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This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] See more...
Aliases for TRA2B Gene
Aliases for TRA2B Gene
External Ids for TRA2B Gene
- HGNC: 10781
- Entrez Gene: 6434
- Ensembl: ENSG00000136527
- OMIM: 602719
- UniProtKB: P62995
Previous HGNC Symbols for TRA2B Gene
- SFRS10
Previous GeneCards Identifiers for TRA2B Gene
- GC03M187110
- GC03M185632
- GC03M183042
Summaries for TRA2B Gene
-
This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
GeneCards Summary for TRA2B Gene
TRA2B (Transformer 2 Beta Homolog) is a Protein Coding gene. Diseases associated with TRA2B include Frontotemporal Dementia and Spinal Muscular Atrophy. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is TRA2A.
UniProtKB/Swiss-Prot Summary for TRA2B Gene
-
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.
Additional gene information for TRA2B Gene
- HGNC(10781)
- Entrez Gene(6434)
- Ensembl(ENSG00000136527)
- OMIM(602719)
- UniProtKB(P62995)
- Open Targets Platform(ENSG00000136527)
- Search for TRA2B at DataMed
- Search for TRA2B at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRA2B Gene
Genomics for TRA2B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TRA2B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TRA2B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRA2B
- Top Transcription factor binding sites by QIAGEN in the TRA2B gene promoter:
-
- ATF-2
- Bach2
- CUTL1
- FOXI1
- HFH-3
- MRF-2
- p53
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
Genomic Locations for TRA2B Gene
Genomic Locations for TRA2B Gene
- chr3:185,914,558-185,938,103
- (GRCh38/hg38)
- Size:
- 23,546 bases
- Orientation:
- Minus strand
- chr3:185,632,356-185,655,924
- (GRCh37/hg19)
- Size:
- 23,569 bases
- Orientation:
- Minus strand
Genomic View for TRA2B Gene
Genes around TRA2B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q27.2 by HGNC
- 3q27.2 by Entrez Gene
- 3q27.2 by Ensembl
TRA2B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRA2B Gene
Proteins for TRA2B Gene
-
Protein details for TRA2B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62995-TRA2B_HUMAN
- Recommended name:
- Transformer-2 protein homolog beta
- Protein Accession:
- P62995
- B4DVK2
- D3DNU3
- O15449
- Q15815
- Q64283
Protein attributes for TRA2B Gene
- Size:
- 288 amino acids
- Molecular mass:
- 33666 Da
- Quaternary structure:
-
- Interacts with SAFB/SAFB1 (By similarity). Found in a pre-mRNA exonic splicing enhancer (ESE) complex with TRA2B/SFRS10, SNRNP70, SNRPA1 and SRRM1. Binds to A3 enhancer proteins SFRS4, SFRS5, SFRS6 and SFRS9. Interacts with CPSF6, RBMY1A1, RBMX, RNPS1 and phosphorylated SFRS13A.
Three dimensional structures from OCA and Proteopedia for TRA2B Gene
Alternative splice isoforms for TRA2B Gene
- UniProtKB/Swiss-Prot:
Protein Expression for TRA2B Gene
Post-translational modifications for TRA2B Gene
- Phosphorylated in the RS domains.
- Dimethylation at Arg-241 is probably asymmetric.
-
Ubiquitination at Lys140 and Lys197
- NX_P62995 (NX_P62995-1)
- Modification sites at PhosphoSitePlus
Other Protein References for TRA2B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TRA2B
- Novus Biologicals Antibodies for TRA2B
-
Abcam antibodies for TRA2B
- Invitrogen Antibodies for TRA2B (AFLGC-TRA2B)
-
Santa Cruz Biotechnology (SCBT) Antibodies for TRA2B
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for TRA2B
- Origene Custom Protein Services for TRA2B
- antibodies-online: Show 8 available TRA2B Proteins ranked by validation data
- Compare Top TRA2B Proteins
-
Quality Products:
-
Abcam proteins for TRA2B
Assay Products
- antibodies-online: Show 5 available TRA2B Elisa Kits ranked by validation data
- Compare Top TRA2B Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for TRA2B Gene
Domains & Families for TRA2B Gene
Gene Families for TRA2B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for TRA2B Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TRA2B Gene
- GenScript: Design optimal peptide antigens:
-
- Transformer-2 protein homolog B (TRA2B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P62995- Family:
-
- Belongs to the splicing factor SR family.
Function for TRA2B Gene
Molecular function for TRA2B Gene
- UniProtKB/Swiss-Prot Function:
- Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.
Phenotypes From GWAS Catalog for TRA2B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IBA,IMP | 10749975 |
| GO:0003729 | mRNA binding | IDA | 12165565 |
| GO:0005515 | protein binding | IPI | 10749975 |
| GO:0019904 | protein domain specific binding | IPI | 10749975 |
Phenotypes for TRA2B Gene
- MGI mutant phenotypes for TRA2B:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for TRA2B:
Animal Models for TRA2B Gene
- MGI Knock Outs for TRA2B:
-
- Tra2b Tra2b<tm1.2Bwir>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRA2B - Select products 50% OFF >
- * TRA2B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TRA2B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRA2B
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRA2B
miRNA for TRA2B Gene
- miRTarBase miRNAs that target TRA2B
-
- hsa-miR-10a-5p (MIRT006537)
- hsa-miR-10b-5p (MIRT006538)
- hsa-miR-1-3p (MIRT024099)
- hsa-miR-378a-3p (MIRT043884)
- hsa-miR-30c-5p (MIRT047840)
- hsa-miR-196a-5p (MIRT048194)
- hsa-miR-17-5p (MIRT050923)
- hsa-let-7c-3p (MIRT355011)
- hsa-miR-3591-5p (MIRT444559)
- hsa-miR-921 (MIRT444560)
- hsa-miR-3606-5p (MIRT444561)
- hsa-miR-145-3p (MIRT444562)
- hsa-miR-27b-5p (MIRT444563)
- hsa-miR-539-5p (MIRT444564)
- hsa-miR-3174 (MIRT444565)
- hsa-miR-590-3p (MIRT444566)
- hsa-miR-4282 (MIRT444567)
- hsa-miR-190b (MIRT520515)
- hsa-miR-190a-5p (MIRT520516)
- hsa-miR-559 (MIRT520517)
- hsa-miR-548y (MIRT520518)
- hsa-miR-548w (MIRT520519)
- hsa-miR-548o-5p (MIRT520520)
- hsa-miR-548j-5p (MIRT520521)
- hsa-miR-548i (MIRT520522)
- hsa-miR-548h-5p (MIRT520523)
- hsa-miR-548d-5p (MIRT520524)
- hsa-miR-548c-5p (MIRT520525)
- hsa-miR-548bb-5p (MIRT520526)
- hsa-miR-548b-5p (MIRT520527)
- hsa-miR-548ay-5p (MIRT520528)
- hsa-miR-548au-5p (MIRT520529)
- hsa-miR-548as-5p (MIRT520530)
- hsa-miR-548ar-5p (MIRT520531)
- hsa-miR-548aq-5p (MIRT520532)
- hsa-miR-548ap-5p (MIRT520533)
- hsa-miR-548am-5p (MIRT520534)
- hsa-miR-548ak (MIRT520535)
- hsa-miR-548ae-5p (MIRT520536)
- hsa-miR-548ad-5p (MIRT520537)
- hsa-miR-548ab (MIRT520538)
- hsa-miR-548a-5p (MIRT520539)
- hsa-miR-548n (MIRT520540)
- hsa-miR-548c-3p (MIRT520541)
- hsa-miR-493-5p (MIRT565242)
- hsa-let-7g-3p (MIRT565243)
- hsa-let-7a-2-3p (MIRT565244)
- hsa-miR-4670-3p (MIRT565245)
- hsa-miR-338-5p (MIRT565246)
- hsa-miR-1252-3p (MIRT565247)
- hsa-miR-3646 (MIRT565248)
- hsa-miR-548z (MIRT565249)
- hsa-miR-548h-3p (MIRT565250)
- hsa-miR-548d-3p (MIRT565251)
- hsa-miR-548bb-3p (MIRT565252)
- hsa-miR-548ac (MIRT565253)
- hsa-miR-362-3p (MIRT609594)
- hsa-miR-329-3p (MIRT609595)
- hsa-miR-8485 (MIRT609596)
- hsa-miR-497-3p (MIRT613533)
- hsa-miR-548t-3p (MIRT613534)
- hsa-miR-548ap-3p (MIRT613535)
- hsa-miR-548aa (MIRT613536)
- hsa-miR-3613-3p (MIRT652240)
- hsa-miR-6818-3p (MIRT707132)
- hsa-miR-4684-5p (MIRT707133)
- hsa-miR-6715b-3p (MIRT707134)
- hsa-miR-593-3p (MIRT707135)
- hsa-miR-6895-3p (MIRT707136)
- hsa-miR-5699-3p (MIRT707137)
- hsa-miR-4421 (MIRT707138)
- hsa-miR-339-5p (MIRT707139)
- hsa-miR-6715a-3p (MIRT707140)
- hsa-miR-6732-3p (MIRT707141)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRA2B
- Browse OriGene Inhibitory RNA Products For TRA2B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRA2B
Clone Products
- Applied Biological Materials (abm): Clones for TRA2B - Select products 50% OFF >
- * TRA2B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG202755
- MG203931
- MR202755
- MR202755L3
- MR202755L4
- MR203931
- MR203931L3
- MR203931L4
- RC201542
- RC201542L1
- RC201542L2
- RC201542L3
- RC201542L4
- RC233393
- RG201542
- RG233393
- RR200909
- RR200909L3
- RR200909L4
- MR202755L3V
- MR202755L4V
- MR203931L3V
- MR203931L4V
- RC201542L1V
- RC201542L2V
- RC201542L3V
- RC201542L4V
- RR200909L3V
- RR200909L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TRA2B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRA2B
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRA2B Gene
Localization for TRA2B Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRA2B Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Nucleoplasm (4)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005623 | cell | IEA | -- |
| GO:0005634 | nucleus | IBA,IDA | 9546399 |
| GO:0005637 | nuclear inner membrane | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005681 | spliceosomal complex | IMP | 25689357 |
Pathways & Interactions for TRA2B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.47
.41
|
| 2 | Gene Expression |
.48
|
|
Pathways by source for TRA2B Gene
1 BioSystems pathway for TRA2B Gene
4 Reactome pathways for TRA2B Gene
1 KEGG pathway for TRA2B Gene
Interacting Proteins for TRA2B Gene
Selected Interacting proteins:
P62995-TRA2B_HUMAN
ENSP00000416959
for TRA2B Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TRA2B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000302 | response to reactive oxygen species | IEA | -- |
| GO:0000375 | RNA splicing, via transesterification reactions | TAS | 9546399 |
| GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | IMP | 25689357 |
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006397 | mRNA processing | IEA | -- |
No data available for SIGNOR curated interactions for TRA2B Gene
Transcripts for TRA2B Gene
mRNA/cDNA for TRA2B Gene
- 2 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000259043 943 nts (view in UCSC)
- ENST00000342294 288 nts (view in UCSC)
- ENST00000382191 976 nts (view in UCSC)
- ENST00000414862 710 nts (view in UCSC)
- ENST00000453386 4178 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRA2B - Select products 50% OFF >
- * TRA2B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TRA2B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRA2B
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRA2B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRA2B
- Browse OriGene Inhibitory RNA Products For TRA2B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRA2B
Clone Products
- Applied Biological Materials (abm): Clones for TRA2B - Select products 50% OFF >
- * TRA2B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG202755
- MG203931
- MR202755
- MR202755L3
- MR202755L4
- MR203931
- MR203931L3
- MR203931L4
- RC201542
- RC201542L1
- RC201542L2
- RC201542L3
- RC201542L4
- RC233393
- RG201542
- RG233393
- RR200909
- RR200909L3
- RR200909L4
- MR202755L3V
- MR202755L4V
- MR203931L3V
- MR203931L4V
- RC201542L1V
- RC201542L2V
- RC201542L3V
- RC201542L4V
- RR200909L3V
- RR200909L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TRA2B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRA2B
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - |
Relevant External Links for TRA2B Gene
- GeneLoc Exon Structure for
- TRA2B
Expression for TRA2B Gene
This gene is overexpressed in Peripheral blood mononuclear cells (8.1), Fetal Brain (6.4), and Fetal ovary (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRA2B Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRA2B
SOURCE GeneReport for Unigene cluster for TRA2B Gene:
Hs.533122mRNA Expression by UniProt/SwissProt for TRA2B Gene:
P62995-TRA2B_HUMAN
Tissue specificity:
Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver.
Evidence on tissue expression from TISSUES for TRA2B Gene
- Nervous system(5)
- Skin(4.7)
- Lung(4.7)
- Blood(4.4)
- Spleen(4.4)
- Intestine(3.6)
- Kidney(3.2)
- Liver(2.7)
- Eye(2.5)
- Muscle(2.5)
- Bone marrow(2.3)
- Heart(2.3)
- Lymph node(2.3)
- Stomach(2.3)
- Thyroid gland(2.2)
Primer Products
-
OriGene qPCR primer pairs for TRA2B
-
OriGene qPCR primer pairs and template standards for TRA2B
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRA2B Gene
Orthologs for TRA2B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TRA2B 31 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | TRA2B 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TRA2B 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TRA2B 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Tra2b 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tra2b 30 |
|
||
| Chicken (Gallus gallus) |
Aves | TRA2B 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TRA2B 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tra2b 30 |
|
||
| Str.7343 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398448 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | tra2b 31 |
|
OneToOne | |
| zgc56612 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | tra2 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | rsp-8 31 |
|
OneToMany |
- Species where no ortholog for TRA2B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for TRA2B Gene
- ENSEMBL:
- Gene Tree for TRA2B (if available)
- TreeFam:
- Gene Tree for TRA2B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TRA2B: view image
Paralogs for TRA2B Gene
Variants for TRA2B Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2660289 | CNV | deletion | 23128226 |
| esv3598980 | CNV | gain | 21293372 |
| esv3598981 | CNV | loss | 21293372 |
| nsv1142591 | CNV | deletion | 24896259 |
| nsv461035 | CNV | loss | 19166990 |
| nsv592705 | CNV | loss | 21841781 |
| nsv950022 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.19;
4.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TRA2B Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRA2B Gene
Disorders for TRA2B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| frontotemporal dementia |
|
|
| spinal muscular atrophy |
|
|
| endometrial stromal tumor |
|
|
| endometrial stromal sarcoma |
|
|
Search TRA2B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TRA2B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TRA2B Gene
Publications for TRA2B Gene
- Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform. (PMID: 9790768) Nayler O … Stamm S (Genomics 1998) 2 3 4 23
- Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo. (PMID: 14729963) Sakashita E … Mayeda A (Molecular and cellular biology 2004) 3 4 23
- Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing. (PMID: 9212162) Beil B … Stamm S (DNA and cell biology 1997) 3 4 23
- Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks CE … Murray A (Nature genetics 2010) 3 41
- Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA. (PMID: 19282290) Heinrich B … Stamm S (The Journal of biological chemistry 2009) 3 4
ExternalLinks
Products for TRA2B Gene
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Sources for TRA2B Gene
- (1) GeneCards
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