Aliases for TRABD2A Gene
External Ids for TRABD2A Gene
Previous HGNC Symbols for TRABD2A Gene
Previous GeneCards Identifiers for TRABD2A Gene
GeneCards Summary for TRABD2A Gene
TRABD2A (TraB Domain Containing 2A) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and Wnt-protein binding. An important paralog of this gene is TRABD2B.
UniProtKB/Swiss-Prot for TRABD2A Gene
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.