Aliases for TRADD Gene
- TNFRSF1A Associated Via Death Domain 2 3 5
- Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein 3 4
- TNFRSF1A-Associated Via Death Domain 2 4
- Tumor Necrosis Factor Receptor Type 1 Associated Death Domain Protein 3
- Tumor Necrosis Factor Receptor-1-Associated Protein 3
- TNFR1-Associated Death Domain Protein 3
- TNFR1-Associated DEATH Domain Protein 4
- Hs.89862 3
External Ids for TRADD Gene
Previous GeneCards Identifiers for TRADD Gene
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRADD Gene
TRADD (TNFRSF1A Associated Via Death Domain) is a Protein Coding gene. Diseases associated with TRADD include Breast Cancer and Cone-Rod Dystrophy 2. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and ERK Signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding.
UniProtKB/Swiss-Prot Summary for TRADD Gene
The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.