The gene encodes a protein that mediates cell growth by modulating the c-Jun N-terminal kinase signal transduction pathway. The encoded protein may also interact with a large multi-protein assembly containing the phosphatase 2A catalytic subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] See more...

Aliases for TRAF3IP3 Gene

Aliases for TRAF3IP3 Gene

  • TRAF3 Interacting Protein 3 2 3 5
  • TRAF3 Interacting Jun N Terminal Kinase (JNK) Activating Modulator 2 3
  • TRAF3-Interacting JNK-Activating Modulator 3 4
  • T3JAM 3 4
  • TRAF3-Interacting Protein 3 4

External Ids for TRAF3IP3 Gene

Previous GeneCards Identifiers for TRAF3IP3 Gene

  • GC01P206318
  • GC01P207996
  • GC01P209929
  • GC01P180604

Summaries for TRAF3IP3 Gene

Entrez Gene Summary for TRAF3IP3 Gene

  • The gene encodes a protein that mediates cell growth by modulating the c-Jun N-terminal kinase signal transduction pathway. The encoded protein may also interact with a large multi-protein assembly containing the phosphatase 2A catalytic subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for TRAF3IP3 Gene

TRAF3IP3 (TRAF3 Interacting Protein 3) is a Protein Coding gene. Diseases associated with TRAF3IP3 include Pityriasis Rubra Pilaris. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is SLMAP.

UniProtKB/Swiss-Prot Summary for TRAF3IP3 Gene

  • May function as an adapter molecule that regulates TRAF3-mediated JNK activation.

Gene Wiki entry for TRAF3IP3 Gene

Additional gene information for TRAF3IP3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRAF3IP3 Gene

Genomics for TRAF3IP3 Gene

GeneHancer (GH) Regulatory Elements for TRAF3IP3 Gene

Promoters and enhancers for TRAF3IP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J209754 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 517.3 +1.0 1044 5.1 SP1 ZIC2 RCOR1 TRIM22 POLR2A BCL11A CBFB GABPA NBN SPI1 TRAF3IP3 HSD11B1-AS1 G0S2 IRF6 C1orf74 lnc-TRAF3IP3-1
GH01J209782 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 24.9 +29.6 29615 6 ZBTB40 ZNF217 EP300 SIN3A NRF1 POLR2G SP1 GTF2E2 PHF8 JUND C1orf74 TRAF3IP3 IRF6 SYT14 lnc-C1orf74-1
GH01J209800 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.5 +49.9 49888 10.2 NRF1 JUND SIX5 FOS ZFX ZNF10 REST POLR2A AFF1 TRIM28 IRF6 TRAF3IP3 UTP25 SYT14 LAMB3 lnc-C1orf74-1
GH01J209765 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 17.6 +12.2 12240 6.3 EP300 POLR2A RELA MEF2C RCOR1 ZEB1 NFYB TCF12 CBFB GABPA lnc-HSD11B1-4 G0S2 TRAF3IP3 UTP25 ENSG00000224260 LAMB3 IRF6 C1orf74 lnc-C1orf74-2 HSD11B1-AS1
GH01J209746 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.8 -8.6 -8580 2.3 CTCF ZSCAN5C NRF1 MYC TEAD4 FOS ZNF639 ZIC2 CLOCK ZNF623 G0S2 TRAF3IP3 LAMB3 lnc-HSD11B1-1 lnc-TRAF3IP3-1 HSD11B1-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRAF3IP3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRAF3IP3

Top Transcription factor binding sites by QIAGEN in the TRAF3IP3 gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • c-Jun
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Pbx1a

Genomic Locations for TRAF3IP3 Gene

Genomic Locations for TRAF3IP3 Gene
chr1:209,756,032-209,782,323
(GRCh38/hg38)
Size:
26,292 bases
Orientation:
Plus strand
chr1:209,929,377-209,955,668
(GRCh37/hg19)
Size:
26,292 bases
Orientation:
Plus strand

Genomic View for TRAF3IP3 Gene

Genes around TRAF3IP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAF3IP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAF3IP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF3IP3 Gene

Proteins for TRAF3IP3 Gene

  • Protein details for TRAF3IP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y228-T3JAM_HUMAN
    Recommended name:
    TRAF3-interacting JNK-activating modulator
    Protein Accession:
    Q9Y228
    Secondary Accessions:
    • A1L464
    • A6NIU9
    • Q2YDB5
    • Q4VY06
    • Q7Z706

    Protein attributes for TRAF3IP3 Gene

    Size:
    551 amino acids
    Molecular mass:
    63626 Da
    Quaternary structure:
    • Binds to the isoleucine zipper of TRAF3 via its coiled-coil domain.

    Alternative splice isoforms for TRAF3IP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAF3IP3 Gene

Post-translational modifications for TRAF3IP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Boster Bio Antibodies for TRAF3IP3

No data available for DME Specific Peptides for TRAF3IP3 Gene

Domains & Families for TRAF3IP3 Gene

Gene Families for TRAF3IP3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TRAF3IP3 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TRAF3IP3 Gene

GenScript: Design optimal peptide antigens:
  • TRAF3 interacting protein 3 (B1AJU3_HUMAN)
  • cDNA FLJ52976, highly similar to TRAF3-interacting JNK-activating modulator (B4DU99_HUMAN)
  • TRAF3-interacting protein 3 (T3JAM_HUMAN)
genes like me logo Genes that share domains with TRAF3IP3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TRAF3IP3 Gene

Function for TRAF3IP3 Gene

Molecular function for TRAF3IP3 Gene

UniProtKB/Swiss-Prot Function:
May function as an adapter molecule that regulates TRAF3-mediated JNK activation.

Phenotypes From GWAS Catalog for TRAF3IP3 Gene

Gene Ontology (GO) - Molecular Function for TRAF3IP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18782753
genes like me logo Genes that share ontologies with TRAF3IP3: view
genes like me logo Genes that share phenotypes with TRAF3IP3: view

Animal Models for TRAF3IP3 Gene

MGI Knock Outs for TRAF3IP3:

Animal Model Products

CRISPR Products

miRNA for TRAF3IP3 Gene

miRTarBase miRNAs that target TRAF3IP3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRAF3IP3 Gene

Localization for TRAF3IP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAF3IP3 Gene

Membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAF3IP3 gene
Compartment Confidence
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRAF3IP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TRAF3IP3: view

Pathways & Interactions for TRAF3IP3 Gene

PathCards logo

SuperPathways for TRAF3IP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAF3IP3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRAF3IP3 Gene

Drugs & Compounds for TRAF3IP3 Gene

No Compound Related Data Available

Transcripts for TRAF3IP3 Gene

mRNA/cDNA for TRAF3IP3 Gene

4 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF3IP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c ^ 16 ^
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - -
SP5:
SP6: - - -
SP7: -
SP8: - - -
SP9: -
SP10: -
SP11:
SP12:
SP13:

ExUns: 17a · 17b · 17c ^ 18 ^ 19a · 19b ^ 20a · 20b
SP1: - - -
SP2: -
SP3: -
SP4: - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:

Relevant External Links for TRAF3IP3 Gene

GeneLoc Exon Structure for
TRAF3IP3

Expression for TRAF3IP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAF3IP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRAF3IP3 Gene

This gene is overexpressed in Whole Blood (x20.7), Spleen (x6.5), and Small Intestine - Terminal Ileum (x4.0).

Protein differential expression in normal tissues from HIPED for TRAF3IP3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.6), Lymph node (9.2), and Pancreas (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRAF3IP3 Gene



Protein tissue co-expression partners for TRAF3IP3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRAF3IP3

SOURCE GeneReport for Unigene cluster for TRAF3IP3 Gene:

Hs.147434

Evidence on tissue expression from TISSUES for TRAF3IP3 Gene

  • Blood(4.6)
  • Nervous system(4.1)
  • Spleen(2.3)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with TRAF3IP3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAF3IP3 Gene

Orthologs for TRAF3IP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAF3IP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAF3IP3 31 30
  • 99.09 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TRAF3IP3 31 30
  • 88.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TRAF3IP3 31 30
  • 87.17 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Traf3ip3 17 31 30
  • 82.91 (n)
rat
(Rattus norvegicus)
Mammalia Traf3ip3 30
  • 81.33 (n)
oppossum
(Monodelphis domestica)
Mammalia TRAF3IP3 31
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAF3IP3 31
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRAF3IP3 31 30
  • 57.94 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAF3IP3 31
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145338 30
  • 51.52 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100534789 30
  • 43.78 (n)
CR847543.1 31
  • 26 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17494 31
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M4.1 31
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8207 31
  • 20 (a)
OneToMany
Species where no ortholog for TRAF3IP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAF3IP3 Gene

ENSEMBL:
Gene Tree for TRAF3IP3 (if available)
TreeFam:
Gene Tree for TRAF3IP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRAF3IP3: view image

Paralogs for TRAF3IP3 Gene

Paralogs for TRAF3IP3 Gene

(2) SIMAP similar genes for TRAF3IP3 Gene using alignment to 7 proteins:

  • T3JAM_HUMAN
  • B1AJU2_HUMAN
  • C9J0C0_HUMAN
  • C9JBA0_HUMAN
  • C9JXB3_HUMAN
  • E2QRE5_HUMAN
  • H0YF09_HUMAN
genes like me logo Genes that share paralogs with TRAF3IP3: view

Variants for TRAF3IP3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRAF3IP3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
VAR_035664 A colorectal cancer sample p.Pro529Ser
rs669694 - p.Gln373Glu

Additional dbSNP identifiers (rs#s) for TRAF3IP3 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRAF3IP3 Gene

Variant ID Type Subtype PubMed ID
esv2491231 CNV deletion 19546169
esv2722162 CNV deletion 23290073
esv2722173 CNV deletion 23290073
esv2722184 CNV deletion 23290073
esv2722195 CNV deletion 23290073
esv3393757 CNV duplication 20981092
esv3449118 CNV duplication 20981092
esv3545800 CNV deletion 23714750
nsv1001588 CNV gain 25217958
nsv1006632 CNV gain 25217958
nsv1150782 CNV deletion 26484159
nsv159698 CNV deletion 16902084
nsv4343 CNV deletion 18451855
nsv952685 CNV deletion 24416366

Variation tolerance for TRAF3IP3 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAF3IP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAF3IP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF3IP3 Gene

Disorders for TRAF3IP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRAF3IP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pityriasis rubra pilaris
  • prp
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRAF3IP3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRAF3IP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAF3IP3 Gene

Publications for TRAF3IP3 Gene

  1. T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK(1). (PMID: 14572659) Dadgostar H … Cheng G (FEBS letters 2003) 2 3 23 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. TRAF3-interacting protein 3, a new oncotarget, promotes tumor growth in melanoma. (PMID: 29553967) Nasarre P … Klauber-DeMore N (Melanoma research 2018) 3 54

Products for TRAF3IP3 Gene

Sources for TRAF3IP3 Gene