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Aliases for TRABD2B Gene

Aliases for TRABD2B Gene

  • TraB Domain Containing 2B 2 3 5
  • Heart, Kidney And Adipose-Enriched Transmembrane Protein Homolog 3 4
  • TRAB Domain-Containing Protein 2B 3 4
  • TIKI2 3 4
  • Metalloprotease TIKI2 3
  • UPF0632 Protein A 3
  • EC 3.4.-.- 4
  • HKAT 4

External Ids for TRABD2B Gene

Previous GeneCards Identifiers for TRABD2B Gene

  • GC01M048238

Summaries for TRABD2B Gene

GeneCards Summary for TRABD2B Gene

TRABD2B (TraB Domain Containing 2B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and Wnt-protein binding. An important paralog of this gene is TRABD2A.

UniProtKB/Swiss-Prot for TRABD2B Gene

  • Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.

Additional gene information for TRABD2B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRABD2B Gene

Genomics for TRABD2B Gene

GeneHancer (GH) Regulatory Elements for TRABD2B Gene

Promoters and enhancers for TRABD2B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I047996 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.0 2 1.9 SIN3A ZNF2 YY1 GLIS2 ARID2 ZNF143 DEK ZNF263 SP3 REST TRABD2B SLC5A9 GC01M047950 PIR61209
GH01I047932 Enhancer 1 Ensembl ENCODE 5.7 +63.6 63565 2.8 GLIS2 ZNF366 ZSCAN5C EGR2 USF2 CEBPB ZEB2 TSHZ1 ZNF843 ZFP69B TRABD2B PIR61209 GC01M047950 GC01P047902
GH01I047870 Enhancer 1 Ensembl ENCODE 5 +125.1 125070 3 NFIB ZNF133 KLF17 RAD21 RARA GLIS2 SCRT2 FOS EGR2 ZEB2 TRABD2B GC01P047902 ENSG00000225028
GH01I047848 Enhancer 0.5 ENCODE 5.4 +148.1 148090 1.3 POLR2A HLF RCOR1 CHD2 TRABD2B ENSG00000225028 GC01P047902
GH01I047938 Enhancer 0.2 ENCODE 5.3 +58.7 58665 1.1 TRABD2B GC01M047950 PIR61209 GC01P047902
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRABD2B on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRABD2B Gene

Genomic Locations for TRABD2B Gene
236,844 bases
Minus strand

Genomic View for TRABD2B Gene

Genes around TRABD2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRABD2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRABD2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRABD2B Gene

Proteins for TRABD2B Gene

  • Protein details for TRABD2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metalloprotease TIKI2
    Protein Accession:
    Secondary Accessions:
    • I6U4Y0

    Protein attributes for TRABD2B Gene

    517 amino acids
    Molecular mass:
    57421 Da
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828;
    Quaternary structure:
    No Data Available
    • Was named TIKI in reference to large-headed humanoid in Polynesian mythology.

neXtProt entry for TRABD2B Gene

Post-translational modifications for TRABD2B Gene

  • Glycosylation at isoforms=228 and isoforms=335
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRABD2B Gene

Domains & Families for TRABD2B Gene

Gene Families for TRABD2B Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for TRABD2B Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TIKI family.
  • Belongs to the TIKI family.
genes like me logo Genes that share domains with TRABD2B: view

No data available for Suggested Antigen Peptide Sequences for TRABD2B Gene

Function for TRABD2B Gene

Molecular function for TRABD2B Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by 1,10-phenanthroline, a metalloprotease inhibitor which is a divalent metal chelator. Also inhibited by EDTA. Not inhibited by Bestatin, an aminopeptidase inhibitor, nor to a mixture of inhibitors for serine, cysteine, and aspartic proteases and aminopeptidases.
UniProtKB/Swiss-Prot Function:
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.

Enzyme Numbers (IUBMB) for TRABD2B Gene

Phenotypes From GWAS Catalog for TRABD2B Gene

Gene Ontology (GO) - Molecular Function for TRABD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IDA 22726442
GO:0005515 protein binding IPI 22726442
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TRABD2B: view

Phenotypes for TRABD2B Gene

GenomeRNAi human phenotypes for TRABD2B:
genes like me logo Genes that share phenotypes with TRABD2B: view

miRNA for TRABD2B Gene

miRTarBase miRNAs that target TRABD2B

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRABD2B Gene

Localization for TRABD2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRABD2B Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRABD2B gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for TRABD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IDA 22726442
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031301 integral component of organelle membrane IDA 22726442
genes like me logo Genes that share ontologies with TRABD2B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRABD2B Gene

Pathways & Interactions for TRABD2B Gene

SuperPathways for TRABD2B Gene

No Data Available

Interacting Proteins for TRABD2B Gene

Selected Interacting proteins: A6NFA1-TIKI2_HUMAN for TRABD2B Gene via UniProtKB

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TRABD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 22726442
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway IDA 22726442
GO:0032461 positive regulation of protein oligomerization IDA 22726442
GO:1904808 positive regulation of protein oxidation IDA 22726442
genes like me logo Genes that share ontologies with TRABD2B: view

No data available for Pathways by source and SIGNOR curated interactions for TRABD2B Gene

Drugs & Compounds for TRABD2B Gene

No Compound Related Data Available

Transcripts for TRABD2B Gene

mRNA/cDNA for TRABD2B Gene

Unigene Clusters for TRABD2B Gene

TraB domain containing 2B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRABD2B Gene

No ASD Table

Relevant External Links for TRABD2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRABD2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRABD2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRABD2B Gene

This gene is overexpressed in Artery - Tibial (x9.3), Artery - Coronary (x7.0), Kidney - Cortex (x5.5), and Artery - Aorta (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of TRABD2B Gene:


SOURCE GeneReport for Unigene cluster for TRABD2B Gene:

genes like me logo Genes that share expression patterns with TRABD2B: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRABD2B Gene

Orthologs for TRABD2B Gene

This gene was present in the common ancestor of animals.

Orthologs for TRABD2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRABD2B 33
  • 99.29 (n)
(Bos Taurus)
Mammalia TRABD2B 33
  • 87.99 (n)
(Rattus norvegicus)
Mammalia Trabd2b 33
  • 85.89 (n)
(Mus musculus)
Mammalia Trabd2b 33 16 34
  • 85.75 (n)
(Canis familiaris)
Mammalia TRABD2B 33 34
  • 85.74 (n)
(Monodelphis domestica)
Mammalia TRABD2B 34
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia TRABD2B 34
  • 69 (a)
(Gallus gallus)
Aves TRABD2B 33 34
  • 73.37 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 68 (a)
-- 34
  • 55 (a)
(Danio rerio)
Actinopterygii LOC566028 33
  • 68.98 (n)
  • 58 (a)
(Caenorhabditis elegans)
Secernentea C05G5.5 33 34
  • 42.84 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
Species where no ortholog for TRABD2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRABD2B Gene

Gene Tree for TRABD2B (if available)
Gene Tree for TRABD2B (if available)

Paralogs for TRABD2B Gene

Paralogs for TRABD2B Gene

(1) SIMAP similar genes for TRABD2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRABD2B: view

Variants for TRABD2B Gene

Sequence variations from dbSNP and Humsavar for TRABD2B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000051836 -- 47,812,588(-) A/C intron_variant
rs1000059633 -- 47,908,944(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000070687 -- 47,771,824(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000077716 -- 47,827,298(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000099261 -- 47,851,863(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRABD2B Gene

Variant ID Type Subtype PubMed ID
esv1265813 CNV deletion 17803354
esv2671445 CNV deletion 23128226
esv3577840 CNV loss 25503493
esv3585959 CNV gain 21293372
esv3585961 CNV loss 21293372
esv3585962 CNV loss 21293372
nsv1001126 CNV gain 25217958
nsv1003161 CNV loss 25217958
nsv1113115 CNV deletion 24896259
nsv1122341 CNV deletion 24896259
nsv1126198 CNV deletion 24896259
nsv461450 CNV loss 19166990
nsv511691 CNV loss 21212237
nsv546191 CNV loss 21841781
nsv766 CNV insertion 18451855
nsv829760 CNV loss 17160897
nsv998583 CNV gain 25217958

Variation tolerance for TRABD2B Gene

Gene Damage Index Score: 5.35; 70.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRABD2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRABD2B Gene

Disorders for TRABD2B Gene

Additional Disease Information for TRABD2B

No disorders were found for TRABD2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRABD2B Gene

Publications for TRABD2B Gene

  1. Expression and evolution of the Tiki1 and Tiki2 genes in vertebrates. (PMID: 25354456) Reis AH … He XI (The International journal of developmental biology 2014) 2 3 58
  2. Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. (PMID: 22726442) Zhang X … He X (Cell 2012) 3 4 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Characterization of Tiki, a New Family of Wnt-specific Metalloproteases. (PMID: 26631728) Zhang X … He X (The Journal of biological chemistry 2016) 3 58
  5. TIKI2 is upregulated and plays an oncogenic role in renal cell carcinoma. (PMID: 26942462) Yuan X … Huang Y (Oncotarget 2016) 3 58

Products for TRABD2B Gene

Sources for TRABD2B Gene

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