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Aliases for TRABD2A Gene

Aliases for TRABD2A Gene

  • TraB Domain Containing 2A 2 3 5
  • TRAB Domain-Containing Protein 2A 3 4
  • C2orf89 3 4
  • TIKI1 3 4
  • Chromosome 2 Open Reading Frame 89 2
  • UPF0632 Protein C2orf89 3
  • Metalloprotease TIKI1 3
  • EC 3.4.-.- 4

External Ids for TRABD2A Gene

Previous HGNC Symbols for TRABD2A Gene

  • C2orf89

Previous GeneCards Identifiers for TRABD2A Gene

  • GC02M085049

Summaries for TRABD2A Gene

GeneCards Summary for TRABD2A Gene

TRABD2A (TraB Domain Containing 2A) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and Wnt-protein binding. An important paralog of this gene is TRABD2B.

UniProtKB/Swiss-Prot for TRABD2A Gene

  • Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.

Additional gene information for TRABD2A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRABD2A Gene

Genomics for TRABD2A Gene

GeneHancer (GH) Regulatory Elements for TRABD2A Gene

Promoters and enhancers for TRABD2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I084904 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 560.2 +0.0 8 5.6 HDGF SMAD1 FOXA2 MLX ARID4B SIN3A YBX1 DMAP1 SLC30A9 POLR2B TRABD2A LOC105374836 TMSB10 USP39 TCF7L1 ELMOD3 C2orf68 LOC100996506 VAMP8 GC02P084898
GH02I084878 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 558.5 +26.3 26261 4.2 PKNOX1 ARID4B SIN3A ZNF2 IRF4 BRCA1 ZNF48 ZNF121 ZNF143 RUNX3 TRABD2A GC02P084874 LOC105374837
GH02I084842 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 22.7 +61.4 61391 5.5 STAT1 NFE2 ATF2 TRABD2A RPS2P17 DNAH6 RN7SL113P ENSG00000276362 GC02P084793
GH02I084856 Enhancer 1.1 Ensembl ENCODE dbSUPER 20.7 +49.8 49820 0.7 ESRRA KLF1 ATF1 FOXA2 BACH1 ZBTB40 FOSL1 CTBP1 MTA3 VEZF1 GC02P084858 TRABD2A RPS2P17 ENSG00000276362
GH02I084956 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -51.9 -51869 4.7 FOXA2 SIN3A FEZF1 GTF3C2 SLC30A9 GLIS2 E2F8 ATF7 FOS DEK RPS2P17 TRABD2A GC02M084965 LOC105374838 GC02M084928 GC02M084958
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRABD2A on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRABD2A Gene

Genomic Locations for TRABD2A Gene
chr2:84,821,650-84,907,008
(GRCh38/hg38)
Size:
85,359 bases
Orientation:
Minus strand
chr2:85,048,774-85,134,132
(GRCh37/hg19)

Genomic View for TRABD2A Gene

Genes around TRABD2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRABD2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRABD2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRABD2A Gene

Proteins for TRABD2A Gene

  • Protein details for TRABD2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V40-TIKI1_HUMAN
    Recommended name:
    Metalloprotease TIKI1
    Protein Accession:
    Q86V40
    Secondary Accessions:
    • B4DKK8
    • I6UMB9

    Protein attributes for TRABD2A Gene

    Size:
    505 amino acids
    Molecular mass:
    57676 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Was named TIKI in reference to large-headed humanoid in Polynesian mythology.
    SequenceCaution:
    • Sequence=AAH51789.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRABD2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRABD2A Gene

Post-translational modifications for TRABD2A Gene

  • Glycosylation at posLast=220220, isoforms=229, isoforms=2278, and isoforms=2336

Other Protein References for TRABD2A Gene

No data available for DME Specific Peptides for TRABD2A Gene

Domains & Families for TRABD2A Gene

Gene Families for TRABD2A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TRABD2A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRABD2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86V40

UniProtKB/Swiss-Prot:

TIKI1_HUMAN :
  • Belongs to the TIKI family.
Family:
  • Belongs to the TIKI family.
genes like me logo Genes that share domains with TRABD2A: view

Function for TRABD2A Gene

Molecular function for TRABD2A Gene

UniProtKB/Swiss-Prot Function:
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.

Enzyme Numbers (IUBMB) for TRABD2A Gene

Gene Ontology (GO) - Molecular Function for TRABD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 22726442
GO:0004222 metalloendopeptidase activity ISS 22726442
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TRABD2A: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRABD2A Gene

Localization for TRABD2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRABD2A Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRABD2A gene
Compartment Confidence
plasma membrane 5
golgi apparatus 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TRABD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IDA 22726442
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031301 integral component of organelle membrane IDA 22726442
genes like me logo Genes that share ontologies with TRABD2A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRABD2A Gene

Pathways & Interactions for TRABD2A Gene

genes like me logo Genes that share pathways with TRABD2A: view

Pathways by source for TRABD2A Gene

1 R&D Systems pathway for TRABD2A Gene

Interacting Proteins for TRABD2A Gene

Gene Ontology (GO) - Biological Process for TRABD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 22726442
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway IDA 22726442
GO:0032461 positive regulation of protein oligomerization ISS 22726442
GO:0060322 head development ISS --
genes like me logo Genes that share ontologies with TRABD2A: view

No data available for SIGNOR curated interactions for TRABD2A Gene

Drugs & Compounds for TRABD2A Gene

No Compound Related Data Available

Transcripts for TRABD2A Gene

Unigene Clusters for TRABD2A Gene

TraB domain containing 2A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRABD2A Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - -
SP5: -
SP6: - - - - -
SP7: - - -
SP8: - - -
SP9:

Relevant External Links for TRABD2A Gene

GeneLoc Exon Structure for
TRABD2A
ECgene alternative splicing isoforms for
TRABD2A

Expression for TRABD2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRABD2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRABD2A Gene

This gene is overexpressed in Colon - Transverse (x13.9), Ovary (x10.2), and Whole Blood (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRABD2A Gene



NURSA nuclear receptor signaling pathways regulating expression of TRABD2A Gene:

TRABD2A

SOURCE GeneReport for Unigene cluster for TRABD2A Gene:

Hs.469134

Evidence on tissue expression from TISSUES for TRABD2A Gene

  • Intestine(4.4)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with TRABD2A: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRABD2A Gene

Orthologs for TRABD2A Gene

This gene was present in the common ancestor of animals.

Orthologs for TRABD2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRABD2A 33 34
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia TRABD2A 33 34
  • 86.04 (n)
oppossum
(Monodelphis domestica)
Mammalia TRABD2A 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRABD2A 33 34
  • 71.56 (n)
lizard
(Anolis carolinensis)
Reptilia TRABD2A 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trabd2a 33
  • 64.35 (n)
zebrafish
(Danio rerio)
Actinopterygii wu:fc66h01 33 34
  • 72.16 (n)
worm
(Caenorhabditis elegans)
Secernentea C05G5.5 34
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToMany
Species where no ortholog for TRABD2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRABD2A Gene

ENSEMBL:
Gene Tree for TRABD2A (if available)
TreeFam:
Gene Tree for TRABD2A (if available)

Paralogs for TRABD2A Gene

Paralogs for TRABD2A Gene

(1) SIMAP similar genes for TRABD2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TRABD2A: view

Variants for TRABD2A Gene

Sequence variations from dbSNP and Humsavar for TRABD2A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000007927 -- 84,840,794(-) T/C intron_variant
rs1000010704 -- 84,833,347(-) A/T genic_downstream_transcript_variant, intron_variant
rs1000044367 -- 84,873,848(-) C/T intron_variant
rs1000100003 -- 84,869,242(-) T/C intron_variant
rs1000190569 -- 84,840,228(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRABD2A Gene

Variant ID Type Subtype PubMed ID
nsv961799 CNV duplication 23825009
nsv527911 CNV loss 19592680
nsv527061 CNV loss 19592680
esv3591522 CNV loss 21293372
esv3583913 CNV loss 25503493
esv2720287 CNV deletion 23290073
esv2720286 CNV deletion 23290073

Variation tolerance for TRABD2A Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.10; 75.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRABD2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRABD2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRABD2A Gene

Disorders for TRABD2A Gene

Additional Disease Information for TRABD2A

No disorders were found for TRABD2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRABD2A Gene

Publications for TRABD2A Gene

  1. Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. (PMID: 22726442) Zhang X … He X (Cell 2012) 2 3 4 58
  2. Expression and evolution of the Tiki1 and Tiki2 genes in vertebrates. (PMID: 25354456) Reis AH … He XI (The International journal of developmental biology 2014) 2 3 58
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for TRABD2A Gene

Sources for TRABD2A Gene

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