29 16 30
  • 87.1 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Traf6 29
  • 85.57 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia TRAF6 30
  • 81 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TRAF6 30
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TRAF6 29 30
  • 72.67 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TRAF6 30
  • 70 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia traf6 29
  • 66.35 (n)
Str.8271 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.14682 29
Zebrafish
(Danio rerio)
Actinopterygii traf6 29 30
  • 60.14 (n)
OneToOne
wufi15f02 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1398 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003004 29
  • 46.32 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Traf6 29
  • 43.22 (n)
Traf-like 30
  • 14 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea trf-1 30
  • 23 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 40 (a)
OneToMany
-- 30
  • 36 (a)
OneToMany
Species where no ortholog for TRAF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TRAF6 Gene

ENSEMBL:
Gene Tree for TRAF6 (if available)
TreeFam:
Gene Tree for TRAF6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRAF6: view image
Alliance of Genome Resources:
Additional Orthologs for TRAF6

Paralogs for TRAF6 Gene

Paralogs for TRAF6 Gene

(1) SIMAP similar genes for TRAF6 Gene using alignment to 1 proteins:

  • TRAF6_HUMAN

Pseudogenes.org Pseudogenes for TRAF6 Gene

genes like me logo Genes that share paralogs with TRAF6: view

Variants for TRAF6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRAF6 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs140668198 Likely Benign: not provided 36,497,165(-) T/C
NM_004620.4(TRAF6):c.549A>G (p.Pro183=)
SYNONYMOUS
rs1590639252 Likely Benign: not provided 36,497,186(-) A/T
NM_004620.4(TRAF6):c.528T>A (p.Ile176=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TRAF6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TRAF6 Gene

Variant ID Type Subtype PubMed ID
esv1601897 CNV insertion 17803354
esv1648317 CNV insertion 17803354
esv2422305 CNV duplication 17116639
esv2678965 CNV deletion 23128226
esv3416520 CNV insertion 20981092
esv3625956 CNV loss 21293372
nsv1042014 CNV loss 25217958
nsv467791 CNV gain 19166990
nsv554003 CNV gain 21841781
nsv975903 CNV duplication 23825009

Variation tolerance for TRAF6 Gene

Residual Variation Intolerance Score: 19.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAF6 Gene

Human Gene Mutation Database (HGMD)
TRAF6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAF6
Leiden Open Variation Database (LOVD)
TRAF6

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF6 Gene

Disorders for TRAF6 Gene

MalaCards: The human disease database

(21) MalaCards diseases for TRAF6 Gene - From: ORP, COP, and GCD

Disorder Aliases PubMed IDs
ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant
  • ectd10a
streptococcus pneumonia
incontinentia pigmenti
  • ip
b-cell lymphoma
  • b-cell lymphocytic neoplasm
osteopetrosis
  • albers-schonberg disease
- elite association - COSMIC cancer census association via MalaCards
Search TRAF6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TRAF6

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TRAF6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAF6 Gene

Publications for TRAF6 Gene

  1. TRAF6 is a signal transducer for interleukin-1. (PMID: 8837778) Cao Z … Goeddel DV (Nature 1996) 2 3 4 22
  2. NUMBL interacts with TRAF6 and promotes the degradation of TRAF6. (PMID: 20079715) Zhou L … Huo K (Biochemical and biophysical research communications 2010) 3 4 22
  3. Direct activation of protein kinases by unanchored polyubiquitin chains. (PMID: 19675569) Xia ZP … Chen ZJ (Nature 2009) 3 4 22
  4. E2 interaction and dimerization in the crystal structure of TRAF6. (PMID: 19465916) Yin Q … Wu H (Nature structural & molecular biology 2009) 3 4 22
  5. Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE. (PMID: 19254290) Tewfik MA … Desrosiers M (Allergy 2009) 3 22 40

Products for TRAF6 Gene

Sources for TRAF6 Gene