Free for academic non-profit institutions. Other users need a Commercial license
Aliases for TPX2 Gene
Aliases for TPX2 Gene
- TPX2 Microtubule Nucleation Factor 2 3 5
- DIL-2 2 3 4
- P100 2 3 4
- Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 2 3 4
- Hepatocellular Carcinoma-Associated Antigen 519 3 4
- Hepatocellular Carcinoma-Associated Antigen 90 3 4
- Targeting Protein For Xklp2 3 4
- Protein Fls353 3 4
- C20orf1 3 4
- C20orf2 3 4
- HCA519 3 4
- DIL2 3 4
- Restricted Expression Proliferation Associated Protein 100 3
- Restricted Expression Proliferation-Associated Protein 100 4
- TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) 2
- Preferentially Expressed In Colorectal Cancer 3
- TPX2, Microtubule-Associated Protein Homolog 3
- Differentially Expressed In Lung Cells 3
- TPX2, Microtubule-Associated, Homolog 3
- Chromosome 20 Open Reading Frame 1 2
- TPX2, Microtubule-Associated 2
- GD:C20orf1 3
- FLS353 3
- REPP86 3
- HCTP4 3
- TPX2 5
External Ids for TPX2 Gene
- HGNC: 1249
- Entrez Gene: 22974
- Ensembl: ENSG00000088325
- OMIM: 605917
- UniProtKB: Q9ULW0
Previous HGNC Symbols for TPX2 Gene
- C20orf2
- C20orf1
Previous GeneCards Identifiers for TPX2 Gene
- GC20P031024
- GC20P031072
- GC20P031071
- GC20P029790
- GC20P030326
- GC20P027115
Summaries for TPX2 Gene
GeneCards Summary for TPX2 Gene
TPX2 (TPX2 Microtubule Nucleation Factor) is a Protein Coding gene. Diseases associated with TPX2 include Colorectal Cancer and Capillary Leak Syndrome. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include GTP binding and protein kinase binding.
UniProtKB/Swiss-Prot Summary for TPX2 Gene
-
Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).
Additional gene information for TPX2 Gene
- HGNC(1249)
- Entrez Gene(22974)
- Ensembl(ENSG00000088325)
- OMIM(605917)
- UniProtKB(Q9ULW0)
- Open Targets Platform(ENSG00000088325)
- Search for TPX2 at DataMed
- Search for TPX2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TPX2 Gene
Genomics for TPX2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TPX2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TPX2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TPX2
- Top Transcription factor binding sites by QIAGEN in the TPX2 gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- Lmo2
- Pax-4a
- Sox9
- SREBP-1a
Genomic Locations for TPX2 Gene
Genomic Locations for TPX2 Gene
- chr20:31,739,248-31,801,805
- (GRCh38/hg38)
- Size:
- 62,558 bases
- Orientation:
- Plus strand
- chr20:30,326,904-30,389,608
- (GRCh37/hg19)
- Size:
- 62,705 bases
- Orientation:
- Plus strand
Genomic View for TPX2 Gene
Genes around TPX2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q11.21 by HGNC
- 20q11.21 by Entrez Gene
- 20q11.21 by Ensembl
TPX2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TPX2 Gene
Proteins for TPX2 Gene
-
Protein details for TPX2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9ULW0-TPX2_HUMAN
- Recommended name:
- Targeting protein for Xklp2
- Protein Accession:
- Q9ULW0
- Q96RR5
- Q9H1R4
- Q9NRA3
- Q9UFN9
- Q9UL00
- Q9Y2M1
Protein attributes for TPX2 Gene
- Size:
- 747 amino acids
- Molecular mass:
- 85653 Da
- Quaternary structure:
-
- Interacts with AURKA (PubMed:14580337, PubMed:18662907, PubMed:18663142). Interacts with importin-alpha; leading to inactivate TPX2 (PubMed:26165940). Interacts with HNRNPU; this interaction recruits HNRNPU to spindle microtubules (MTs) (PubMed:21242313, PubMed:25986610).
Three dimensional structures from OCA and Proteopedia for TPX2 Gene
Protein Expression for TPX2 Gene
Post-translational modifications for TPX2 Gene
Other Protein References for TPX2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences TPX2 Monoclonal Antibody and TPX2 Antibody
- G Biosciences Immunotag™ DIL-2 Antibody
- Creative Diagnostics Anti-TPX2 monoclonal antibody, clone 29E6-2
- BioLegend TPX2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for TPX2
- Novus Biologicals Antibodies for TPX2
-
Abcam antibodies for TPX2
- Invitrogen Antibodies for TPX2 (AFLGC-Tpx2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for TPX2
Protein Products
-
OriGene Purified Proteins for TPX2
- Search Origene for MassSpec and Protein Over-expression Lysates for TPX2
- Origene Custom Protein Services for TPX2
- antibodies-online: Show 7 available TPX2 Proteins ranked by validation data
- Compare Top TPX2 Proteins
-
Quality Products:
-
Signalway Proteins for TPX2
-
Abcam proteins for TPX2
Assay Products
- antibodies-online: Show 5 available TPX2 Elisa Kits ranked by validation data
- Compare Top TPX2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for TPX2 Gene
Domains & Families for TPX2 Gene
Gene Families for TPX2 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for TPX2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TPX2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ92922 (Q643R0_HUMAN)
- TPX2 protein (Q96FC3_HUMAN)
- Restricted expression proliferation-associated protein 100 (TPX2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9ULW0- Family:
-
- Belongs to the TPX2 family.
Function for TPX2 Gene
Molecular function for TPX2 Gene
- UniProtKB/Swiss-Prot Function:
- Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).
Phenotypes From GWAS Catalog for TPX2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 14580337 |
| GO:0019901 | protein kinase binding | IPI | 14580337 |
| GO:0061676 | importin-alpha family protein binding | IDA | 26165940 |
Phenotypes for TPX2 Gene
- MGI mutant phenotypes for TPX2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for TPX2:
-
- no effect
- Decreased viability
- Increased gamma-H2AX phosphorylation
- Decreased cell number
- Inconclusive
- Cell division defect
- Decreased homologous recombination repair frequency
- Mitotic spindle defects
- Increased number of mitotic cells
- Abundance of large cells with protrusions and bright nuclei
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Multipolar spindles
- Decreased cell number, increased G2M DNA content, increased 8N DNA content
- Inhibition of centrosomal clustering
- Increased cell number in G2M, increased number of polyploid cells, increased number of cells with high perimeter-to-area ratio nuclei
- Increased mitotic delay (prometaphase or metaphase alignment problems, MAP), polylobed nuclei, many micronuclei (grape), decreased viability (cell death)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TPX2 - Select products 50% OFF >
- * TPX2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TPX2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TPX2
-
Santa Cruz Biotechnology (SCBT) CRISPR for TPX2
miRNA for TPX2 Gene
- miRTarBase miRNAs that target TPX2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TPX2
- Browse OriGene Inhibitory RNA Products For TPX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TPX2
Clone Products
- Applied Biological Materials (abm): Clones for TPX2 - Select products 50% OFF >
- * TPX2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210424
- MG221964
- MG221966
- MG221968
- MG222203
- MR210424
- MR210424L3
- MR210424L4
- MR221964
- MR221964L3
- MR221964L4
- MR221966
- MR221966L3
- MR221966L4
- MR221968
- MR221968L3
- MR221968L4
- MR222203
- MR222203L3
- MR222203L4
- RC205821
- RC205821L1
- RC205821L2
- RC205821L3
- RC205821L4
- RG205821
- RR208711
- RR208711L3
- RR208711L4
- MR210424L3V
- MR210424L4V
- MR221964L3V
- MR221964L4V
- MR221966L3V
- MR221966L4V
- MR221968L3V
- MR221968L4V
- MR222203L3V
- MR222203L4V
- RC205821L1V
- RC205821L2V
- RC205821L3V
- RC205821L4V
- RR208711L3V
- RR208711L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TPX2
- Addgene plasmids for TPX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TPX2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPX2 Gene
Localization for TPX2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TPX2 Gene
- Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. {ECO:0000269 PubMed:19208764}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| extracellular | 4 |
| cytosol | 4 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytokinetic bridge (3)
- Mitotic spindle (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000922 | colocalizes_with spindle pole | IDA | 14718566 |
| GO:0005634 | nucleus | TAS | 9207457 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005819 | spindle | TAS,ISS | 18663142 |
Pathways & Interactions for TPX2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of PLK1 Activity at G2/M Transition |
.50
|
|
| 2 | Regulation of TP53 Activity | ||
| 3 | Cell Cycle, Mitotic |
.83
|
|
| 4 | Gene Expression |
.48
|
|
| 5 | DNA Damage | ||
Pathways by source for TPX2 Gene
3 BioSystems pathways for TPX2 Gene
10 Reactome pathways for TPX2 Gene
1 GeneGo (Thomson Reuters) pathway for TPX2 Gene
- Cell cycle_Spindle assembly and chromosome separation
1 Cell Signaling Technology pathway for TPX2 Gene
Interacting Proteins for TPX2 Gene
Selected Interacting proteins:
Q9ULW0-TPX2_HUMAN
ENSP00000300403
for TPX2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TPX2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000278 | mitotic cell cycle | TAS | 9207457 |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007020 | microtubule nucleation | IDA | 26414402 |
| GO:0007026 | negative regulation of microtubule depolymerization | IDA | 26414402 |
| GO:0007049 | cell cycle | IEA | -- |
No data available for SIGNOR curated interactions for TPX2 Gene
Transcripts for TPX2 Gene
mRNA/cDNA for TPX2 Gene
- 1 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000300403 3473 nts (view in UCSC)
- ENST00000340513 3605 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TPX2 - Select products 50% OFF >
- * TPX2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TPX2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TPX2
-
Santa Cruz Biotechnology (SCBT) CRISPR for TPX2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TPX2
- Browse OriGene Inhibitory RNA Products For TPX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TPX2
Clone Products
- Applied Biological Materials (abm): Clones for TPX2 - Select products 50% OFF >
- * TPX2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210424
- MG221964
- MG221966
- MG221968
- MG222203
- MR210424
- MR210424L3
- MR210424L4
- MR221964
- MR221964L3
- MR221964L4
- MR221966
- MR221966L3
- MR221966L4
- MR221968
- MR221968L3
- MR221968L4
- MR222203
- MR222203L3
- MR222203L4
- RC205821
- RC205821L1
- RC205821L2
- RC205821L3
- RC205821L4
- RG205821
- RR208711
- RR208711L3
- RR208711L4
- MR210424L3V
- MR210424L4V
- MR221964L3V
- MR221964L4V
- MR221966L3V
- MR221966L4V
- MR221968L3V
- MR221968L4V
- MR222203L3V
- MR222203L4V
- RC205821L1V
- RC205821L2V
- RC205821L3V
- RC205821L4V
- RR208711L3V
- RR208711L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TPX2
- Addgene plasmids for TPX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TPX2
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - |
| ExUns: | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||
| SP12: |
Relevant External Links for TPX2 Gene
- GeneLoc Exon Structure for
- TPX2
Expression for TPX2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Blood (Hematopoietic System)
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- XX Germ Cells Ovigerous Cord
- Oviduct
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
- Leydig Cells Testis Interstitium
- Mesenchymal Stem Cells
- Umbilical Cord (Extraembryonic Tissues)
-
Heart (Cardiovascular System)
- Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
-
Gonad
- XX Germ Cells Ovigerous Cord
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for TPX2 Gene
This gene is overexpressed in Testis (x5.8).
This gene is overexpressed in Lung (27.8), Urinary Bladder (11.3), Liver (11.3), and Rectum (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TPX2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TPX2
SOURCE GeneReport for Unigene cluster for TPX2 Gene:
Hs.244580mRNA Expression by UniProt/SwissProt for TPX2 Gene:
Q9ULW0-TPX2_HUMAN
Tissue specificity:
Expressed in lung carcinoma cell lines but not in normal lung tissues.
Evidence on tissue expression from TISSUES for TPX2 Gene
- Nervous system(4.7)
- Liver(4.7)
- Lung(4.5)
- Intestine(3.8)
- Skin(3.3)
- Blood(2.7)
- Lymph node(2.6)
- Kidney(2.3)
- Pancreas(2.3)
- Bone marrow(2.1)
Primer Products
-
OriGene qPCR primer pairs for TPX2
-
OriGene qPCR primer pairs and template standards for TPX2
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPX2 Gene
Orthologs for TPX2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TPX2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TPX2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TPX2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tpx2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Tpx2 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TPX2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TPX2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TPX2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TPX2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tpx2 30 |
|
||
| Str.8066 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | TPX2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | tpx2 31 |
|
OneToOne | |
| wufa12d08 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2378 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10570 31 |
|
OneToOne |
- Species where no ortholog for TPX2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TPX2 Gene
- ENSEMBL:
- Gene Tree for TPX2 (if available)
- TreeFam:
- Gene Tree for TPX2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TPX2: view image
Paralogs for TPX2 Gene
(2) SIMAP similar genes for TPX2 Gene using alignment to 2 proteins:
- TPX2_HUMAN
- Q96FC3_HUMAN
No data available for Paralogs for TPX2 Gene
Variants for TPX2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TPX2 Gene
| SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 769085 | Benign: not provided | 31,783,825(+) | A/G | SYNONYMOUS_VARIANT | |
| 775646 | Benign: not provided | 31,771,626(+) | A/G | SYNONYMOUS_VARIANT | |
| 785652 | Benign: not provided | 31,766,608(+) | C/T | SYNONYMOUS_VARIANT | |
| VAR_036269 | A colorectal cancer sample | p.Thr464Asn |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4300n100 | CNV | gain | 25217958 |
| esv3394936 | CNV | insertion | 20981092 |
| esv3556995 | CNV | deletion | 23714750 |
| esv3645656 | CNV | loss | 21293372 |
| nsv3346 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.14;
38.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TPX2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPX2 Gene
Disorders for TPX2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| colorectal cancer |
|
|
| capillary leak syndrome |
|
|
| capillary disease |
|
|
| hepatocellular carcinoma |
|
|
| gastric cancer |
|
|
Search TPX2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TPX2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TPX2 Gene
Publications for TPX2 Gene
- Assignment of human proliferation associated p100 gene (C20orf1) to human chromosome band 20q11.2 by in situ hybridization. (PMID: 10393424) Zhang Y … Parwaresch R (Cytogenetics and cell genetics 1999) 2 3 4 23
- p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M. (PMID: 9207457) Heidebrecht HJ … Parwaresch R (Blood 1997) 2 3 4 23
- Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase. (PMID: 19208764) Moss DK … Lane JD (Journal of cell science 2009) 3 4 23
- Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A. (PMID: 18663142) Bird AW … Hyman AA (The Journal of cell biology 2008) 3 4 23
- Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2. (PMID: 18662907) Zhao B … Lai Z (Protein science : a publication of the Protein Society 2008) 3 4 23
ExternalLinks
Products for TPX2 Gene
- Custom Antibody ServicesOriGene Antibodies for TPX2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TPX2
- Search Origene for MassSpec and Protein Over-expression Lysates for TPX2
- Origene Custom Protein Services for TPX2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TPX2
- Browse OriGene Inhibitory RNA Products For TPX2
- OriGene qPCR primer pairs for TPX2
- OriGene qPCR primer pairs and template standards for TPX2
- OriGene CRISPR knockouts for TPX2
- MG210424
- MG221964
- MG221966
- MG221968
- MG222203
- MR210424
- MR210424L3
- MR210424L4
- MR221964
- MR221964L3
- MR221964L4
- MR221966
- MR221966L3
- MR221966L4
- MR221968
- MR221968L3
- MR221968L4
- MR222203
- MR222203L3
- MR222203L4
- RC205821
- RC205821L1
- RC205821L2
- RC205821L3
- RC205821L4
- RG205821
- RR208711
- RR208711L3
- RR208711L4
- MR210424L3V
- MR210424L4V
- MR221964L3V
- MR221964L4V
- MR221966L3V
- MR221966L4V
- MR221968L3V
- MR221968L4V
- MR222203L3V
- MR222203L4V
- RC205821L1V
- RC205821L2V
- RC205821L3V
- RC205821L4V
- RR208711L3V
- RR208711L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TPX2
- Sino Biological Human cDNA Clone for TPX2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TPX2
- Novus Biologicals proteins and lysates for TPX2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TPX2
- Abcam proteins for TPX2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for TPX2 (AFLGC-Tpx2)
- VectorBuilder Custom and pre-made DNA vectors for TPX2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TPX2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TPX2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TPX2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TPX2
- Addgene plasmids for TPX2
- antibodies-online: Show 129 available TPX2 Antibodies ranked by validation data
- Compare Top TPX2 Antibodies
- Quality Products:
- antibodies-online: Show 5 available TPX2 Elisa Kits ranked by validation data
- Compare Top TPX2 Elisa Kits
- Quality Products:
- antibodies-online: Show 7 available TPX2 Proteins ranked by validation data
- Compare Top TPX2 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for TPX2
- Search Santa Cruz Biotechnology (SCBT) for TPX2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TPX2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TPX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TPX2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TPX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TPX2
- Signalway Proteins for TPX2
Sources for TPX2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB