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Aliases for TRADD Gene

Aliases for TRADD Gene

  • TNFRSF1A Associated Via Death Domain 2 3 5
  • TNFRSF1A-Associated Via Death Domain 2 4
  • Tumor Necrosis Factor Receptor Type 1 Associated Death Domain Protein 3
  • Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein 3
  • Tumor Necrosis Factor Receptor-1-Associated Protein 3
  • TNFR1-Associated Death Domain Protein 3
  • TNFR1-Associated DEATH Domain Protein 4
  • Hs.89862 3

External Ids for TRADD Gene

Previous GeneCards Identifiers for TRADD Gene

  • GC16M057882
  • GC16M067565
  • GC16M066923
  • GC16M066964
  • GC16M065745
  • GC16M067188
  • GC16M053061

Summaries for TRADD Gene

Entrez Gene Summary for TRADD Gene

  • The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRADD Gene

TRADD (TNFRSF1A Associated Via Death Domain) is a Protein Coding gene. Among its related pathways are Apoptosis Modulation and Signaling and Apoptosis and survival Caspase cascade. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein complex binding.

UniProtKB/Swiss-Prot for TRADD Gene

  • The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.

Gene Wiki entry for TRADD Gene

Additional gene information for TRADD Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRADD Gene

Genomics for TRADD Gene

GeneHancer (GH) Regulatory Elements for TRADD Gene

Promoters and enhancers for TRADD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I067157 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.9 858 4.6 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 FBXL8 TRADD ENSG00000260465 CTCF ZDHHC1 SLC12A4 ELMO3 THAP11 LRRC36 B3GNT9
GH16I068077 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18 -925.4 -925383 16 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC NFATC3 GC16M068083 PRMT7 CTCF EDC4 TRADD ZDHHC1 DPEP2 DUS2 E2F4
GH16I066899 Enhancer 1.4 Ensembl ENCODE dbSUPER 20.8 +259.6 259571 3.4 HDGF SMAD1 FOXA2 ARNT POLR2B ZNF766 REST ZNF592 KAT8 MEF2D CES2 CTCF E2F4 FBXL8 TRADD ZDHHC1 ENSG00000260465 RRAD FAM96B ENKD1
GH16I066547 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.1 +609.2 609247 6.6 MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF416 ZNF143 SP3 NFYC TK2 CKLF CKLF-CMTM1 PIR51465 PIR54425 ENSG00000275745 ENSG00000261519 NAE1 ZDHHC1 BEAN1
GH16I066603 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.9 +555.4 555424 3.6 HDGF PKNOX1 FOXA2 ARNT MLX ARID4B SIN3A DMAP1 ZNF766 ZNF143 CMTM3 TK2 BEAN1 ZDHHC1 ENSG00000260465 CTCF NAE1 TRADD FBXL8 CES2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRADD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRADD gene promoter:

Genomic Locations for TRADD Gene

Genomic Locations for TRADD Gene
chr16:67,154,180-67,160,298
(GRCh38/hg38)
Size:
6,119 bases
Orientation:
Minus strand
chr16:67,188,083-67,194,201
(GRCh37/hg19)

Genomic View for TRADD Gene

Genes around TRADD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRADD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRADD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRADD Gene

Proteins for TRADD Gene

  • Protein details for TRADD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15628-TRADD_HUMAN
    Recommended name:
    Tumor necrosis factor receptor type 1-associated DEATH domain protein
    Protein Accession:
    Q15628
    Secondary Accessions:
    • B2RDS3
    • B3KQZ9
    • Q52NZ1

    Protein attributes for TRADD Gene

    Size:
    312 amino acids
    Molecular mass:
    34247 Da
    Quaternary structure:
    • Stimulation of TNF-alpha receptor TNFRSF1A leads to the formation of two distinct signaling complexes. Plasma membrane-bound complex I is composed of TNFRSF1A, TRADD, RIPK1, TRAF2 and BIRC2/c-IAP1 or BIRC3 which interacts with CHUCK/IKK-alpha, IKBKB/IKK-beta and IKBKG/IKK-gamma promoting cell survival (PubMed:7758105, PubMed:8612133, PubMed:14585990, PubMed:21307340). Subsequently, TRADD, RIPK1 and TRAF2 dissociate from TNFRSF1A and form cytoplasmic complex II with FADD and caspase CASP8 promoting cell apoptosis (PubMed:21307340). Within complex I, interacts with TNFRSF1A/TNFR1, TRAF2 and kinase RIPK1 (PubMed:7758105, PubMed:10892748, PubMed:8612133). Within complex I, interacts with TRPC4AP; the interaction promotes NF-kappa B activation (PubMed:14585990). UXT1 associates with complex I; the interaction prevents the formation of complex II (PubMed:21307340). Within complex I Interacts with scaffold protein DAB2IP (PubMed:15310755). Interacts with autophagy receptor SQSTM1 (PubMed:10356400). Interacts with E3 ligase TRIP12 (By similarity). Interacts with kinase HIPK2 (PubMed:11032752). Interacts with keratin KRT14 (PubMed:11684708). Interacts with keratin KRT18 (PubMed:11684708). Interacts with keratins KRT16 and KRT17 (By similarity).
    SequenceCaution:
    • Sequence=AAA98482.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRADD Gene

    Alternative splice isoforms for TRADD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRADD Gene

Post-translational modifications for TRADD Gene

No Post-translational modifications

Other Protein References for TRADD Gene

No data available for DME Specific Peptides for TRADD Gene

Domains & Families for TRADD Gene

Gene Families for TRADD Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TRADD Gene

Suggested Antigen Peptide Sequences for TRADD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15628

UniProtKB/Swiss-Prot:

TRADD_HUMAN :
  • Requires the intact death domain to associate with TNFRSF1A/TNFR1.
Domain:
  • Requires the intact death domain to associate with TNFRSF1A/TNFR1.
genes like me logo Genes that share domains with TRADD: view

Function for TRADD Gene

Molecular function for TRADD Gene

GENATLAS Biochemistry:
tumor necrosis receptor 1,associated protein interacting with cytoplasmic domain of TNFRSF1A,mediating programmed cell death apoptosis and activating NF-Kappa B distinctly
UniProtKB/Swiss-Prot Function:
The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.

Phenotypes From GWAS Catalog for TRADD Gene

Gene Ontology (GO) - Molecular Function for TRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 1040062
GO:0019900 kinase binding IPI 8612133
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with TRADD: view
genes like me logo Genes that share phenotypes with TRADD: view

Animal Models for TRADD Gene

MGI Knock Outs for TRADD:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRADD Gene

Localization for TRADD Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRADD Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRADD gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 4
cytoskeleton 3
extracellular 2
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IDA 11684708
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA 22510408
genes like me logo Genes that share ontologies with TRADD: view

Pathways & Interactions for TRADD Gene

genes like me logo Genes that share pathways with TRADD: view

SIGNOR curated interactions for TRADD Gene

Gene Ontology (GO) - Biological Process for TRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 7758105
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0007165 signal transduction TAS 7758105
GO:0007249 I-kappaB kinase/NF-kappaB signaling TAS --
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors TAS 8612133
genes like me logo Genes that share ontologies with TRADD: view

Drugs & Compounds for TRADD Gene

(3) Drugs for TRADD Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TRADD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRADD: view

Transcripts for TRADD Gene

Unigene Clusters for TRADD Gene

TNFRSF1A-associated via death domain:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRADD Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - - -
SP2: - -
SP3: - -
SP4:

Relevant External Links for TRADD Gene

GeneLoc Exon Structure for
TRADD
ECgene alternative splicing isoforms for
TRADD

Expression for TRADD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRADD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRADD Gene

This gene is overexpressed in Bone (13.1), Peripheral blood mononuclear cells (10.1), and Lymph node (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRADD Gene



Protein tissue co-expression partners for TRADD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRADD Gene:

TRADD

SOURCE GeneReport for Unigene cluster for TRADD Gene:

Hs.460996

mRNA Expression by UniProt/SwissProt for TRADD Gene:

Q15628-TRADD_HUMAN
Tissue specificity: Found in all examined tissues.

Evidence on tissue expression from TISSUES for TRADD Gene

  • Nervous system(4.3)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with TRADD: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRADD Gene

Orthologs for TRADD Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRADD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRADD 33 34
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia TRADD 33 34
  • 86.86 (n)
cow
(Bos Taurus)
Mammalia TRADD 33 34
  • 84.99 (n)
mouse
(Mus musculus)
Mammalia Tradd 33 16 34
  • 80.11 (n)
rat
(Rattus norvegicus)
Mammalia Tradd 33
  • 79.78 (n)
oppossum
(Monodelphis domestica)
Mammalia TRADD 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRADD 33 34
  • 57.67 (n)
lizard
(Anolis carolinensis)
Reptilia TRADD 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tradd 33
  • 48.78 (n)
zebrafish
(Danio rerio)
Actinopterygii tradd 33 34
  • 49.81 (n)
Species where no ortholog for TRADD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRADD Gene

ENSEMBL:
Gene Tree for TRADD (if available)
TreeFam:
Gene Tree for TRADD (if available)

Paralogs for TRADD Gene

No data available for Paralogs for TRADD Gene

Variants for TRADD Gene

Sequence variations from dbSNP and Humsavar for TRADD Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000134243 -- 67,157,605(-) A/C intron_variant
rs1000270435 -- 67,157,283(-) C/T intron_variant
rs1000371785 -- 67,155,968(-) C/T 5_prime_UTR_variant, intron_variant
rs1000879920 -- 67,161,279(-) A/G upstream_transcript_variant
rs1001230278 -- 67,161,479(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TRADD Gene

Variant ID Type Subtype PubMed ID
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv827707 CNV loss 20364138
nsv952044 CNV deletion 24416366

Variation tolerance for TRADD Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRADD Gene

Human Gene Mutation Database (HGMD)
TRADD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRADD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRADD Gene

Disorders for TRADD Gene

Additional Disease Information for TRADD

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TRADD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRADD Gene

Publications for TRADD Gene

  1. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. (PMID: 7758105) Hsu H … Goeddel DV (Cell 1995) 2 3 4 22 58
  2. Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma. (PMID: 18990758) Cerhan JR … Slager SL (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 22 44 58
  3. AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation. (PMID: 15310755) Zhang H … Min W (The Journal of biological chemistry 2004) 3 4 22 58
  4. Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD. (PMID: 11684708) Inada H … Inagaki M (The Journal of cell biology 2001) 3 4 22 58
  5. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. (PMID: 8612133) Hsu H … Goeddel DV (Immunity 1996) 3 4 22 58

Products for TRADD Gene

Sources for TRADD Gene

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