Aliases for TRADD Gene
- TNFRSF1A Associated Via Death Domain 2 3 5
- TNFRSF1A-Associated Via Death Domain 2 4
- Tumor Necrosis Factor Receptor Type 1 Associated Death Domain Protein 3
- Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein 3
- Tumor Necrosis Factor Receptor-1-Associated Protein 3
- TNFR1-Associated Death Domain Protein 3
- TNFR1-Associated DEATH Domain Protein 4
- Hs.89862 3
External Ids for TRADD Gene
Previous GeneCards Identifiers for TRADD Gene
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRADD Gene
TRADD (TNFRSF1A Associated Via Death Domain) is a Protein Coding gene. Among its related pathways are Apoptosis Modulation and Signaling and Apoptosis and survival Caspase cascade. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein complex binding.
UniProtKB/Swiss-Prot for TRADD Gene
The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.