The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of ... See more...

Aliases for TRAF5 Gene

Aliases for TRAF5 Gene

  • TNF Receptor Associated Factor 5 2 3 5
  • RNF84 2 3 4
  • TNF Receptor-Associated Factor 5 3 4
  • RING Finger Protein 84 3 4
  • MGC:39780 3
  • TRAF5 5

External Ids for TRAF5 Gene

Previous GeneCards Identifiers for TRAF5 Gene

  • GC01P210231
  • GC01P207335
  • GC01P208139
  • GC01P208579
  • GC01P207888
  • GC01P209566
  • GC01P211499
  • GC01P182176

Summaries for TRAF5 Gene

Entrez Gene Summary for TRAF5 Gene

  • The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for TRAF5 Gene

TRAF5 (TNF Receptor Associated Factor 5) is a Protein Coding gene. Diseases associated with TRAF5 include Immunodeficiency With Hyper-Igm, Type 3 and Ectodermal Dysplasia. Among its related pathways are NF-KappaB Family Pathway and LT-BetaR Pathway. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin protein ligase binding. An important paralog of this gene is TRAF3.

UniProtKB/Swiss-Prot Summary for TRAF5 Gene

  • Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.

Gene Wiki entry for TRAF5 Gene

Additional gene information for TRAF5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRAF5 Gene

Genomics for TRAF5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRAF5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRAF5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRAF5

Top Transcription factor binding sites by QIAGEN in the TRAF5 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • NF-kappaB1

Genomic Locations for TRAF5 Gene

Genomic Locations for TRAF5 Gene
chr1:211,326,594-211,374,946
(GRCh38/hg38)
Size:
48,353 bases
Orientation:
Plus strand
chr1:211,499,957-211,548,288
(GRCh37/hg19)
Size:
48,332 bases
Orientation:
Plus strand

Genomic View for TRAF5 Gene

Genes around TRAF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF5 Gene

Proteins for TRAF5 Gene

  • Protein details for TRAF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00463-TRAF5_HUMAN
    Recommended name:
    TNF receptor-associated factor 5
    Protein Accession:
    O00463
    Secondary Accessions:
    • B4DIS9
    • B4E0A2
    • Q6FHY1

    Protein attributes for TRAF5 Gene

    Size:
    557 amino acids
    Molecular mass:
    64406 Da
    Quaternary structure:
    • Homotrimer (Probable). Heteromer with TRAF3. Associates with TNFRSF5/CD40 through interaction with TRAF3. Associates with LTBR/TNFRSF3, TNFRSF4, TNFRSF8/CD30, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF17, TNFRSF19/TROY, RIPK2, MAP3K14, MAP3K5, and TRAF and TNF receptor associated protein TDP2. Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain).

    Alternative splice isoforms for TRAF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAF5 Gene

Post-translational modifications for TRAF5 Gene

  • Ubiquitination at Lys8 and Lys534
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRAF5 Gene

Domains & Families for TRAF5 Gene

Gene Families for TRAF5 Gene

Protein Domains for TRAF5 Gene

InterPro:
Blocks:
  • Zn-finger, RING
  • Meprin/TRAF-like MATH
  • Zn-finger, TRAF type
ProtoNet:

Suggested Antigen Peptide Sequences for TRAF5 Gene

GenScript: Design optimal peptide antigens:
  • TNF receptor-associated factor 5, isoform CRA_a (D3DT93_HUMAN)
  • TRAF5 protein (Q6FHY1_HUMAN)
  • RING finger protein 84 (TRAF5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00463

UniProtKB/Swiss-Prot:

TRAF5_HUMAN :
  • The MATH/TRAF domain binds to receptor cytoplasmic domains.
  • Belongs to the TNF receptor-associated factor family. A subfamily.
Domain:
  • The MATH/TRAF domain binds to receptor cytoplasmic domains.
Family:
  • Belongs to the TNF receptor-associated factor family. A subfamily.
genes like me logo Genes that share domains with TRAF5: view

Function for TRAF5 Gene

Molecular function for TRAF5 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
GENATLAS Biochemistry:
tumor necrosis factor (TNF)-receptor-associated factor 5,expressed in all visceral organs,interacting with the lymphotoxin beta receptor,activating NFKB through the cytoplasmic domain of CD40 (TNFRSF5) and modulating of its activity

Phenotypes From GWAS Catalog for TRAF5 Gene

Gene Ontology (GO) - Molecular Function for TRAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA 21873635
GO:0005164 tumor necrosis factor receptor binding IBA 21873635
GO:0005515 protein binding IPI 9153189
GO:0008270 zinc ion binding IEA --
GO:0031625 ubiquitin protein ligase binding IPI 11279055
genes like me logo Genes that share ontologies with TRAF5: view
genes like me logo Genes that share phenotypes with TRAF5: view

Animal Models for TRAF5 Gene

MGI Knock Outs for TRAF5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRAF5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRAF5 Gene

Localization for TRAF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAF5 Gene

Cytoplasm. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAF5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 4
nucleus 4
extracellular 2
mitochondrion 2
endosome 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TRAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol IEA,IDA 15121867
GO:0009898 cytoplasmic side of plasma membrane IBA,ISS --
GO:0035631 CD40 receptor complex ISS --
genes like me logo Genes that share ontologies with TRAF5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRAF5 Gene

Pathways & Interactions for TRAF5 Gene

PathCards logo

SuperPathways for TRAF5 Gene

SuperPathway Contained pathways
1 RANK Signaling in Osteoclasts
.92
.92
.45
.39
.38
2 Human cytomegalovirus infection
3 4-1BB Pathway
.54
.48
4 LT-BetaR Pathway
.46
.46
5 TRAF Pathway
.42
.42
genes like me logo Genes that share pathways with TRAF5: view

Pathways by source for TRAF5 Gene

4 GeneGo (Thomson Reuters) pathways for TRAF5 Gene
  • Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
  • Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
  • Apoptosis and survival APRIL and BAFF signaling
  • Apoptosis and survival Lymphotoxin-beta receptor signaling
11 Qiagen pathways for TRAF5 Gene
  • APRIL Pathway
  • BAFF in B-Cell Signaling
  • CD27 Pathway
  • CD40 Signaling
  • LT-BetaR Pathway
2 Cell Signaling Technology pathways for TRAF5 Gene

SIGNOR curated interactions for TRAF5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TRAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction TAS 9511754
GO:0033209 tumor necrosis factor-mediated signaling pathway IBA 21873635
GO:0042981 regulation of apoptotic process IEA --
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IBA 21873635
genes like me logo Genes that share ontologies with TRAF5: view

Drugs & Compounds for TRAF5 Gene

(1) Drugs for TRAF5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TRAF5: view

Transcripts for TRAF5 Gene

mRNA/cDNA for TRAF5 Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRAF5

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - -
SP7: -
SP8:
SP9:

Relevant External Links for TRAF5 Gene

GeneLoc Exon Structure for
TRAF5

Expression for TRAF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRAF5 Gene

This gene is overexpressed in Uterus (59.5) and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRAF5 Gene



Protein tissue co-expression partners for TRAF5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRAF5

SOURCE GeneReport for Unigene cluster for TRAF5 Gene:

Hs.523930

mRNA Expression by UniProt/SwissProt for TRAF5 Gene:

O00463-TRAF5_HUMAN
Tissue specificity: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.

Evidence on tissue expression from TISSUES for TRAF5 Gene

  • Nervous system(4.4)
  • Blood(3.1)
  • Lymph node(2.9)
  • Spleen(2.8)
  • Intestine(2.5)
  • Bone marrow(2.3)
  • Kidney(2.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with TRAF5: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAF5 Gene

Orthologs for TRAF5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAF5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRAF5 30 31
  • 99.34 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TRAF5 30 31
  • 88.69 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TRAF5 30 31
  • 88.63 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Traf5 30 17 31
  • 81.93 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC684173 30
  • 81.26 (n)
Oppossum
(Monodelphis domestica)
Mammalia TRAF5 31
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TRAF5 31
  • 75 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TRAF5 30
  • 73.18 (n)
TRAF-5 31
  • 71 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TRAF5 31
  • 68 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100491604 30
  • 64.22 (n)
Zebrafish
(Danio rerio)
Actinopterygii traf5 30 31
  • 51.07 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Traf-like 31
  • 16 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea trf-1 30
  • 44.57 (n)
Y110A7A.2 31
  • 19 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 58 (a)
ManyToMany
Species where no ortholog for TRAF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TRAF5 Gene

ENSEMBL:
Gene Tree for TRAF5 (if available)
TreeFam:
Gene Tree for TRAF5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRAF5: view image

Paralogs for TRAF5 Gene

Paralogs for TRAF5 Gene

(4) SIMAP similar genes for TRAF5 Gene using alignment to 3 proteins:

  • TRAF5_HUMAN
  • D3DT93_HUMAN
  • F5H1P7_HUMAN
genes like me logo Genes that share paralogs with TRAF5: view

Variants for TRAF5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRAF5 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
800316 Likely Pathogenic: Multiple myeloma 211,372,277(+) AAGAG/A FRAMESHIFT_VARIANT
rs200398415 - p.His268Tyr
rs2230780 - p.Leu358Val
rs2271458 - p.Asn186His
rs3946808 - p.Val120Gly

Additional dbSNP identifiers (rs#s) for TRAF5 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRAF5 Gene

Variant ID Type Subtype PubMed ID
esv2762141 CNV loss 21179565
esv3588730 CNV loss 21293372
nsv508059 OTHER sequence alteration 20534489

Variation tolerance for TRAF5 Gene

Residual Variation Intolerance Score: 70.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAF5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF5 Gene

Disorders for TRAF5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TRAF5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency with hyper-igm, type 3
  • higm3
ectodermal dysplasia
  • congenital ectodermal defect
cone-rod dystrophy 2
  • cord2
cone-rod dystrophy 6
  • retinitis pigmentosa 6
- elite association - COSMIC cancer census association via MalaCards
Search TRAF5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TRAF5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TRAF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAF5 Gene

Publications for TRAF5 Gene

  1. Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma. (PMID: 18990758) Cerhan JR … Slager SL (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 23 41
  2. Investigation of association between the TRAF family genes and RA susceptibility. (PMID: 17277003) Potter C … Barton A (Annals of the rheumatic diseases 2007) 3 23 41
  3. TRAF family proteins link PKR with NF-kappa B activation. (PMID: 15121867) Gil J … Esteban M (Molecular and cellular biology 2004) 3 4 23
  4. Tumor necrosis factor receptor-associated factors (TRAFs). (PMID: 11607847) Bradley JR … Pober JS (Oncogene 2001) 3 4 23
  5. B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1. (PMID: 10908663) Shu HB … Johnson H (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 23

Products for TRAF5 Gene

Sources for TRAF5 Gene