Aliases for TRAF3IP2 Gene
External Ids for TRAF3IP2 Gene
Previous HGNC Symbols for TRAF3IP2 Gene
Previous GeneCards Identifiers for TRAF3IP2 Gene
This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]
GeneCards Summary for TRAF3IP2 Gene
TRAF3IP2 (TRAF3 Interacting Protein 2) is a Protein Coding gene. Diseases associated with TRAF3IP2 include Candidiasis, Familial, 8 and Psoriasis 13. Among its related pathways are IL-17 Family Signaling Pathways and Cytokine production by Th17 cells in CF (Mouse model).
UniProtKB/Swiss-Prot Summary for TRAF3IP2 Gene
E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828).