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TPX2 (TPX2 Microtubule Nucleation Factor) is a Protein Coding gene. Diseases associated with TPX2 include Colorectal Cancer and Capillary Leak Syndrome. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include GTP binding and protein kinase binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 14580337 |
GO:0019901 | protein kinase binding | IPI | 14580337 |
GO:0061676 | importin-alpha family protein binding | IDA | 26165940 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000922 | colocalizes_with spindle pole | IDA | 14718566 |
GO:0005634 | nucleus | TAS | 9207457 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005819 | spindle | TAS,ISS | 18663142 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of PLK1 Activity at G2/M Transition |
.50
|
|
2 | Regulation of TP53 Activity | ||
3 | Cell Cycle, Mitotic |
.83
|
|
4 | Gene Expression |
.48
|
|
5 | DNA Damage |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000278 | mitotic cell cycle | TAS | 9207457 |
GO:0006915 | apoptotic process | IEA | -- |
GO:0007020 | microtubule nucleation | IDA | 26414402 |
GO:0007026 | negative regulation of microtubule depolymerization | IDA | 26414402 |
GO:0007049 | cell cycle | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - |
ExUns: | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||
SP10: | |||||||||||||||||||||||||
SP11: | |||||||||||||||||||||||||
SP12: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TPX2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TPX2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TPX2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tpx2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Tpx2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TPX2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TPX2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TPX2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TPX2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tpx2 30 |
|
||
Str.8066 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | TPX2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tpx2 31 |
|
OneToOne | |
wufa12d08 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2378 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10570 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
769085 | Benign: not provided | 31,783,825(+) | A/G | SYNONYMOUS_VARIANT | |
775646 | Benign: not provided | 31,771,626(+) | A/G | SYNONYMOUS_VARIANT | |
785652 | Benign: not provided | 31,766,608(+) | C/T | SYNONYMOUS_VARIANT | |
VAR_036269 | A colorectal cancer sample | p.Thr464Asn |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4300n100 | CNV | gain | 25217958 |
esv3394936 | CNV | insertion | 20981092 |
esv3556995 | CNV | deletion | 23714750 |
esv3645656 | CNV | loss | 21293372 |
nsv3346 | CNV | insertion | 18451855 |
Disorder | Aliases | PubMed IDs |
---|---|---|
colorectal cancer |
|
|
capillary leak syndrome |
|
|
capillary disease |
|
|
hepatocellular carcinoma |
|
|
gastric cancer |
|
|