The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex ... See more...

Aliases for TRAF1 Gene

Aliases for TRAF1 Gene

  • TNF Receptor Associated Factor 1 2 3 5
  • EBI6 2 3 4
  • TNF Receptor-Associated Factor 1 3 4
  • Epstein-Barr Virus-Induced Protein 6 4
  • Epstein-Bar Virus-Induced Protein 6 3
  • MGC:10353 3
  • TRAF1 5

External Ids for TRAF1 Gene

Previous GeneCards Identifiers for TRAF1 Gene

  • GC09M114770
  • GC09M115311
  • GC09M117118
  • GC09M119040
  • GC09M120744
  • GC09M122704
  • GC09M123664
  • GC09M093282

Summaries for TRAF1 Gene

Entrez Gene Summary for TRAF1 Gene

  • The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for TRAF1 Gene

TRAF1 (TNF Receptor Associated Factor 1) is a Protein Coding gene. Diseases associated with TRAF1 include Anaplastic Large Cell Lymphoma and Lymphoma, Hodgkin, Classic. Among its related pathways are Apoptosis Modulation and Signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and thioesterase binding. An important paralog of this gene is TRAF2.

UniProtKB/Swiss-Prot Summary for TRAF1 Gene

  • Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.

Gene Wiki entry for TRAF1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRAF1 Gene

Genomics for TRAF1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRAF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRAF1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRAF1

Top Transcription factor binding sites by QIAGEN in the TRAF1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • c-Rel
  • Elk-1
  • Ik-1
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for TRAF1 Gene

Latest Assembly
chr9:120,902,393-120,929,173
(GRCh38/hg38)
Size:
26,781 bases
Orientation:
Minus strand

Previous Assembly
chr9:123,664,671-123,691,449
(GRCh37/hg19 by Entrez Gene)
Size:
26,779 bases
Orientation:
Minus strand

chr9:123,664,671-123,691,451
(GRCh37/hg19 by Ensembl)
Size:
26,781 bases
Orientation:
Minus strand

Genomic View for TRAF1 Gene

Genes around TRAF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF1 Gene

Proteins for TRAF1 Gene

  • Protein details for TRAF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13077-TRAF1_HUMAN
    Recommended name:
    TNF receptor-associated factor 1
    Protein Accession:
    Q13077
    Secondary Accessions:
    • B4DJ77
    • Q658U1
    • Q8NF13

    Protein attributes for TRAF1 Gene

    Size:
    416 amino acids
    Molecular mass:
    46164 Da
    Quaternary structure:
    • Homotrimer (PubMed:15383523, PubMed:20385093). Heterotrimer with TRAF2 (PubMed:8069916, PubMed:19287455, PubMed:20385093). Interacts with TNFRSF1A/TNFR1, TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13C, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP and RIPK2 (PubMed:10037686, PubMed:10809768, PubMed:10903733, PubMed:11035039, PubMed:11313261, PubMed:16323247, PubMed:19287455, PubMed:19698991, PubMed:8069916, PubMed:8627180, PubMed:8710854, PubMed:9418902, PubMed:9607925, PubMed:9642260, PubMed:9705938, PubMed:9718306, PubMed:9774460). Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2 (PubMed:11907583, PubMed:20447407, PubMed:20385093). Interacts with NFATC2IP, TRAFD1 and with HIVEP3 (By similarity). Interacts with MAP3K14. Interacts with GPS2 (By similarity).
    SequenceCaution:
    • Sequence=BAC03449.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRAF1 Gene

    Alternative splice isoforms for TRAF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAF1 Gene

Post-translational modifications for TRAF1 Gene

  • Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation.
  • Ubiquitination at Lys185 and Lys193
  • Modification sites at PhosphoSitePlus

Other Protein References for TRAF1 Gene

No data available for DME Specific Peptides for TRAF1 Gene

Domains & Families for TRAF1 Gene

Gene Families for TRAF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for TRAF1 Gene

InterPro:
Blocks:
  • Pancreatic trypsin inhibitor (Kunitz)
  • Meprin/TRAF-like MATH

Suggested Antigen Peptide Sequences for TRAF1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53047, highly similar to TNF receptor-associated factor 1 (B4DJ77_HUMAN)
  • Epstein-Barr virus-induced protein 6 (TRAF1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13077

UniProtKB/Swiss-Prot:

TRAF1_HUMAN :
  • The coiled coil domain mediates homo- and hetero-oligomerization.
Domain:
  • The coiled coil domain mediates homo- and hetero-oligomerization.
  • The MATH/TRAF domain binds to receptor cytoplasmic domains.
  • Cleavage by CASP8 liberates a C-terminal fragment that promotes apoptosis and inhibits the activation of NF-kappa-B in response to TNF signaling.
genes like me logo Genes that share domains with TRAF1: view

Function for TRAF1 Gene

Molecular function for TRAF1 Gene

UniProtKB/Swiss-Prot Function:
Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
GENATLAS Biochemistry:
tumor necrosis factor (TNF)-receptor-associated factor 1,cytoplasmic,expressed in spleen,lung,testis,inducible molecule taking part in the signal transduction of TNFR2,LTBR,CD40,(TNFRSF5),CD30,LMP,and activating NFKB,involved in the blockage of apoptotic pathway,overexpressed in Hodgkin's disease and EBV + lymphoid cells

Phenotypes From GWAS Catalog for TRAF1 Gene

Gene Ontology (GO) - Molecular Function for TRAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005164 tumor necrosis factor receptor binding IBA,IPI 11728344
GO:0005515 protein binding IPI 8069916
GO:0008270 zinc ion binding IEA --
GO:0031625 ubiquitin protein ligase binding IPI 11279055
GO:0031996 thioesterase binding IPI 11279055
genes like me logo Genes that share ontologies with TRAF1: view
genes like me logo Genes that share phenotypes with TRAF1: view

Animal Models for TRAF1 Gene

MGI Knock Outs for TRAF1:

miRNA for TRAF1 Gene

miRTarBase miRNAs that target TRAF1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRAF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRAF1 Gene

Localization for TRAF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAF1 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 4
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8069916
GO:0005829 cytosol TAS --
GO:0009898 cytoplasmic side of plasma membrane IBA 21873635
GO:0098802 plasma membrane receptor complex IBA 21873635
genes like me logo Genes that share ontologies with TRAF1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRAF1 Gene

Pathways & Interactions for TRAF1 Gene

PathCards logo

SuperPathways for TRAF1 Gene

SuperPathway Contained pathways
1 TNFR1 Pathway
.87
.46
.42
.40
.35
2 TNF signaling
3 4-1BB Pathway
.54
.54
.42
.37
4 Apoptosis Modulation and Signaling
.41
.31
5 RANK Signaling in Osteoclasts
.38
genes like me logo Genes that share pathways with TRAF1: view

Pathways by source for TRAF1 Gene

13 Qiagen pathways for TRAF1 Gene
  • 4-1BB Pathway
  • Apoptotic Pathways Triggered By HIV1
  • CD40 Signaling
  • Fas Signaling
  • GITR Pathway
2 Cell Signaling Technology pathways for TRAF1 Gene

SIGNOR curated interactions for TRAF1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TRAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS --
GO:0033209 tumor necrosis factor-mediated signaling pathway IBA 21873635
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with TRAF1: view

Drugs & Compounds for TRAF1 Gene

(10) Drugs for TRAF1 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adalimumab Approved, Experimental Pharma 623
Etanercept Approved, Investigational Pharma 468
Infliximab Approved Pharma 485
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0

(6) Additional Compounds for TRAF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRAF1: view

Transcripts for TRAF1 Gene

mRNA/cDNA for TRAF1 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRAF1

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF1 Gene

No ASD Table

Relevant External Links for TRAF1 Gene

GeneLoc Exon Structure for
TRAF1

Expression for TRAF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRAF1 Gene

This gene is overexpressed in Plasma (37.8), Lymph node (14.5), CD8 Tcells (7.0), and Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRAF1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRAF1

SOURCE GeneReport for Unigene cluster for TRAF1 Gene:

Hs.531251

Evidence on tissue expression from TISSUES for TRAF1 Gene

  • Spleen(4.5)
  • Nervous system(4.4)
  • Skin(4.4)
  • Stomach(4.3)
  • Lymph node(2.7)
  • Lung(2.5)
  • Blood(2.4)
  • Intestine(2.4)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with TRAF1: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAF1 Gene

Orthologs for TRAF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAF1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRAF1 29 30
  • 99.44 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TRAF1 29 30
  • 88.92 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Traf1 29 16 30
  • 85.62 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Traf1 29
  • 85.05 (n)
Dog
(Canis familiaris)
Mammalia TRAF1 29 30
  • 79.26 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TRAF1 30
  • 54 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TRAF1 30
  • 52 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TRAF1 29 30
  • 59.83 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TRAF1 30
  • 51 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii traf1 29 30
  • 55.62 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Traf-like 30
  • 14 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea trf-1 30
  • 17 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 47 (a)
ManyToMany
Species where no ortholog for TRAF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for TRAF1 Gene

ENSEMBL:
Gene Tree for TRAF1 (if available)
TreeFam:
Gene Tree for TRAF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRAF1: view image
Alliance of Genome Resources:
Additional Orthologs for TRAF1

Paralogs for TRAF1 Gene

Paralogs for TRAF1 Gene

(3) SIMAP similar genes for TRAF1 Gene using alignment to 1 proteins:

  • TRAF1_HUMAN
genes like me logo Genes that share paralogs with TRAF1: view

Variants for TRAF1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRAF1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs112060909 Benign: not provided 120,909,335(-) C/T
NM_005658.5(TRAF1):c.927G>A (p.Leu309=)
SYNONYMOUS
rs2239657 Benign: not specified 120,909,242(-) G/A
NM_005658.5(TRAF1):c.1020C>T (p.Pro340=)
SYNONYMOUS
rs372841168 Likely Benign: not provided 120,913,574(-) G/A
NM_005658.5(TRAF1):c.459C>T (p.Ala153=)
SYNONYMOUS
rs113495277 -- p.Met139Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TRAF1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TRAF1 Gene

Variant ID Type Subtype PubMed ID
esv2759713 CNV loss 17122850
nsv1051370 CNV gain 25217958
nsv6700 CNV insertion 18451855

Variation tolerance for TRAF1 Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.52; 55.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAF1
Leiden Open Variation Database (LOVD)
TRAF1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF1 Gene

Disorders for TRAF1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for TRAF1 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards
Search TRAF1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TRAF1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TRAF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAF1 Gene

Publications for TRAF1 Gene

  1. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. (PMID: 8069916) Rothe M … Goeddel DV (Cell 1994) 2 3 4 22
  2. Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. (PMID: 20385093) Zheng C … Wu H (Molecular cell 2010) 3 4 22
  3. Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese. (PMID: 19336421) Nishimoto K … Momohara S (Annals of the rheumatic diseases 2010) 3 22 40
  4. Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis. (PMID: 19674979) Hinks A … Thomson W (Annals of the rheumatic diseases 2010) 3 22 40
  5. Lack of association between TRAF1/C5 gene polymorphisms and biopsy-proven giant cell arteritis. (PMID: 19918040) Torres O … Gonzalez-Gay MA (The Journal of rheumatology 2010) 3 22 40

Products for TRAF1 Gene

Sources for TRAF1 Gene