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Aliases for TRA2A Gene

Aliases for TRA2A Gene

  • Transformer 2 Alpha Homolog 2 3 5
  • Transformer-2 Protein Homolog A 3 4
  • TRA-2 Alpha 3 4
  • TRA2-Alpha 3 4
  • Transformer 2 Alpha Homolog (Drosophila) 2
  • Putative MAPK Activating Protein PM24 3
  • Transformer-2 Protein Homolog Alpha 3
  • Transformer-2 Alpha 3
  • Htra-2 Alpha 3
  • Tra2alpha 3
  • HSU53209 3
  • AWMS1 3

External Ids for TRA2A Gene

Previous GeneCards Identifiers for TRA2A Gene

  • GC07M023252
  • GC07M023286
  • GC07M023317
  • GC07M023510
  • GC07M023544
  • GC07M023429

Summaries for TRA2A Gene

Entrez Gene Summary for TRA2A Gene

  • This gene is a member of the transformer 2 homolog family and encodes a protein with several RRM (RNA recognition motif) domains. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for TRA2A Gene

TRA2A (Transformer 2 Alpha Homolog) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is TRA2B.

UniProtKB/Swiss-Prot for TRA2A Gene

  • Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.

Gene Wiki entry for TRA2A Gene

Additional gene information for TRA2A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRA2A Gene

Genomics for TRA2A Gene

GeneHancer (GH) Regulatory Elements for TRA2A Gene

Promoters and enhancers for TRA2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J023529 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 681.7 +0.7 673 3.2 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 YY1 POLR2B ZNF213 ZNF143 TRA2A GC07P023532 PIR50375 NUPL2 NPY GC07M023491 ENSG00000200847
GH07J023462 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 37.7 +62.7 62672 13.3 MLX FEZF1 DMAP1 IRF4 ZNF213 E2F8 ZNF263 SP3 NFYC MEF2D IGF2BP3 TRA2A ENSG00000227930 CCDC126 NUPL2 EEF1A1P6 CLK2P1 STK31 KLHL7-DT MALSU1
GH07J022852 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 28.6 +675.2 675169 8.9 PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B ZNF207 SNORD93 GC07P022859 TOMM7 SNHG26 TRA2A NUPL2 FAM126A ENSG00000179428 IL6 ENSG00000226329
GH07J022819 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 23 +710.3 710261 4.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B TOMM7 GC07P022823 TRA2A SNHG26 EEF1A1P6 NUPL2 FAM126A PIR54491
GH07J023297 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.5 +232.8 232753 3.4 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 MALSU1 KLHL7-DT CLK2P1 TRA2A CCDC126 ENSG00000232627
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRA2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRA2A gene promoter:
  • POU2F1c
  • POU2F1b
  • POU2F1a
  • POU2F1
  • C/EBPalpha
  • HNF-3beta
  • Pbx1a
  • C/EBPbeta

Genomic Locations for TRA2A Gene

Genomic Locations for TRA2A Gene
chr7:23,504,780-23,532,041
(GRCh38/hg38)
Size:
27,262 bases
Orientation:
Minus strand
chr7:23,544,399-23,571,660
(GRCh37/hg19)
Size:
27,262 bases
Orientation:
Minus strand

Genomic View for TRA2A Gene

Genes around TRA2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRA2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRA2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRA2A Gene

Proteins for TRA2A Gene

  • Protein details for TRA2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13595-TRA2A_HUMAN
    Recommended name:
    Transformer-2 protein homolog alpha
    Protein Accession:
    Q13595
    Secondary Accessions:
    • B4DQI6
    • B4DUA9
    • E9PD75

    Protein attributes for TRA2A Gene

    Size:
    282 amino acids
    Molecular mass:
    32689 Da
    Quaternary structure:
    • Binds to A3 enhancer proteins SRp75, SRp55, SRp40 and SRp30.

    Alternative splice isoforms for TRA2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRA2A Gene

Post-translational modifications for TRA2A Gene

No data available for DME Specific Peptides for TRA2A Gene

Domains & Families for TRA2A Gene

Gene Families for TRA2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q13595

UniProtKB/Swiss-Prot:

TRA2A_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with TRA2A: view

Function for TRA2A Gene

Molecular function for TRA2A Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.

Phenotypes From GWAS Catalog for TRA2A Gene

Gene Ontology (GO) - Molecular Function for TRA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA,IEA 22658674
genes like me logo Genes that share ontologies with TRA2A: view
genes like me logo Genes that share phenotypes with TRA2A: view

Animal Model Products

CRISPR Products

miRNA for TRA2A Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRA2A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRA2A Gene

Localization for TRA2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRA2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRA2A gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 9546399
GO:0005730 nucleolus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TRA2A: view

Pathways & Interactions for TRA2A Gene

SuperPathways for TRA2A Gene

SuperPathway Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with TRA2A: view

Pathways by source for TRA2A Gene

1 KEGG pathway for TRA2A Gene

Gene Ontology (GO) - Biological Process for TRA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IDA 9546399
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with TRA2A: view

No data available for SIGNOR curated interactions for TRA2A Gene

Drugs & Compounds for TRA2A Gene

No Compound Related Data Available

Transcripts for TRA2A Gene

Unigene Clusters for TRA2A Gene

Transformer 2 alpha homolog (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRA2A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRA2A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13
SP1: - - - - - - -
SP2: -
SP3: - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - -
SP8:
SP9: -
SP10: -
SP11:

Relevant External Links for TRA2A Gene

GeneLoc Exon Structure for
TRA2A
ECgene alternative splicing isoforms for
TRA2A

Expression for TRA2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRA2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRA2A Gene

This gene is overexpressed in Nasal epithelium (19.3) and Fetal Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRA2A Gene



Protein tissue co-expression partners for TRA2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRA2A Gene:

TRA2A

SOURCE GeneReport for Unigene cluster for TRA2A Gene:

Hs.445652

Evidence on tissue expression from TISSUES for TRA2A Gene

  • Nervous system(2.7)
  • Lung(2.6)
genes like me logo Genes that share expression patterns with TRA2A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRA2A Gene

Orthologs for TRA2A Gene

This gene was present in the common ancestor of animals.

Orthologs for TRA2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRA2A 34 33
  • 99.41 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRA2A 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRA2A 34 33
  • 95.63 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TRA2A 34 33
  • 95.24 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRA2A 34
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tra2a 33
  • 89.24 (n)
mouse
(Mus musculus)
Mammalia Tra2a 16 34 33
  • 88.45 (n)
chicken
(Gallus gallus)
Aves TRA2A 34 33
  • 82.66 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRA2A 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tra2a 33
  • 75.67 (n)
Str.6565 33
zebrafish
(Danio rerio)
Actinopterygii tra2a 34 33
  • 70.03 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3457 33
fruit fly
(Drosophila melanogaster)
Insecta tra2 34
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-8 34
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea Cin.4304 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4304 33
Species where no ortholog for TRA2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRA2A Gene

ENSEMBL:
Gene Tree for TRA2A (if available)
TreeFam:
Gene Tree for TRA2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRA2A: view image

Paralogs for TRA2A Gene

(5) SIMAP similar genes for TRA2A Gene using alignment to 4 proteins:

  • TRA2A_HUMAN
  • B4DQI6_HUMAN
  • B4DUA9_HUMAN
  • F8WEH2_HUMAN

Pseudogenes.org Pseudogenes for TRA2A Gene

genes like me logo Genes that share paralogs with TRA2A: view

Variants for TRA2A Gene

Sequence variations from dbSNP and Humsavar for TRA2A Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000039298 -- 23,519,949(-) T/C intron_variant
rs1000208761 -- 23,531,812(-) C/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000308887 -- 23,504,300(-) TCTCT/TCT downstream_transcript_variant
rs1000326273 -- 23,526,332(-) G/A intron_variant
rs1000495848 -- 23,520,096(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRA2A Gene

Variant ID Type Subtype PubMed ID
esv3891087 CNV loss 25118596
nsv509193 CNV insertion 20534489
nsv5662 CNV insertion 18451855
nsv7393 OTHER inversion 18451855

Variation tolerance for TRA2A Gene

Residual Variation Intolerance Score: 28.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRA2A Gene

Human Gene Mutation Database (HGMD)
TRA2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRA2A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRA2A Gene

Disorders for TRA2A Gene

Additional Disease Information for TRA2A

No disorders were found for TRA2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRA2A Gene

Publications for TRA2A Gene

  1. A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions. (PMID: 8799144) Dauwalder B … Mattox W (Proceedings of the National Academy of Sciences of the United States of America 1996) 2 3 4 22 58
  2. Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. (PMID: 9546399) Tacke R … Manley JL (Cell 1998) 2 3 4 58
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TRA2A Gene

Sources for TRA2A Gene

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