Aliases for TPX2 Gene
Aliases for TPX2 Gene
- TPX2, Microtubule Nucleation Factor 2 3 5
- Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 2 3 4
- Hepatocellular Carcinoma-Associated Antigen 519 3 4
- Hepatocellular Carcinoma-Associated Antigen 90 3 4
- Protein Fls353 3 4
- C20orf1 3 4
- C20orf2 3 4
- HCA519 3 4
- DIL-2 3 4
- DIL2 3 4
- P100 3 4
- Restricted Expression Proliferation Associated Protein 100 3
- Restricted Expression Proliferation-Associated Protein 100 4
- TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) 2
- Preferentially Expressed In Colorectal Cancer 3
- TPX2, Microtubule-Associated Protein Homolog 3
- Differentially Expressed In Lung Cells 3
- TPX2, Microtubule-Associated, Homolog 3
- Chromosome 20 Open Reading Frame 1 2
- TPX2, Microtubule-Associated 2
- Targeting Protein For Xklp2 3
- GD:C20orf1 3
- FLS353 3
- REPP86 3
- HCTP4 3
External Ids for TPX2 Gene
- HGNC: 1249
- Entrez Gene: 22974
- Ensembl: ENSG00000088325
- OMIM: 605917
- UniProtKB: Q9ULW0
Previous HGNC Symbols for TPX2 Gene
- C20orf2
- C20orf1
Previous GeneCards Identifiers for TPX2 Gene
- GC20P031024
- GC20P031072
- GC20P031071
- GC20P029790
- GC20P030326
- GC20P027115
Summaries for TPX2 Gene
GeneCards Summary for TPX2 Gene
TPX2 (TPX2, Microtubule Nucleation Factor) is a Protein Coding gene. Diseases associated with TPX2 include Hepatocellular Carcinoma. Among its related pathways are Gene Expression and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include GTP binding and protein kinase binding.
UniProtKB/Swiss-Prot for TPX2 Gene
-
Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at Thr-288 and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPX2 Gene
Genomics for TPX2 Gene
GeneHancer (GH) Regulatory Elements for TPX2 Gene
Promoters and enhancers for TPX2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around TPX2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TPX2 gene promoter:
-
- Sox9
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- Pax-4a
- Lmo2
- SREBP-1a
Regulatory Element Products
Genomic Locations for TPX2 Gene
Genomic Locations for TPX2 Gene
- chr20:31,733,819-31,801,805
- (GRCh38/hg38)
- Size:
- 67,987 bases
- Orientation:
- Plus strand
- chr20:30,326,904-30,389,608
- (GRCh37/hg19)
- Size:
- 62,705 bases
- Orientation:
- Plus strand
Genomic View for TPX2 Gene
Genes around TPX2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q11.21 by Entrez Gene
- 20q11.21 by HGNC
- 20q11.21 by Ensembl
TPX2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TPX2 Gene
Proteins for TPX2 Gene
-
Protein details for TPX2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9ULW0-TPX2_HUMAN
- Recommended name:
- Targeting protein for Xklp2
- Protein Accession:
- Q9ULW0
- Q96RR5
- Q9H1R4
- Q9NRA3
- Q9UFN9
- Q9UL00
- Q9Y2M1
Protein attributes for TPX2 Gene
- Size:
- 747 amino acids
- Molecular mass:
- 85653 Da
- Quaternary structure:
-
- Interacts with AURKA (PubMed:14580337, PubMed:18662907, PubMed:18663142). Interacts with importin-alpha; leading to inactivate TPX2 (PubMed:26165940). Interacts with HNRNPU; this interaction recruits HNRNPU to spindle microtubules (MTs) (PubMed:21242313, PubMed:25986610).
Three dimensional structures from OCA and Proteopedia for TPX2 Gene
Protein Expression for TPX2 Gene
Post-translational modifications for TPX2 Gene
Other Protein References for TPX2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TPX2
- Novus Biologicals Antibodies for TPX2
-
Abcam antibodies for TPX2
- Invitrogen Antibodies for TPX2
- GeneTex TPX2 Antibody for TPX2
-
Santa Cruz Biotechnology (SCBT) Antibodies for TPX2
Protein Products
-
OriGene Purified Proteins for TPX2
- Search Origene for MassSpec and Protein Over-expression Lysates for TPX2
- Origene Custom Protein Services for TPX2
- antibodies-online: Search results for 5 available TPX2 Proteins ranked by validation data
- Compare Top TPX2 Proteins
-
Quality Products:
- Search GeneTex for Proteins for TPX2
-
Abcam proteins for TPX2
Assay Products
- antibodies-online: Search results for 3 available TPX2 Elisa Kits ranked by validation data
- Compare Top TPX2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for TPX2 Gene
Domains & Families for TPX2 Gene
Gene Families for TPX2 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for TPX2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TPX2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9ULW0- Family:
-
- Belongs to the TPX2 family.
Function for TPX2 Gene
Molecular function for TPX2 Gene
- UniProtKB/Swiss-Prot Function:
- Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at Thr-288 and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).
Phenotypes From GWAS Catalog for TPX2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 14580337 |
| GO:0005524 | ATP binding | TAS | 10512675 |
| GO:0005525 | GTP binding | TAS | 10512675 |
| GO:0019901 | protein kinase binding | IPI | 14580337 |
| GO:0061676 | importin-alpha family protein binding | IDA | 26165940 |
Phenotypes for TPX2 Gene
- MGI mutant phenotypes for TPX2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for TPX2:
-
- Inhibition of centrosomal clustering
- Multipolar spindles
- Increased number of mitotic cells
- G0/1 arrest
- Increased G1 DNA content
- Effect on mitosis
- Dynamic nuclei (hole, folded or small irregular)
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased viability
- no effect
- Decreased cell number
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased homologous recombination repair frequency
- Decreased NF-kappaB reporter expression
- Increased cell number in S
- Mitotic spindle defects
- Increased viability
- Lamellipodia cells
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TPX2
-
CRISPR Products
-
OriGene CRISPR knockouts for TPX2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TPX2
- genomics-online: gRNA clones - Search results for 141 available TPX2 gene related products
- Overview of 141 available TPX2 gene related products
- Applied Biological Materials CRISPR for TPX2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TPX2
- GenScript: Design CRISPR guide RNA sequences for TPX2
miRNA for TPX2 Gene
- miRTarBase miRNAs that target TPX2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TPX2
- Browse OriGene Inhibitory RNA Products For TPX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TPX2
- genomics-online: shRNA clones - Search results for 141 available TPX2 gene related products
- Overview of 141 available TPX2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for TPX2
- VectorBuilder custom plasmid, inducible vectors for TPX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TPX2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TPX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TPX2
- Applied Biological Materials Clones for TPX2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPX2 Gene
Localization for TPX2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TPX2 Gene
- Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. {ECO:0000269 PubMed:19208764}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 4 |
- Cytokinetic bridge (4)
- Microtubule organizing center (4)
- Mitotic spindle (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000922 | colocalizes_with spindle pole | IDA | 14718566 |
| GO:0005634 | nucleus | TAS | 9207457 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005815 | microtubule organizing center | IDA | -- |
Pathways & Interactions for TPX2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of PLK1 Activity at G2/M Transition |
.49
|
|
| 2 | Regulation of TP53 Activity | ||
| 3 | Cell Cycle, Mitotic |
.83
|
|
| 4 | Gene Expression |
.48
|
|
| 5 | DNA Damage | ||
Pathways by source for TPX2 Gene
3 BioSystems pathways for TPX2 Gene
10 Reactome pathways for TPX2 Gene
1 GeneGo (Thomson Reuters) pathway for TPX2 Gene
1 Cell Signaling Technology pathway for TPX2 Gene
Interacting Proteins for TPX2 Gene
Selected Interacting proteins:
Q9ULW0-TPX2_HUMAN
ENSP00000300403
for TPX2 Gene via
UniProtKB
STRING
IID
MINT
GPS-Prot Interaction Network for TPX2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000278 | mitotic cell cycle | TAS | 9207457 |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0008283 | cell proliferation | TAS | 10512675 |
| GO:0010389 | regulation of G2/M transition of mitotic cell cycle | TAS | -- |
No data available for SIGNOR curated interactions for TPX2 Gene
Transcripts for TPX2 Gene
mRNA/cDNA for TPX2 Gene
- (4) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (462) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000300403 3497 bps (uc002wwp.2)
- ENST00000340513 3605 bps (uc010gdv.2)
Unigene Clusters for TPX2 Gene
- TPX2, microtubule-associated, homolog (Xenopus laevis):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for TPX2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TPX2
- genomics-online: gRNA clones - Search results for 141 available TPX2 gene related products
- Overview of 141 available TPX2 gene related products
- Applied Biological Materials CRISPR for TPX2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TPX2
- GenScript: Design CRISPR guide RNA sequences for TPX2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TPX2
- Browse OriGene Inhibitory RNA Products For TPX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TPX2
- genomics-online: shRNA clones - Search results for 141 available TPX2 gene related products
- Overview of 141 available TPX2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for TPX2
- VectorBuilder custom plasmid, inducible vectors for TPX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TPX2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TPX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TPX2
- Applied Biological Materials Clones for TPX2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - |
| ExUns: | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||
| SP12: |
Expression for TPX2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Blood (Hematopoietic System)
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- XX Germ Cells Ovigerous Cord
- Oviduct
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
- Leydig Cells Testis Interstitium
- Mesenchymal Stem Cells
- Umbilical Cord (Extraembryonic Tissues)
-
Heart (Cardiovascular System)
- Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
-
Gonad
- XX Germ Cells Ovigerous Cord
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for TPX2 Gene
This gene is overexpressed in Testis (x5.8).
This gene is overexpressed in Lung (27.8), Urinary Bladder (11.3), Liver (11.3), and Rectum (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TPX2 Gene
NURSA nuclear receptor signaling pathways regulating expression of TPX2 Gene:
TPX2SOURCE GeneReport for Unigene cluster for TPX2 Gene:
Hs.244580mRNA Expression by UniProt/SwissProt for TPX2 Gene:
Q9ULW0-TPX2_HUMAN
Tissue specificity:
Expressed in lung carcinoma cell lines but not in normal lung tissues.
Evidence on tissue expression from TISSUES for TPX2 Gene
- Liver(4.6)
- Nervous system(4.6)
- Lung(4.5)
- Intestine(3.3)
- Skin(2.2)
- Lymph node(2.1)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for TPX2
-
OriGene qPCR primer pairs for TPX2
- genomics-online: primer clones - Search results for 141 available TPX2 gene related products
- Overview of 141 available TPX2 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPX2 Gene
Orthologs for TPX2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TPX2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TPX2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | TPX2 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Tpx2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Tpx2 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TPX2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TPX2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TPX2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | TPX2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tpx2 33 |
|
||
| Str.8066 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | TPX2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tpx2 34 |
|
OneToOne | |
| wufa12d08 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2378 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10570 34 |
|
OneToOne |
- Species where no ortholog for TPX2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for TPX2 Gene
- ENSEMBL:
- Gene Tree for TPX2 (if available)
- TreeFam:
- Gene Tree for TPX2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TPX2: view image
Paralogs for TPX2 Gene
(2) SIMAP similar genes for TPX2 Gene using alignment to 2 proteins:
- TPX2_HUMAN
- Q96FC3_HUMAN
No data available for Paralogs for TPX2 Gene
Variants for TPX2 Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036269 | A colorectal cancer sample | p.Thr464Asn | |||
| rs1000019961 | -- | 31,738,867(+) | C/T | upstream_transcript_variant | |
| rs1000046520 | -- | 31,781,670(+) | A/C | intron_variant | |
| rs1000109871 | -- | 31,787,459(+) | G/C | intron_variant | |
| rs1000154924 | -- | 31,743,069(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4300n100 | CNV | gain | 25217958 |
| esv3394936 | CNV | insertion | 20981092 |
| esv3556995 | CNV | deletion | 23714750 |
| esv3645656 | CNV | loss | 21293372 |
| nsv3346 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.14;
38.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TPX2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPX2 Gene
Disorders for TPX2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hepatocellular carcinoma |
|
Search TPX2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TPX2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TPX2 Gene
Publications for TPX2 Gene
- Assignment of human proliferation associated p100 gene (C20orf1) to human chromosome band 20q11.2 by in situ hybridization. (PMID: 10393424) Zhang Y … Parwaresch R (Cytogenetics and cell genetics 1999) 2 3 4 22 58
- p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M. (PMID: 9207457) Heidebrecht HJ … Parwaresch R (Blood 1997) 2 3 4 22 58
- Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase. (PMID: 19208764) Moss DK … Lane JD (Journal of cell science 2009) 3 4 22 58
- Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2. (PMID: 18662907) Zhao B … Lai Z (Protein science : a publication of the Protein Society 2008) 3 4 22 58
- Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A. (PMID: 18663142) Bird AW … Hyman AA (The Journal of cell biology 2008) 3 4 22 58
Products for TPX2 Gene
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- Custom Antibody ServicesOriGene Antibodies for TPX2
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- OriGene Purified Proteins for TPX2
- Search Origene for MassSpec and Protein Over-expression Lysates for TPX2
- Origene Custom Protein Services for TPX2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TPX2
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- OriGene qPCR primer pairs and template standards for TPX2
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping of latest version cDNA ORF clones for TPX2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for TPX2
- GenScript Custom Assay Services for TPX2
- GenScript Custom overexpressing Cell Line Services for TPX2
- GenScript: Design CRISPR guide RNA sequences for TPX2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Cyagen custom Knockout/knockin (KOKI) mouse models for TPX2
- VectorBuilder custom plasmid, inducible vectors for TPX2
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TPX2
- antibodies-online: Search results for 171 available TPX2 Antibodies ranked by validation data
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- antibodies-online: Search results for 3 available TPX2 Elisa Kits ranked by validation data
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- antibodies-online: Search results for 5 available TPX2 Proteins ranked by validation data
- Compare Top TPX2 Proteins
- Quality Products:
- GeneTex TPX2 Antibody for TPX2
- Search GeneTex for Proteins for TPX2
- Santa Cruz Biotechnology (SCBT) Antibodies for TPX2
- Search Santa Cruz Biotechnology (SCBT) for TPX2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TPX2
- genomics-online: cdna clones - Search results for 141 available TPX2 gene related products
- Overview of 141 available TPX2 gene related products
- orf clones - Search results for 141 available TPX2 gene related products
- Overview of 141 available TPX2 gene related products
- genomics-online: gRNA clones - Search results for 141 available TPX2 gene related products
- Overview of 141 available TPX2 gene related products
- genomics-online: primer clones - Search results for 141 available TPX2 gene related products
- Overview of 141 available TPX2 gene related products
- genomics-online: shRNA clones - Search results for 141 available TPX2 gene related products
- Overview of 141 available TPX2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TPX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TPX2
- GeneCopoeia miRNA 3'UTR Target clone products for TPX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TPX2
Sources for TPX2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (120) Genetics Home Reference
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt