TRAF4 Gene (Protein Coding)

TNF Receptor Associated Factor 4

GC17P028756
GIFtS:
44
This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been... See more...

Aliases for TRAF4 Gene

Aliases for TRAF4 Gene

  • TNF Receptor Associated Factor 4 2 3 5
  • Cysteine-Rich Domain Associated With RING And Traf Domains Protein 1 3 4
  • Metastatic Lymph Node Gene 62 Protein 3 4
  • TNF Receptor-Associated Factor 4 3 4
  • RING Finger Protein 83 3 4
  • MLN 62 3 4
  • CART1 3 4
  • MLN62 3 4
  • RNF83 3 4
  • Cysteine-Rich Domain Associated With Ring And TRAF Domain 3
  • Tumor Necrosis Receptor-Associated Factor 4A 3
  • TRAF4 Variant 6 3
  • Malignant 62 3

External Ids for TRAF4 Gene

Previous GeneCards Identifiers for TRAF4 Gene

  • GC17P026916
  • GC17P028970
  • GC17P026922
  • GC17P027216
  • GC17P024095
  • GC17P027071
  • GC17P023279
  • GC17P028743
  • GC17P028748

Summaries for TRAF4 Gene

Entrez Gene Summary for TRAF4 Gene

  • This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRAF4 Gene

TRAF4 (TNF Receptor Associated Factor 4) is a Protein Coding gene. Diseases associated with TRAF4 include Nephronophthisis. Among its related pathways are TRAF Pathway and LT-BetaR Pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and ubiquitin protein ligase binding. An important paralog of this gene is TRAF2.

UniProtKB/Swiss-Prot Summary for TRAF4 Gene

  • Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.

Gene Wiki entry for TRAF4 Gene

Additional gene information for TRAF4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRAF4 Gene

Genomics for TRAF4 Gene

GeneHancer (GH) Regulatory Elements for TRAF4 Gene

Promoters and enhancers for TRAF4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRAF4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRAF4 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPalpha
  • CHOP-10
  • E47
  • FOXI1
  • HFH-3
  • Nkx3-1
  • Tal-1beta

Genomic Locations for TRAF4 Gene

Genomic Locations for TRAF4 Gene
chr17:28,744,005-28,750,958
(GRCh38/hg38)
Size:
6,954 bases
Orientation:
Plus strand
chr17:27,071,002-27,077,976
(GRCh37/hg19)
Size:
6,975 bases
Orientation:
Plus strand

Genomic View for TRAF4 Gene

Genes around TRAF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAF4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TRAF4 Gene

Proteins for TRAF4 Gene

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  • Protein details for TRAF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUZ4-TRAF4_HUMAN
    Recommended name:
    TNF receptor-associated factor 4
    Protein Accession:
    Q9BUZ4
    Secondary Accessions:
    • O75615
    • Q14848
    • Q2KJU4
    • Q2PJN8

    Protein attributes for TRAF4 Gene

    Size:
    470 amino acids
    Molecular mass:
    53543 Da
    Quaternary structure:
    • Homotrimer (Probable). Interacts with LTBR/TNFRSF3, NGFR/TNFRSF16, RPS6KB1 and TGFB1I1. Interacts with SMURF1. Interacts (via TRAF domain) with MAP3K4 (via kinase domain). Interacts with NCF1, TICAM1, IRAK1 and TRAF6, and is probably part of a complex containing TRAF4, NCF1, TICAM1, IRAK1 and TRAF6.

    Three dimensional structures from OCA and Proteopedia for TRAF4 Gene

    Alternative splice isoforms for TRAF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAF4 Gene

Protein Expression for TRAF4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TRAF4 Gene

  • Polyubiquitinated, leading to its proteasomal degradation.
  • Ubiquitination at Lys170 and Lys415
  • Modification sites at PhosphoSitePlus

Other Protein References for TRAF4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRAF4 Gene

Domains & Families for TRAF4 Gene

Gene Families for TRAF4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TRAF4 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRAF4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60166, highly similar to TNF receptor-associated factor 4 (B4DUU9_HUMAN)
  • RING finger protein 83 (TRAF4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BUZ4

UniProtKB/Swiss-Prot:

TRAF4_HUMAN :
  • The coiled coil domain mediates homo- and hetero-oligomerization.
  • Belongs to the TNF receptor-associated factor family. B subfamily.
Domain:
  • The coiled coil domain mediates homo- and hetero-oligomerization.
  • The MATH/TRAF domain binds to receptor cytoplasmic domains.
Family:
  • Belongs to the TNF receptor-associated factor family. B subfamily.
genes like me logo Genes that share domains with TRAF4: view

Function for TRAF4 Gene

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  2. CRISPR
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Molecular function for TRAF4 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.
UniProtKB/Swiss-Prot Induction:
Up-regulated by bacterial lipopolysaccharides (LPS) and by single-stranded CpG oligodeoxynucleotide.
GENATLAS Biochemistry:
tumor necrosis factor (TNF)-receptor-associated factor 4,specifically expressed in epithelial cells ,?nuclear

Phenotypes From GWAS Catalog for TRAF4 Gene

Gene Ontology (GO) - Molecular Function for TRAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 7592751
GO:0005164 tumor necrosis factor receptor binding IEA,IPI 11728344
GO:0005515 protein binding IPI,IEA 10514511
GO:0008270 zinc ion binding IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with TRAF4: view
genes like me logo Genes that share phenotypes with TRAF4: view

Animal Models for TRAF4 Gene

MGI Knock Outs for TRAF4:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for TRAF4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRAF4 Gene

Localization for TRAF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAF4 Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAF4 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytoskeleton 3
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS 18087216
GO:0005737 cytoplasm IDA,IEA 16157600
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction IEA --
genes like me logo Genes that share ontologies with TRAF4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRAF4 Gene

Pathways & Interactions for TRAF4 Gene

PathCards logo

SuperPathways for TRAF4 Gene

genes like me logo Genes that share pathways with TRAF4: view

Pathways by source for TRAF4 Gene

6 Qiagen pathways for TRAF4 Gene
  • LT-BetaR Pathway
  • NF-KappaB Family Pathway
  • NGF Pathway
  • TNF Superfamily Pathway
  • TRAF Pathway
2 Cell Signaling Technology pathways for TRAF4 Gene

SIGNOR curated interactions for TRAF4 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for TRAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA,TAS 7592751
GO:0007250 activation of NF-kappaB-inducing kinase activity IEA --
GO:0007275 multicellular organism development IEA --
GO:0007585 respiratory gaseous exchange IEA --
genes like me logo Genes that share ontologies with TRAF4: view

Drugs & Compounds for TRAF4 Gene

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  1. Drug

(1) Additional Compounds for TRAF4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRAF4: view

Transcripts for TRAF4 Gene

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mRNA/cDNA for TRAF4 Gene

(2) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(291) Selected AceView cDNA sequences:
(17) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for TRAF4

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b
SP1: - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - - - - - - - -
SP8: - - - -
SP9:
SP10: - - - - -
SP11:
SP12: - - - -
SP13: - - - -
SP14: -

Relevant External Links for TRAF4 Gene

GeneLoc Exon Structure for
TRAF4
ECgene alternative splicing isoforms for
TRAF4

Expression for TRAF4 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAF4 Gene

mRNA expression in normal human tissues for TRAF4 Gene
mRNA expression by BioGPS for TRAF4 GenemRNA expression by GTEx for TRAF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRAF4 Gene

This gene is overexpressed in Lung (46.2) and Heart (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRAF4 Gene



Protein tissue co-expression partners for TRAF4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRAF4 Gene:

TRAF4

SOURCE GeneReport for Unigene cluster for TRAF4 Gene:

Hs.8375

mRNA Expression by UniProt/SwissProt for TRAF4 Gene:

Q9BUZ4-TRAF4_HUMAN
Tissue specificity: Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus.

Evidence on tissue expression from TISSUES for TRAF4 Gene

  • Lung(4.3)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with TRAF4: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAF4 Gene

Orthologs for TRAF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TRAF4 33 32
  • 99.81 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia TRAF4 33 32
  • 91.28 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Traf4 17 33 32
  • 89.65 (n)
dog
(Canis familiaris)
 Mammalia TRAF4 33 32
  • 89.35 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Traf4 32
  • 89.29 (n)
oppossum
(Monodelphis domestica)
 Mammalia TRAF4 33
  • 87 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 33
  • 82 (a)
 OneToMany
-- 33
  • 77 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves TRAF4 33 32
  • 78.59 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 33
  • 22 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia traf4 32
  • 71.56 (n)
Str.392 32
African clawed frog
(Xenopus laevis)
 Amphibia Xl.2466 32
zebrafish
(Danio rerio)
 Actinopterygii traf4a 33 32
  • 72.77 (n)
 OneToOne
Dr.15893 32
fruit fly
(Drosophila melanogaster)
 Insecta Traf4 33 32
  • 53.79 (n)
 OneToOne
Traf1 34
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP010017 32
  • 52.97 (n)
worm
(Caenorhabditis elegans)
 Secernentea trf-1 33 34
  • 26 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 33
  • 51 (a)
 OneToOne
Cin.2595 32
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.2595 32
Species where no ortholog for TRAF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAF4 Gene

ENSEMBL:
Gene Tree for TRAF4 (if available)
TreeFam:
Gene Tree for TRAF4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRAF4: view image

Paralogs for TRAF4 Gene

Paralogs for TRAF4 Gene

(3) SIMAP similar genes for TRAF4 Gene using alignment to 9 proteins:

  • TRAF4_HUMAN
  • C9JJ10_HUMAN
  • F6SA91_HUMAN
  • J3QR87_HUMAN
  • J3QS94_HUMAN
  • J9JIG0_HUMAN
  • K7EJG7_HUMAN
  • K7EM06_HUMAN
  • K7ER49_HUMAN

Pseudogenes.org Pseudogenes for TRAF4 Gene

genes like me logo Genes that share paralogs with TRAF4: view

Variants for TRAF4 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for TRAF4 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1142899 benign, Nephronophthisis 28,742,375(+) C/T upstream_transcript_variant
rs183805648 uncertain-significance, Nephronophthisis 28,742,407(+) C/T upstream_transcript_variant
rs185303602 uncertain-significance, Nephronophthisis 28,742,565(+) A/C upstream_transcript_variant
rs186791558 uncertain-significance, Nephronophthisis 28,742,143(+) G/A upstream_transcript_variant
rs191309632 uncertain-significance, Nephronophthisis 28,742,315(+) C/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TRAF4 Gene

Variant ID Type Subtype PubMed ID
esv24071 CNV loss 19812545
nsv1064087 CNV gain 25217958

Variation tolerance for TRAF4 Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAF4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF4 Gene

Disorders for TRAF4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRAF4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
nephronophthisis
  • medullary cystic disease
- elite association - COSMIC cancer census association via MalaCards
Search TRAF4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TRAF4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRAF4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAF4 Gene

Publications for TRAF4 Gene

  1. Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma. (PMID: 7592751) Régnier CH … Rio MC (The Journal of biological chemistry 1995) 2 3 4 23 56
  2. Tumor necrosis factor receptor-associated factor 4 is a dynamic tight junction-related shuttle protein involved in epithelium homeostasis. (PMID: 18953416) Kédinger V … Rio MC (PloS one 2008) 3 4 23 56
  3. TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN. (PMID: 18087216) Gu X … Nylander K (Cancer biology & therapy 2007) 3 4 23 56
  4. TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF. (PMID: 16052631) Takeshita F … Suzuki K (European journal of immunology 2005) 3 4 23 56
  5. MEKK4 is an effector of the embryonic TRAF4 for JNK activation. (PMID: 16157600) Abell AN … Johnson GL (The Journal of biological chemistry 2005) 3 4 23 56

ExternalLinks

View latest publications for TRAF4 gene in Mastermind

Products for TRAF4 Gene

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Sources for TRAF4 Gene